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Multi-omics analysis of human tendon adhesion reveals that ACKR1-regulated macrophage migration is involved in regeneration

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Bone Research 2024年第2期12卷 390-406页

作者： Xinshu Zhang Yao xiao Bo Hu Yanhao Li Shaoyang Zhang Jian Tian shuo Wang Zaijin Tao Xinqi Zeng Ning-Ning Liu Baojie Li Shen Liu Department of Orthopaedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine600 Yishan RdShanghai 200233PR China Section of Spine Surgery Department of OrthopaedicsChangzheng HospitalNaval Medical UniversityShanghai 200003PR China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200241PR China Department of Orthopaedics Wuxi Ninth People’s Hospital Affiliated to Soochow UniversityWuxi 214062PR China State Key Laboratory of Systems Medicine for Cancer Center for Single-Cell OmicsSchool of Public HealthShanghai Jiao Tong University School of MedicineShanghai 200025China

Tendon adhesion is a common complication after tendon injury with the development of accumulated fibrotic tissues without effective anti-fibrotic therapies,resulting in severe *** are widely recognized as a fibrotic trigger during peritendinous adhesion ***,different clusters of macrophages have various functions and receive multiple regulation,which are both still *** our current study,multi-omics analysis including single-cell RNA sequencing and proteomics was performed on both human and mouse tendon adhesion tissue at different stages after tendon *** transcriptomes of over 74000 human single cells were *** results,we found that SPP1^(+)macrophages,RGCC^(+)endothelial cells,ACKR1^(+)endothelial cells and ADAM12^(+)fibroblasts participated in tendon adhesion ***,despite specific fibrotic clusters in tendon adhesion,FOLR2^(+)macrophages were identified as an antifibrotic cluster by in vitro experiments using human ***,ACKR1 was verified to regulate FOLR2^(+)macrophages migration at the injured peritendinous site by transplantation of bone marrow from Lysm-Cre;R26R^(tdTomato) mice to lethally irradiated Ackr1^(-/-)mice(Ackr1^(-/-)chimeras;deficient in ACKR1)and control mice(WT chimeras).Compared with WT chimeras,the decline of FOLR2^(+)macrophages was also observed,indicating that ACKR1 was specifically involved in FOLR2^(+)macrophages *** together,our study not only characterized the fibrosis microenvironment landscape of tendon adhesion by multi-omics analysis,but also uncovered a novel antifibrotic cluster of macrophages and their *** results provide potential therapeutic targets against human tendon adhesion.

关键词： tendon analysis landscape

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Influence of modulated structure on magnetic properties of NdFeB/Co multilayer thin films

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Journal of Central South University 2015年第9期22卷 3282-3286页

作者：傅宇东王诗阳朱小硕方博闫峰 College of Materials Science and Chemical Engineering Harbin Engineering University

The Nd Fe B/Co multilayer films were prepared by magnetron sputtering. After that, the samples were annealed at 600 ℃ for 20 min. The surface morphology, phase structures and magnetic properties of Mo（50 nm）/[Nd Fe B（100 nm）/Co（y）]×10/Mo（50 nm） thin films were researched by AFM, XRD and VSM, respectively. The results show that the films show stronger perpendicular magnetic anisotropy. When the thickness of Co layers is 10 nm, the coercivity Hc⊥ is the maximum, 295 k A/m. However, for y=10-20, the reduced remanence M/Ms of films has increased. When the thickness of Co layers is 20-30 nm, the Nd Fe B/Co multilayer films obtained more superior magnetic properties with M/Ms =0.95.

关键词： Nd Fe B/Co film modulated structure perpendicular magnetic anisotropy coercivity reduced remanence

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Effects of antibacterial compounds produced by Saccharomyces cerevisiae in Koumiss on pathogenic Escherichia coli O8 and its cell surface characteristics

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Journal of Integrative Agriculture 2017年第3期16卷 742-748页

作者： CHEN Yu-jie WANG Chun-jie HOU Wen-qian WANG xiao-shuo GALI Bing-ga HUASAI Si-mu-jide YANG Si-qin WU A-qi-ma ZHAO Yu-fei WU Ying-ga CHEN Ao-ri-ge-le Vocational and Technical College Inner Mongolia Agricultural University Baotou 014109 P.R. China College of Animal Science Inner Mongolia Agricultural university Hohhot 010018 P.R. China College of Veterinary Medicine Inner Mongolia Agricultural University Hohhot 010018 P.R. China

The effects of antibacterial compounds produced by Saccharomyces cerevisiae in Koumiss on pathogenic Escherichia coli O8 and its cell surface characteristics were *** isolated from Koumiss produced antibacterial compounds which were active against pathogenic *** O8 as determined by the Oxford cup *** aqueous phases from *** at p H=2.0（S2）and pH=8.0（S8）were extracted and tested,*** organic acids of S2 and S8 were determined by high performance liquid chromatography（HPLC）,and the concentrations of killer toxins were determined by enhanced bicinchoninic acid（BCA）Protein Assay *** minimum inhibition concentration（MIC）and the minimum bactericidal concentration（MBC）of S2 and S8 on *** O8 were determined by the broth microdilution *** effects of S2 and S8 on the growth curve of *** O8 were determined by turbidimetry,and the hydrophobicities of *** O8 cell surface were determined using the microbial adhesion to solvents method,the permeation of *** O8 cell membrane were determined by the o-nitrophenyl-β-D-galactoside（ONPG）*** phases at pH 2.0 and 8.0had larger inhibition zones and then S2 and S8 were obtained by *** main component in S2 was citric acid and it was propanoic acid in *** organic acids and killer toxins were also *** the MICs of S2 and S8 on *** O8 were 0.025 g m L^-1,the MBCs were 0.100 and 0.200 g m L^-1,*** normal growth curve of *** O8was S-shaped,however,it changed after addition of S2 and *** O8 was the basic character,and had a relatively hydrophilic *** hydrophobicity of *** O8 cell surface and the permeation of *** O8 cell membrane were increased after adding S2 and *** present study showed that S2 and S8 inhibit the growth of pathogenic *** O8and influence its cell surface characteristics.

关键词： antibacterial compound Saccharomyces cerevisiae Escherichia coil hydrophobicity permeation

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基于极小曲面的高阶PDE图像去噪模型

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铁道学报 2009年第1期31卷 64-67页

作者：王钰魏学业肖硕北京交通大学电子信息工程学院北京100044

2000年Yu-Li和***将高阶偏微分方程思想应用到图像去噪处理过程,同时提出高阶偏微分方程去噪模型,其模型虽然保持了原低阶偏微分方程在图像去噪过程中的优点,但却具有两个缺点:对椒盐噪声没有任何的去除能力;在图像处理过程中容易造成... 详细信息

2000年Yu-Li和***将高阶偏微分方程思想应用到图像去噪处理过程,同时提出高阶偏微分方程去噪模型,其模型虽然保持了原低阶偏微分方程在图像去噪过程中的优点,但却具有两个缺点:对椒盐噪声没有任何的去除能力;在图像处理过程中容易造成原本平滑的区域出现不平整的现象。这就使其在图像去噪过程中很难得到良好的处理效果。作者借助于Yu-Li和***所提出的高阶偏微分方程的思想,提出一种基于微分几何学极小曲面定理的高阶偏微分方程去噪模型,此模型一方面保持了Yu-Li和***所提出的高阶偏微分方程去噪模型的优点,另一方面克服了Yu-Li和***模型的两个缺点,同时从理论分析与实验验证两个方面证明了本文模型具有良好的去噪效果。

关键词：图像去噪极小曲面偏微分方程噪声

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论法的形式正义与守法

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河北大学学报（哲学社会科学版） 2009年第4期34卷 42-45页

作者：王晓烁河北经贸大学法学院河北石家庄050061

法与正义有着紧密的联系,正义可以做不同的分类,其中形式正义是一种重要类型。我国选择了法治作为治理国家的方式,而法的形式正义是法治的首要标准和重要内容,在必要的情况下可以优先选择形式正义而牺牲实质正义。守法是法治实现的关键... 详细信息

法与正义有着紧密的联系,正义可以做不同的分类,其中形式正义是一种重要类型。我国选择了法治作为治理国家的方式,而法的形式正义是法治的首要标准和重要内容,在必要的情况下可以优先选择形式正义而牺牲实质正义。守法是法治实现的关键环节,由于我国目前法治建设处于初级阶段,因此首要的是尊重法的形式正义,承认法律规则的权威,积极守法。

关键词：形式正义实质正义法治守法

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论中国法官的个案法律解释权

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河北大学学报（哲学社会科学版） 2005年第5期30卷 81-85页

作者：王晓烁河北经贸大学法学院石家庄050061

虽然中国法律实践中默许法官享有个案法律解释权,但法律上并未赋予法官个案法律解释权,且主流观点不支持法官进行个案法律解释。借鉴其他国家经验并结合中国实际情况来看,中国有必要赋予法官个案法律解释权,但必须结合中国实际情况进行... 详细信息

虽然中国法律实践中默许法官享有个案法律解释权,但法律上并未赋予法官个案法律解释权,且主流观点不支持法官进行个案法律解释。借鉴其他国家经验并结合中国实际情况来看,中国有必要赋予法官个案法律解释权,但必须结合中国实际情况进行严格限制,使之在合法、合理的范围内行使。

关键词：个案法律解释个案法律解释权法律适用合法合理公正判案

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Sirolimus can promote the disappearance of renal angiomyolipoma associated with tuberous sclerosis complex:a prospective cohort study

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World Journal of Pediatrics 2024年第6期20卷 602-610页

作者： shuo Dun Yang-Yang Wang Lin Wan Qiu-Hong Wang Qian Lu xiao-Yan Yang Qi Zhang Hui-Min Chen Lu-Peng Qiu Li-Ping Zou Medical School of Chinese PLA Beijing 100853China Department of Pediatrics The First Medical CenterChinese PLA General HospitalBeijing 100853China Center of Epilepsy Beijing Institute for Brain DisordersBeijing 100069China

Background Renal angiomyolipoma(RAML)is the most common kidney lesion in patients with tuberous sclerosis complex(TSC),affecting about 80%of *** is a benign tumor that grows over time,usually bilaterally,and can easily lead to kidney complications such as acute ***,we investigated the efficacy and safety of sirolimus in children with TSC-associated RAML and explored the factors affecting tumor disappearance under sirolimus treatment through subgroup *** A prospective cohort study was *** was initiated at 1 mg/(m^(2)×day),and dose adjustments were made by a 2-week titration period to attain a trough blood concentration of 5-10 ng/*** disappearance of RAML in chil-dren after sirolimus treatment was observed,and Cox regression was used to screen the factors affecting tumor *** One hundred and twenty-six patients who met the criteria were *** 3 months,6 months,12 months,and 24 months of follow-up,tumors disappeared in 18(14.3%),30(23.8%),39(31.0%),and 42(33.3%)children,*** disappeared in 50(39.7%)children by the last visit of each individual,and 30(60%)of them occurred within 6 *** multivariate Cox regression analysis showed that patients with a smaller maximum tumor diameter at baseline had a higher tumor disappearance ***-six(29%)patients had stomatitis during the entire treatment period,and no serious *** Sirolimus could promote the disappearance of TSC-related *** disappearance rate was correlated with the maximum diameter at baseline,and the smaller the tumor was,the higher the disappearance *** is well tolerated in the treatment of RAML associated with TSC.

关键词： Angiomyolipoma mTOR inhibitor Sirolimus Tuberous sclerosis

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Chiral Pair Density Waves with Residual Fermi Arcs in RbV3Sb5

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Chinese Physics Letters 2024年第9期41卷 88-92页

作者： xiao-Yu Yan Hanbin Deng Tianyu Yang Guowei Liu Wei Song Hu Miao Zhijun Tu Hechang Lei shuo Wang Ben-Chuan Lin Hailang Qin Jia-Xin Yin Department of Physics Southern University of Science and TechnologyShenzhen 518055China Materials Science and Technology Division Oak Ridge National LaboratoryOak RidgeTennessee 37831USA Beijing Key Laboratory of Optoelectronic Functional Materials MicroNano Devices Department of PhysicsRenmin University of ChinaBeijing 100872China Key Laboratory of Quantum State Construction and Manipulation(Ministry of Education) Renmin University of ChinaBeijing 100872China Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Guangdong Provincial Key Laboratory of Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Quantum Science Center of Guangdong-Hong Kong-Macao Greater Bay Area Shenzhen 518055China

The chiral 2×2 charge order has been reported and confirmed in the kagome superconductor RbV3Sb5,while its interplay with superconductivity remains elusive owing to its lowest superconducting transition temperature Tc of about 0.85K in the AV3Sb5 family(A=K,Rb,Cs)that severely challenges electronic spectroscopic ***,utilizing dilution-refrigerator-based scanning tunneling microscopy down to 30 mK,we observe chiral 2×2 pair density waves with residual Fermi arcs in *** find a superconducting gap of 150eV with substantial residual in-gap *** spatial distribution of this gap exhibits chiral 2×2 modulations,signaling a chiral pair density wave(PDW).Our quasi-particle interference imaging of the zero-energy residual states further reveals arc-like *** discuss the relation of the gap modulations with the residual Fermi arcs under the space-momentum correspondence between PDW and Bogoliubov Fermi states.

关键词： Fermi chiral utilizing

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Clinical practice guideline for acupuncture and moxibustion:Allergic rhinitis

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Journal of Integrative Medicine 2024年第3期22卷 245-257页

作者： Shi-hao Du Sheng Chen Shan-ze Wang Guan-qun Wang shuo Du Wei Guo xiao-long Xie Bi-hui Peng Chao Yang Ji-ping Zhao Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Department of Acupuncture and Moxibustion Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Traditional Chinese Medicine Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Acupuncture is one of the most effective complementary therapies for allergic rhinitis(AR)and has been recommended by several clinical practice guidelines(CPGs)for ***,these CPGs mentioned acupuncture without making recommendations for clinical implementation and therapeutic protocols,therefore limiting the applicability of acupuncture therapies for ***,for the benefit of acupuncture practitioners around the world,the World Federation of Acupuncture-moxibustion Societies have initiated a project to develop the CPG for the use of acupuncture and moxibustion to treat *** CPG was developed according to the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)methodology,referring to the principles of the World Health Organization Handbook for Guideline *** the development of the CPG,the guideline development group(GDG)played an important *** clinical questions,recommendations and therapeutic protocols were all formulated by the GDG using the modified Delphi *** CPG contains recommendations for 15 clinical questions about the use of acupuncture and moxibustion *** include one strong recommendation for the intervention based on high-quality evidence,three conditional recommendations for either the intervention or standard care,and 11 conditional recommendations for the intervention based on very low quality of *** CPG also provides one filiform needle acupuncture protocol and five moxibustion protocols extracted based on the protocols presented in randomized controlled trials reviewed by the GDG.

关键词： Clinical practice guideline Allergic rhinitis Acupuncture Moxibustion GRADE

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Effects of Nitrogen Application Rate and Seeding Density on Plant Growth and Seed Yield of Direct-seeding Rape

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Agricultural Biotechnology 2018年第4期7卷 153-156页

作者： Tengfang LAN Youyuan WANG Mingxiang ZHU Lu XIONG Yin HAN shuo xiao Tianmen Agricultural Product Quality and Safety Administration Tianmen 431700China Tianmen Academy of Agricultural Sciences Tianmen 431700China

[Objectives] This study was conducted to explore the effects of different N application rates and densities on the growth and development of direct-seeding rape as well as on its yield.[Methods] A field experiment was carried out by setting five N fertilizer treatments and three density levels.[Results] Increasing seeding density and N application rate could improve the seed yield of rape. The suitable N application rate for the three densities were calculated using the fitted fertilizer efficiency models, respectively, to be 186.77, 221.35 and 236.14 kg/hm^2, at which the yields were the highest. The results showed that in this area, the seeding density of direct-seeding rape could be selected in the range of 6.0×10^5-7.5×10^5 plants/hm^2, and the suitable N application rate could be in the range of 221.35-236.14 kg/hm^2.[Conclusions] This study provides a theoretical basis for the maximization of spatial resource and efficient utilization of fertilizer.

关键词： N application rate Seeding density Direct-seeding rape Fertilizer response model

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