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Attenuated retinoic acid signaling is among the early responses in mouse uterus approaching embryo attachment

生殖与发育医学(英文) 2024年第1期08卷 61-65页

作者： Diao Honglu xiao shuo Zhou Tong Martin Taylor E. Watford Wendy T. Ye xiaoqin Department of Infectious Diseases Department of Physiology and Pharmacology College of Veterinary Medicine 3. University of Georgia 4. Athens 5. GA 30602 6. USA Department of Physiology and Cell Biology University of Nevada 9. Reno School of Medicine 10. Reno 11. NV 89557

The uterus is transiently receptive for embryo implantation. It remains to be understood why the uterus does not reject a semi-allogeneic embryo (to the biological mother) or an allogeneic embryo (to a surrogate) for implantation. To gain insights, we examined uterine early response genes approaching embryo attachment on day 3 post coitum (D3) at 22 hours when blue dye reaction, an indication of embryo attachment, had not manifested in mice. C57BL/6 pseudo-pregnant (control) and pregnant mouse uteri were collected on D3 at 22 hours for microarray analysis. The self-assembling-manifold (SAM) algorithm identified 21,858 unique probesets. Principal component analysis indicated a clear separation between the pseudo-pregnant and pregnant groups. There were 106 upregulated and five downregulated protein-coding genes in the pregnant uterus with fold change (fc) >1.5 andq value <5%. Gene ontology (GO) analysis of the 106 upregulated genes revealed 38 significant GO biological process (GOBP) terms (P <0.05), and 32 (84%) of them were associated with immune responses, with a dominant natural killer (NK) cell activation signature. Among the top eight upregulated protein-coding genes,Cyp26a1 inactivates retinoic acid (RA) whileLrat promotes vitamin A storage, both of which are expected to attenuate RA bioavailability;Atp6v0d2 andGjb2 play roles in ion transport and transmembrane transport;Gzmb,Gzmc, andIl2rb are involved in immune responses; andTdo2 is important for kynurenine pathway. Most of these genes or their related pathways have functions in immune regulations. RA signaling has been implicated in immune tolerance and immune homeostasis, and uterine NK cells have been implicated in immunotolerance at the maternal-fetal interface in the placenta. The mechanisms of immune responses approaching embryo attachment remain to be elucidated. The coordinated effects of the early response genes may hold the keys to the question of why the uterus does not reject an implanting embryo

关键词： Embryo attachment Pseudo-pregnant uterus Pregnant uterus Natural killer cell activation signature Retinoic acid bioavailability Transmembrane transport and ion transport

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Applying Hybrid Clustering in Pulsar Candidate Sifting with Multi-modality for FAST Survey

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Research in Astronomy and Astrophysics 2024年第3期24卷 283-296页

作者： Zi-Yi You Yun-Rong Pan Zhi Ma Li Zhang shuo xiao Dan-Dan Zhang Shi-Jun Dang Ru-Shuang Zhao Pei Wang Ai-Jun Dong Jia-Tao Jiang Ji-Bing Leng Wei-An Li Si-Yao Li School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550025China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550025China College of Big Data and Information Engineering Guizhou UniversityGuiyang 550025China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Key Laboratory of Information and Computing Guizhou Province Guizhou Normal UniversityGuiyang 550001China School of Big data and Computer Science Guizhou Normal UniversityGuiyang 550025China Guizhou Software Engineering Research Center Guiyang 550000China

Pulsar search is always the basis of pulsar navigation,gravitational wave detection and other research ***,the volume of pulsar candidates collected by the Five-hundred-meter Aperture Spherical radio Telescope(FAST)shows an explosive growth rate that has brought challenges for its pulsar candidate filtering ***,the multi-view heterogeneous data and class imbalance between true pulsars and non-pulsar candidates have negative effects on traditional single-modal supervised classification *** this study,a multi-modal and semi-supervised learning based on a pulsar candidate sifting algorithm is presented,which adopts a hybrid ensemble clustering scheme of density-based and partition-based methods combined with a feature-level fusion strategy for input data and a data partition strategy for *** on both High Time Resolution Universe SurveyⅡ(HTRU2)and actual FAST observation data demonstrate that the proposed algorithm could excellently identify pulsars:On HTRU2,the precision and recall rates of its parallel mode reach0.981 and 0.988 *** FAST data,those of its parallel mode reach 0.891 and 0.961,meanwhile,the running time also significantly decreases with the increment of parallel nodes within ***,we can conclude that our algorithm could be a feasible idea for large scale pulsar candidate sifting for FAST drift scan observation.

关键词： methods data analysis-surveys-methods numerical

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Time-resolved Spectral Properties of Fermi-GBM Bright Long Gamma-Ray Bursts

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Research in Astronomy and Astrophysics 2024年第2期24卷 58-73页

作者： Wan-Kai Wang Wei Xie Zhi-Fu Gao shuo xiao Ai-Jun Dong Bin Zhang Qi-Jun Zhi Department of Astronomy School of Physics and Electronic ScienceGuizhou Normal UniversityGuiyang 550001China Guizhou Provincial Key Laboratory of Radio Astronomy Data Processing Guizhou Normal UniversityGuiyang 550001China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China

The prompt emission mechanism of gamma-ray bursts(GRBs)is still unclear,and the time-resolved spectral analysis of GRBs is a powerful tool for studying their underlying physical *** performed a detailed time-resolved spectral analysis of 78 bright long GRB samples detected by Fermi/Gamma-ray Burst Monitor.A total of 1490 spectra were obtained and their properties were studied using a typical Band-shape ***,the parameter distributions of the time-resolved spectrum are given as follows:the low-energy spectral indexα~-0.72,high-energy spectral indexβ~2.42,the peak energy E_(p)~221.69 keV,and the energy flux F~7.49×10^(-6)erg cm^(-2)s^(-1).More than 80%of the bursts exhibit the hardest low-energy spectral indexα_(max),exceeding the synchrotron limit(-2/3).Second,the evolution patterns of a and E_(p)were statistically *** results show that for multi-pulse GRBs the intensity-tracking pattern is more common than the hard-to-soft pattern in the evolution of both E_(p)andα.The hard-to-soft pattern is generally shown in single-pulse GRBs or in the initial pulse of multi-pulse ***,we found a significant positive correlation between F and E_(p),with half of the samples exhibiting a positive correlation between F andα.We discussed the spectral evolution of different radiation *** diversity of spectral evolution patterns indicates that there may be more than one radiation mechanism occurring in the GRB radiation process,including photo spheric radiation and synchrotron ***,it may also involve only one radiation mechanism,but more complicated physical details need to be considered.

关键词： (stars:)gamma-ray burst general-methods statistical-methods data analysis

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基于迁移学习和参数优化的干扰效能评估方法

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电子与信息学报 2024年第6期46卷 2515-2524页

作者：孙志国肖硕吴毅杰李诗铭王震铎哈尔滨工程大学通信与信息工程学院哈尔滨150001 上海航天电子技术研究所上海201109

针对数字通信系统中传统误码率评估导致干扰效能评估结果单一的问题,该文提出了一种基于迁移学习和参数优化的干扰效能评估方法。该方法选取各信号处理模块的核心参数作为机器学习的训练指标,并以优劣解距离的评估结果作为分类标准,采... 详细信息

针对数字通信系统中传统误码率评估导致干扰效能评估结果单一的问题,该文提出了一种基于迁移学习和参数优化的干扰效能评估方法。该方法选取各信号处理模块的核心参数作为机器学习的训练指标,并以优劣解距离的评估结果作为分类标准,采用支持向量机训练评估模型。通过改进蚁群算法的全局搜索能力和迁移学习的知识传递特性分别解决了支持向量机中的参数优化问题和训练样本中的数据缺失问题。仿真实验结果表明,掌握源域数据集的支持向量机在模型准确度方面提升4.2%,牺牲初始收敛能力的参数优化与最优解的靠近程度提升4.7%,并且可以应用于数字通信系统的干扰效能评估。

关键词：干扰效能评估数字通信支持向量机蚁群优化迁移学习

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产业协同集聚与城镇化发展:效应与机制

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技术经济与管理研究 2024年第5期 90-96页

作者：王晓硕吕延方沈阳航空航天大学理学院辽宁沈阳110136 华侨大学统计学院、数量经济研究院福建厦门361021

城镇化作为内需的最大潜力,是高质量发展阶段“双循环”政策的重要内涵之一。基于高技术产业与生产性服务业协同集聚视角,选取2010—2021年30个省级面板数据,从基础、异质性、调节作用角度实证分析对城镇化的影响,并结合“以国内大循环... 详细信息

城镇化作为内需的最大潜力,是高质量发展阶段“双循环”政策的重要内涵之一。基于高技术产业与生产性服务业协同集聚视角,选取2010—2021年30个省级面板数据,从基础、异质性、调节作用角度实证分析对城镇化的影响,并结合“以国内大循环为主”的新发展格局背景和外部性理论,使用门槛和空间杜宾模型对作用机制进行检验。研究发现:协同集聚助力城镇化,且存在异质性影响;政府干预抑制协同集聚的提升作用;本土规模市场效应增强协同集聚效应;MAR&Jacobs外部性的空间溢出是协同集聚促进城镇化的主要作用机制。

关键词：高技术产业生产性服务业协同集聚城镇化外部性

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Observation of spectral lines in the exceptional GRB 221009A

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 187-206页

作者： Yan-Qiu Zhang Shao-Lin Xiong Ji-Rong Mao Shuang-Nan Zhang Wang-Chen Xue Chao Zheng Jia-Cong Liu Zhen Zhang Xi-Lu Wang Ming-Yu Ge Shu-Xu Yi Li-Ming Song Zheng-Hua An Ce Cai Xin-Qiao Li Wen-Xi Peng Wen-Jun Tan Chen-Wei Wang Xiang-Yang Wen Yue Wang shuo xiao Fan Zhang Peng Zhang Shi-Jie Zheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Yunnan Observatories Chinese Academy of SciencesKunming 650011China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100012China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang 050024China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China College of Electronic and Information Engineering Tongji UniversityShanghai 201804China

As the brightest gamma-ray burst ever observed,GRB 221009A provided a precious opportunity to explore spectral line *** this article,we performed a comprehensive spectroscopy analysis of GRB 221009A jointly with GECAM-C and Fermi/GBM data to search for emission and absorption *** the first time we investigated the line feature throughout this GRB including the most bright part where many instruments suffered problems,and identified prominent emission lines in multiple time *** central energy of the Gaussian emission line evolves from about 37 to 6 MeV,with a nearly constant ratio(about 10%)between the line width and central ***,we find that both the central energy and the energy flux of the emission line evolve with time as a power law decay with power law index of–1 and–2,*** suggest that the observed emission lines most likely origin from the blue-shifted electron positron pair annihilation 511 ke V *** find that a standard high latitude emission scenario cannot fully interpret the observation,thus we propose that the emission line comes from some dense clumps with electron positron pairs traveling together with the *** this scenario,we can use the emission line to directly,for the first time,measure the bulk Lorentz factor of the jet(Γ)and reveal its time evolution(i.e.,Γ~t^(-1))during the prompt ***,we find that the flux of the annihilation line in the co-moving frame keeps *** discoveries of the spectral line features shed new and important lights on the physics of GRB and relativistic jet.

关键词： GRB GRB 221009A emission line

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废旧电池回收过程中磷酸铁渣的提纯

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矿冶工程 2024年第2期44卷 78-82,87页

作者：刘晓峰黄自力肖骁肖硕黄涛郑洁淼吴纪龙武汉科技大学资源与环境工程学院湖北武汉430081 湖南顺华新能源科技有限公司湖南长沙410012

为实现磷酸铁渣高附加值资源回收利用,采用盐酸浸出渣中铁、铁粉置换除铜、水解-化学沉淀法去除浸出液中钛、铝。结果表明,盐酸浓度25%、液固比6 mL/g、浸出温度60℃、浸出时间60 min时,磷酸铁渣中铁浸出率达98.7%;控制溶液初始pH=0.6,... 详细信息

为实现磷酸铁渣高附加值资源回收利用,采用盐酸浸出渣中铁、铁粉置换除铜、水解-化学沉淀法去除浸出液中钛、铝。结果表明,盐酸浓度25%、液固比6 mL/g、浸出温度60℃、浸出时间60 min时,磷酸铁渣中铁浸出率达98.7%;控制溶液初始pH=0.6,铁粉添加量为浸出液中铁物质的量0.55倍、反应温度60℃、反应时间35 min时,铜去除率达96.2%,钛去除率达83.6%;水解-化学沉淀法除钛、铝的过程中,氟化钠与铝物质的量比8∶1、反应pH=1.9、反应温度40℃、反应时间30 min时,钛去除率达97.6%,铝去除率达99.3%,浸出液中杂质元素含量满足后续电池级磷酸铁的制备要求。

关键词：废旧电池回收磷酸铁锂磷酸铁盐酸浸出置换除铜水解除钛化学沉淀法除铝提纯

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铁尾矿酸浸液制备聚氯化铁的试验研究

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无机盐工业 2024年第2期56卷 121-126页

作者：黄涛黄自力肖硕郑洁淼刘晓峰吴纪龙武汉科技大学资源与环境工程学院冶金矿产资源高效利用与造块湖北省重点试验室湖北武汉430081

为探索某选矿厂铁尾矿回收利用的新途径,对铁尾矿酸浸液制备聚氯化铁的试验过程进行了研究,并将自制的聚氯化铁应用到高岭土悬浊液的混凝试验中测试产品的絮凝性能。结果表明:聚合的适宜条件为温度为40℃、pH为1.0、聚合时间为3h,在该... 详细信息

为探索某选矿厂铁尾矿回收利用的新途径,对铁尾矿酸浸液制备聚氯化铁的试验过程进行了研究,并将自制的聚氯化铁应用到高岭土悬浊液的混凝试验中测试产品的絮凝性能。结果表明:聚合的适宜条件为温度为40℃、pH为1.0、聚合时间为3h,在该条件下合成的聚氯化铁盐基度为20.91%,符合相关标准,影响聚合过程因素的主次顺序依次为聚合温度、pH、聚合时间;混凝的适宜条件为聚氯化铁投加量为250 mg/L、pH为7.0、搅拌时间为3min、温度为20℃、混凝时间为60min,在该条件下浊度去除率为95.54%,产品除浊效果良好。

关键词：聚氯化铁铁尾矿酸浸液聚合混凝

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合模线飞边在线测量与机器人智能磨抛加工技术

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制造业自动化 2024年第2期46卷 129-135页

作者：杨平杨冰雅肖硕男厦门大学航空航天学院厦门361102

传统合模线飞边的打磨方式多为人工打磨,不仅效率低,产品一致性也难以保证。为了进一步提升加工效率及稳定性,利用线激光测量与六轴工业机器人开展智能磨抛加工技术研究。首先,采用基于标准球的手眼标定方法进行线激光测量坐标系与机器... 详细信息

传统合模线飞边的打磨方式多为人工打磨,不仅效率低,产品一致性也难以保证。为了进一步提升加工效率及稳定性,利用线激光测量与六轴工业机器人开展智能磨抛加工技术研究。首先,采用基于标准球的手眼标定方法进行线激光测量坐标系与机器人加工坐标系坐标转换研究,对工作区进行分区域标定,以降低大负载机器人在不同工作区域性能指标的不同对标定结果的影响;其次,对线激光器采集的工件点云数据进行分析处理,采用距离法提取特征点,并利用三次B样条曲线拟合和基于最小二乘的曲面拟合方法求解机器人的姿态,将得到的机器人位姿与手眼标定结果相结合,实现对机器人的加工引导;最后,基于上述加工数据信息开展机器人智能识别定位与打磨加工试验测试。实验结果表明,经一次打磨后去除的材料体积约为543mm^(3),材料去除率约为5.8mm^(3)/s,并且,提取出的点云轮廓曲线粗糙度的平均值由打磨前的0.609减少为0.097,减少率约为84.1%。

关键词：工业机器人线激光测量仪手眼标定加工位姿打磨加工

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Tumor budding in gastric cancer

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World Journal of Gastrointestinal Surgery 2023年第4期15卷 578-591页

作者： shuo-Meng xiao Jian Li Department of Gastric Surgery Sichuan Cancer HospitalChengdu 610041Sichuan ProvinceChina Department of General Surgery The Third Hospital of MianyangSichuan Mental Health CenterMianyang 621000Sichuan ProvinceChina

The tumor,nodes,metastasis(TNM)staging system has long been the gold standard for the classification and prognosis of solid ***,the TNM staging system is not without *** heterogeneity exists within patients at the same ***,the pursuit of other biomarkers with the potential to classify patients with cancer has never *** of them,tumor budding(TB),has gained much success in colorectal *** recent years,TB in gastric cancer has attracted much attention from researchers,beginning to reveal the molecular and biological aspects of this phenomenon in gastric cancer,and has emerged as a promising prognostic biomarker in gastric cancer,predicting disease progression and unfavorable ***,it is time and essential to provide a holistic overview of TB in gastric cancer,which has not been achieved and is the aim of this review.

关键词： Tumor budding Gastric cancer Poorly differentiated cluster Prognosis Lymph node metastasis

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