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Imaging biomarkers for the treatment of esophageal cancer

World Journal of Gastroenterology 2019年第24期25卷 3021-3029页

作者： Koichi Hayano Gaku Ohira Atsushi Hirata Tomoyoshi Aoyagi shunsuke imanishi Toru Tochigi Toshiharu Hanaoka Kiyohiko Shuto Hisahiro Matsubara Department of Frontier Surgery Chiba University Graduate School of MedicineChiba 260-8677Japan Department of Surgery Teikyo University Medical CenterChiba 299-0111Japan

Esophageal cancer is known as one of the malignant cancers with poor *** improve the outcome,combined multimodality treatment is *** the other hand,advances in genomics and other“omic”technologies are paving way to the patient-oriented treatment called“personalized”or“precision”*** advancements of imaging techniques such as functional imaging make it possible to use imaging features as biomarker for diagnosis,treatment response,and prognosis in cancer *** this review,we will discuss how we can use imaging derived tumor features as biomarker for the treatment of esophageal cancer.

关键词： Esophageal cancer Computed tomography perfusion Dynamic-contrastenhanced magnetic resonance imaging Texture analysis Diffusion-weighted imaging Positron emission tomography

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Utility of arterial phase of dynamic CT for detection of intestinal ischemia associated with strangulation ileus

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World Journal of Radiology 2012年第11期4卷 450-454页

作者： Gaku Ohira Kiyohiko Shuto Tsuguaki Kono Takayuki Tohma Hisashi Gunji Kazuo Narushima shunsuke imanishi Takeshi Fujishiro Tohru Tochigi Toshiharu Hanaoka Hideaki Miyauchi Naoyuki Hanari Hisahiro Matsubara Noriyuki Yanagawa Department of Frontier Surgery Chiba University Graduate School of Medicine 1-8-1InohanaChu-ou-kuChiba 260-8670Japan

AIM: To clarify the usefulness of arterial phase scans in contrast computed tomography (CT) imaging of strangulation ileus in order to make an early diagnosis. METHODS: A comparative examination was carried out with respect to the CT value of the intestinal tract wall in each scanning phase, the CT value of the content in the intestinal tract, and the CT value of ascites fluid in the portal vein phase for a group in which ischemia was observed (Group I) and a group in which ischemia was not observed (Group N) based on the pathological findings or intra-surgical findings. Moreover, a comparative examination was carried out in Group I subjects for each scanning phase with respect to average differences in the CT values of the intestinal tract wall where ischemia was suspected and in the intestinal tract wall in non-ischemic areas. RESULTS: There were 15 subjects in Group I and 30 subjects in Group N. The CT value of the intestinal tract wall was 41.8 ± 11.2 Hounsfield Unit (HU) in Group I and 69.6 ± 18.4 HU in Group N in the arterial phase, with the CT value of the ischemic bowel wall being significantly lower in Group I. In the portal vein phase, the CT value of the ischemic bowel wall was 60.6 ± 14.6 HU in Group I and 80.7 ± 17.7 HU in Group N, with the CT value of the ischemic bowel wall being significantly lower in Group I; however, no significant differences were observed in the equilibrium phase. The CT value of the solution in the intestine was 18.6 ± 9.5 HU in Group I and 10.4 ± 5.1 HU in Group N, being significantly higher in Group I. No significant differences were observed in the CT value of the accumulation of ascites fluid. The average difference in the CT values between the ischemic bowel wall and the non-ischemic bowel wall for each subject in Group I was 33.7 ± 20.1 HU in the arterial phase, being significantly larger compared to the other two phases. CONCLUSION: This is a retrospective study using a small number of subjects; however, it suggests that

关键词： Arterial phase Strangulation ileus Small bowel obstruction Computed tomography Retrospective study

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