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Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of the MALT1 gene

World Journal of Gastroenterology 2017年第33期23卷 6155-6163页

作者： Masaya Iwamuro Ryuta Takenaka Masahiro Nakagawa Yuki Moritou shunsuke saito Shinichiro Hori Tomoki Inaba Yoshinari Kawai Tatsuya Toyokawa Takehiro Tanaka Tadashi Yoshino Hiroyuki Okada Department of Gastroen-terology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical Sciences Department of Internal Medicine Tsuyama Chuo Hospital Department of Internal Medicine Hiroshima City Hospital Department of Gastroenterology Mitoyo General Hospital Department of Internal Medicine Okayama Saiseikai General Hospital Department of Gastroenterology Shikoku Cancer Center Department of Gastroenterology Kagawa Prefectural Central Hospital Department of Gastroenterology Onomichi Municipal Hospital Department of Gastroenterology Fukuyama Medical Center Department of Pathology Okayama University Hospital Department of Pathology Okayama University Graduate School of MedicineDentistryand Pharmaceutical Sciences

AIM To identify the clinical features of gastric mucosaassociated lymphoid tissue(MALT) lymphoma with extra copies of *** This is a multi-centered,retrospective study. We reviewed 146 patients with MALT lymphoma in the stomach who underwent fluorescence in situ hybridization analysis for t(11;18) translocation. Patients were subdivided into patients without t(11;18) translocation or extra copies of MALT1(Group A,n = 88),patients with t(11;18) translocation(Group B,n = 27),and patients with extra copies of MALT1(Group C,n = 31). The clinical background,treatment,and outcomes of each group were *** Groups A and C showed slight female predominance,whereas Group B showed slight male predominance. Mean ages and clinical stages at lymphoma diagnosis were not different between groups. Complete response was obtained in 61 patients in Group A(69.3%),22 in Group B(81.5%),and 21 in Group C(67.7%). Helicobacter pylori(H. pylori) eradication alone resulted in complete remission in 44 patients in Group A and 13 in Group C. In Group B,14 patients underwent radiotherapy alone,which resulted in lymphoma disappearance. Although the difference was not statistically significant,event-free survival in Group C tended to be inferior to that in Group A(P = 0.10).CONCLUSION Patients with t(11;18) translocation should be treated differently from others. Patients with extra copies of MALT1 could be initially treated with H. pylori eradication,similar to patients without t(11;18) translocation or extra copies of MALT1.

关键词： Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue Gastric neoplasms Esophagogastroduodenoscopy t(11 18) translocation Trisomy 18

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Field-deployable rapid multiple biosensing system for detection of chemical and biological warfare agents

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Microsystems & Nanoengineering 2018年第1期4卷 498-508页

作者： Masato saito Natsuko Uchida shunsuke Furutani Mizuho Murahashi Wilfred Espulgar Naoki Nagatani Hidenori Nagai Yuki Inoue Tomohiko Ikeuchi Satoshi Kondo Hirotaka Uzawa Yasuo Seto Eiichi Tamiya Department of Applied Physics Graduate School of EngineeringOsaka University2-1YamadaokaSuitaOsaka 565-0871Japan Advanced Photonics and Biosensing Open Innovation Laboratory(PhotoBIO-OIL) National Institute of Advanced Industrial Science and Technology(AIST)Photonics Center Osaka University P3 Bldg2-1 Yamada-OkaSuitaOsaka 565-0871Japan Nanomaterials Research Institute National Institute of Advanced Industrial Science and Technology(AIST)1-1-1 HigashiTsukuba 305-8565Japan Health Research Institute National Institute of Advanced Industrial Science and Technology(AIST)1-8-31 MidorigaokaIkedaOsaka 563-8577Japan Department of Applied Chemistry Graduate School of EngineeringOkayama University of Science1-1Ridai-choKita-kuOkayama-shi 700-0005Japan National Research Institute of Police Science 6-3-1 KashiwanohaKashiwaChiba 277-0882Japan

The threat of biological and chemical terror acts remains a growing worldwide *** is therefore a need to develop appropriate technology for the detection of chemical and biological warfare agents,with early identification intended for use by first ***,we disclose the developed autonomous air sampling and detection system for evaluation of the presence of chemical and biological warfare agents that can be harmful to the *** current device utilizes the designed mist generator-assisted air collection system(338 l min^(−1))and biosensing chip technologies,such as electrochemical measurement,Au nanoparticle-based localized surface plasmon resonance,and rapid microfluidic chip PCR for detection of minute concentrations lower than the mean lethal dose(LD_(50))of nerve gases(sarin and VX),toxic proteins(BTX/A/Hc and ricin),and pathogens(anthrax simulant).An operation time of only 5–15 min is needed for the collection and detection;sample preparation is already integrated into the system without the need for direct human *** addition to the system’s sensitivity and ease of use,its portability makes it highly beneficial for first responders,which could aid in immediate risk assessment and mitigation of on-site events.

关键词： biological and chemical agents biosensing electrochemical detection LSPR PCR rapid detection

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Numerical Investigation for the Effect of Unsaturated Aliphatic Hydrocarbons Addition on Precursors on Carbon Black

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Journal of Chemistry and Chemical Engineering 2012年第10期6卷 936-941页

作者： Kiminori Ono shunsuke Takeya Yasuhiro saito Hideyuki Aoki Okiteru Fukuda Takayuki Aoki TogoYamaguchi Department of Chemical Engineering Graduate School of Engineering Tohoku University Miyagi 980-8579 Japan ASAHI CARBON CO. LTD. Niigata 950-0883 Japan

To investigate the effect of unsaturated aliphatic hydrocarbons on PAHs （polycyclic aromatic hydrocarbons） formation, numerical analysis using detailed reaction mechanism is performed. For the carbon black produced by benzene feedstock, three kinds of unsaturated aliphatic hydrocarbons （acetylene, diacetylene, and vinylacetylene） are added. The detailed reaction mechanism which is proposed by Wang and Frenklach is consisted by 527 reactions and 99 chemical species. The formations of PAHs and nuclei are promoted by unsaturated aliphatic hydrocarbons addition. There exits optimal benzene/acetylene ratio （XA/XB = 0.50）, benzene/diacetylene mixture ratio （XD/XB = 0.60）, benzene/vinyl-acetylene mixture ratio （XV/XB = 0.25）. The formation of nuclei is most promoted by acetylene addition, and the benzene/acetylene mixture ratio is 0.50.

关键词： Carbon black soot unsaturated hydrocarbon.

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