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TGF-β-regulated different iron metabolism processes in the development and cisplatin resistance of ovarian cancer

Oncology Research 2024年第2期32卷 373-391页

作者： JIANFA WU QIANYI LIAO LI zhang SUQIN WU ZHOU LIU Department of Gynecology Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghaiChina Department of Gynecology Shanghai University of Medicine&Health SciencesShanghaiChina Department of Gynecology Gongshan People’s HospitalNujiang Lisu Autonomous PrefectureChina

The impact of different iron metabolism processes(DIMP)on ovarian cancer remains *** this study,we employed various gene chips and databases to investigate the role of DIMP in the initiation and development of ovarian *** was used to determine mutations in DIMP-associated genes in ovarian ***-Meier plotter was used to examine the influence of DIMP on the prognosis of ovarian *** analyzing 1669 serous ovarian cancer cases,we identified a range of mutations in iron metabolism genes,notably in those coding for the transferrin receptor(19%),melanotransferrin(19%),and ceruloplasmin(10%)in the iron import process,and glucose-6-phosphate isomerase(9%),hepcidin antimicrobial peptide(9%),metal regulatory transcription factor 1(8%),and bone morphogenetic protein 6(8%)in the iron regulation *** to the unaltered group,the group with gene alterations exhibited a higher tumor mutation burden count(43 vs.54)and more advanced histologic grade(78.19%vs.87.90%).Compared to the normal ovarian counterparts,a reduction in expression was observed in 9 out of the 14 genes involved in iron utilization and 4 out of the 5 genes involved in iron export in ovarian cancer;in contrast,an increase in expression was observed in 2 out of the 3 genes involved in iron storage in ovarian ***,in cisplatin-resistant cells compared to cisplatin-sensitive ones,the expression of all genes in iron storage and 13 out of 14 genes in iron import was decreased,while that of 8 out of the 10 genes in iron utilization was *** addition,survival curve analysis indicated that a higher expression in the majority of genes in the iron import process(12/21),or a reduced expression in most genes in the iron export process(4/5)correlated with poor progression-free ***,TGF-βcould regulate the expression of most iron metabolism-associated genes;particularly,expression of genes involved in the iron storage process(2/2)was inhibited aft

关键词： Chemoresistance Cisplatin Iron Ovarian neoplasms TGF-β

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Construction and performance test of charged particle detector array for MATE

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Nuclear Science and Techniques 2024年第8期35卷 92-100页

作者： Xiao‑Bin Li Long‑Hui Ru Zhi‑Chao zhang Bing‑Feng Lv Ning‑Tao zhang Jin‑Long zhang Chen‑Gui Lu Bing‑Shui Gao Jun‑Bing Ma Fu‑Shuai Shi Satoru Terashima Xiao‑Dong Xu Zhen Bai Shi‑Wei Xu Yan‑Yun Yang Hooi‑Jin Ong Xiao‑Dong Tang Institute of Modern Physics(IMP) Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Research Center for Nuclear Physics Osaka UniversityIbarakiOsaka 567‑0047Japan RIKEN Nishina Center WakoSaitama 351‑0198Japan Joint Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China

A charged particle array named MATE-PA,which serves as an auxiliary detector system for a Multi-purpose Active-target Time projection chamber used in nuclear astrophysical and exotic beam Experiments(MATE),was *** array comprised of 20 single-sided strip-silicon detectors covering approximately 10%of the solid *** detectors facilitated the detection of reaction-induced charged particles that penetrate the active volume of the *** performance of MATE-PA has been experimentally studied using an alpha source and a 36-MeV 14 N beam injected into the MATE chamber on the radioactive ion beam line in Lanzhou(RIBLL).The chamber was filled with a gas mixture of 95%4 He and 5%CO_(2) at a pressure of 500 *** results indicated good separation of light-charged particles using the forward double-layer silicon detectors of *** energy resolution of the Si detectors was deduced to be approximately 1%(σ)for an energy loss of approximately 10 MeV caused by theα*** inclusion of MATE-PA improves particle identification and increases the dynamic range of the kinetic energy of charged particles,particularly that of theαparticles,up to approximately 15 MeV.

关键词： Silicon detector array Active target Time projection chamber

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Syringa pubescens Turcz ethyl acetate extract improves non-alcoholic steatohepatitis by regulating the Nrf2， IκBα and TGF-β1 signaling pathways

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Food Science and Human Wellness 2024年

作者： Weidong Xu Yanfang Wu Jiameng zhang Zichen zhang Xinyi Guan Suya zhang Xinsheng Wang Pu Liu Enguo Fan College of Chemistry and Chemical Engineering， Henan University of Science and Technology College of Basic Medical and Forensic Medicine， Henan University of Science and Technology Department of Microbiology and Parasitology， Institute of Basic Medical Sciences， Chinese Academy of Medical Sciences/School of Basic Medicine， Peking Union Medical College

The flower of Syringa pubescens Turcz. （SP）， was used as both medicine and food in China， exhibited a variety of biological activities. However， it remains unknown whether SP has an effect on ameliorative nonalcoholic fatty liver disease （NASH）. In this study， the improvement of SP ethyl acetate extract （SPE） on NASH was evaluated and the potential mechanisms were explored. The glycosides of SPE were determined by an HPLC method. HepG2 cell lines were treated with free fatty acid to clarify the improvement effect and mechanisms of SPE on NASH in vitro. C57BL/6J mice were treated by 60 kcal% high-fat diet （HFD） combined with carbon tetrachloride (CCl4) to establish the NASH model in vivo. The results showed SPE could inhibited the hepatic injury and lipid steatosis by decreasing the levels of ALT， AST， TG and TC in vitro and vivo. The SPE suppressed the oxidative stress and inflammation by restraining the generation of ROS， MDA， IL-1β， IL-6 and TNF-α and enhancing the activity of antioxidant enzymes including SOD， CAT and GSH-Px in NASH model. Moreover， SPE declined the level of fibrosis markers including HYP， Col Ⅰ and α-SMA in HFD combined CCl4（HC）-induced mice. Mechanically， SPE inhibited hepatocellular Keap1 expression and promoted Nrf2 nuclear translocation， which suppressing the phosphorylation of IκBα/NF-κB. In addition， SPE down-regulated the level of TGF-β1 and phosphorylation of Smad2 to mitigate fibrosis. In brief， SPE could significantly alleviate lipid accumulation， oxidative stress， inflammation and fibrosis via regulating Nrf2/HO-1， IκBα/NFκB and TGF-β1/Smad2 pathways in the progression of NASH， which indicated that SPE had the potential to be a novel and effective drug or food supplements for the improvement of NASH.

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Improving Satellite-Retrieved Cloud Base Height with Ground-Based Cloud Radar Measurements

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Advances in Atmospheric Sciences 2024年第11期41卷 2131-2140页

作者： Zhonghui TAN Ju WANG Jianping GUO Chao LIU Miao zhang Shuo MA College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044China Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological Administration School of Atmospheric PhysicsNanjing University of Information Science&TechnologyNanjing 210044China National Satellite Meteorological Center(National Center for Space Weather) China Meteorological AdministrationBeijing 100081China

Cloud base height(CBH) is a crucial parameter for cloud radiative effect estimates, climate change simulations, and aviation guidance. However, due to the limited information on cloud vertical structures included in passive satellite radiometer observations, few operational satellite CBH products are currently available. This study presents a new method for retrieving CBH from satellite radiometers. The method first uses the combined measurements of satellite radiometers and ground-based cloud radars to develop a lookup table(LUT) of effective cloud water content(ECWC), representing the vertically varying cloud water content. This LUT allows for the conversion of cloud water path to cloud geometric thickness(CGT), enabling the estimation of CBH as the difference between cloud top height and CGT. Detailed comparative analysis of CBH estimates from the state-of-the-art ECWC LUT are conducted against four ground-based millimeter-wave cloud radar(MMCR) measurements, and results show that the mean bias(correlation coefficient) is0.18±1.79 km(0.73), which is lower(higher) than 0.23±2.11 km(0.67) as derived from the combined measurements of satellite radiometers and satellite radar-lidar(i.e., Cloud Sat and CALIPSO). Furthermore, the percentages of the CBH biases within 250 m increase by 5% to 10%, which varies by location. This indicates that the CBH estimates from our algorithm are more consistent with ground-based MMCR measurements. Therefore, this algorithm shows great potential for further improvement of the CBH retrievals as ground-based MMCR are being increasingly included in global surface meteorological observing networks, and the improved CBH retrievals will contribute to better cloud radiative effect estimates.

关键词： cloud base height passive radiometer ground-based cloud radar remote sensing

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Nitrogen–sulfur co-doped porous carbon derived from asphalt as efficient catalyst for oxygen reduction

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Rare Metals 2024年第1期43卷 380-388页

作者： Jing-Sheng Ma Ming-Zai Wu Ling Chen Li-Xing zhang Ying Xiong Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of EducationInstitute of EnergyHefei Comprehensive National Science CenterAnhui UniversityHefei 230601China

As an environment-friendly and low-cost petrochemical by-product, asphalt has great potential in the preparation of metal-free oxygen reduction electrocatalysts with excellent performance and outstanding stability. In this paper, we converted asphalt into porous carbon nanosheets by a simple activation method, using potassium citrate as the swelling agent.

关键词： stability porous catalyst

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Oxygen uptake response to switching stairs exercise by non-parametric modeling

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Control Theory and Technology 2024年第2期22卷 315-325页

作者： Hairong Yu Chenyu zhang Kai Cao Hamzah M.Alqudah Steven Weidong Su Key Laboratory of Child Development and Learning Science of Ministry of Education and the School of Biological Science and Medical Engineering Southeast UniversityNanjing210096JiangsuChina College of Artificial Intelligence and Big Data for Medical Science Shandong First Medical University and Shandong Academy of Medical SciencesJinan250117ShandongChina Faculty of Engineering and Information Technology University of Technology SydneyUltimoNSW2007Australia

Oxygen uptake plays a crucial role in the evaluation of endurance performance during exercise and is extensively utilized for metabolic assessment. This study records the oxygen uptake during the exercise phase (i.e., ascending or descending) of the stair exercise, utilizing an experimental dataset that includes ten participants and covers various exercise periods. Based on the designed experiment protocol, a non-parametric modeling method with kernel-based regularization is generally applied to estimate the oxygen uptake changes during the switching stairs exercise, which closely resembles daily life activities. The modeling results indicate the effectiveness of the non-parametric modeling approach when compared to fixed-order models in terms of accuracy, stability, and compatibility. The influence of exercise duration on estimated fitness reveals that the model of the phase-oxygen uptake system is not time-invariant related to respiratory metabolism regulation and muscle fatigue. Consequently, it allows us to study the humans’ conversion mechanism at different metabolic rates and facilitates the standardization and development of exercise prescriptions.

关键词： Non-parametric modeling Interval stair training exercise Kernel method.Cardiorespiratory response Oxygen uptake

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The 2022 report of synergetic roadmap on carbon neutrality and clean air for China:Accelerating transition in key sectors

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Environmental Science and Ecotechnology 2024年第3期19卷 4-18页

作者： Yu Lei Zhicong Yin Xi Lu Qiang zhang Jicheng Gong Bofeng Cai Cilan Cai Qimin Chai Huopo Chen Renjie Chen Shi Chen Wenhui Chen Jing Cheng Xiyuan Chi Hancheng Dai Xiangzhao Feng Guannan Geng Jianlin Hu Shan Hu Cunrui Huang Tiantian Li Wei Li Xiaomei Li Jun Liu Xin Liu Zhu Liu Jinghui Ma Yue Qin Dan Tong Xuhui Wang Xuying Wang Rui Wu Qingyang Xiao Yang Xie Xiaolong Xu Tao Xue Haipeng Yu Da zhang Ning zhang Shaohui zhang Shaojun zhang Xian zhang Xin zhang Zengkai zhang Bo Zheng Yixuan Zheng Jian Zhou Tong Zhu Jinnan Wang Kebin He Center of Air Quality Simulation and System Analysis Chinese Academy of Environmental PlanningBeijing100041China Center for Carbon Neutrality Chinese Academy of Environmental PlanningBeijing100041China Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science&TechnologyNanjing210044China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing100084China Institute for Carbon Neutrality Tsinghua UniversityBeijing100084China Ministry of Education Key Laboratory for Earth System Modelling Department of Earth System ScienceTsinghua UniversityBeijing100084China State Key Joint Laboratory for Environment Simulation and Pollution Control College of Environmental Sciences and Engineering and Center for Environment and HealthPeking UniversityBeijing100871China National Center for Climate Change Strategy and International CooperationBeijing100035China Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing100029China School of Public Health Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of HealthFudan UniversityShanghai200032China School of Economics and Management Beijing University of Chemical TechnologyBeijing100029China Department of Earth System Science University of CaliforniaIrvineCA92697USA National Meteorological Center China Meteorological AdministrationBeijing100081China College of Environmental Sciences and Engineering Peking UniversityBeijing100871China Policy Research Center for Environment and Economy Ministry of Ecology and Environment of the People's Republic of ChinaBeijing100029China Jiangsu Key Laboratory of Atmospheric Environment Monitoring

China is now confronting the intertwined challenges of air pollution and climate *** the high synergies between air pollution abatement and climate change mitigation,the Chinese government is actively promoting synergetic control of these two *** Synergetic Roadmap project was launched in 2021 to track and analyze the progress of synergetic control in China by developing and monitoring key *** Synergetic Roadmap 2022 report is the first annual update,featuring 20 indicators across five aspects:synergetic governance system and practices,progress in structural transition,air pollution and associated weather-climate interactions,sources,sinks,and mitigation pathway of atmospheric composition,and health impacts and benefits of coordinated *** to the comprehensive review presented in the 2021 report,the Synergetic Roadmap 2022 report places particular emphasis on progress in 2021 with highlights on actions in key sectors and the relevant *** milestones include the proportion of non-fossil power generation capacity surpassing coal-fired capacity for the first time,a decline in the production of crude steel and cement after years of growth,and the surging penetration of electric ***,in 2022,China issued the first national policy that synergizes abatements of pollution and carbon emissions,marking a new era for China's pollution-carbon *** changes highlight China's efforts to reshape its energy,economic,and transportation structures to meet the demand for synergetic control and sustainable ***,the country has witnessed a slowdown in carbon emission growth,improved air quality,and increased health benefits in recent years.

关键词： Synergetic roadmap Carbon neutrality Clean air

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Bipartite consensus problems of Lurie multi-agent systems over signed graphs: A contraction approach

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Chinese Physics B 2024年第7期33卷 137-145页

作者：张晓娇吴祥 School of Mathematics and Information Science Nanchang Normal UniversityNanchang 330032China School of Mathematical Sciences Guizhou Normal UniversityGuiyang 550001China

This paper examines the bipartite consensus problems for the nonlinear multi-agent systems in Lurie dynamics form with cooperative and competitive communication between different agents. Based on the contraction theory, some new conditions for the nonlinear Lurie multi-agent systems reaching bipartite leaderless consensus and bipartite tracking consensus are presented. Compared with the traditional methods, this approach degrades the dimensions of the conditions, eliminates some restrictions of the system matrix, and extends the range of the nonlinear function. Finally, two numerical examples are provided to illustrate the efficiency of our results.

关键词： contraction theory virtual system bipartite consensus Lurie multi-agent systems

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Logical stochastic resonance in a cross-bifurcation non-smooth system

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Chinese Physics B 2024年第3期33卷 659-667页

作者：张宇青雷佑铭 School of Mathematics and Statistics Northwestern Polytechnical UniversityXi'an 710072China Ministry of Industry and Information Technology Key Laboratory of Dynamics and Control of Complex Systems Northwestern Polytechnical UniversityXi'an 710072China

This paper investigates logical stochastic resonance(LSR)in a cross-bifurcation non-smooth system driven by Gaussian colored *** this system,a bifurcation parameter triggers a transition between monostability,bistability and *** using Novikov's theorem and the unified colored noise approximation method,the approximate Fokker-Planck equation is *** we derive the generalized potential function and the transition rates to analyze the LSR phenomenon using numerical *** simulate the logic operation of the system in the bistable and tristable regions *** assess the impact of Gaussian colored noise on the LSR and discover that the reliability of the logic response depends on the noise strength and the bifurcation ***,it is found that the bistable region has a more extensive parameter range to produce reliable logic operation compared with the tristable region,since the tristable region is more sensitive to noise than the bistable one.

关键词： logical stochastic resonance bifurcation mean first passage time

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Synergistic mechanisms of AMF and biochar driving rhizosphere fungal community in shallot in barren soil

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Horticultural Plant Journal 2024年第5期10卷 1252-1256页

作者： Zishan Li Yingyue Li Qing zhang Zihua zhang Jiaqing Jiang Tao Huang Chunge Mei Fulang Wu Beijiu Cheng Xiaoyu Li Jin Chen National Engineering Laboratory of Crop Stress Resistance Breeding Schools of Life SciencesAnhui Agricultural UniversityHefeiAnhui 230036China

The addition of biochar(BC)or Arbuscular mycorrhizal fungi(AMF)alone has been reported to promote plant growth,while their synergistic effects on Allium schoenoprasum root morphology and rhizosphere fungal community in barren soil is still *** this study,we investigated the effects of BC and AMF(Funneliformis mosseae)on plant growth and root morphology in barren soil and revealed the structure of soil fungal communities Therefore,a greenhouse pot trial consisting of five treatments was *** results showed that the combination of biochar and AMF significantly improved plant biomass,nutrient uptake,mycorrhizal colonization rates and soil properties and significantly impacted rhizosphere fungal community composition and *** significantly increased the fungal community stability and enhanced their positive correlation with *** findings indicated that the combination of AMF and biochar play synergic role for plant growth and rhizosphere fungal community in barren soil.

关键词： soil rhizosphere barren

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