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Development and Validation of a Clinical Risk Score to Predict Immune-mediated Liver Injury Caused by Sintilimab:Assessed for Causality Using Updated RUCAM

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Journal of Clinical and Translational hepatology 2023年第6期11卷 1387-1396页

作者： Caiyun Zheng shunmin Huang Meimei Lin Baohui Hong hengfen Dai Jing Yang Department of Pharmacy Fujian Medical University Union HospitalFuzhouFujianChina Fuqing City Hospital Affiliated to Fujian Medical University FuzhouFujianChina College of Pharmacy Fujian Medical UniversityFuzhouFujianChina The Second Hospital of Sanming City SanmingFujianChina Affiliated Fuzhou First Hospital of Fujian Medical University FuzhouFujianChina

Background and Aims:Immune-mediated liver injury is a fatal side effect of *** study aimed to shed light on the associated risk factors and characteristics of this adverse ***:The clinical records of 772 patients treated with sintilimab were retrospectively reviewed to investigate risk factors associated with sintilimab immune-related hepatotoxicity,as well as its incidence and *** Roussel Uclaf Causality Assessment Method was used o identify cases of sintilimab-induced ***,logistic regressions were performed to compare the clinical and bloodwork characteristics of patients with and without immune-mediated liver injury caused by checkpoint ***/ts:Of the 585 patients included in the study,71(12.1%)developed liver injury during sintili-mab *** median RUCAM score with interquartile range was 7(6,8).Hypoproteinemia,dyslipidemia,and the pres-ence of thyroid peroxidase antibodies were risk factors for sintilimab-related hepatotoxicity.A nomogram model was constructed for sintilimab-induced immune-mediated liver injury based on these risk factors,which had a C-index value of 0.713 and a good calibration *** applied o patients with grade≥3 and≥4 sintilimab-induced immune-mediated liver injury,it achieved C-index values of 0.752 and 0.811,*** nomogram model also showed a good prediction potential in patients≥65 years and *** of the patients with sintilimab-related hepatotoxicity showed improved liver function upon treatment with ***:This study demonstrated that hypoproteinemia,dyslipidemia,and the presence of thyroid peroxidase antibodies were clinically feasible prognostic biomarkers to predict liver injury in patients treated with sintilimab.

关键词： Risk factors hepatotoxicity Sintilimab Checkpoint inhibitor-related immune-mediated liver injury Updated RUCAM

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三种鲜食葡萄的主要成分及抗氧化能力对比分析

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安徽工程大学学报 2024年第4期39卷 16-25,81页

作者：董雨露徐为雯王楠王顺民束志伟安徽工程大学生物与食品工程学院安徽芜湖241000

为了解我国三种鲜食葡萄的品质差异,选定安徽芜湖地区主栽和新培育的巨峰、春香无核、夏黑(夏黑1和夏黑2)3个品种的葡萄作为研究对象,通过测定葡萄中的主要成分(pH、花色苷、含糖量、Vc、单宁)、氨基酸、微量元素、风味物质、抗氧化酶... 详细信息

为了解我国三种鲜食葡萄的品质差异,选定安徽芜湖地区主栽和新培育的巨峰、春香无核、夏黑(夏黑1和夏黑2)3个品种的葡萄作为研究对象,通过测定葡萄中的主要成分(pH、花色苷、含糖量、Vc、单宁)、氨基酸、微量元素、风味物质、抗氧化酶活性及自由基清除能力,分析比较了不同葡萄品种的营养成分及抗氧化能力。结果表明:三种葡萄香味突出,主要呈香物质均为酯类和醇类,春香无核葡萄的色泽和感官最佳,总氨基酸和微量元素含量较高;夏黑品种的葡萄抗氧化能力最好,抗逆性最强。其中夏黑2葡萄中Se元素含量最高,而夏黑1葡萄中的药用氨基酸(精氨酸、异亮氨酸和谷氨酸)含量最高;巨峰葡萄的必需氨基酸含量是最高的。不同品种的鲜食葡萄营养差异明显,具有不同的潜在开发价值。

关键词：鲜食葡萄成分抗氧化能力氨基酸微量元素风味物质

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Effectiveness of Qiangjijianli capsule on experimental autoimmune myasthenia gravis

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Neural Regeneration Research 2006年第7期1卷 638-641页

作者： shunmin Li Bo Fu Yuyan Li Dong Yang Shudong Yang First Department of Internal Medicine Shenzhen Hospital of Traditional Chinese MedicineShenzhen 518033Guangdong ProvinceChina

BACKGROUND:Experimental autoimmune myasthenia gravis(EAMG)and anti-AchR antibody of human myasthenia gravis are the same immune *** antibody restricts the activity of nicotinic acetylcholine receptor and the amount of receptor binding sites is decreased,so myasthenia gravis ***:To observe the therapeutic effect and mechanism of action of Qiangjijianli capsule on EAMG ***:A randomized controlled animal ***:Experimental Animal Center of Guangzhou University of Traditional Chinese ***:Acetylcholine receptors(AchR)were extracted from electric skate's electric organ which lives in the sea near *** had high biological activity and the protein content was 1.63 g/*** capsule(Astragalus mongholicus,Codonopsis pilosula,Atractylodes macrocephala,Angelica sinensis,Bupleurum chinense,Cairo morningglory root or leaf,Glycyrrhiza uralensis,etc.0.5 g crude drug per capsule)was bought from the Manufacturing Laboratory of Guangzhou University of Traditional Chinese Medicine with the Batch ***:This experiment was carried out in the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine from May to August 1990.①Adult female SD rats were immunized with *** animals'movement condition was observed and recorded *** rats were chosen as normal control group,and they were not given any treatment and raised *** modeled,20 successful rats were randomly assigned into 2 groups:treatmental group and model group.2 mL Qiangjijianli capsule suspension(1 g)was intragastrically administrated into each rat of treatmental group for 30 days;The same amount of clean water was intragastrically administrated into the rats of model group for 30 days.②Serum AchR antibody was measured with ABC-ELISA *** administration,the rats were *** complete diaphragmatic muscle was extracted for in vitro receptor binding *** constitution of N-AchR per m

关键词： AchR EAMG

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15种杀菌剂对异色瓢虫的影响

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植物保护 2024年第3期50卷 327-332,349页

作者：吕佳赵战马徐晞晟蒲占湑朱莉鹿连明刘顺民陈国庆黄振东浙江省柑橘研究所台州318000 浙江省台州市农资股份有限公司台州318000

异色瓢虫Harmonia axyridis(Pallas)是一种重要的天敌昆虫,在田间应用时常会受到施用药剂的影响。为了解浙江地区常用杀菌剂对异色瓢虫的影响,本文选用该地区田间15种常用杀菌剂,采用喷雾法,在实验室条件下测定了其对异色瓢虫2龄和4龄... 详细信息

异色瓢虫Harmonia axyridis(Pallas)是一种重要的天敌昆虫,在田间应用时常会受到施用药剂的影响。为了解浙江地区常用杀菌剂对异色瓢虫的影响,本文选用该地区田间15种常用杀菌剂,采用喷雾法,在实验室条件下测定了其对异色瓢虫2龄和4龄幼虫、蛹以及成虫的影响。结果显示:不同杀菌剂对异色瓢虫不同虫态有不同程度的影响,但大多数杀菌剂对异色瓢虫相对安全。60%唑醚·代森联WG、50%异菌脲SC、99%矿物油EC、43%氟菌·肟菌酯SC、42.4%唑醚·氟酰胺SC对异色瓢虫2龄幼虫影响较大,其中42.4%唑醚·氟酰胺SC对异色瓢虫2龄幼虫影响最大,平均校正死亡率最高达到93.22%。30%氧氯化铜SC、1亿cfu/g枯草芽孢杆菌CG、0.5%几丁聚糖AS、42.4%唑醚·氟酰胺SC、40%噻唑锌SC对异色瓢虫蛹有一定程度的影响,其中40%噻唑锌SC对异色瓢虫蛹的影响最大,平均校正死亡率达到31.04%。试验的15种杀菌剂对异色瓢虫4龄幼虫和成虫相对安全,平均校正死亡率皆小于21%。从安全性考虑,当异色瓢虫处于2龄幼虫阶段时,不建议使用60%唑醚·代森联WG、50%异菌脲SC、99%矿物油EC、43%氟菌·肟菌酯SC、42.4%唑醚·氟酰胺SC。当异色瓢虫处于4龄幼虫、蛹和成虫时,15种供试杀菌剂都比较安全,使用时可选用对其影响较小的杀菌剂。

关键词：杀菌剂异色瓢虫安全性

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Construction of mesoporous ceria-supported gold catalysts with rich oxygen vacancies for efficient CO oxidation

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Journal of Rare Earths 2022年第3期40卷 434-442,I0003页

作者： Xin Shen Wang Li shunmin Ding Xiaohua Ma Shaohua Wu Weiming Xiao Rong Zeng Sanguo Hong Chao Chen Key Laboratory of Jiangxi Province for Environment and Energy Catalysis College of ChemistryNanchang UniversityNanchang 330031China Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices School of ChemistryBiology and Materials ScienceEast China University of TechnologyNanchang 330013China

Bearing unique redox nature and high oxygen storage capacity,ceria(CeO_(2))has always been a promising CO oxidation catalyst support for gold(Au)catalysts and the ***,a series of Au-CeO_(2)-P(P stands for pH value)samples was prepared by a co-precipitation method with the assistance of an alkaline environment and amino groups functionalized ordered mesoporous polymer(OMP-NH_(2)).Afterward,all samples described above were characterized that the Au-CeO_(2)-P catalysts are made of Au-Ce-O solid solution and Au nanoparticles(NPs)supported on CeO_(2).It turns out that OMP-NH_(2) is not just a simple sacrificial template for mesoporous structure,but also plays an important role as an amino source,explaining the presence of rich oxygen *** to the concentration of oxygen vacancies in Au-Ce-O solid solution is the key factor for the oxygen mobility of CO oxidation,the catalytic results also demonstrate that the catalytic activity of Au-CeO_(2)-P catalysts is related to the concentration of their oxygen ***,Au-CeO_(2)-9.6 with a highest concentration of oxygen vacancies(as high as 13.98%)in Au-CeO_(2)-P catalysts exhibits the best catalytic activity(complete conversion at 10℃).

关键词： Ceria Oxygen vacancies Au-Ce-O solid Solution Amino groups functionalized ordered mesoporous polymer CO oxidation Rare earths

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果蝇基因组DNA的6mA修饰研究

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科学新闻 2016年第1期 40-40页

作者： Guoqiang Zhang Hua Huang Di Liu Ying Cheng Xiaoling Liu Wenxin Zhang Ruichuan Yin Dapeng Zhang Peng Zhang Jianzhao Liu Chaoyi Li Baodong Liu Yuewan Luo Yuanxiang Zhu Ning Zhang shunmin he Chuan he 汪海林陈大华中国科学院生态环境研究中心中国科学院动物研究所

关键词：基因组调控染色体组调节控制果蝇高等真核生物 DNA

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Longling-Lancang fault zone in southwest Yunnan, China——A newly-generated rupture zone in Continental crust

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Chinese Science Bulletin 2000年第4期45卷 376-379页

作者： QUO shunmin XIANG Hongfa ZHOU Ruiqi XU Xiwei DONG Xingquan ZHANG Wanxia Institute of Geology China Seismological BureauBeijing 100029China Seismological Bureau of Yunnan Province Kunming 650041China

The Longling-Lancang fault zone, consisting of sets of en echelon or clustered faults, is a newly-generated rupture zone. it is characterized by the distribution of active faults, earthquake faults and earthguakes in zones. Formed in the Early-Middle Pleistocene, stili active in the late, it moves dextrally and extensionally. it tends to cut off the locked segments and discontinuous segments at first, then pervades totally along the zone, accompanied by strong earthguakes.

关键词： southwest Yunnan fault zone newly-generated rupture zone.

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丝裂霉素膀胱灌注热化疗联合瑞柯恩钬激光电切对非浸润性膀胱癌患者血清Dickkopf-1及α-FR的影响

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国际泌尿系统杂志 2024年第1期44卷 28-33页

作者：潘润阳王顺民苏文星张剑平林荣凯解放军联勤保障部队第910医院泌尿外科泉州362000

目的探讨丝裂霉素膀胱灌注热化疗联合瑞柯恩钬激光电切对非浸润性膀胱癌患者血清Dickkopf-1及α-叶酸受体(alpha-folate receptor, α-FR)表达的影响。方法选取2017年5月至2020年1月于本院就诊并接受治疗的136例非浸润性膀胱癌患者为研... 详细信息

目的探讨丝裂霉素膀胱灌注热化疗联合瑞柯恩钬激光电切对非浸润性膀胱癌患者血清Dickkopf-1及α-叶酸受体(alpha-folate receptor, α-FR)表达的影响。方法选取2017年5月至2020年1月于本院就诊并接受治疗的136例非浸润性膀胱癌患者为研究对象, 采用随机数字表法将其分为对照组和观察组, 每组各68例。对照组给予瑞柯恩钬激光电切治疗, 观察组给予丝裂霉素膀胱灌注热化疗联合瑞柯恩钬激光电切治疗, 对比两组患者治疗2个月前后的临床疗效、免疫功能相关指标、血清Dickkopf-1和α-FR水平、不良反应、复发及远期生存情况。结果治疗2个月后对照组的控制率为55.88%(38/68), 缓解率为79.41%(54/68);观察组的控制率为79.41%(54/68), 缓解率为94.12%(64/68), 两组差异均有统计学意义(均P0.05)。观察组治疗后的2年内复发率显著低于对照组(P<0.05)。结论丝裂霉素膀胱灌注热化疗联合瑞柯恩钬激光电切治疗非浸润性膀胱癌效果显著, 可增强抗肿瘤作用, 有效改善临床疗效、机体体液免疫和细胞免疫功能, 降低血清Dickkopf-1和α-FR水平, 提高疾病控制率和缓解率, 且未增加不良反应。

关键词：膀胱肿瘤丝裂霉素膀胱灌注膀胱切除术 Dickkopf-1 α-FR

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Monitoring of Cerebral Oxygenation by Near-infrared Spectroscopy during Cardiopulmonary Bypass in Infants

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工程科学（英文版） 2006年第3期4卷 11-16,28页

作者： Su Zhaokang Huang Jihong Wang shunmin Department of Pediatric Thoracic and Cardiovascular Surgery Shanghai Children＇s Medical Center Shanghai Jiaotong University Medical College Shanghai 200127

Objective: To evaluate the use of near-infrared spectroscopy for monitoring cerebral oxygenation under different cardiopulmonary bypass models. Method: Twenty-four patients with ventricular septal defect and pulmonary hypertension undergoing open-heart surgery were assigned eight each to three groups, with respect to different cardiopulmonary bypass models: moderate hypothermia cardiopulmonary bypass, deep hypothermia low flow and deep hypothermia circulatory arrest. For each patient, cerebral oxygenation with near-infrared spectroscopy were monitored and the relative concentration changes in cerebral oxygenated hemoglobin, deoxygenated hemoglobin and oxidized cytochrome aa3 were calculated. Electroencephalography, biochemical indicators such as neuron-specific enolase and lactate, and performed correlation analyses for near-infrared spectroscopy data and biochemical indicators were also measured. Results: Near-infrared spectroscopy data and biochemical indicators for moderate hypothermia cardiopulmonary bypass and deep hypothermia low flow group showed no correlation. For deep hypothermia circulatory arrest group, oxygenated hemoglobin signal declined to a plateau （nadir） during the circulatory arrest period. The duration from reaching nadir until reperfusion “oxygenated hemoglobin signal nadir-time", and the minimum values of oxygenated hemoglobin, and oxidized cytochrome aa3 were closely correlated with increasing neuron-specific enolase and lactate. And, all patients whose oxygenated hemoglobin signal nadir-time was less than 35 min were free from behavioral evidence of brain injury. Conclusion: Near-infrared spectroscopy data including oxygenated hemoglobin signal nadir-time and the minimum of oxygenated hemoglobin and oxidized cytochrome aa3 showed strong correlation with other cerebral function assessment for deep hypothermia circulatory arrest. Oxygenated hemoglobin signal nadir-time determined by near-infrared spectroscopy can be useful in predicting the sa

关键词：新生儿近红外分光学低温心肺分流术深低温低流动性深低温循环骤停氧络血红蛋白

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The Principle and Method for Delineation of Potential Seismic Sources in Northwest Yunnan

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Earthquake Research in China 2005年第2期19卷 201-213页

作者： Zhou Qing Guo shunmin Xiang Hongfa Institute of Geology China Earthquake Administration Beijing 100029 China

Based on the collection and analysis of achievements of other scholars, and by consulting the results of seismic safety evaluation of engineering sites and field surveys of recent years, the seismotectonic indicators are determined for northwest Yunnan and its vicinity, and then potential seismic sources are further delineated. In practice, the following principles are applied: for areas with strong historical earthquakes, the recurrence principle is used to determine the upper bound magnitude; for areas with distinct seismogenic structure but no historical strong earthquake records, the tectonic analogy principle is used in the light of the size and activity behavior of the structure; for areas where the segmentation of the active fault is well studied, the potential sources will be demarcated more precisely; and for areas with buried fault, the seismicity pattern and geophysical abnormity are used to determine the direction of the major axis of the potential seismic source.

关键词： Potential seismic source Seismic safety evaluation Northwest Yunnan

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