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第三届亚洲机械电子学学术会议

作者： Yasuhito Yoshizawa shunji shimizu Nobuhide Hirai Fumikazu Miwakeichi Senichiro Kikuchi Hironori Tedzuka Eiju Watanabe Graduate School of Engineering Management Tokyo University of Science Suwa Tokyo University of Science Suwa Department of Psychiatry Jichi Medical University Faculty of Engineering Chiba University Graduate School of Engineering Management Tokyo University of Science Suwa

There have been numerous single-channel measurements performed in one area of the prefrontal cortex regarding brain activity while driving.[1]The steering action while driving a vehicle is simulated,and the seated subjects move each of their hands in a clockwise and counterclockwise circular motion. Simultaneously,the brain act ivity of the subjects was measured using near infrared spectroscopy(NIRS).Since the optic pathways in the brain process information using two pathways,a ventral(objects’shape and color)and dorsal(movement and position)pathway, which are believed to be integrated in the prefrontal cortex of the frontal lobe,the area we measured was the area in the vicinity of the prefrontal cortex of the frontal *** details regarding the circular movement include holding a mouse at a desk,and drawing a circle with a diameter of about 30 *** circles are drawn at a pace of about one circle every four seconds,with the measurements taken over a durat ion of 20 s(total 5 circles).The measurement intervals consist of a 10-s break, the 20-s task,followed by another 10-s break, repeated over 5 *** subjects used in our study were all right-handed males in their twent ies who had a histor y of driving.

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Clinical significance of programmed cell death-ligand expression in small bowel adenocarcinoma is determined by the tumor microenvironment

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World Journal of Gastroenterology 2023年第40期29卷 5566-5581页

作者： Aitoshi Hoshimoto Atsushi Tatsuguchi Ryohei Hamakubo Takayoshi Nishimoto Jun Omori Naohiko Akimoto Shu Tanaka shunji Fujimori Tsutomu Hatori Akira shimizu Katsuhiko Iwakiri Department of Gastroenterology Nippon Medical SchoolTokyo 113-8603Japan Department of Analytic Human Pathology Nippon Medical SchoolTokyo 113-8603Japan Department of Pathology Nippon Medical SchoolChiba Hokusoh HospitalChiba 270-1694Japan

BACKGROUND Comprehensive genomic analysis has shown that small bowel adenocarcinoma(SBA)has different genomic profiles from gastric and colorectal ***,it is essential to establish chemotherapeutic regimens based on SBA *** expression of programmed cell death-ligand 1(PD-L1)and programmed cell death-ligand 2(PD-L2)in SBA is not fully ***-PD-L1/PD-1 therapy uses tumor-infiltrating lymphocytes(TILs);therefore,the status of TILs in the tumor microenvironment(TME)may influence their *** ratio of FoxP3+to CD8+T cells has been reported to be useful in predicting the prognosis of digestive system *** To investigate the clinicopathological significance of PD-L1/2 expression according to the status of TILs in SBA *** We performed immunohistochemical analysis for PD-L1,PD-L2,CD8,FoxP3,and DNA mismatch repair(MMR)proteins using formalin-fixed,paraffin-embedded tissues from 50 patients diagnosed with primary *** immunoreactivities of PD-L1 and PD-L2 were determined separately in tumor cells and tumor-infiltrating immune cells throughout the tumor center and invasive margins,and finally evaluated using the combined positive score(CPS).We assessed CD8+and FoxP3+T cells in the intratumoral and tumor-surrounding ***,we calculated and summed the ratio of FoxP3 to CD8+T cell ***-related cell densities were graded as low or *** results were compared with clinicopathological factors and patient *** distribution of cancer-specific survival(CSS)was estimated using the Kaplan–Meier method,and the log-rank test was used to test for significant differences in CSS.A Cox proportional hazard model was also used to assess the effect of tumor variables on *** PD-L1 expression was positive in 34%in tumor cells(T-PD-L1)and 54%in tumor-infiltrating immune cells(I-PDL1)of the cases examined.T-PD-L2 was positive in 34%and I-PD-L2 was positive in 42%of the ***-L1

关键词： Small bowel adenocarcinoma Programmed cell death-ligand 1 Programmed cell death-ligand 2 Tumor microenvironment Tumor-infiltrating lymphocytes Regulatory T-cells

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