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Change of Accessory Genital Glands Markers in the Patients with Oligoasthenospermia

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Journal of Reproduction and Contraception 2009年第4期20卷 217-221页

作者： shun-mei deng Ren-qian WEN mei-yi LIU Yan-jia JIANG shun-jie MA Ai-ping CHEN Li-xing TANG Guangdong Family Planning Institute Guangzhou 510600 China

Objective To evaluate the effect of the accessory gential gland on the male fertility. Methods The relevant seminal parameters of 32 normal donors and 35 patients with olioasthenospermia were measured by seminal routine analysis, sperm morphology and accessory, gentital glands markers.Results The percentage of normal spermatozoa, the function of sperm penetration through cervical mucus and the enzyme activity of neutral α-1,4-glucosidase significantly declined as compared with the control. There was a significant negative relationship between the semen volume and the sperm motility for the oligoasthenospermia （r= -0.415, P〈0.05）, and a significant positive relationship between the sperm count and the percentage of normal sperm （r=0.393, P〈0.05）.Conclusion The abnormal function of epididymis exists in patients with oligoasthenospermia. Sperm function,for the oligoasthenospermia declines with an increase of the percentage of the abnormal sperm. The poorer the spermatogenises function of the testis is, the higher the percentage of the abnormal sperm appears.

关键词： oligoasthenospermia fructose neutral α-1,4-glucosidase acid phosphatase sperm morphology

Chloride channels are involved in sperm motility and are downregulated in spermatozoa from patients with asthenozoospermia

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Asian Journal of Andrology 2017年第4期19卷 418-424页

作者： Shan-Wen Liu Yuan Li Li-Li Zou Yu-Tao Guan Shuang Peng Li-Xin Zheng shun-mei deng Lin-Yan Zhu Li-Wei Wang Li-Xin Chen Department of Pharmacology Medical College Jinan University Guangzhou China Department of Pathology and Pathophysiology Medical College Jinan University Guangzhou China Department of Physiology Medical College Jinan University Guangzhou China Male Reproductive Center Family Planning Special Hospital of Guangdong Guangzhou China

Human spermatozoa encounter an osmotic decrease from 330 to 290 mOsm I-z when passing through the female reproductive tract. We aimed to evaluate the role of chloride channels in volume regulation and sperm motility from patients with asthenozoospermia. Spermatozoa were purified using Percoll density gradients. Sperm volume was measured as the forward scatter signal using flow cytometry. Sperm motility was analyzed using computer-aided sperm analysis （CASA）. When transferred from an isotonic solution （330 mOsm I-z） to a hypotonic solution （290 mOsm I-Z）, cell volume was not changed in spermatozoa from normozoospermic men; but increased in those from asthenozoospermic samples. The addition of the chloride channel blockers, 4,4＇-diisothiocyanatostilbene-2,2＇- isulfonic acid （DIDS） or 5-nitro-2-（3-phenylpropylamino） benzoic acid （NPPB） to the hypotonic solution caused the normal spermatozoa to swell but did not increase the volume of those from the asthenozoospermic semen. DIDS and NPPB decreased sperm motility in both sets of semen samples. The inhibitory effect of NPPB on normal sperm motility was much stronger than on spermatozoa from the asthenozoospermic samples. Both sperm types expressed CIC-3 chloride channels, but the expression levels in the asthenozoospermic samples were much lower, especially in the neck and mid-piece areas. Spermatozoa from men with asthenozoospermia demonstrated lower volume regulating capacity, mobility, and CIC-3 expression levels （especially in the neck） than did normal spermatozoa. Thus, chloride channels play important roles in the regulation of sperm volume and motility and are downregulated in cases of asthenozoospermia.

关键词： asthenozoospermia chloride channels CIC-3 sperm motility volume regulation

供精精液参数与受精妇女妊娠结局的Logistic回归分析

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生殖与避孕 2009年第10期29卷 688-692页

作者：王奇玲唐立新江芳黄江涛邓顺美文任乾马春杰广东省计划生育专科医院广州510600

目的:探讨供精精液参数与受精妇女妊娠结局的关系。方法:回顾性分析本院生殖中心实施供精人工授精(AID)治疗的1903个周期,对女方年龄、授精精液采集后冷冻保存前和冻融复苏后各项参数和同一周期授精次数与术后妊娠结局进行单因素和多因... 详细信息

目的:探讨供精精液参数与受精妇女妊娠结局的关系。方法:回顾性分析本院生殖中心实施供精人工授精(AID)治疗的1903个周期,对女方年龄、授精精液采集后冷冻保存前和冻融复苏后各项参数和同一周期授精次数与术后妊娠结局进行单因素和多因素Logistic回归分析。结果:精子采集后冷冻保存前活动率(OR=1.982,P=0.042)、精子冻融复苏后前向运动精子总数(OR=1.699,P=0.031)和同一周期授精次数(OR=2.178,P=0.010)显著影响受精妇女的妊娠几率。结论:精子采集后冷冻保存前活动率>70%、精子冻融复苏后前向运动精子总数>30×106、同一周期授精2次能提高受精妇女的妊娠几率。

关键词：冷冻精液供精人工授精(AID) 妊娠 Logistic回归

Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang Yi Jiang Hua-Wei Zhang Xiao-mei Song Yu-Ze Li Wen-Li Huang Dong-Dong Zhang Chong deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

The transformation between τ and TCB for deep space missions under IAU resolutions

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Research in Astronomy and Astrophysics 2012年第6期12卷 703-712页

作者： Xue-mei deng Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China

For tracking spacecraft and performing radio science, the transformation between the proper time （τ） given by a clock carried onboard a spacecraft and the barycentric coordinate time （TCB） is investigated under IAU resolutions. In order to more clearly demonstrate manifestations of a physical model and improve computa- tional efficiency, an analytic approach is adopted. After numerical verification, it is confirmed that this method is adequate to describe a Mars orbiter during one year, and is particularly good at describing the influence from perturbing bodies. Further analyses demonstrate that there are two main effects in the transformation： the gravi- tational field of the Sun and the velocity of the spacecraft in the barycentric coordinate reference system. The combined contribution of these effects is at the level of a few sub-seconds.

关键词： reference systems -- time -- method: analytical -- method: numerical-- space vehicles

Selective binding of unsaturated aliphatic hydrocarbons by a pillar[5]arene

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Chinese Chemical Letters 2013年第8期24卷 707-709页

作者： Xiao-Shi Hu Hong-mei deng Jian Li Xue-shun Jia Chun-Ju Li Department of Chemistry Shanghai University

The complexation behavior of unsaturated fatty hydrocarbons,i.e.,1,7-octadiyne and 1,7-octadiene,by a perethylated pillar[5]arene has been investigated,which was compared with that for saturated n-octane. It was found that the host-guest binding strength increased in accordance with the electron-negativity of the terminal carbon atom on the guests：alkyne〉alkene〉alkane.

关键词： Molecular recognition Pillararenes Unsaturated hydrocarbons Supramolecular chemistry

A Note on Calculation of Threshold Resonance by the Method of Complex Scaling

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Chinese Physics Letters 1996年第4期13卷 241-244页

作者： ZHAO mei-shan XIE Xi-shun The Janies Franck Institute The University of ChicagoChicagoIllinois 60637USA Department of Physics University of MinnesotaMinneapolisMinnesota 55455USA Department of Physics Southeastern UniversityNanjing210096

A new approach to threshold resonance calculation by the complex scaling method is *** to scattering over a model potential barrier is presented and compared to a direct quantum scattering calculation.

关键词： calculation. scaling quantum

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精液分析区域性外部质量控制研究

生殖与避孕 2015年第12期35卷 888-892页

作者：王奇玲唐运革邓顺美庄嘉明李月华唐雨倩陈曦马婷马春杰国家卫生和计划生育委员会男性生殖与遗传重点实验室广东省计划生育科学技术研究所人类精子库广州510600

目的:探讨精液分析区域性外部质量控制实践中参评实验室检测结果的准确性和结果的可比性。方法:制作2个水平的精子浓度、活动率和正常形态率的质控品发放给参评实验室进行外部质量控制测试,分析质控结果。评价指标为均值和实验室间变异... 详细信息

目的:探讨精液分析区域性外部质量控制实践中参评实验室检测结果的准确性和结果的可比性。方法:制作2个水平的精子浓度、活动率和正常形态率的质控品发放给参评实验室进行外部质量控制测试,分析质控结果。评价指标为均值和实验室间变异系数(CV)。结果:精子浓度、前向运动精子百分率(PR)和正常形态精子百分率(NR)CV分别为34.09%、24.96%和62.01%;各实验室精子浓度、PR结果差异均无统计学意义(P>0.05),NR差异有统计学意义(P<0.05)。结论:外部质控结果CV较大,尤其正常形态精子的检测结果,提示技术人员亟需进行规范培训,开展标准化精液分析质量控制活动,提高分析结果的重复性和准确性。

关键词：精液分析区域性外部质量控制平均变异值变异系数(CV)

The effect of f(T) gravity on an interplanetary clock and its time transfer link

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Research in Astronomy and Astrophysics 2013年第10期13卷 1225-1230页

作者： Xue-mei deng Yi Xie Purple Mountain Observatory Chinese Academy of Sciences Key Laboratory of Modern Astronomy and Astrophysics Nanjing University Ministry of Education School of Astronomy & Space Science Nanjing University

As an extension of the＂teleparallel＂equivalent of general relativity,f（T）gravity is proposed to explain some puzzling cosmological behaviors,such as accelerating expansion of the *** the fact that modified gravity also has impacts on the Solar System,we might test it during future interplanetary missions with ultrastable *** this work,we investigate the effects of f（T）gravity on the dynamics of the clock and its time transfer *** these influences,theΛ-term and theα-term of f（T）gravity play important ***,Λis the cosmological constant andαrepresents a model parameter in f（T）gravity that determines the divergence from teleparallel gravity at the first order *** find that the signal of f（T）gravity in the time transfer is much more difficult to detect with the current state of development for clocks than those effects on dynamics of an interplanetary spacecraft with a bounded orbit with parameters 0.5 au≤a≤5.5 au and 0≤e≤0.1.

关键词： gravitation celestial mechanics space vehicles:clock time