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World Journal of Gastroenterology 2023年第20期29卷 3084-3102页

作者： Hao Wang Zheng-Lu Wang Sai Zhang De-Jun Kong Rui-Ning Yang Lei Cao Jian-Xi Wang Sei Yoshida Zhuo-Lun Song Tao liu shun-li fan Jia-Shu Ren Jiang-Hong li Zhong-Yang Shen Hong Zheng The First Central Clinical School Tianjin Medical UniversityTianjin 300190China Department of Organ Transplant Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300190China Key Laboratory of Transplant Medicine Chinese Academy of Medical SciencesTianjin 300190China School of Medicine Nankai UniversityTianjin 300190China Research Institute of Transplant Medicine Nankai UniversityTianjin 300071China Tianjin Key Laboratory for Organ Transplantation Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300071China National Health Commission’s Key Laboratory for Critical Care Medicine Tianjin First Central HospitalTianjin 300071China

BACKGROUND Capecitabine(CAP)is a classic antimetabolic drug and has shown potential antirejection effects after liver transplantation(LT)in clinical *** previous study showed that metronomic CAP can cause the programmed death of T cells by inducing oxidative stress in healthy ***,a newly defined non-apoptotic cell death that occurs in response to iron overload and lethal levels of lipid peroxidation,is an important mechanism by which CAP induces cell ***,ferroptosis may also play an important role in CAP-induced T cell death and play an immunosuppressive role in acute rejection after *** To investigate the functions and underlying mechanisms of antirejection effects of metronomic *** A rat LT model of acute rejection was established,and the effect of metronomic CAP on splenic hematopoietic function and acute graft rejection was evaluated 7 d after *** vitro,primary CD3+T cells were sorted from rat spleens and human peripheral blood,and co-cultured with or without 5-fluorouracil(5-FU)(active agent of CAP).The levels of ferroptosis-related proteins,ferrous ion concentration,and oxidative stress-related indicators were *** changes in mitochondrial structure were observed using electron *** With no significant myelotoxicity,metronomic CAP alleviated graft injury(Banff score 9 vs 7.333,Pliver graft(7.459 vs 3.432,Plism,induced the degradation of the ferritin heavy chain by upregulating nuclear receptor coactivator 4,which caused the accumulation of ferrous *** also inhibited nuclear erythroid 2 p45-related factor 2,heme oxygenase-1,and glutathione peroxidase 4,eventually leading to oxidati

关键词： Capecitabine Ferroptosis T Lymphocytes Immunosuppressive agents Graft rejection liver transplantation

COMPrompter: reconceptualized segment anything model with multiprompt network for camouflaged object detection

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Science China(Information Sciences) 2025年第1期68卷 189-203页

作者： Xiaoqin ZHANG Zhenni YU li ZHAO Deng-Ping fan Guobao XIAO Zhejiang Province Key Laboratory of Intelligent Informatics for Safety and Emergency Wenzhou University Nankai International Advanced Research Institute (SHENZHEN FUTIAN) College of Computer Science Nankai University School of Computer Science and Technology Tongji University

We rethink the segment anything model(SAM) and propose a novel multiprompt network called COMPrompter for camouflaged object detection(COD). SAM has zero-shot generalization ability beyond other models and can provide an ideal framework for COD. Our network aims to enhance the single prompt strategy in SAM to a multiprompt strategy. To achieve this, we propose an edge gradient extraction module, which generates a mask containing gradient information regarding the boundaries of camouflaged objects. This gradient mask is then used as a novel boundary prompt, enhancing the segmentation process. Thereafter, we design a box-boundary mutual guidance module, which fosters more precise and comprehensive feature extraction via mutual guidance between a boundary prompt and a box prompt. This collaboration enhances the model's ability to accurately detect camouflaged objects. Moreover, we employ the discrete wavelet transform to extract high-frequency features from image embeddings. The high-frequency features serve as a supplementary component to the multiprompt ***, our COMPrompter guides the network to achieve enhanced segmentation results, thereby advancing the development of SAM in terms of COD. Experimental results across COD benchmarks demonstrate that COMPrompter achieves a cutting-edge performance, surpassing the current leading model by an average positive metric of 2.2% in COD10K. In the specific application of COD, the experimental results in polyp segmentation show that our model is superior to top-tier methods as well. The code will be made available at https://***/guobaoxiao/COMPrompter.

关键词： segment anything model camouflaged object detection boundary prompt

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Defect Engineering:Can it Mitigate Strong Coulomb Effect of Mg^(2+)in Cathode Materials for Rechargeable Magnesium Batteries?

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Nano-Micro Letters 2025年第1期17卷 135-159页

作者： Zhengqing fan Ruimin li Xin Zhang Wanyu Zhao Zhenghui Pan Xiaowei Yang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China School of Materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage ***,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical *** engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for *** this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further ***,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are *** applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also ***,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described.

关键词： Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration

Tackling the microlensing wave effects of strong lensing gravitational waves with TAAH

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 257-258页

作者： Zuhui fan South-Western Institute for Astronomy Research Yunnan University

The rapid development of gravitational wave（GW） observations since their first detection in 2015 [1] has opened a completely new window for exploring the Universe. Consequently, astronomical research has entered the multimessenger era, allowing us to use different tracers to view the cosmos from various perspectives. Among others, the appealing application of gravitational wave events from compact binary mergers is that they can act as standard sirens to determine absolute cosmic distances entirely independent of standard candles. This approach is one of the most promising means to solve the current H0tension problem.

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播散性马尔尼菲青霉病

临床皮肤科杂志 2006年第7期35卷 461-463页

作者：李顺凡黄文明吴国凤李文樊翌明广东医学院附属医院皮肤科广东湛江524001

报告播散性马尔尼菲青霉病1例。患者男,65岁。面部溃疡、口腔糜烂伴发热20余天。皮肤科检查见面部多个溃疡,口腔、咽部大片糜烂,全身浅表淋巴结及肝、脾增大。皮损分泌物、淋巴结穿刺液、血液和皮损组织直接涂片和真菌培养均发现马尔尼... 详细信息

报告播散性马尔尼菲青霉病1例。患者男,65岁。面部溃疡、口腔糜烂伴发热20余天。皮肤科检查见面部多个溃疡,口腔、咽部大片糜烂,全身浅表淋巴结及肝、脾增大。皮损分泌物、淋巴结穿刺液、血液和皮损组织直接涂片和真菌培养均发现马尔尼菲青霉。

关键词：马尔尼菲青霉病马尔尼菲青霉感染真菌

Long-read sequencing reveals novel genetic polymorphisms in the major histocompatibility complex region and their impacts on the Han Chinese population

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Science China life Sciences 2025年

作者： Cong Zhou Tingting Gong Shuhang li li Jin Shaohua fan State Key Laboratory of Genetic Engineering Lab for Evolutionary Synthesis School of Life Sciences Human Phenome Institute Fudan University Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058) Chinese Academy of Medical Sciences

Human leukocyte antigen(HLA) genes in the major histocompatibility complex(MHC) region are crucial for immunity and are associated with numerous diseases and phenotypes. The MHC region's complexity and high genetic diversity make it challenging to analyze using short-read sequencing(SRS) technology. We sequence the MHC region of 100 Han Chinese individuals using both long-read sequencing(LRS) and SRS platforms at approximately 30X coverage to study genetic alterations and their potential functional impacts. LRS provides significantly greater coverage of the MHC region and eight classical HLA genes, particularly at the HLA-DRB1 locus, compared with SRS. We detect 78,249 single nucleotide polymorphisms(SNPs) using LRS, with 26.0% undetectable by SRS. Based on SNP and inferred HLA allele types, we construct an LRS-based MHC reference panel for the Han Chinese, containing approximately 2.6 times more genetic variants than the SRS-based Han-MHC reference panel. A phenome-wide association study assessing 26,024 phenotypes across 15 categories identifies significant associations for 7,879 independent variants(including 809 LRS-specific SNPs) with 409 phenotypes in nine categories. This analysis reveals 24 unreported HLA allele associations in the bioelectric and cellular categories. The conditional analysis identifies 530independent signals across the 409 phenotypes, including 28 previously unreported signals of eight classical HLA genes associated with 33phenotypes. Of the top-associated SNPs, 191 are detected by LRS only. Fine-mapping identifies 126 independent candidate causal SNPs for three immune-related cellular phenotypes, with 17 detected exclusively by LRS. Our study reveals previously unreported variants and their functional impacts in the MHC region, enhancing our understanding of genetic diversity and its potential biological implications in the Han Chinese population.

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Industrial solid wastes to environmental protection materials for removal of gaseous pollutants:A review

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Green Energy & Environment 2025年第1期10卷 34-83页

作者： Jiacheng Bao Xin Sun Ping Ning Kai li Jie Yang Fei Wang Lei Shi Maohong fan Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming650500China College of Engineering and Physical Sciences and School of Energy ResourcesUniversity of WyomingLaramieWY82071USA College of Engineering Georgia Institute of TechnologyAtlantaGA30332USA

The application of industrial solid wastes as environmentally functional materials for air pollutants control has gained much attention in recent years due to its potential to reduce air pollution in a cost-effective *** this review,we investigate the development of industrialwaste-based functional materials for various gas pollutant removal and consider the relevant reaction mechanism according to different types of industrial solid *** see a recent effort towards achieving high-performance environmental functional materials via chemical or physical modification,in which the active components,pore size,and phase structure can be *** review will discuss the potential of using industrial solid wastes,these modified materials,or synthesized materials from raw waste precursors for the removal of air pollutants,including SO_(2),NO_(x),Hg^(0),H_(2)S,VOCs,and CO_(2).The challenges still need to be addressed to realize this potential and the prospects for future research *** suggestions for future directions include determining the optimal composition of these materials,calculating the real reaction rate and turnover frequency,developing effective treatment methods,and establishing chemical component databases of raw industrial solid waste for catalysts/adsorbent preparation.

关键词： Industrial solid waste Reaction mechanism Modification method Air pollutants

窄谱UVB照射对寻常性银屑病皮损中角质形成细胞P53、半胱天冬酶-3及bax表达的影响

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临床皮肤科杂志 2011年第10期40卷 598-600页

作者：张成国朱铖垚李顺凡樊翌明湖北省汉川市人民医院皮肤科 436100 广东医学院附院医院皮肤科广东湛江524001

目的:了解窄谱UVB对寻常性银屑病皮损中角质形成细胞P53、半胱天冬酶(casp)-3及bax表达的影响,探讨窄谱UVB治疗银屑病的作用机制。方法:将60例寻常性银屑病患者随机分成对照组、UVBⅠ组和UVBⅡ组3组,分别在光疗前和光疗后4周、8周作银... 详细信息

目的:了解窄谱UVB对寻常性银屑病皮损中角质形成细胞P53、半胱天冬酶(casp)-3及bax表达的影响,探讨窄谱UVB治疗银屑病的作用机制。方法:将60例寻常性银屑病患者随机分成对照组、UVBⅠ组和UVBⅡ组3组,分别在光疗前和光疗后4周、8周作银屑病皮损面积和严重度指数(PASI)评分和背部皮损活检,采用免疫组化SABC法检测皮损中P53、casp3及bax表达。结果:UVB I组皮损中P53表达明显低于对照组,UVBⅠ组、UVBⅡ组皮损中casp-3和bax表达明显高于对照组(P<0.01);UVBⅠ组、UVBⅡ组中P53与PASI改善率呈负相关,而casp-3、bax表达呈正相关(P<0.05)。结论:皮损中角质形成细胞P53蛋白表达下调和casp-3、bax表达上调是窄谱UVB治疗寻常性银屑病的作用机制之一。

关键词：寻常性银屑病窄谱UVB 角质形成细胞凋亡

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多形性荨麻疹

临床皮肤科杂志 2015年第4期44卷 224-226页

作者：杨朝晖罗单李顺凡南方医科大学附属花都医院皮肤科广东广州510800 广东医学院附属医院皮肤科广东湛江524000

报告1例多形性荨麻疹。患儿男,1岁。因全身皮疹伴发热2 d就诊。皮肤科检查:面部、躯干及四肢大片环形及多环形红色风团,中央呈灰蓝色,无坏死、水疱,黏膜未受累,面部、手足显著肿胀(血管性水肿),皮肤划痕试验阳性。诊断为多形性荨麻疹,... 详细信息

报告1例多形性荨麻疹。患儿男,1岁。因全身皮疹伴发热2 d就诊。皮肤科检查:面部、躯干及四肢大片环形及多环形红色风团,中央呈灰蓝色,无坏死、水疱,黏膜未受累,面部、手足显著肿胀(血管性水肿),皮肤划痕试验阳性。诊断为多形性荨麻疹,系统应用糖皮质激素等疗效不显著,单纯应用苯海拉明治疗效果良好。

关键词：荨麻疹多形性