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Gastrointestinal stromal tumor presenting with prominent calcification

World Journal of Gastroenterology 2012年第39期18卷 5645-5648页

作者： Naoki Izawa Takeshi Sawada Ryuichi Abiko Daisuke Kumon Mami Hirakawa Mika Kobayashi Nobuyuki Obinata Masahito Nomoto Tadateru Maehata shun-ichi yamauchi Takefumi Kouro Takashi Tsuda Satoshi Kitajima Hiroshi Yasuda Keiichi Tanaka ichiro Tanaka Masahiro Hoshikawa Masayuki Takagi Fumio Itoh Division of Gastroenterology and Hepatology St.Marianna University School of MedicineKawasaki 216-8511Japan Division of Gastroenterological and General Surgery St.Marianna University School of MedicineKawasaki 216-8511Japan Department of Pathology St.Marianna University School of MedicineKawasak 216-8511Japan

We present a rare case of a gastrointestinal stromal tumor (GIST) in the stomach with prominent calcifica-tion at presentation. A 61-year-old woman visited our hospital because of epigastric discomfort. A spherical calcified lesion with a diameter of about 30 mm was incidentally shown in the left upper quadrant on an abdominal X-ray. Computed tomography demonstrated that the tumor was growing from the upper gastric body, with calcification in the peripheral ring area. A laparoscopic partial gastrectomy was performed, and the resected specimen revealed a well-circumscribed tumor with exophytic growth from the gastric muscularis propria. Microscopic examination revealed spindle- shaped tumor cells with calcification and hemorrhage. Additionally, positive immunoreactivity of the tumor to KIT and CD34 and a low mitotic index resulted in the diagnosis of very low risk GIST. There are a few case reports of heavily calcified GIST, although solitary or punctate calcification of primary GIST has been reported in several case series. Dystrophic calcification of necrotic or degenerative tissue is the supposed cause of primary calcified GISTs. In contrast, appearance of calcification after administration of imatinib mesylate, which may be one indicator of disease response, is possibly caused by a different mechanism.

关键词： Gastrointestinal stromal tumor Calcifica-tion Stomach Computed tomography Imatinib me-sylate

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Superconducting joints using reacted multifilament MgB_(2)wires:A technology toward cryogen-free MRI magnets

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Journal of Magnesium and Alloys 2024年第1期12卷 159-170页

作者： Dipak Patel Akiyoshi Matsumoto Hiroaki Kumakura Yuka Hara Toru Hara Minoru Maeda Hao Liang Yusuke yamauchi Seyong Choi Jung Ho Kim Md Shahriar A.Hossain School of Mechanical and Mining Engineering The University of QueenslandSt LuciaQueensland 4072Australia National Institute for Materials Science(NIMS) 1-2-1 SengenTsukubaIbaraki 305-0047Japan Department of Electrical Engineering and Kangwon High Magnetic Field Center Institute of Quantum Convergence TechnologyKangwon National UniversityGangwon 24341Republic of Korea Australian Institute for Bioengineering and Nanotechnology(AIBN) The University of QueenslandSt LuciaQueensland 4072Australia Department of Materials Process Engineering Graduate School of EngineeringNagoya UniversityNagoyaAichi 464-8603Japan Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of WollongongNorth WollongongNew South Wales 2500Australia

The development of superconducting joining technology for reacted magnesium diboride(MgB_(2))conductors remains a critical challenge for the advancement of cryogen-free MgB_(2)-based magnets for magnetic resonance imaging(MRI).Herein,the fabrication of superconducting joints using reacted carbon-doped multifilament MgB_(2)wires for MRI magnets is *** achieve successful superconducting joints,the powder-in-mold method was employed,which involved tuning the filament protection mechanism,the powder compaction pressure,and the heat treatment *** fabricated joints demonstrated clear superconducting-to-normal transitions in self-field,with effective magnetic field screening up to 0.5 T at 20 *** evaluate the interface between one of the MgB_(2)filaments and the MgB_(2)bulk within the joint,serial sectioning was conducted for the first time in this type of superconducting *** serial sectioning revealed space formation at the interface,potentially caused by the volume shrinkage associated with the MgB_(2)formation or the combined effect of the volume shrinkage and the different thermal expansion coefficients of the MgB_(2)bulk,the filament,the mold,and the sealing *** findings are expected to be pivotal in developing MgB_(2)superconducting joining technology for MRI magnet applications through interface engineering.

关键词： Mg B2 superconducting joint MgB_(2)conductor MRI applications Cryogen-free magnet Persistent-mode operation

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Ageing Society and Assistive Products

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稀有金属材料与工程 2006年第A3期35卷 67-70页

作者： Shigeru yamauchi Department of Health Science and Social Welfare Faculty of Human Sciences Waseda UniversityMikajima 2-579-15TokorozawaSaitama 359-1192Japan

North East Asian countries are facing to rapid increase in aged population *** most recent values of aged population ratios are 19.5%,8.7%,and 6.9%,for Japan,Korea and China,*** of the welfare services in the aged society is provision of assistive *** control systems are commonly adopted in modern assistive products and sensors are indispensable for control *** systems,such as fire alarm,smoke detectors,and gas leak detectors,have been regarded as indispensable to safety of elderly persons and persons with *** application of chemical sensors in home care of elderly persons is in the field of personal care and personal medical *** for personal medical treatment include that for medical treatment in home care and that to keep elderly persons *** market is expected in the latter one.

关键词： population ageing assistive products long term care personal mental treatment

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Effectiveness and safety of a laparoscopic training system combined with modified reconstruction techniques for total laparoscopic distal gastrectomy

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World Journal of Gastroenterology 2020年第13期26卷 1490-1500页

作者： shun Zhang Hajime Orita Hiroyuki Egawa Ryota Matsui Suguru yamauchi Yukinori Yube Sanae Kaji Toru Takahashi Shinichi Oka Noriyuki Inaki Tetsu Fukunaga Department of Gastroenterology and Minimally Invasive Surgery Juntendo University HospitalTokyo 113-8431Japan Department of Gastrointestinal Surgery Shanghai East HospitalTongji UniversityShanghai 200120China Department of Surgery Juntendo Urayasu HospitalJuntendo UniversityChiba 2790021Japan

BACKGROUND Total laparoscopic distal gastrectomy(TLDG)is increasing due to some advantages over open surgery,which has generated interest in gastrointestinal ***,TLDG is technically demanding especially for lymphadenectomy and gastrointestinal *** the course of training,trainee surgeons have less chances to perform open gastrectomy compared with that of senior *** To evaluate an appropriate,efficient and safe laparoscopic training procedures suitable for trainee *** Ninety-two consecutive patients with gastric cancer who underwent TLDG plus Billroth I reconstruction using an augmented rectangle technique and involving trainees were *** trainees were taught a laparoscopic view of surgical anatomy,standard operative procedures and practiced essential laparoscopic *** TLDG procedure was divided into regional lymph node dissections and gastrointestinal reconstruction for analyzing trainee *** surgical outcomes were compared between trainees and trainers to clarify the feasibility and safety of TLDG performed by *** curves were used to assess the utility of our training *** Five trainees performed a total of 52 TLDGs(56.5%),while 40 TLDGs were conducted by two trainers(43.5%).Except for depth of invasion and pathologic stage,there were no differences in clinicopathological *** performed more D2 gastrectomies than *** total operation time was significantly longer in the trainee *** time spent during the lesser curvature lymph node dissection and the Billroth I reconstruction were similar between the two *** difference was found in postoperative complications between the two *** learning curve of the trainees plateaued after five TLDG *** Preparing trainees with a laparoscopic view of surgical anatomy,standard operative procedures and practice in essential laparoscopic skills enabled trainees to perform TLDG sa

关键词： Gastric cancer Total laparoscopic gastrectomy Education system Trainees Augmented rectangle technique Standard procedure

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Species-dependent effects of the phenolic herbicide ioxynil with potential thyroid hormone disrupting activity: modulation of its cellular uptake and activity by interaction with serum thyroid hormone-binding proteins

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Journal of Environmental Sciences 2012年第5期24卷 949-955页

作者： Sakura Akiyoshi Gobun Sai Kiyoshi yamauchi Department of Biological Science Faculty of Science Shizuoka University

Ioxynil, a phenolic herbicide, is known to exert thyroid hormone （TH） disrupting activity by interfering with TH-binding to plasma proteins and a step of the cellular TH-signaling pathway in restricted animal species. However, comparative studies are still lacking on the TH disruption. We investigated the interaction of [125I] ioxynil with serum proteins from rainbow trout, bullfrog, chicken, pig, rat, and mouse, using native polyacrylamide gel electrophoresis. Candidate ioxynil-binding proteins, which included lipoproteins, albumin and transthyretin （TTR）, differed among the vertebrates tested. Rainbow trout and bullfrog tadpole serum had the lowest binding activity for ioxynil, whereas the eutherian serum had the highest binding activity. The cellular uptake of, and response to, ioxynil were suppressed by rat serum greater than by tadpole serum. The cellular uptake of [125I]ioxynil competed strongly with phenols with a single ring, but not with THs. Our results suggested that ioxynil interferes with TH homeostasis in plasma and with a step of cellular TH-signaling pathway other than TH-uptake system, in a species-specific manner.

关键词： endocrine disruption ioxynil thyroid hormone serum transthyretin uptake

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Bin-scanning:Segmentation of X-ray CT volume of binned parts using Morse skeleton graph of distance transform

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Computational Visual Media 2023年第2期9卷 319-333页

作者： Yuta yamauchi Tatsuya Yatagawa Yutaka Ohtake Hiromasa Suzuki School of Engineering The University of Tokyo7–3–1HongoBunkyo-kuTokyoJapan

X-ray CT scanners,due to the transmissive nature of X-rays,have enabled the non-destructive evaluation of industrial products,even inside their *** light of its effectiveness,this study introduces a new approach to accelerate the inspection of many mechanical parts with the same shape in a *** input to this problem is a volumetric image(i.e.,CT volume)of many parts obtained by a single CT *** need to segment the parts in the volume to inspect each of them;however,random postures and dense contacts of the parts prohibit part segmentation using traditional template *** address this problem,we convert both the scanned volumetric images of the template and the binned parts to simpler graph structures and solve a subgraph matching problem to segment the *** perform a distance transform to convert the CT volume into a distance ***,we construct a graph based on Morse theory,in which graph nodes are located at the extremum points of the distance *** experimental evaluation demonstrates that our fully automatic approach can detect target parts appropriately,even for a heap of 50 ***,the overall computation can be performed in approximately 30 min for a large CT volume of approximately 2000×2000×1000 voxels.

关键词： X-ray computed tomography(CT) volume segmentation graph matching non-destructive inspection

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Gas6-Tyro3 signaling is required for Schwann cell myelination and possible remyelination

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Neural Regeneration Research 2016年第2期11卷 215-216页

作者： Tomohiro Torii Junji yamauchi apan Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Bunkyo Tokyo lapan

Myelin plays important roles in vertebrates,ensuring the rapid propagation of action potentials and the long-term integrity of axons,but the molecular mechanisms of myelin formation remain poorly *** studies have demo... 详细信息

关键词： cell Gas6-Tyro3 signaling is required for Schwann cell myelination and possible remyelination LINGO

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Changes in serum thyroid hormone levels and thyroid gland activity of artificially maturing female Japanese eel (Anguilla japonica)

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Acta Oceanologica Sinica 2003年第1期22卷 111-122页

作者：曲宪成 Massaki Nagae Sinji Adachi Kohei yamauchi Fisheries College Shanghai Fisheries University334 Jungong RoadShanghai 200090China Faculty of Environmental Studies Course of Environmental Conservation and PlanningNagasaki University1-14 Bunkyo-machiNagasaki 852-8521Japan Department of Biology Faculty of FisheriesHokkaido University3-1-1 Minato-choHakodate 041-0821Japan

In order to evaluate the involvement of the thyroid gland in reproduction, thyroid functioning was described in female cultivated Japanese eel (Anguilla japonica) in progressive stages of sexual maturation induced by chum salmon pituitary homogenate (SPH) treatment. Serum thyroid hormones, thyroxine (T4) and triiodothyronine (T3) were also measured in each stage. Thyroid gland activity (epithelial cell height) was high before SPH injection (previtellogenic stage), further increasing at the early vitellogenic stage, thereafter decreasing to late vitellogenic and migratory nucleus stages. The profiles of both T3 and T4 changed during vitellogenesis, being high during previtellogenic and early vitellogenic stages, and subsequently declining, thus mimicking thyroid gland activity. These results suggest that the thyroid has relation with eel ovarian development during artificial maturation.

关键词： Thyroid activity thyroxine (T4) triiodothyronine (T3) Japanese eel artificial maturation

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Study of Optical Fibers Strain-Temperature Sensitivities Using Hybrid Brillouin-Rayleigh System

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Photonic Sensors 2014年第1期4卷 1-11页

作者： Kinzo Kishida Yoshiaki yamauchi Artur Guzik Neubrex Co.Ltd. Sakaemachi-dori 1-1-24Chuo-kuKobeHyogo650-0023Japan

In this paper, the most recent progress as well as challenges of distributed optical fiber sensing （DOFS） in industrial applications is discussed. Compared to the vast market of sensors used to measure strain or temperature, the success of distributed optical fiber sensing （DOFS） at the industrial level is very limited, at best. One of the reasons for this lack of the wider acceptance is the mismatch between the commercially available systems and actual industrial requirements, especially for the spatial resolution and precision. These requirements are organized and clarified in the paper. It also describes the hybrid Brillouin-Rayleigh system, which exhibits capabilities surpassing those of strain gauges. The principles of the system are illustrated considering the fiber calibration methodology. Formulas required for determining strain, temperature, and hydro-pressure are derived and discussed. Finally, the examples of applications are presented.

关键词： Hybrid Brillouin/Rayleigh system cross-sensitivity material dependence

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Non-genetic contributions of the sperm nucleus to embryonic development

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Asian Journal of Andrology 2011年第1期13卷 31-35页

作者： Yasuhiro yamauchi Jeffrey A Shaman W Steven Ward Department Anatomy and Reproductive Biology Institute for Biogenesis Research John A. Burns School of Medicine University of Hawaii at Manoa Honolulu HI USA GLP Services GENEWlZ Inc. 115 Corporate Blvd. South Plainfield NJ 07080 USA

Recent data from several laboratories have provided evidence that the newly fertilized oocyte inherits epigenetic signals from the sperm chromatin that are required for proper embryonic development. For the purposes of this review, the term epigenetic is used to describe all types of molecular information that are transmitted from the sperm cell to the embryo. There are at least six different forms of epigenetic information that have already been established as being required for proper embryogenesis in mammals or for which there is evidence that it may do so. These are （i） DNA methylation; （ii） sperm-specific histones, （iii） other chromatin-associated proteins; （iv） the perinuclear theca proteins; （v） sperm-born RNAs and, the focus of this review; and （vi） the DNA loop domain organization by the sperm nuclear matrix. These epigenetic signals should he considered when designing protocols for the manipulation and cryopreservation of spermatozoa for assisted reproductive technology as necessary components for effective fertilization and subsequent embryo development.

关键词： embryogenesis epigenetics sperm DNA sperm nuclear matrix DNA loop domain organization

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