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Unraveling colorectal cancer prevention:The vitamin D-gut flora-immune system nexus

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2394-2403页

作者： Zhi-Song Zhan Zu-shun Zheng Jing Shi Juan Chen Si-Yi wu Shi-Yan Zhang Department of Dentistry Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina Department of Physical Examination Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina Department of Anesthesiology Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina Department of Clinical Laboratory Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina Department of Surgery Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina

Colorectal cancer(CRC)is one of the most common cancers diagnosed in the *** environmental and genetic factors play a major role in the pathogenesis of CRC,extensive research has suggested that vitamin D may play a pivotal role in the development of *** D,primarily obtained through sunlight exposure,dietary sources,and supplements,has long been recognized for its essential functions in maintaining health,including immune *** article delves into the intricate relationship between vitamin D,the immune system,gut flora,and the prevention of *** presents a synthesis of epidemiological data,experimental studies,and clinical trials,highlighting the mechanisms by which vitamin D influences immune cell function,cytokine production,and *** enhancing the immune system’s surveillance and antitumor activity,vitamin D may offer a promising avenue for CRC ***,this comprehensive review delves into the prospective clinical applications of vitamin D supplementation and delineates the forthcoming avenues of research in this dynamic ***,the paper tentatively outlines a spectrum of prophylactic impacts of vitamin D on CRC,emphasizing its significant potential in reducing CRC risk through shedding light on its mechanisms,encompassing antineoplastic mechanisms,influences on the immune system,and modulation of the gut microbiome.

关键词： Colorectal cancer Vitamin D Immune system Gut flora Immunomodulation Microbial dysbiosis Cancer prevention

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High glucose reduces Nrf2-dependent cRAGE release and enhances inflammasome-dependent IL-1βproduction in monocytes:the modulatory effects of EGCG

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Food Science and Human Wellness 2024年第3期13卷 1531-1542页

作者： Chi-Hao wu Yin-Hsuan Chang Chin-Lin Hsu sheng-Yi Chen Gow-Chin Yen Graduate Programs of Nutrition Science School of Life ScienceTaiwan Normal UniversityTaipei 106209TaiwanChina Department of Food Science and Biotechnology Chung Hsing UniversityTaichung 40227TaiwanChina School of Nutrition Chung Shan Medical UniversityTaichung 40201TaiwanChina

Soluble receptor for advanced glycation end products(sRAGE)acts as a decoy sequestering of RAGE ligands,thus preventing the activation of the ligand-RAGE axis linking human ***,the molecular mechanisms underlying sRAGE remain *** this study,THP-1 monocytes were cultured in normal glucose(NG,5.5 mmol/L)and high glucose(HG,15 mmol/L)to investigate the effects of diabetesrelevant glucose concentrations on sRAGE and interleukin-1β(IL-1β)*** modulatory effects of epigallocatechin gallate(EGCG)in response to HG challenge were also *** enhanced intracellular reactive oxygen species(ROS)generation and RAGE *** secretion of sRAGE,including esRAGE and cRAGE,was reduced under HG conditions,together with the downregulation of a disintegrin and metallopeptidase 10(ADAM10)and nuclear factor erythroid 2-related factor 2(Nrf2)nuclear ***,the HG effects were counteracted by siRAGE and exacerbated by *** immunoprecipitation results showed that Nrf2 binding to the ADAM10 promoter and HG interfered with this *** data reinforce the notion that RAGE and Nrf2 might be sRAGE-regulating *** HG conditions,the treatment of EGCG reduced ROS generation and RAGE ***-stimulated cRAGE release was likely caused by the upregulation of the Nrf2-ADAM10 *** inhibited HG-mediated NLRP3 inflammasome activation at least partly by stimulating sRAGE,thereby reducing IL-1βrelease.

关键词： Epigallocatechin gallate(EGCG) Inflammasome Nuclear factor erythroid 2-related factor 2(Nrf2) Receptor for advanced glycation end products(RAGE) Soluble RAGE(sRAGE)

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Electroacupuncture improves myocardial fibrosis in heart failure rats by attenuating ECM collagen deposition through modulation of TGF-β1/Smads signaling pathway

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Traditional Medicine Research 2024年第8期9卷 1-10页

作者： Wen-Hui Wang Qian-Lan Zeng Jiao-Jiao Zhang Hao-sheng wu sheng-Bing wu Mei-Qi Zhou College of Acupuncture and Massage Anhui University of Chinese MedicineHefei 230038China Anhui Province Key Laboratory of Meridian Viscera Correlationship Anhui University of Chinese MedicineHefei 230038China

Background: To explore the effects of electroacupuncture on cardiac function and myocardial fibrosis in rat models of heart failure, and to elucidate the underlying mechanism of electroacupuncture in heart failure treatment. Methods: Healthy male Sprague-Dawley rats were allocated into three groups: Sham group, Model group, and electroacupuncture (Model + EA) group, with each group comprising 8 rats. The model underwent a procedure involving the ligation of the left anterior descending coronary artery to induce a model of heart failure. The Model + EA group was used for 7 consecutive days for electroacupuncture of bilateral Shenmen (HT7) and Tongli (HT5), once a day for 30 min each time. Left ventricular parameters in rats were assessed using a small-animal ultrasound machine to analyze changes in left ventricular end-diastolic volume, left ventricular end-systolic volume, left ventricular ejection fraction, and left ventricular fractional shortening. Serum interleukin-1β (IL-1β), cardiac troponin (cTn), and N-terminal brain natriuretic peptide precursor levels were measured using ELISA. Histopathological changes in rat myocardium were observed through HE staining, while collagen deposition in rat myocardial tissue was assessed using the Masson staining method. Picro sirius red staining, immunohistochemical staining, and RT-qPCR were utilized to distinguish between the various types of collagen deposition. The expression level of TGF-β1 and SMAD2/3/4/7 mRNA in rat myocardial tissues was determined using RT-qPCR. Additionally, western blot analysis was conducted to assess the protein expression levels of TGF-β1, SMAD3/7, and p-SMAD3 in rat myocardial tissues. Results: Compared with the Sham group, the left ventricular ejection fraction and left ventricular fractional shortening values of the Model group were significantly decreased (P < 0.01);the left ventricular end-diastolic volume and left ventricular end-systolic volume values were remarkably increased (P < 0.01)

关键词： heart failure electroacupuncture heart meridian of Hand-Shaoyin collagen deposition TGF-β1/Smads signaling pathway myocardial fibrosis

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Multi-UAV Collaborative Edge Computing Algorithm for Joint Task Offloading and Channel Resource Allocation

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Journal of Communications and Information Networks 2024年第2期9卷 137-150页

作者： Yuting Wei sheng wu Zhe Ji Zhigang Yu Chunxiao Jiang Linling Kuang School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China China Academy of Electronics and Information Technology Beijing 100041China Beijing National Research Center for Information Science and Technology Tsinghua Space CenterTsinghua UniversityBeijing 100084China

Unmanned aerial vehicle (UAV)-based edge computing is an emerging technology that provides fast task processing for a wider area. To address the issues of limited computation resource of a single UAV and finite communication resource in multi-UAV networks, this paper joints consideration of task offloading and wireless channel allocation on a collaborative multi-UAV computing network, where a high altitude platform station (HAPS)is adopted as the relay device for communication between UAV clusters consisting of UAV cluster heads (ch-UAVs) and mission UAVs (m-UAVs). We propose an algorithm, jointing task offloading and wireless channel allocation to maximize the average service success rate (ASSR)of a period time. In particular,the simulated annealing(SA)algorithm with random perturbations is used for optimal channel allocation,aiming to reduce interference and minimize transmission delay.A multi-agent deep deterministic policy gradient (MADDPG) is proposed to get the best task offloading strategy. Simulation results demonstrate the effectiveness of the SA algorithm in channel allocation. Meanwhile,when jointly considering computation and channel resources,the proposed scheme effectively enhances the ASSR in comparison to other benchmark algorithms.

关键词： UAV-based edge computing multi-UAV collaboration joint task offloading and wireless channel allocation simulated annealing(SA)algorithm multi-agent deep deterministic policy gradient(MADDPG)

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MicroRNA-630 alleviates inflammatory reactions in rats with diabetic kidney disease by targeting toll-like receptor 4

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World Journal of Diabetes 2024年第3期15卷 488-501页

作者： Qi-shun wu Dan-Na Zheng Cheng Ji Hui Qian Juan Jin Qiang He Graduate School Medical College of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Nephrology Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou 314408Zhejiang ProvinceChina Department of Nephrology Affiliated Hospital of Jiangsu UniversityZhenjiang 212001Jiangsu ProvinceChina Department of Nephrology Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 314408Zhejiang ProvinceChina Molecular Inspection Laboratory School of MedicineJiangsu UniversityZhenjiang 212000Jiangsu ProvinceChina Department of Nephrology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityZhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310060Zhejiang ProvinceChina

BACKGROUND Diabetic kidney disease(DKD)is a major complication of diabetes *** tubular epithelial cell(TEC)damage,which is strongly associated with the inflammatory response and mesenchymal trans-differentiation,plays a significant role in DKD;However,the precise molecular mechanism is *** recently identified microRNA-630(miR-630)has been hypothesized to be closely associated with cell migration,apoptosis,and ***,the association between miR-630 and DKD and the underlying mechanism remain *** To investigate how miR-630 affects TEC injury and the inflammatory response in DKD *** Streptozotocin was administered to six-week-old male rats to create a hypergly cemic diabetic *** the second week of modeling,the rats were divided into control,DKD,negative control of lentivirus,and miR-630 overexpression *** 8 wk,urine and blood samples were collected for the kidney injury assays,and renal tissues were removed for further molecular *** target gene for miR-630 was predicted using bioinformatics,and the association between miR-630 and toll-like receptor 4(TLR4)was confirmed using in vitro investigations and double luciferase reporter gene *** of miR-630 in DKD rats led to changes in body weight,renal weight index,basic blood parameters and histopathological *** The expression level of miR-630 was reduced in the kidney tissue of rats with DKD(P<0.05).The miR-630 and TLR4 expressions in rat renal TECs(NRK-52E)were measured using quantitative reverse transcription polymerase chain *** mRNA expression level of miR-630 was significantly lower in the high-glucose(HG)and HG+mimic negative control(NC)groups than in the normal glucose(NG)group(P<0.05).In contrast,the mRNA expression level of TLR4 was significantly higher in these groups(P<0.05).However,miR-630 mRNA expression increased and TLR4 mRNA expression significantly decreased in the HG+miR-630 mimic group than in the HG

关键词： Diabetic kidney disease MicroRNA-630 Toll-like receptor 4 Mouse model Renal tubular epithelial cells damage Hyperglycemic model

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Active components of Dengzhan shengmai ameliorate cognitive impairment by facilitating hippocampal long-term potentiation via the NMDA receptor-mediated Ca^(2+)/CaMKII pathway

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Journal of Pharmaceutical Analysis 2024年第3期14卷 435-438页

作者： Congyu Ma Ning sheng Jun wu Lulu Wang Jiandong Jiang Haibo Yu Jinlan Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China

Abnormal synaptic plasticity causes cognitive *** long-term potentiation(LTP)is a critical synaptic plasticity process[1].Rescuing impaired LTP is challenging;hence,novel agents are required for LTP *** medicine Dengzhan shengmai(DzSM)has shown notable clinical efficacy against cognitive deficits[2].However,it remains unclear how DzSM modulates *** previous study[3]revealed the influence of DZSM on glutamatergic and GABAergic synapses following chronic cerebral hypoperfusion(CCH),which motivated us to assess how DzSM affects synaptic functions.

关键词： impaired impairment hence

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Transition-Metal-Free Allylic Defluorination Cross-Electrophile Coupling Employing Rongalite

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Chinese Journal of Chemistry 2024年第12期42卷 1360-1366页

作者： Xiang-Long Chen Chun-Yan wu Dong-sheng Yang Bo-Cheng Tang Huai-Yu Wang Zhi-Cheng Yu Anling Li Yan-Dong wu An-Xin wu National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhanHubei 430079China state Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical Technology The HongKong Polytechnic UniversityKowloonHong Kong SARChina Department of Clinical Laboratory Center for Gene Diagnosisand Program of Clinical Laboratory MedicineZhongnan Hospital of Wuhan UniversityWuhanHubei 430062China

Comprehensive Summary The conversion of CF3-alkenes to gem-difluoroalkenes using reductive cross-coupling strategy has received much attention in recent years,however,the use of green and readily available reducing salt to mediate these reactions remains to be *** this work,a concise construction of gem-difluoroalkenes,which requires neither a catalyst nor a metal reducing agent,was ***,a safe and inexpensive industrial product,was employed as both a radical initiator and *** procedure was compatible with both linear and cyclic diaryliodonium salts,enabling a wide variety of substrates(>70 examples).The utility of this approach was demonstrated through gram-scale synthesis and efficient late-stage functionalizations of anti-inflammatory drugs.

关键词： Defluoroarylation Transition metal free gem-Difluoroalkenes Rongalite Single electron transfer C-C coupling Redox reactions Cross-coupling

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Potential effects of aerosol generation and transmission during bedside endoscope cleaning

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 628-632页

作者： Tingting sheng Xin wu Li CEN Ye LU Chenying ZHOU Qing GU Nursing Department the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Gastroenterology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051China

Airborne transmission is among the most frequent types of nosocomial *** years have witnessed frequent outbreaks of airborne diseases,such as severe acute respiratory syndrome(SARS)in 2002,Middle East respiratory syndrome(MERS)in 2012,and coronavirus disease 2019(COVID-19),with the latter being on the rampage since the end of 2019 and bringing the effect of aerosols on health back to the fore(Gralton et al.,2011;Wang et al.,2021).An increasing number of studies have shown that certain highly transmissible pathogens can maintain long-term stability and efficiently spread through aerosols(Leung,2021;Lv et al.,2021).As reported previously,influenza viruses that can spread efficiently through aerosols remain stable for a longer period compared to those that *** World Health Organization(WHO)has stated that aerosol-generating procedures(AGPs)play an important role in aerosol transmission in hospitals(Calderwood et al.,2021).AGPs,referring to medical procedures that produce aerosols,including dental procedures,endotracheal intubation,sputum aspiration,and laparoscopic surgeries,have been reported to be significantly associated with an increased risk of nosocomial infection among medical personnel(Hamilton,2021).

关键词： Endoscopy Endoscopic surgery Aerosol transmission Bedside endoscope precleaning

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Achieving Synergistic Improvement in Dielectric and Energy Storage Properties of All-Organic Poly(Methyl Methacrylate)-Based Copolymers Via Establishing Charge Traps

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Energy & Environmental Materials 2024年第2期7卷 312-323页

作者： Guanghu He Huang Luo Chuanfang Yan Yuting Wan Dang wu Hang Luo Yuan Liu sheng Chen Key Laboratory of Polymeric Materials and Application Technology of Hunan Province College of Chemistry Xiangtan University State Key Laboratory of Powder Metallurgy Central South University Guangdong University of Petrochemical Technology

How to achieve synergistic improvement of permittivity（εr） and breakdown strength（Eb） is a huge challenge for polymer ***,for the first time,the π-conjugated comonomer（MHT） can simultaneously promote theεrand Ebof linear poly（methyl methacrylate）(PMMA) *** PMMA-based random copolymer films(P（MMA-co-MHT）),block copolymer films（PMMA-b-PMHT）,and PMMA-based blend films were prepared to investigate the effects of sequential structure,phase separation structure,and modification method on dielectric and energy storage properties of PMMA-based dielectric *** a result,the random copolymer P（MMA-coMHT） can achieve a maximum εrof 5.8 at 1 kHz owing to the enhanced orientation polarization and electron *** electron injection and charge transfer are limited by the strong electrostatic attraction ofπ-conjugated benzophenanthrene group analyzed by the density functional theory（DFT）,the discharge energy density value of P（MMA-co-PMHT）containing 1 mol% MHT units with the efficiency of 80% reaches15.00 J cm-3at 872 MV m-1,which is 165% higher than that of pure *** study provides a simple and effective way to fabricate the high performance of polymer dielectrics via copolymerization with the monomer of P-type semi-conductive polymer.

关键词： dielectric capacitor electrical properties energy density polymer dielectric semiconductor polymer

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Loosely coordinating diluted highly concentrated electrolyte toward -60℃ Li metal batteries

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Journal of Energy Chemistry 2024年第3期90卷 380-387,I0009页

作者： Han Zhang Ziqi Zeng Qiang wu Xinlan Wang Mingsheng Qin sheng Lei Shijie Cheng Jia Xie State Key Laboratory of Advanced Electromagnetic Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina

Lithium metal batteries(LMBs) promise energy density over 400 Wh kg^(-1).However,they suffer severe electrochemical performance deterioration at sub-zero *** failure behavior highly correlates to inferior lithium metal anode(LMA) compatibility and sluggish Li^(+) ***,we demonstrate that cyclopentylmethyl ether(CPME) based diluted high-concentration electrolyte(DHCE)enables-60℃ LMBs *** leveraging the loose coordination between Li^(+) and CPME,such developed electrolyte boosts the formation of ion clusters to derive anion-dominant interfacial chemistry for enhancing LMA compatibility and greatly accelerates Li^(+) desolvation *** resulting electrolyte demonstrates high Coulombic efficiencies(CE),providing over 99.5%,99.1%,98.5% and 95% at 25,-20,-40,and-60℃*** assembled Li-S battery exhibits remarkable cyclic stability in-20,and-40℃ at 0.2 C charging and 0.5 C *** at-60℃,Li-S cell with this designed electrolyte retains> 70% of the initial capacity over 170 ***,lithium metal coin cell and pouch cell with10 mg cm^(-2) high S cathode loading exhibit cycling stability at-20℃.This work offers an opportunity for rational designing electrolytes toward low temperature LMBs.

关键词： Lithium metal batteries -60℃operation Lithium metal anode compatibility Li^(+) desolvation kinetics

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