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Thalidomide-based multidisciplinary treatment for patients with advanced hepatocellular carcinoma:A retrospective analysis

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World Journal of Gastroenterology 2012年第5期18卷 466-471页

作者： Yang-Yuan Chen Hsu-Heng Yen Kun-Ching Chou shun-sheng wu Department of Gastroenterology ChinaMedical University Hospital China Medical University Taic-hung 40000 Taiwan China Depart-ment of Gastroenterology Changhua Christian Medical CenterChanghua 50000 Taiwan China

AIM： To evaluate the efficacy of thalidomide in com- bination with other therapies to treat patients with ad- vanced hepatocellular carcinoma （HCC）. METHODS： We performed a retrospective analysis of all patients with HCC who were treated with thalido- mide for at least two months. The medical records of patients with HCC who were treated at our institution between April 2003 and March 2008 were reviewed. Image studies performed before and after treatment, tumor response, overall survival, and the decrease in o-fetoprotein （AFP） levels were evaluated. RESULTS： A total of 53 patients with HCC received either 100 or 200 mg/d of thalidomide. The patient population consisted of 9 women and 44 men with a median age of 61 years. Thirty patients （56.6%） were classified as Child-Pugh A, and 12 patients （22.6%） were classified as Child-Pugh B. Twenty-six patients had portal vein thrombosis （49.1%）, and 25 patients had extrahepatic metastasis （47.1%）. The median duration of thalidomide treatment was 6.0 mo. Six of the 53 patients achieved a confirmed response （11.3%）, one achieved a complete response （1.9%） and 5 achieved a partial response （9.4%）. The disease control rate （CR ＋ PR ＋ SD） was 28.3% （95% CI： 17.8-42.4）, and the median overall survival rate was 10.5 too. The 1- and 2-year survival rates were 45% and 20%, respectively. Only one complete response patient showed an im- proved overall survival rate of 66.8 mo. Sixteen patients （30.2%） showed more than a 50% decrease in their serum AFP levels from baseline, indicating a better re- sponse rate （31.3%）, disease control rate （43.8%）, and overall survival time （20.7 mo）. The therapy was well tolerated, and no significant toxicities were observed. CONCLUSION： Thalidomide was found to be safe for advanced HCC patients, demonstrating anti-tumor ac- tivity including response, survival, and AFP decreases of greater than 50% from baseline.

关键词： Thalidomide Hepatocellular carcinoma

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Two case reports of gastroendoscopy-associated Acinetobacter baumannii bacteremia

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World Journal of Gastroenterology 2013年第18期19卷 2835-2840页

作者： Chang-Hua Chen shun-sheng wu Chieh-Chen Huang Section of Infectious Diseases Department of Internal Medicine Changhua Christian Hospital Changhua 500 Taiwan Section of Gastroenterology Department of Internal Medicine Changhua Christian Hospital Changhua 500 Taiwan Department of Life Science College of Life Science National Chung Hsing University Taichung 402 Taiwan

Two cases of gastroendoscopy-associated Acinetobacter baumannii (A. baumannii ) bacteremia were discovered at the study hospital. The first case was a 66-year-old woman who underwent endoscopic retrograde cholangiopancreatography and endoscopic retrograde papillotomy, and then A. baumannii bacteremia occurred. The second case was a 70-year-old female who underwent endoscopic retrograde biliary drainage due to obstruction of intra-hepatic ducts, and bacteremia occurred due to polymicrobes (Escherichia coli , viridans streptococcus , and A. baumannii ). After a literature review, we suggest that correct gastroendoscopy technique and skill in drainage procedures, as well as antibiotic prophylaxis, are of paramount importance in minimizing the risk of gastroendoscopy-associated bacteremia.

关键词： Endoscopy Acinetobacter baumannii Bacteremia Antibiotic prophylaxis

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Global-local combined features to detect pain intensity from facial expression images with attention mechanism

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Journal of Electronic Science and Technology 2024年第3期22卷 80-93页

作者： Jiang wu Yi Shi shun Yan Hong-Mei Yan Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou313001China MOE Key Laboratory for Neuroinformation School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu611731China College of Engineering University of California at Santa BarbaraSanta Barbara93106USA

The estimation of pain intensity is critical for medical diagnosis and treatment of *** the development of image monitoring technology and artificial intelligence,automatic pain assessment based on facial expression and behavioral analysis shows a potential value in clinical *** paper reports a framework of convolutional neural network with global and local attention mechanism(GLA-CNN)for the effective detection of pain intensity at four-level thresholds using facial expression ***-CNN includes two modules,namely global attention network(GANet)and local attention network(LANet).LANet is responsible for extracting representative local patch features of faces,while GANet extracts whole facial features to compensate for the ignored correlative features between *** the end,the global correlational and local subtle features are fused for the final estimation of pain *** under the UNBC-McMaster Shoulder Pain database demonstrate that GLA-CNN outperforms other state-of-the-art ***,a visualization analysis is conducted to present the feature map of GLA-CNN,intuitively showing that it can extract not only local pain features but also global correlative facial *** study demonstrates that pain assessment based on facial expression is a non-invasive and feasible method,and can be employed as an auxiliary pain assessment tool in clinical practice.

关键词： Attention Convolutional neural network Facial expression Pain intensity

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Demixing microwave signals using system-on-chip photonic processor

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Light(Science & Applications) 2024年第3期13卷 399-401页

作者： sheng Gao Chu wu Xing Lin Department of Electronic Engineering Tsinghua University100084 BeijingChina Beijing National Research Center for Information Science and Technology Tsinghua University100084 BeijingChina

The integrated photonic processor,co-packaged with electronic peripherals,is proposed for blind source separation of microwave signals,which separates signal-of-interest from dynamic interference with real-time adapta... 详细信息

关键词： processor microwave mixing

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Imide-pillared covalent organic framework protective films as stable zinc ion-conducting interphases for dendrite-free Zn metal anodes

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Journal of Energy Chemistry 2024年第10期97卷 470-477页

作者： Xiaoman Ye Xuemei Xiao Zhijing wu Xin wu Lin Gu sheng Liu School of Chemical Engineering and Technology Sun Yat-sen University The Key Lab of Low-Carbon Chemistry & Energy Conservation of Guangdong Province Sun Yat-sen University

The notorious growth of zinc dendrite and the water-induced corrosion of zinc metal anodes（ZMAs）restrict the practical development of aqueous zinc ion batteries（AZIBs）.In this work,a zinc metallized,imide-pillared covalent organic framework（ZPC） protective film has been engineered as a stable Zn2+ion-conducting interphase to modulate interfacial kinetics and suppress side reactions for *** to bare Zn,ZPC@Zn exhibits a higher Zn2+ionic conductivity,a larger Zn2+transference number,a lower electronic conductivity,a smaller desolvation activation energy and correspondingly a significant suppression of corrosion,hydrogen evolution and Zn ***,the ZPC@Zn||ZPC@Zn symmetric cell obtains a cycling lifespan over 3000 h under 5 mA cm-2for 1 mA h *** ZPC@Zn||NH4V4O10coin-type full battery delivers a specific capacity of 195.8 mA h g-1with a retention rate of78.5% at 2 A g-1after 1100 cycles,and the ZPC@Zn||NH4V4O10pouch full cell shows a retention of70.1% in reversible capacity at 3 A g-1after 1100 *** present incorporation of imide-linked covalent organic frameworks in the surface modification of ZMAs will offer fresh perspectives in the search for ideal protective films for the practicality of AZIBs.

关键词： Aqueous zinc ion batteries Covalent organic frameworks Imide linkage Surface modification Zinc metal anodes

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Efficacy of hepatic arterial infusion chemotherapy and its combination strategies for advanced hepatocellular carcinoma:A network meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3672-3686页

作者： shun-An Zhou Qing-Mei Zhou Lei wu Zhi-Hong Chen Fan wu Zhen-Rong Chen Lian-Qun Xu Bi-LingGan Hao-sheng Jin Ning Shi Department of General Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Geriatrics Ganzhou Hospital-Nanfang HospitalSouthern Medical UniversityGanzhou 341000Jiangxi ProvinceChina Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510000Guangdong ProvinceChina Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China

BACKGROUND With the rapid progress of systematic therapy for hepatocellular carcinoma(HCC),therapeutic strategies combining hepatic arterial infusion chemotherapy(HAIC)with systematic therapy arised increasing ***,there have been no systematic review comparing HAIC and its combination strategies in the first-line treatment for advanced *** To investigate the efficacy and safety of HAIC and its combination therapies for advanced *** A network meta-analysis was performed by including 9 randomized controlled trails and 35 cohort studies to carry out our *** outcomes of interest comprised overall survival(OS),progression-free survival(PFS),tumor response and adverse *** ratios(HR)and odds ratios(OR)with a 95% confidence interval(CI)were calculated and agents were ranked based on their ranking *** HAIC outperformed Sorafenib(HR=0.55,95%CI:0.42-0.72;HR=0.51,95%CI:0.33-0.78;OR=2.86,95%CI:1.37-5.98;OR=5.45,95%CI:3.57-8.30;OR=7.15,95%CI:4.06-12.58;OR=2.89,95%CI:1.99-4.19;OR=0.48,95%CI:0.25-0.92,respectively)and transarterial chemoembolization(TACE)(HR=0.50,95%CI:0.33-0.75;HR=0.62,95%CI:0.39-0.98;OR=3.08,95%CI:1.36-6.98;OR=2.07,95%CI:1.54-2.80;OR=3.16,95%CI:1.71-5.85;OR=2.67,95%CI:1.59-4.50;OR=0.16,95%CI:0.05-0.54,respectively)in terms of efficacy and ***+lenvatinib+ablation,HAIC+ablation,HAIC+anti-programmed cell death 1(PD-1),and HAIC+radiotherapy had the higher likelihood of providing better OS and PFS outcomes compared to HAIC ***+TACE+S-1,HAIC+lenvatinib,HAIC+PD-1,HAIC+TACE,and HAIC+sorafenib had the higher likelihood of providing better partial response and objective response rate outcomes compared to ***+PD-1,HAIC+TACE+S-1 and HAIC+TACE had the higher likelihood of providing better complete response and disease control rate outcomes compared to HAIC *** HAIC proved more effective and safer than sorafenib and ***,combined with other interventions,HAIC showed imp

关键词： Hepatic arterial infusion chemotherapy Hepatocellular carcinoma Network meta-analysis Interventional therapy Systemic treatment

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Clinical and genomic analysis of baseline and acquired MET fusions with an intact kinase domain in lung cancer patients

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Genes & Diseases 2024年第1期11卷 76-79页

作者： Bo Jin Yutong Ma Qian wu Qiuxiang Ou Yang Shao shun Xu Department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoning 110001China Geneseeq Research Institute Nanjing Geneseeq Technology Inc.NanjingJiangsu 210000China School of Public Health Nanjing Medical UniversityNanjingJiangsu 211166China Department of Thoracic Surgery The First Hospital of China Medical UniversityShenyangLiaoning110001China

MET gene alterations in lung cancer patients mainly include exon 14 skipping and gene amplification,which are the key therapeutic targets and drive resistance to tyrosine kinase inhibitors(TKls).1 However,the structural variants of MET,such as MET fusions,are much rarer(0.26%),as reported in a Chinese non-small cell lung cancer(NSCLC)cohort.2 Several recurrent MET fusions,such as KIF5B-MET and HLADRB1-MET,were reported as oncogenic drivers and showed favorable responses to crizotinib.

关键词： lung patients alterations

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Synergic catalysis of W and Ni originating from substitution of trivacant phosphotungstate for the selective oxidation of aniline to azoxybenzene

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Chinese Chemical Letters 2024年第2期35卷 558-563页

作者： sheng Cai Xiao-Yuan wu Weiming wu Sa-Sa Wang Can-Zhong Lu CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China Xiamen Institute of Rare Earth Materials Chinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China

Partial substitution of polyoxometalate(POM)is an efficient route to modulate the catalytic property of maternal *** this work,a new Keggin type POM involving{Ni 6}cluster,{[Ni(H_(2) O)_(2)(Dach)_(2)][Ni(Dach)_(2)]_(2)}{[Ni_(6)Cl(μ-OH)_(3)(H_(2) O)(Dach)_(3)(WO_(4))(PW9 O_(3)_(4))][Ni_(6)(μ-OH)_(3)(H_(2) O)_(2)(Dach)_(3)(WO_(4))(PW9 O_(3)_(4))]}Cl·27H_(2) O,(1,Dach=1,2-diaminocyclohexane)was *** 1 shows excellent catalytic performance in the selective oxidation of aniline to azoxybenzene(AOB)in *** apparently different results from that with the matrix{PW 9 O_(3)_(4)}({PW9})suggest the successful regulation of the catalytic property of{PW9}by the introduction of the{Ni6}cluster into the *** experimental results indicate that the highlighted performance of 1 is contributed by the synergy of W and Ni sites,which are respectively responsible for the oxidation and condensation steps in the production of *** good selectivity to AOB is essentially attributed to the effective modulation of the reaction rates of oxidation and condensation steps by W and Ni sites,respectively.

关键词： Polyoxometalate {Ni6}cluster Modulated catalytic property Aniline oxidation Azoxybenzene

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Preferential adsorption control: Ca-based LDO for regenerating used lubricating oil

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Progress in Natural Science:Materials International 2024年第1期34卷 155-161页

作者： Xiao-lei Zhang Jian-zhong wu Yun Liu Zai-wu Zhang Chao Hu Yong-sheng Lu School of Environmental and Chemical Engineering Shanghai University Shanghai Chengtou Wastewater Treatment CO. LTD Shanghai Shangsheng Ecological Engineering Co. Ltd. Shencai Technology Co. Ltd

Different Ca-based layered double oxides（LDO） were applied in the removal of contaminants in used lubricating oil as an alternative decolorant. CaAl-LDO and CaFeAl-LDO achieved much greater decoloration efficiency than the traditional decolorants, where 0.93 and 0.91 of the decoloration efficiency under the optimum conditions were obtained, respectively. The decoloration activity with CaFeAl-LDO > CaAl-LDO >> CaFe-LDO was revealed by both Density Functional Theory（DFT） calculations and experimental analysis. Ca12Al14O33was shown to be the active component for decoloration. Fe3+doped into CaAl-LDO could improve decoloration activity via a changed charge distribution of decolorant. High preferential adsorption activity, which originated from different charge distribution for contaminants instead of the oil components, contributed to outstanding decoloration performance. The activity depended on the adsorption intensity of contaminants, where the most of the active decolorant neither too strongly or weakly bound with the contaminants. The results of this study suggested the Cabased LDOs could be a potentially alternative decolorants for regenerating the used lubricating oil.

关键词： Used lubrication oil Adsorption Ca-LDO Decoloration DFT calculation

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Towards designing high mechanical performance low-alloyed wrought magnesium alloys via grain boundary segregation strategy:A review

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Journal of Magnesium and Alloys 2024年第5期12卷 1774-1791页

作者： Zhi Zhang Jinshu Xie Jinghuai Zhang Xu-sheng Yang Ruizhi wu Key Laboratory of Superlight Material and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China State Key Laboratory of Ultra-Precision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518060China

Low-alloyed magnesium(Mg)alloys have emerged as one of the most promising candidates for lightweight ***,their further application potential has been hampered by limitations such as low strength,poor plasticity at room temperature,and unsatisfactory *** address these challenges,grain refinement and grain structure control have been identified as crucial factors to achieving high performance in low-alloyed Mg *** effective way for regulating grain structure is through grain boundary(GB)*** review presents a comprehensive summary of the distribution criteria of segregated atoms and the effects of solute segregation on grain size and growth in Mg *** analysis encompasses both single element segregation and multi-element co-segregation behavior,considering coherent interfaces and incoherent ***,we introduce the high mechanical performance low-alloyed wrought Mg alloys that utilize GB segregation and analyze the potential impact mechanisms through which GB segregation influences materials *** upon these studies,we propose strategies for the design of high mechanical performance Mg alloys with desirable properties,including high strength,excellent ductility,and good formability,achieved through the implementation of GB *** findings of this review contribute to advancing the understanding of grain boundary engineering in Mg alloys and provide valuable insights for future alloy design and optimization.

关键词： Magnesium alloys Grain boundary segregation High strength High plasticity High formability

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