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Impact of prophylactic/preemptive donor lymphocyte infusion and intensified conditioning for relapsed/refractory leukemia:a real-world study

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Science China(Life Sciences) 2020年第10期63卷 1552-1564页

作者： Yu wang Qi-Fa Liu De-Pei Wu Jing-Bo wang Xi Zhang Heng-Xiang wang Feng Gao shun-qing wang Zi-Min Sun Jian Ouyang Kai-Lin Xu Su-Jun Gao Lan-Ping Xu Chen-Hua Yan Xiao-Jun Huang Department of Hematology Peking University People’s HospitalPeking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Hematology the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Hematology Aero Center Space HospitalBeijing 100049China Department of Hematology Xinqiao HospitalThird Military Medical UniversityChongqing 400037China Department of Hematology Air Force General HospitalPLABeijing 100142China Department of Hematology the Affiliated Hospital of North China University Science and TechnologyTangshan 063210China Department of Hematology Guangzhou First People’s HospitalGuangzhou 510180China Department of Hematology Anhui Provincial HospitalHefei 230001China Department of Hematology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Hematology the Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000China Department of Hematology the First Affiliated Hospital of Jilin UniversityChangchun 130021China Peking-Tsinghua Center for Life Sciences Beijing 100871China Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies Chinese Academy of Medical Sciences2019RU029Beijing 100730China Collaborative Innovation Center of Hematology Beijing 100044China

Prophylactic/preemptive donor lymphocyte infusion(p/pDLI)and intensified conditioning have shown promising results in experimental studies of refractory/relapsed acute leukemia(RRAL),but real-world data remain *** conducted a multicenter,population-based analysis of 932 consecutive *** three-year leukemia-free survival(LFS)rates were 56%for patients receiving both p/pDLI and intensified myeloablative conditioning(MAC)(intenseMAC)and 30%for those who received neither therapy per landmark *** analyses were run separately for acute myeloid leukemia(AML)and acute lymphoblastic leukemia(ALL),and p/pDLI treatment was linked to significantly higher LFS than non-DLI for both AML and ALL patients without increasing the nonrelapse *** was associated with significantly lower relapse and higher LFS than nonintensified MAC despite higher nonrelapse mortality rates in ALL,while there was no impact of intenseMAC observed in AML.p/pDLI achieved superior outcomes in both matched-sibling donor(MSD)and haploidentical donor transplantation,while intenseMAC only influenced MSD *** suggest that RRAL patients receiving“total therapy”by way of p/pDLI and intensified conditioning treatment have an improved chance for LFS,with p/pDLI being safer with a more extensive impact relative to *** with RRAL can tolerate both interventions and achieve a reasonable outcome.

关键词： donor lymphocyte infusion intensified conditioning refractory/relapsed leukemia haploidentical prophylactic

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三轴转台初始位姿对准误差的测试方法

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光学精密工程 2017年第3期25卷 712-719页

作者：刘庆博任顺清王常虹哈尔滨工业大学空间控制与惯性技术研究中心黑龙江哈尔滨150080

雷达仿真实验用卧式三轴飞行仿真转台的三轴交汇中心与射频阵列仿真系统球面的球心同心,转台的初始姿态满足一定要求,以减小雷达仿真时的误差。为了三轴转台位姿的精确对准,提出了一种能补偿经纬仪竖直轴线铅垂度误差和俯仰轴零位误差... 详细信息

雷达仿真实验用卧式三轴飞行仿真转台的三轴交汇中心与射频阵列仿真系统球面的球心同心,转台的初始姿态满足一定要求,以减小雷达仿真时的误差。为了三轴转台位姿的精确对准,提出了一种能补偿经纬仪竖直轴线铅垂度误差和俯仰轴零位误差的对准方案,首先根据精确的已知基点的坐标,通过经纬仪对各基点的观测结果采用最小二乘迭代处理方法,确定了经纬仪的三轴交汇中心的位置,再通过经纬仪对转台的内、中环轴轴端安装的靶标进行观测,确定了三轴转台的位置与初始姿态。通过实际测试与调整,解算出了三轴转台的三轴交汇中的坐标为-0.485,0.203和-0.475mm,外环轴指向误差为-59″。该测试结果在位置误差1mm,姿态误差2′的要求范围之内,实现了三轴转台的位姿对准任务。

关键词：三轴飞行仿真转台位姿对准经纬仪最小二乘法迭代算法

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Long-term follow-up of haploidentical transplantation in relapsed/refractory severe aplastic anemia:a multicenter prospective study

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Science Bulletin 2022年第9期67卷 963-970,M0004页

作者： Lan-Ping Xu Zheng-Li Xu shun-qing wang De-Pei Wu Su-Jun Gao Jian-Min Yang Ling-Hui Xia Qi-Fa Liu Ming Jiang Hai Bai Xi Zhang Xin wang Xiao-Jun Huang Peking University People's Hospital Peking University Institute of HematologyBeijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Department of Hematology Guangzhou First People's HospitalGuangzhou 510180China Department of Hematology The First Affiliated Hospital of Soochow UniversitySoochow 215004China Department of Hematology The First Hospital of Jilin UniversityChangchun 130061China Department of Hematology Changhai Hospital Affiliated to Second Military Medical UniversityShanghai 200433China Department of Hematology Xiehe Hospital Affiliated to Huazhong University of Science and Technology.Wuhan 430022China Department of Hematology Nanfang Hospital Affiliated to Southern Medical UniversityGuangzhou 510515China Department of Hematology The First Affiliated Hospital of Xinjiang Medical UniversityUrumchi 830054China Department of Hematology General Hospital of Lanzhou Military Region of PLALanzhou 730050China Medical Center of Hematology The Second Affiliated Hospital of Army Medical UniversityChongqing 400037China Department of Hematology Shandong Provincial HospitalJinan 250021China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China Peking-Tsinghua Center for Life Sciences Beijing 100044China

In recent decades,haploidentical stem cell transplantation(haplo-SCT)to treat severe aplastic anemia(SAA)has achieved remarkable ***,long-term results are still *** conducted a multicenter prospective study involving SAA patients who underwent haplo-SCT as salvage ***-term outcomes were assessed,mainly focusing on survival and quality of life(QoL).Longitudinal QoL was prospectively evaluated during pretransplantation and at 3 and 5 years posttransplantation using the SF-36 scale in adults and the PedsQL 4.0 scale in children.A total of 287 SAA patients were enrolled,and the median follow-up was 4.56 years(range,3.01–9.05 years)among surviving *** the long-term follow-up,268 of 275 evaluable patients(97.5%)obtained sustained full donor chimerism,and 93.4%had complete hematopoietic *** estimated overall survival and failure-free survival for the whole cohort at 9 years were 85.4%±2.1%and 84.0%±2.2%,***(≥18 years)and a poorer performance status(ECOG>1)were identified as risk factors for survival *** Qo L recovery after haplo-SCT,we found that QoL progressively improved from pretransplantation to the 3-year and 5-year time points with statistical *** occurrence of chronic graft versus host disease was a risk factor predicting poorer QoL scores in both the child and adult *** the last followup,74.0%of children and 72.9%of adults returned to normal school or *** inspiring long-term outcomes suggest that salvage transplantation with haploidentical donors can be routine practice for SAA patients without human leukocyte antigen(HLA)-matched donors.

关键词： Aplastic anemia Haploidentical Long-term follow-up Quality of life

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两种眼前节分析系统测量屈光手术前后波前像差的一致性

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国际眼科杂志 2018年第11期18卷 2016-2018页

作者：张小兰王顺清孙成淑马可四川大学华西医院眼科中国四川省成都市610041

目的:研究SCHWIND和SIRIUS眼前节分析系统测量屈光手术患者手术前后像差结果的一致性。方法:前瞻性对照研究。选取2017-06/12于四川大学华西医院眼科行飞秒制瓣准分子激光原位角膜磨镶术的屈光不正患者180例360眼,采用SCHWIND和SIRIUS... 详细信息

目的:研究SCHWIND和SIRIUS眼前节分析系统测量屈光手术患者手术前后像差结果的一致性。方法:前瞻性对照研究。选取2017-06/12于四川大学华西医院眼科行飞秒制瓣准分子激光原位角膜磨镶术的屈光不正患者180例360眼,采用SCHWIND和SIRIUS眼前节分析系统测量角膜平轴和陡轴曲率的度数和轴向、Kappa角度数及高阶像差等数据。结果:采用SCHWIND和SIRIUS眼前节分析系统测得的本组患者术前和术后1mo的角膜平轴度数和方向、陡轴度数和方向、术后1mo的Kappa角度数和方向、术前和术后1mo的彗差和三叶草数据差异均无统计学意义(P>0. 05)。术前,两种检测方法检测的总高阶像差和球差数据差异均有统计学意义(P0. 05)。结论:SCHWIND和SIRIUS眼前节分析系统测量屈光手术患者手术前后影响成像质量的相关数据具有较好的一致性。

关键词：眼前节分析系统波前像差飞秒激光

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Effect of pyrite content on chalcopyrite flotation under different regrinding conditions

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 49-57页

作者： Zejun wang qing Shi Guofan Zhang Yuxuan Zhu Binbin Li School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China

This study aimed to investigate the effect of varying pyrite(Py)content on copper(Cu)in the presence of different regrinding conditions,which were altered using different types of grinding media:iron,ceramic balls,and their mixture,followed by flotation in the cleaner *** flotation performance of rough Cu concentrate can be improved by changing the regrinding conditions based on the Py *** electron microscopy,X-ray spectrometry,ethylenediaminetetraacetic acid disodium salt extraction,and X-ray photoelectron spectroscopy studies illustrated that when the Py content was high,the use of iron media in regrinding promoted the generation of hydrophilic Fe OOH on the surface of Py and improved the Cu *** ceramic medium with a low Py content prevented excessive Fe OOH from covering the surface of chalcopyrite(Cpy).Electrochemical studies further showed that the galvanic corrosion current of Cpy-Py increased with the addition of Py and became stronger with the participation of iron media.

关键词： chalcopyrite regrinding media pyrite galvanic corrosion flotation

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五种检查仪器对角膜水平直径测量的对比分析

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国际眼科杂志 2019年第4期19卷 704-708页

作者：张小兰龚芮王顺清黄永志四川大学华西医院眼科中国四川省成都市610041

目的:分析五种角膜直径测量方法对角膜水平直径测量的相关性和一致性。方法:纳入2018-02/03在四川大学华西医院眼科行双眼ICL植入的患者25例50眼,术前分别采用规尺、眼前节分析系统SIRIUS、IOL Master500、眼前节OCT和UBM 5种方法测量... 详细信息

目的:分析五种角膜直径测量方法对角膜水平直径测量的相关性和一致性。方法:纳入2018-02/03在四川大学华西医院眼科行双眼ICL植入的患者25例50眼,术前分别采用规尺、眼前节分析系统SIRIUS、IOL Master500、眼前节OCT和UBM 5种方法测量角膜水平直径,比较5种方法测量结果的相关性及一致性。结果:规尺、眼前节分析系统SIRIUS、IOL Master500、眼前节OCT和UBM测量的角膜水平直径分别为11.54±0.30、11.77±0.33、11.98±0.33、11.63±0.35、11.53±0.34mm(P0.05),直线相关分析发现五种检查方法测量值之间均具有显著相关性,Bland-Altman分析发现,规尺与SIRIUS、UBM、眼前节OCT检查值的95%LoA上下限绝对值均≤0.50mm。结论:五种测量角膜水平直径的结果,规尺与SIRIUS,UBM和前节OCT的结果可以互换,其他结果不能互换。IOL Master500测量值最大,不宜作为测量角膜水平直径大小的诊断依据,其他测量设备检查结果应结合临床实践。

关键词：角膜水平直径规尺 SIRIUS眼前节分析系统 IOL Master500 眼前节OCT 超声生物显微镜一致性分析

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Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： qing He Zhen wang Yuchen wang Mengjie Zhu Zhile Liang Kanghong Zhang Yuge Xu Gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-qing Qiao Guo Hui Bojing Sun Dongfang Hou Meidi wang Xueqian Wu Tao Wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

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汽车前后轴制动力数字电液比例分配系统

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同济大学学报（自然科学版） 2001年第12期29卷 1462-1465页

作者：刘顺安王庆年张忠元吉林大学工学部吉林长春130025

为使汽车在不同工况及路面时都能使前后轴制动力接近理想的制动力分配曲线 ,提高汽车运行的安全性 ,提出了用数字高速开关阀及单片机组成制动力电液比例分配装置 ,实现前后制动分泵的压力按比例进行分配 .装置可根据汽车的载重量 ,确定... 详细信息

为使汽车在不同工况及路面时都能使前后轴制动力接近理想的制动力分配曲线 ,提高汽车运行的安全性 ,提出了用数字高速开关阀及单片机组成制动力电液比例分配装置 ,实现前后制动分泵的压力按比例进行分配 .装置可根据汽车的载重量 ,确定与之相对应的标准制动力分配曲线 .实施制动时 ,由压力传感器检测制动器出口压力 ,由PWM信号控制的两个高速开关阀 ,适时调节前、后制动分泵中的压力 ,跟踪标准制动力分配曲线 .理论分析及台架试验表明 ,文中提出的方法可行 ,基本上能实现四轮同时制动而不抱死。

关键词：汽车制动力分配电液数字控制前轴后轴制动器

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Branched module-modified SN38 prodrug nanoassemblies for improved colorectal cancer therapy:Effectively balance efficacy and safety

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Nano Research 2025年第1期18卷 572-585页

作者： qing wang Shiyi Zuo Shufang Zheng Cuiyun Liu Yaqiao Li Jiayu Guo Danping wang Shuo wang Wenjing wang Bowen Zhang Minglong Huang Xianbao Shi Jin Sun Zhonggui He Bingjun Sun Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Joint International Research Laboratory of Intelligent Drug Delivery Systems Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China School of Chemical Engineering The University of AdelaideAdelaideSA 5005Australia Department of Pharmacy The First Affiliated Hospital of Jinzhou Medical UniversityJinzhou 121001China

The clinical utility of irinotecan is restricted by individual variability in carboxylesterase *** administration of its active metabolite,7-ethyl-10-hydroxycamptothecin(SN38),presents an appealing alternative due to its potent anti-tumor ***,the undesirable properties of SN38,such as poor water solubility and nontarget toxicity,present significant hurdles to its clinical *** nanoassemblies based on modular design strategy show promise in overcoming these challenges by enhancing drug delivery and selective *** modular design,the modification module plays a crucial role in improving the self-assembly capability of *** current studies mainly focus on using straight aliphatic chains for prodrug design,branched aliphatic chains emerge as superior alternatives warranting further *** this study,we selected 2-heptylundecanol(BAlc18)as modification module to construct an SN38 *** exquisite design,SN38-SS-BAlc18 NPs integrated prominent properties in selfassembly capability,specific activation and biocompatibility,resolving the challenges of irinotecan and SN38,ultimately demonstrating excellent anti-tumor *** exploration enriched the design theory of prodrug nanoassemblies that can effectively balance safety and colorectal anti-tumor efficacy.

关键词： irinotecan SN38 prodrug nanoassemblies disulfide bonds branched aliphatic chains

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