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Apoptotic bone marrow CD34+ cells in cirrhotic patients

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World Journal of Gastroenterology 2011年第15期17卷 2044-2048页

作者： Shuang-Suo dang Wen-Jun wang Ning Gao shun-da wang Mei Li La-Yang Liu Ming-Zhun Sun Tao Dong Department of Infectious Diseases Second Affiliated Hospital of Medical School of Xi’an Jiaotong University 157 Xiwu Road Xi’an 710004 Shaanxi Province China MRC Human Immunology Unit Weatherall Institute of Molecular Medicine John Radcliffe Hospital Oxford OX3 9DS United Kingdom

AIM: To access the frequency and level of apoptotic CD34+ cells isolated from the marrow fluid of patients with post-hepatitis cirrhosis. METHODS: The frequency of bone marrow CD34+ cells and apoptotic bone marrow CD34+ cells in 31 inpatients with post-hepatitis cirrhosis (cirrhosis group), and 15 out-patients without liver or blood disorders (control group) was calculated by flow cytometry. Parameters were collected to evaluate liver functions of patients in cirrhosis group. RESULTS: The percentage of normal bone marrow CD34+ cells was 6.30% ± 2.48% and 1.87% ± 0.53% (t = 3.906, P < 0.01) while that of apoptotic marrowCD34+ cells was 15.00% ± 15.81% and 5.73% ± 1.57% (t = 2.367, P < 0.05) in cirrhosis and control groups, respectively. The percentage of apoptotic marrow CD34+ cells was 6.25% ± 3.30% and 20.92 ± 18.5% (t = 2.409, P < 0.05) in Child-Pugh A and Child-Pugh B + C cirrhotic patients, respectively. The percentage of late apoptotic marrow CD34+ cells was positively correlated with the total bilirubin and aspartate aminotransferase serum levels in patients with cirrhosis. CONCLUSION: The status of CD34+ marrow cells in cirrhotic patients may suggest that the ability of hematopoietic progenitor cells to transform into mature blood cells is impaired.

关键词： Cirrhosis CD34 Hematopoietic stem cells/ Hematopoietic progenitor cells Apoptosis

Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu Yu Li-Yun Zhou Xiao Huang Xin-Yue Li Ming-Ke wang Ji-shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

Numerical investigation of windage heating within shrouded rotor-stator cavity system with central inflow

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航空动力学报 2014年第10期29卷 2402-2409页

作者： wang Qian-shun ZHANG da LUO Xiang XU Guo-qiang National Key Laboratory of Science and Technology on Aero-Engine Aero-thermodynamics School of Engergy and Power EngineeringBeijing University of Aeronautics and Astronautics

The rotating disk surface temperature rise due to windage heating effect by numerically modeling the turbulent flow within a rotor-stator cavity which is available with a peripheral shroud and imposed through airflow was dealt *** windage heating may be defined as viscous friction heating caused by relative velocity differences across the boundary layers between the fluid and the rotating disk *** kinetic energy dissipation process could transform the rotating shaft power into thermal *** finite volume based solver,ANSYS/CFX was employed to numerically simulate this physical process by using the shear stress transport(SST)turbulence *** results include the rotating disk surface temperature axial distribution and tangential velocity distribution of the fluid *** velocity difference between the result obtained by particle image velocimetry(PIV)experiments and CFD simulation are within 5%.The adiabatic disk temperature rise can be calculated by the tangential velocity of disk and fluid in large gap ratio and turbulent *** temperature distribution results and those estimated via velocity differences are within 10%.

关键词： windage heating rotor-stator cavity system flow structure recovery temperature gap ratio

Prediction of neoantigens and their application in cancer treatment

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Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 483-484页

作者： Bao Jin Ying-Yi wang shun-da Du Department of Liver Surgery Peking Union Medical College (PUMC) Hospital Chinese Academy of Medical Sciences and PUMC Department of Medical Oncology Peking Union Medical College (PUMC) Hospital Chinese Academy of Medical Sciences and PUMC

Tumor antigens can be divided into tumor-associated antigens and tumor-specific antigens according to their specificity. Tumorassociated antigens are not unique to tumor cells, and can also be synthesized in small amounts by normal cells. Tumor-specific antigens, also called neoantigens, are formed by peptides that are entirely absent from the normal human genome [1]. Neoantigens are

关键词： Prediction of neoantigens and their application in cancer treatment

In situ synthesis of Co_(3)O_(4)nanoparticles confined in 3D nitrogendoped porous carbon as an efficient bifunctional oxygen electrocatalyst

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Rare Metals 2020年第12期39卷 1383-1394页

作者： Zhi-Yuan wang shun-da Jiang Chan-Qin Duan dan wang Shao-Hua Luo Yan-Guo Liu School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Key Laboratory of Dielectric and Electrolyte Functional Material-Hebei Province Qinhuangdao 066004China

The rational exploitation of non-precious metal catalyst with high activity,strong durability and low cost for the oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is of vital importance for metalair ***,a composite of Co_(3)O_(4)nanoparticles confined in three-dimensional(3 D)N-doped porous carbon(Co-NpCs)was prepared by a simple freeze-drying and in situ pyrolysis *** effect of different dosages of Co(NO_(3))_(2)on the catalytic performance was *** Co-NpC-12%exhibits the best catalytic performance(E_(1/2)=0.78 V,better stability than 20%Pt/C)in ORR and in OER among all the as-synthesized ***,it also exhibits the best bifunctional activity(ΔE=0.849 V).The excellent properties of Co-NpCs are mainly due to the synergy between Co_(3)O_(4)and ***,a high Co_(3)O_(4)loading amount can boost the defect level of the N-doped hierarchical porous carbon and expose more active ***,the unique in situ pyrolysis guarantees a largearea contact between Co_(3)O_(4)and carbon as well as a strong C-O-Co bonding,which promotes charge transfer,avoids the peeling of Co_(3)O_(4)nanoparticles and effectively improves the stability of the *** work is expected to offer a feasible strategy to produce metal oxide/carbon nanocomposite and push forward the development of bifunctional electrocatalyst with high activity and stability.

关键词： Bifunctional electrocatalyst Co_(3)O_(4) Nitrogendoped porous carbon In situ synthesis

Unprecedently low thermal conductivity of unique tellurium nanoribbons

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Nano Research 2021年第12期14卷 4725-4731页

作者： Xiangshui Wu Qiqi Tao da Li Qilang wang Xiaoyan Zhang Huile Jin Jun Li shun wang Xiangfan Xu Center for Phononics and Thermal Energy Science China-EU Joint Center for NanophononicsSchool of Physics Science and EngineeringTongji UniversityShanghai200092China College of Chemistry and Materials Engineering Institute of New Materials and Industrial TechnologiesWenzhou UniversityWenzhou325035China

Tellurene,probably one of the most promising two-dimensional(2D)system in the thermoelectric materials,displays ultra-low thermal ***,a linear thickness-dependent thermal conductivity of unique tellurium nanoribbons in this study reveals that unprecedently low thermal conductivity can be achieved via well-defined nanostructures of low-dimensional tellurium instead of pursuing dimension-reduced 2D *** thinnest tellurium nanoribbon with thickness of 144 nm,the thermal conductivity is only∼1.88±0.22 W·m^(−1)·K^(−1) at room ***’s a dramatic decrease(45%),compared with the well-annealed high-purity bulk *** be more specific,an expected thermal conductivity of tellurium nanoribbons is even lower than that of 2D tellurene,as a result of strong phonon-surface *** have faith in low-dimensional tellurium in which the thermoelectric performance could realize further breakthrough.

关键词： tellurium nanoribbons thickness-dependent thermal conductivity linear relationship phonon-surface scattering

Efficacy of concurrent chemoradiotherapy plus adjuvant chemotherapy on advanced cervical cancer

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Chinese Journal of Cancer 2010年第11期29卷 959-963页

作者： shun wang da-Shui Zhang Tao Pan Sha Liu Ming-Kun wang Department of Radiation Oncology the Affiliated Hospital of Hainan Medical College Haikou Hainan 570102 P. R. China Cancer Institute of Hainan Medical College Haikou Hainan 571101 P. R. China

Background and Objective: Concurrent chemoradiotherapy for cervical carcinoma develops rapidly and has become a common and standard therapy in recent years. Both the local control rate and survival rate of patients were increased and the risk of death fell by 30%-50%. This study aimed to explore the efficacy of concurrent chemoradiotherapy plus adjuvant chemotherapy on and the treatment compliance of the patients with advanced cervical squamous cell carcinoma. Methods: A total of 156 patients with stage IIa-IIIb cervical squamous cell carcinoma were randomly divided into the concurrent chemoradiotherapy group (experimental group) and radiotherapy group (control group). Intracavity and external beam radiation therapy were administered. At point A, 40-48 Gy were given by 10-12 fractions; at point B, 46-50 Gy were given by 23-25 fractions. In the same time, experimental group was treated by cisplatin (DDP, 40 mg) on day 1, repeated every week. Ten days after radiation therapy, TP regimen was administered as adjuvant chemotherapy. Results: For the experimental and control groups, the objective response rates were 88.61% and 75.32%, 1-year survival rates were 88.57% and 70.77%, 1-year local control rates were 81.43% and 64.62%, 3-year survival rates were 82.14% and 57.69%, and 3-year local control rates were 75.00% and 46.15%, with significant differences (P < 0.05). Quality of life of all patients were significantly improved after treatment (P< 0.05). Conclusion: Concurrent chemoradiotherapy plus adjuvant chemotherapy for advanced cervical cancer can improve short-term and long-term survival and local control rates of patients, improve the quality of life, and the toxicity can be tolerated.

关键词：子宫颈癌化疗疗效鳞状细胞癌放射治疗生活质量控制率对照组

Characterization and fine mapping of RTMS10, a semi-dominant reverse thermo-sensitive genic male sterile locus in rice

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Journal of Integrative Agriculture 2022年第2期21卷 316-325页

作者： NI Jin-long wang De-zheng NI da-hu SONG Feng-shun YANG Jian-bo YAO da-nian College of Agronomy Anhui Agricultural UniversityHefei 230036P.R.China Rice Genetics and Breeding Key Laboratory of Anhui Province/Rice Research Institute Anhui Academy of Agricultural SciencesHefei 230031P.R.China

The discovery and application of environment-sensitive genic male sterile(EGMS) rice germplasm provide an easy method for hybrid rice breeding and have made great contributions to hybrid rice production. Typically, the photoperiod-and thermosensitive GMS(P/TGMS) lines utilized in two-line hybrid systems are male sterile under long day or/and high temperature but fertile under short day or/and low temperature conditions. However, Yannong S(Yn S), a reverse TGMS(rTGMS) line, is sterile under low temperature(29.5℃). Here, we report a genetic study on the rTGMS trait in Yn S. Interestingly, the F1 plants of the cross between Yn S and a cultivar, L422, were male sterile at 22℃ and completely fertile at 27℃. Moreover, the segregation ratio of fertile and sterile individuals in Yn S/L422 F2 populations changed from 1:3.05 to 2.95:1 when the ambient temperature increased, showing that the rTGMS trait exhibits semidominance in Yn S. We further found a locus on chromosome 10, termed RTMS10, which controls the rTGMS trait in Yn S. We then finely mapped RTMS10 to a ~68 kb interval between markers ID13116 and ID1318 by Yn S/L422 BC6 F2 populations. A near iso-genic line(NIL) NL1 from the BC6 F3 generation was developed and the pollen of NL1 became abnormal from the meiosis stage under low temperature. In summary, we identified an rTGMS locus, RTMS10, and provided co-segregated markers, which could help to accelerate molecular breeding of rTGMS lines and better understand the rTGMS trait in rice.

关键词： rice photoperiod-and thermo-sensitive genic male sterile(P/TGMS) reverse TGMS(rTGMS) gene mapping RTMS10

Variations of extreme temperature in the Mount Qomolangma region in China during 1971-2020

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Journal of Mountain Science 2023年第12期20卷 3488-3499页

作者： wang shun-jiu Sichuan Provincial Climate Centre Chengdu 610072China Institute of Plateau Meteorological China Meteorological AdministrationChengdu 610072China Heavy Rain and Drought-Flood Disasters in Plateau and Basin Key Laboratory of Sichuan Province Chengdu 610072China

According to observational daily temperature data from the meteorological stations during 1971-2020,the variations of the extreme temperature event in the Mount Qomolangma(also known as Mount Everest) region in China have been analyzed using statistical *** extreme temperature indices recommended by the World Meteorological Organization are selected to describe the extreme temperature *** RClimDEX 1.0 software is used to calculate the extreme temperature *** are no tropical nights,and just three summer days at the last 50 *** frost days are the main extreme temperature events all year *** temperature in the north slope is more extreme than that in the south slope of the Mount *** is remarkable decadal variation for the extreme temperature indices except diurnal temperature *** are the warm extremes increasing,however,the cold extremes decreasing with the decadal lapse,which is more remarkable into the 21^(th) *** tendencies for the extreme temperature indices in the north slope are consistent with those in the south *** are statistically significant trends for most extreme temperature indices during the study *** shows that the warm extremes would be more prominent in the future with the global continued *** abrupt changes of the extreme temperature index have occurred mainly in the 20^(th) century especially from the mid to late 1980s and *** periodic changes in the south slope do not synchronize those in the north slope for the most extreme temperature *** is different for most extreme temperature indices between the south and north slope,which has demonstrated that the regional or local changes are not neglectable for extreme temperature *** results of this study are also the consistent response of extreme temperature event to the global warming.

关键词： Extreme temperature Variation Trend Statistical analysis Mount Qomolangma Mount Everest