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Rating Curve Modification at Low Discharges Using Physical Model Tests

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World Journal of Engineering and Technology 2015年第2期3卷 50-56页

作者： shun-chung tsung Jihn-Sung Lai Yun-Ling Chen Hau-Wei Wang Taiwan Typhoon and Flood Research Institute National Applied Research Laboratories Taipei Taiwan

Hydraulic structure is designed based on hydraulic theories or guidelines. To ensure performance, physical model tests are often used at high discharges. However, high discharge in river is rare. Physical model tests at high discharges will probably lead biased hydrological relationship. To improve hydrological relationship at low discharges, in this study, we considered the diversion rating curve of the Yuanshanzi Diversion Work. The 1/100-scaled physical model tests at low and high discharges (90 - 1620 m3/s) were performed and coupled the diversion discharges of 5 flood events (2009-2010) in field. The official diversion rating curve was built only based on physical model tests at high discharges (837 - 1620 m3/s). The results of physical model tests in this study suggested the official diversion rating curve should be modified considering all tests. The modifications showed the official diversion rating curve was over-estimated. A complete series of physical model tests and considering field situations, in this study, indicated expanded physical model tests and constantly field measurements were therefore necessary for hydraulic structure, which provided information to modify used hydrological relationship to fit real situations.

关键词： Physical Model Test Yuanshanzi Diversion Work Rating Curve

Adult sigmoid intussusception resembling rectal prolapse:A case report

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World Journal of Clinical Cases 2024年第6期12卷 1163-1168页

作者： tsung-Jung Tsai Yu Shih Liu Department of Surgery Changhua Christian HospitalChanghua 500209Taiwan Department of Colorectal Surgery Changhua Christian HospitalChanghua 500209Taiwan

BACKGROUND Rectal prolapse arises from benign *** symptoms of internal intussusception mirror those of rectal prolapse,a misdiagnosis is possible,especially under limited clinical *** is crucial to recognize and differentiate rectal prolapse from internal intussusception because the two diagnoses have different ***,we describe a case of adult sigmoid intussusception presenting as rectal *** SUMMARY A 64-year-old woman with no known medical history visited a gastrointestinal outpatient department due to hard bloody stool defecation for 1 wk followed by constipation for 3 *** revealed a huge polypoid ulcerated tumor at the sigmoid colon with lumen *** patient was admitted due to postprocedural dull abdominal *** to failed colonoscopy reduction and stent insertion,the patient underwent sigmoid colon resection with primary end-to-end anastomosis,with the transverse colostomy pathological report showing adenocarcinoma,*** recovered well from the operation and was discharged with regular outpatient clinic *** Presentation and manifestation of sigmoid intussusception may resemble that of rectal prolapse,necessitating careful observation due to distinct prognostic implications.

关键词： Sigmoid intussusception Rectal prolapse Endoscopic reduction Adenocarcinoma Case report

Patient-centered care in diabetes care-concepts,relationships and practice

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World Journal of Diabetes 2024年第7期15卷 1417-1429页

作者： tsung-Tai Chen Wei-Chih Su Mei-I Liu Department of Public Health College of MedicineFu Jen Catholic UniversityNew Taipei 24205Taiwan Department of Gastroenterology Taipei Tzu-Chi HospitalNew Taipei 23142Taiwan Department of Pediatric Endocrinology Mackay Children's HospitalTaipei 10449Taiwan

We still do not have comprehensive knowledge of which framework of patientcentered care(PCC)is appropriate for diabetes care,which elements of PCC are evidence-based,and the mechanism by which PCC elements are associated with outcomes through *** this review,we elaborate on these *** found that for diabetes care,PCC elements such as autonomy support(patient individuality),cooperation and collaboration(system-level approach),communication and education(behavior change techniques),emotional support(biopsychosocial approach),and family/other involvement and support are critically *** of these factors are directly associated with different patient outcomes and indirectly associated with outcomes through patient *** present the practical implications of these PCC elements.

关键词： Diabetes mellitus Patient-centered care Autonomy support Patient activation Patient adherence

Targeting carnitine palmitoyl transferase 1A(CPT1A)induces ferroptosis and synergizes with immunotherapy in lung cancer

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1675-1689页

作者： Lei Ma Chong Chen Chunxing Zhao Tong Li Lingyu Ma Jiayu Jiang Zhaojun Duan Qin Si tsung-Hsien Chuang Rong Xiang Yunping Luo Department of Immunology Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China Collaborative Innovation Center for Biotherapy Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China Department of Lung Cancer Surgery Tianjin Medical University General HospitalTianjin 300052China Immunology Research Center National Health Research InstitutesZhunanMiaoliTaiwanROC Department of Immunology Nankai UniversityTianjin 300071China

Despite the successful application of immune checkpoint therapy,no response or recurrence is typical in lung *** stem cells(CSCs)have been identified as a crucial player in immunotherapy-related ***,a form of cell death driven by iron-dependent lipid peroxidation,is highly regulated by cellular metabolism remolding and has been shown to have synergistic effects when combined with *** adaption of CsCs drives tumor resistance,yet the mechanisms of their ferroptosis defense in tumor immune evasion remain ***,through metabolomics,transcriptomics,a lung epithelialspecific Cptla-knockout mouse model,and clinical analysis,we demonstrate that CPT1A,a key rate-limiting enzyme of fatty acid oxidation,acts with L-carnitine,derived from tumor-associated macrophages to drive ferroptosis-resistance and CD8^(+)T cells inactivation in lung ***,CPT1A restrains ubiquitination and degradation of c-Myc,while c-Myc transcriptionally activates CPT1A *** CPT1A/c-Myc positive feedback loop further enhances the cellular antioxidant capacity by activating the NRF2/GPX4 system and reduces the amount of phospholipid polyunsaturated fatty acids through ACSL4 downregulating,thereby suppressing ferroptosis in ***,targeting CPT1A enhances immune checkpoint blockadeinduced anti-tumor immunity and tumoral ferroptosis in tumor-bearing *** results illustrate the potential of a mechanismguided therapeutic strategy by targeting a metabolic vulnerability in the ferroptosis of CsCs to improve the efficacy of lung cancer immunotherapy.

关键词： immunotherapy metabolism peroxidation

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有限相依随机序列的非贝叶斯变点最优监测

应用概率统计 2024年第2期40卷 277-286页

作者：韩东宗福季上海交通大学数学科学学院统计系上海200240 香港科技大学工业工程及决策分析学系中国香港香港科技大学(广州)数据科学与分析系广州510700

本文研究了有限相依样本序列的非贝叶斯变点检测问题.通过引入非负动态随机控制线,我们不仅构造并证明了两个最优控制图,而且还得到了比原定义更容易计算的Lorden测度和Pollak测度的最小值的表达式.

关键词：最优控制图非贝叶斯变点监测相依样本序列

一句话和一条法则——一句话帮你培养同理心,一条法则帮你取得成功

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空中英语教室（高级版．彭蒙惠英语） 2024年第2期 18-19,42,43页

作者： VICKY tsung 不详

理解他人的一句话“我不知道。”为什么这句话如此有效?原因在于这句话背后的含义及其情商基础也就是理解和管理情绪的能力。下面是其内在原理:有人说了不体谅你的话。你自己默默地想:“他们不知道。”这句话的目的并不是看轻对方。这... 详细信息

理解他人的一句话“我不知道。”为什么这句话如此有效?原因在于这句话背后的含义及其情商基础也就是理解和管理情绪的能力。下面是其内在原理:有人说了不体谅你的话。你自己默默地想:“他们不知道。”这句话的目的并不是看轻对方。这句话只是在说他们不可能对你感同身受。认识到这一点,你就不会对对方所说的话投注过多的情绪。

关键词：同理心理解他人内在原理情绪感同身受法则

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居家或外出享受家庭乐趣

空中英语教室（高级版．彭蒙惠英语） 2024年第4期 20-22,44,45页

作者： VICKY tsung 不详

请教儿科医生:健康的儿童成长可以充满乐趣吗?大多数父母都希望为孩子提供比自己的父母曾提供的更多的东西。但是你可曾注意到,孩子们往往用像纸箱这样简单的东西就能玩得很开心?游戏对孩子的健康成长至关重要,说到玩,像积木、球、跳绳... 详细信息

请教儿科医生:健康的儿童成长可以充满乐趣吗?大多数父母都希望为孩子提供比自己的父母曾提供的更多的东西。但是你可曾注意到,孩子们往往用像纸箱这样简单的东西就能玩得很开心?游戏对孩子的健康成长至关重要,说到玩,像积木、球、跳绳和水桶等简单的玩具,往往对孩子们最有益。事实上,这些东西比昂贵的玩具更能让孩子们发挥想象力和创造力,而那些昂贵的玩具可能是许多家长负担不起的。

关键词：儿童成长儿科医生想象力和创造力玩具健康成长乐趣

非凡与平凡现代科技可救人一命,也可料理餐食

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空中英语教室（高级版．彭蒙惠英语） 2024年第7期 14-16,40-42页

作者： PAGE DESIGN BY VICKY tsung 不详

开创性的新生儿部分心脏移植手术2022年,杜克健康的外科医生们成功地为一名新生儿实施了全世界首例部分心脏移植手术,创造了历史。医生认为,这台历时8小时的开创性手术——将捐赠者心脏的活体动脉与瓣膜缝合于一名新生儿的心脏中——可... 详细信息

开创性的新生儿部分心脏移植手术2022年,杜克健康的外科医生们成功地为一名新生儿实施了全世界首例部分心脏移植手术,创造了历史。医生认为,这台历时8小时的开创性手术——将捐赠者心脏的活体动脉与瓣膜缝合于一名新生儿的心脏中——可以开创心脏外科手术的新领域,使年轻患者在日后的人生当中免于接受多次高风险的手术。

关键词：心脏移植手术心脏外科手术捐赠者年轻患者新生儿外科医生现代科技

Simple bone cysts of the proximal humerus presented with limb length discrepancy:A case report

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World Journal of Clinical Cases 2024年第6期12卷 1130-1137页

作者： Cing Syue Lin Shang Ming Lin Syang-Peng Rwei Chin-Wen Chen tsung-Yu Lan Department of Orthopedic Surgery Far Eastern Memorial HospitalNew Taipei City 220Taiwan Department of Materials and Textiles Asia Eastern University of Science and TechnologyNew Taipei City 220Taiwan Institute of Organic and Polymeric Materials National Taipei University of TechnologyTaipei City 10608Taiwan

BACKGROUND Simple bone cysts(SBC)are benign tumor-like bone lesions typically identified in *** SBC may lead to growth disturbances or growth arrest,such cases are *** mechanisms behind these observations remain ***,research on the etiology of SBC remains inconclusive,and there has been no consensus on the appropriate timing and methodology for *** SUMMARY Here,we present our experience in the successful surgical management of a 10-year-old girl with SBC,who presented with a pathological fracture complicated by malunion of the displaced fracture,varus deformity,and limb length *** hypothesized two possible etiologies for the patient’s growth arrest and subsequent humerus varus deformity:(1)Direct disruption of the physis by fluid from the cyst itself;and(2)damage to the epiphysis due to repetitive pathological fractures associated with *** addressing this case,surgical intervention was undertaken to correct the proximal humerus varus *** approach offered the advantages of simultaneously correcting angular abnormalities,achieving mild limb lengthening,providing definitive SBC treatment,and reducing the overall treatment *** As per current literature,acute correction of acute angular deformity in proximal humeral SBC is not well ***,in this specific case,acute correction was considered an optimal solution.

关键词： Bone cyst Solitary cysts Benign Humerus Growth arrest Limb length discrepancy Case report