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Fish sauce and gastric cancer:an ecological study in Fujian Province,China

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World Journal of Gastroenterology 2000年第5期6卷 671-675页

作者： Lin Cai shun zhang yu Wei Min Ye Ying Nan Yi Department of Epidemiology Fujian Medical UniversityFuzhou 350004China Department of Epidemiology Shanghai Medical UniversityShanghai 200032China

AIM To explore the relationship betweenconsumption of fish sauce and the risk of gastriccancer in Fujian *** An ecological study was carriedout.A total of 11000 subjects from 55 townshipswere randomly selected from 10 counties withinFujian *** subjects were localresidents who had been living in Fujian Provincefor more than 20 years,within the age group of45-74 *** interviewers conductedface-to-face interviews with a standardizedquestionnaire,which covered the frequency andamount of food intake,dietary habit,tobaccoand alcohol consumption and history of chronicgastric *** and multivariateanalyses were performed using Epi-info and SASstatistical packages,*** A significant correlation betweenmonthly consumption of fish sauce and mortalityof gastric cancer was ***’scoefficient of correlation was statisticallysignificant with r=0.7356 for males,r=0.5246for females(P<0.01).In the multivariateanalysis,consumption of fish sauce still showedan association with the risk of gastric *** significant positive correlation betweenesophagus cancer,liver cancer,colon cancerand consumption of fish sauce were *** Long-term intake of fish saucemay be related to high mortality of *** of fish sauce might be oneof important and unique etiologic factors ofgastric cancer in Fujian *** are needed to confirm this ecologicalstudy.

关键词： stomach neoplasm/etiology food habits risk factors nit rosamines epidemiology fish products fish sauce carcinogens

Hepatitis B virus x gene and cyanobacterial toxins promote aflatoxin B_1-induced hepatotumorigenesis in mice

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World Journal of Gastroenterology 2006年第19期12卷 3065-3072页

作者： Min Lian Ying Liu shun-zhang yu Geng-Sun Qian Shu-Guang Wan Kenneth R Dixon School of Public Health Fudan University 138 Yixueyuan Road Shanghai 200032 China Geng-Sun Qian Shu-Guang Wan Shanghai Cancer Institute Shanghai 200032 China Shanghai Cancer Institute Shanghai 200032 China Institute of Environmental and Human Health Texas Tech University and TTU Health Sciences Center Lubbock TX United States

AIM： To assess the combinative role of aflatoxin B1 （AFB1）, cyanobacterial toxins （cyanotoxins）, and hepatitis B virus （HBV） x gene in hepatotumorigenicity. METHODS： One-week-old animals carrying HBV x gene and their wild-type littermates were intraperitoneally （ip） injected with either single-dose AFB1 [6 mg/kg body weight （bw）], repeated-dose cyanotoxins （microcystin- LR or nodularin, 10 μg/kg bw once a week for 15 wk）, DMSO （vehicle control） alone, or AFB1 followed by cyanotoxins a week later, and were sacrificed at 24 and 52 wk post-treatment. RESULTS： AFB1 induced liver tumors in 13 of 29 （44.8%） transcjenic mice at 52 wk post-treatment, significantly more frequent than in wild-type mice （13.3%）. This significant difference was not shown in the 24-wk study. Compared with AFB1 exposure alone, MC-LR and nodularin yielded approximately 3-fold and 6-fold increases in the incidence of AFB1-induced liver tumors in wild-type animals at 24 wk, respectively. HBV x gene did not further elevate the risk associated with coexposure to AFB1 and cyanotoxins. With the exception of an MC-LR-dosed wild-type mouse, no liver tumor was observed in mice treated with cyanotoxins alone at 24 wk. Neither DMSO-treated transgenic mice nor their wild-type littermates had pathologic alterations relevant to hepatotumorigenesis in even up to 52 wk. CONCLUSION： HBV x gene and nodularin promote the development of AFB1-induced liver tumors. Co-exposure to AFB1 and MC-LR tends to elevate the risk of liver tumors at 24 wk relative to exposure to one of them. The combinative effect of AFB1, cyanotoxins and HBVx on hepatotumorigenesis is weak at 24 wk.

关键词： Aflatoxins Cyanobacteria Hepatitis B virus Liver neoplasms Transgenic mice

Refrigerant Control Strategies for Residential Air-Conditioning and Heat-Pump System

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湖南大学学报（自然科学版） 2009年第S1期36卷 91-95页

作者： SU shun-yu,zhang Chun-zhi,CHEN Jian(College of Urban Construction,Wuhan University of Science and Technology,Wuhan,Hubei 430070,China) College of Urban Construction Wuhan University of Science and Technology Wuhan 430070 China

This paper simulated the optimal refrigerant charge inventory of a refrigeration system in air-conditioning operation and heat-pump operation respectively,and studied the refrigerant control strategies in this *** void fraction in two-phase fluid region was calculated by Harms *** based on distributed parameter model and Harms model,the refrigerant charge inventory in condenser and evaporator were calculated and analyzed in air-conditioning conditions and heat-pump conditions,*** calculating results of different refrigerant mass between refrigeration and heating conditions indicate that the optimal refrigerant charge inventory in heat-pump conditions is lower than that in air-conditioning *** avoid the decrease of COP due to the surplus refrigerant in heating conditions,we introduced the liquid reservoir control method and associate capillary control *** of them could increase the heating capacity of the air-source heat *** difference of optimal refrigerant charge inventory in air-conditioning and heat-pump system can be controlled by the liquid reservoir or the associate capillary.

关键词： air-source heat pump control strategy distributed parameter model charge inventory

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Efficient micrometer-scale thick-film perovskite solar cells with superior stability

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Rare Metals 2024年第4期43卷 1647-1657页

作者： Jian-Fei Hu Gang Chen shun-zhang yu yue-Xin Lin Kai-yu Wang Zong-Wei Li Guo-Dong zhang Teng-Fei Pan Ya-Jing Li Ming-Jie Li Ying-Dong Xia Yi-Fan Lv Yong-Hua Chen Key Laboratory of Flexible Electronics(KLoFE)and Institute of Advanced Materials(IAM) School of Flexible Electronics(Future Technologies)Nanjing Tech University(NanjingTech)Nanjing211816China Department of Applied Physics The Hong Kong Polytechnic UniversityHong Kong999077China Shenzhen Research Institute The Hong Kong Polytechnic UniversityShenzhen518057China Optics Valley Laboratory Hubei430074China

It is essential to enhance the thickness of the absorber layer for perovskite solar cells(PSCs)to improve device performance and reduce industry ***,thick perovskite films(>1μm)are difficult to be fabricated by employing traditional solvents,such as N,N-dimethylformamide(DMF),dimethyl sulfoxide(DMSO).Besides,it is a challenge to fabricate thick-film perovskite owing to the deteriorated surface morphology and serious defect ***,a simple method was reported to deposit uniform pinhole-free perovskite films with a thickness of more than 2μm utilizing the methylamine acetate(MAAc)ionic liquid as the *** with methylammonium chloride(MACl)as an additive,thick-film perovskite with~2μm in grain size and few grain boundaries(GBs)was prepared,which dramatically improved the perovskite crystal quality and enhanced carrier transport *** final PSCs exhibited a power conversion efficiency(PCE)of 20.16%.The device showed improved stability with 95%of its initial efficiency in a nitrogen environment over 5000 *** work provides an alternative strategy to produce extremely efficient and stable thick-film *** can be believed that this device has great potential in the application of large areas and laminated PSCs.

关键词： Perovskite solar cells Thick-film Stability Ionic liquid

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Glutathione S-transferases M1,T1 genotypes and the risk of gastric cancer:A case-control study

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World Journal of Gastroenterology 2001年第4期7卷 506-509页

作者： Lin Cai shun-zhang yu Zuo-Feng zhang Department of Epidemiology.Fujian Medical University,Fuzhou 350004,Fujian Province,ChinaDepartment of Epidemiology,Shanghai Medical University,Shanghai 200032,China Department of Epidemiology,UCLA School of Public Health,Los Angeles California,USA Department of Epidemiology Fujian Medical University Fuzhou 350004 Fujian Province China. zjcailin@***

AIM: Glutathione S-transferases (GSTs) are involved in the detoxification of many potential carcinogens and appear to play a critical role in the protection from the effects of carcinogens. The contribution of glutathione S-transferases M1 and T1 genotypes to susceptibility to the risk of gastric cancer and their interaction with cigarette smoking are still unclear. The aim of this study was to determine whether there was any relationship between genetic polymorphisms of GSTT1 and GSTT1 and gastric cancer. METHODS: A population based case-control study was carried out in a high-risk area, Changle County, Fujian Province, China. The epidemiological data were collected by a standard questionnaire and blood samples were obtained from 95 incidence gastric cancer cases and 94 healthy controls. A polymerase chain reaction method was used to detect the presence or absence of the GSTT1 and GSTT1 genes in genomic DNA. Logistic regression model was employed in the data analysis. RESULTS: An increase in risk for gastric cancer was found among carriers of GSTT1 null genotype. The adjusted odds ratio (OR) was 2.63 95% Confidence Interval (95% CI) 1.17-5.88, after controlling for age, gender, cigarette smoking, alcohol drinking, and fish sauce intake. The frequency of GSTT1 null genotype in cancer cases (43.16%) was not significantly different from that in controls (50.00%). However, the risk for gastric cancer in those with GSTT1 null and GSTT1 non-null genotype was significantly higher than in those with both GSTT1 and GSTT1 non-null genotype (OR = 2.77, 95% CI 1.15-6.77). Compared with those subjects who never smoked and had normal GSTT1 genotype, ORs were 1.60 (95% CI:0.62-4.19) for never smokers with GSTT1 null type, 2.33 (95% CI 0.88-6.28) for smokers with normal GSTT1, and 8.06 (95% CI 2.83-23.67) for smokers with GSTT1 null type. CONCLUSIONS: GSTT1 gene polymorphisms may be associated with genetic susceptibility of stomach cancer and may modulate tobacco-related carcinoge

关键词： Adult Aged Case-Control Studies Female Genetic Predisposition to Disease Genotype Glutathione Transferase Humans Male Middle Aged Polymorphism, Genetic Research Support, Non-U.S. Gov't Risk Factors Smoking Stomach Neoplasms

Method for Estimating the State of Health of Lithium-ion Batteries Based on Differential Thermal Voltammetry and Sparrow Search Algorithm-Elman Neural Network

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Energy Engineering 2025年第1期122卷 203-220页

作者： yu zhang Daoyu zhang TiezhouWu School of Electrical and Electronic Engineering Hubei University of TechnologyWuhan430068China

Precisely estimating the state of health(SOH)of lithium-ion batteries is essential for battery management systems(BMS),as it plays a key role in ensuring the safe and reliable operation of battery ***,current SOH estimation methods often overlook the valuable temperature information that can effectively characterize battery aging during capacity ***,the Elman neural network,which is commonly employed for SOH estimation,exhibits several drawbacks,including slow training speed,a tendency to become trapped in local minima,and the initialization of weights and thresholds using pseudo-random numbers,leading to unstable model *** address these issues,this study addresses the challenge of precise and effective SOH detection by proposing a method for estimating the SOH of lithium-ion batteries based on differential thermal voltammetry(DTV)and an SSA-Elman neural ***,two health features(HFs)considering temperature factors and battery voltage are extracted fromthe differential thermal voltammetry curves and incremental capacity ***,the Sparrow Search Algorithm(SSA)is employed to optimize the initial weights and thresholds of the Elman neural network,forming the SSA-Elman neural network *** validate the performance,various neural networks,including the proposed SSA-Elman network,are tested using the Oxford battery aging *** experimental results demonstrate that the method developed in this study achieves superior accuracy and robustness,with a mean absolute error(MAE)of less than 0.9%and a rootmean square error(RMSE)below 1.4%.

关键词： Lithium-ion battery state of health differential thermal voltammetry Sparrow Search Algorithm

东北地方政府创新动力之现状、原因与对策——基于“中国地方政府创新奖”的分析

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东北师大学报（哲学社会科学版） 2013年第5期 18-23页

作者：李靖张舜禹吉林大学行政学院吉林长春130012

地方政府创新动力为其创新行为提供了直接行动理由。同时,对地方政府创新动力的探讨是国内外致力于研究政府创新的学者不断挖掘的重要议题之一。不同的地域受其自然条件、资源禀赋、社会环境、民族文化等因素的影响,地方政府创新动力并... 详细信息

地方政府创新动力为其创新行为提供了直接行动理由。同时,对地方政府创新动力的探讨是国内外致力于研究政府创新的学者不断挖掘的重要议题之一。不同的地域受其自然条件、资源禀赋、社会环境、民族文化等因素的影响,地方政府创新动力并不完全相同。笔者在深入分析东北地区地方政府参与"中国地方政府创新奖"情况的基础上,从现实的角度出发,对目前东北地区地方政府创新动力现状加以述评,得出东北地方政府创新动力相对匮乏之结论,并在解析原因的同时,有针对性地提出增强东北地区地方政府创新动力的对策。

关键词：东北地区地方政府创新动力中国地方政府创新奖

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Cytochrome P450 2E1 genetic polymorphism and gastric cancer in Changle,Fujian Province

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World Journal of Gastroenterology 2001年第6期7卷 792-795页

作者： Lin Cai~1 shun-zhang yu~2 Zuo-Feng zhang~3 1 Department of Epidemiology,Fujian Medical University,Fuzhou 350004,Fujian Province,China2 Department of Epidemiology,Shanghai Medical University,Shanghai 200032,China3 Department of Epidemiology,UCLA School of Public Health,Los Angeles California,USA Department of Epidemiology Fujian Medical University Fuzhou 350004 Fujian Province China. zjcailin@***

AIM: Genetic polymorphism in enzymes of carcinogen metabolism has been found to have the influence on the susceptibility to cancer. Cytochrome P450 2E1 (CYP2E1) is considered to play an important role in the metabolic activation of procarcinogens such as N-nitrosoamines and low molecular weight organic compounds. The purpose of this study is to determine whether CYP450 2E1 polymorphisms are associated with risks of gastric cancer. METHODS: We conducted a population based case-control study in Changle county, Fujian Province, a high-risk region of gastric cancer in China. Ninety-one incident gastric cancer patients and ninety-four healthy controls were included in our study. Datas including demographic characteristics, diet intake, and alcohol and tobacco consumption of individuals in our study were completed by a standardized ***-RFLP revealed three genotypes:heterozygote (C1/C2) and two homozygotes (C1/C1 and C2/C2) in CYP2E1. RESULTS: The frequency of variant genotypes (C1/C2 and C2/C2) in gastric cancer cases and controls was 36.3% and 24.5%, respectively. The rare homozygous C2/C2 genotype was found in 6 individuals in gastric cancer group(6.6%), whereas there was only one in the control group (1.1%). However, there was no statistically significant difference between the two groups (two-tailed Fisher's exact test P=0.066). Individuals in gastric cancer group were more likely to carry genotype C1/C2 (odds ratio, OR=1.50) and C2/C2 (OR=7.34) than individuals in control group (chi(2) =4.597, for trend P=0.032). The frequencies of genotypes with the C2 allele (C1/C2 and C2/C2 genotypes) were compared with those of genotypes without C2 allele (C1/C1 genotype) among individuals in gastric cancer group and control group according to the pattern of gastric cancer risk factors. The results show that individuals who exposed to these gastric cancer risk factors and carry the C2 allele seemed to have a higher risk of developing gastric cancer. CONCLUSION: Poly

关键词： Polymorphism, Genetic Aged Asian Continental Ancestry Group Case-Control Studies China Cytochrome P-450 CYP2E1 Female Gene Frequency Genetic Predisposition to Disease Humans Male Middle Aged Research Support, Non-U.S. Gov't Stomach Neoplasms

Visible-light-responsive homologous heterostructure of oxynitrides constructed to boost charge separation and water splitting

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Science China Chemistry 2025年第1期68卷 186-191页

作者： Hai Zou yunfeng Bao Xueshang Xin yu Qi Tengfeng Xie Fuxiang zhang State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences School of Chemistry and Chemical Engineering Liaoning Normal University College of Chemistry Jilin University

Constructing type II heterostructures represents a widely recognized strategy for enhancing charge separation and photocatalytic efficiency,but it remains challenging to fabricate homologous heterostructures based on visible-light-responsive semiconductors,especially for popularly investigated （oxy）nitrides with low thermal ***,we synthesized a homologous heterostructure （denoted as YTON＿H） based on the oxynitrides of YTaO4-xNyand YTa *** heterostructure exhibits type II band structure alignment and intimate interface achieved through a magnesium （Mg） powder-assisted nitridation *** with widely reported heterologous heterostructures,the as-obtained YTON＿H homologous heterostructure could similarly exhibit enhanced charge separation as well as photocatalytic water splitting performance with respect to its counterparts(YTaO4-xNyand YTaON2).Meanwhile,detailed structural characterizations and spectroscopy analysis have been made to confirm the formation of heterostructure and promotion of spatial charge separation.

关键词： charge separation heterostructure oxynitride photocatalysis visible light