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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1493-1498页

作者： Dong-Yu Guo Xia-Wei Wang Nan Hong yang-shun Gu Department of Ophthalmology the First Affiliated HospitalCollege of Medicine Zhejiang University Hangzhou 310003 Zhejiang Province China

AIM：To analyze the influences of different genotypes（G11778A,T14484 C and G3460A） of Leber hereditary optic neuropathy（LHON） on visual prognosis. METHODS： After a systematic literature search,all relevant studies evaluating the association between the three primary mutations of LHON and visual prognosis were *** statistical tests were calculated with Revman 5.2 and STATA 12.0. RESULTS： Ten independent studies were included finally.A significant association between the three primary mutations and prognostic vision over 0.3 were found in G11778 A versus T14484 C [odds ratio（OR） =0.10,95% confidence interval（CI） =0.05-0.17,P 〈0.001],G11778 A versus G3460A（OR=0.18,95%CI=0.09-0.37,P 〈0.001） and T14484 C versus G3460A（OR =2.45,95% CI =1.10-5.48,P 〈0.05）.In addition,obtained by pairwise comparison,the vision during onset,age of onset and sex ratio of these three kinds of patients,have no statistical significance（P 〉0.05）.CONCLUSION： From pairwise comparison,we conclude that these three different genotypes of LHON are related to patients＇ visual *** T14484 C patients might have a best prognostic vision,G3460 A second,and G11778 A *** there is little relation between the three different genotypes and patients＇ vision,age of onset and sex ratio.

关键词： Leber hereditary optic neuropathy visual acuity G11778A G3460A T14484C Meta-analysis

Research on submesoscale eddy and front near the South Shetland Islands(Antarctic Peninsula)using seismic oceanography data

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Advances in Polar Science 2022年第1期33卷 110-118页

作者： yang shun SONG Haibin ZHANG Kun School of Ocean and Earth Science Tongji UniversityShanghai 200092China State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China

The submesoscale processes, including submesoscale eddies and fronts, have a strong vertical velocity, can thus make important supplements to the nutrients in the upper ocean. Using legacy multichannel seismic data AP25 of cruise EW9101 acquired northeast of the South Shetland Islands(Antarctic Peninsula) in February 1991, we identified an oceanic submesoscale eddy with the horizontal scale of ~4 km and a steep shelf break front that has variable dip angles from 5° to 10°. The submesoscale eddy is an anticyclonic eddy, which carries warm core water, can accelerate ice shelves melting. The upwelling induced by shelf break front may play an important role in transporting nutrients to the sea surface. The seismic images with very high lateral resolution may provide a new insight to understand the submesoscale and even small-scale oceanic phenomena in the interior.

关键词： submesoscale eddy shelf break front seismic oceanography South Shetland Islands

Outcomes of 4 surgical adjuvants used for internal limiting membrane peeling in macular hole surgery: a systematic review and network Meta-analysis

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International Journal of Ophthalmology(English edition) 2020年第3期13卷 481-487页

作者： Xia-Wei Wang Yan Long yang-shun Gu Dong-Yu Guo Department of Ophthalmology the First Affiliated Hospital of Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

AIM:To compare the outcomes of four adjuvants used for internal limiting membrane(ILM)peeling in macular hole surgery,including indocyanine green(ICG),brilliant blue G(BBG),triamcinolone(TA)and trypan blue(TB),through systematic review and random-effects Bayesian network ***:PubMed,Cochrane library databases and Web of Science were searched until August 2018 for clinical trials comparing the above four *** for postoperative best corrected visual acuity(BCVA)improvement and primary macular hole closure rates were compared between the different ***:Twenty-seven eligible articles were *** postoperative BCVA improvement,results of BBGassisted peeling were significantly more favorable than those of ICG(WMD 0.08,95%credible interval 0.01-0.16)and TA ranked *** significant differences were found between any other two groups in postoperative BCVA *** postoperative primary macular hole closure rates,BBG ranked ***,no significant differences were shown between any two ***:TA and BBG are the optimum adjuvants for achieving postoperative BCVA improvement macular hole surgery with adjuvant-assisted ILM *** all adjuvants,the use of BBG is associated with the highest postoperative macular hole closure rate.

关键词： internal limiting membrane surgical adjuvants best corrected visual acuity improvement primary macular hole closure rate network Meta-analysis

A comparative study of four 20-membered N_2S_4-crown ethers as ionophores for polymeric membrane silver selective electrodes

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Chinese Chemical Letters 2010年第4期21卷 464-467页

作者： Zhang, Jun Yu, shun yang Yin, Tan Ji Hu, Xue Feng Qin, Wei Chinese Acad Sci Yantai Inst Coastal Zone Res Key Lab Coastal Environm Proc Yantai 264003 Peoples R China Chinese Acad Sci Inst Oceanol Qingdao 266071 Peoples R China Chinese Acad Sci Grad Univ Beijing 100049 Peoples R China

Four 20-membered N_2S_4-monoazathiacrown ethers have been synthesized and explored as neutral ionophores for Ag^+-selective *** responses reveal that the flexibility of the ligands has great effect on the selectivity and sensitivity to Ag^+ *** electrode based on ionophore 9,10,20,25-tetrahydro-5H,12H-tribenzo[b,n,r][1,7,10,16,4,13]tetrathiadiaza cycloicosine 6,13-(7H,14H)-dione(C) with 2-nitrophenyl octyl ether(o-NPOE) as solvent in a poly(vinyl chloride)(PVC) membrane matrix sho...

关键词： Ion-selective electrodes Silver Ionophore Azathiacrown ether

Genotype-phenotype correlations in Chinese patients with TGFBI gene-linked corneal dystrophy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第4期12卷 287-292页

作者： Yan LONG yang-shun GU Wei HAN Xiu-yi LI Ping YU Ming QI Department of Ophthalmology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Department of Medical Genetics School of Medicine Zhejiang University Hangzhou 310029 China

In this paper,we report the clinical and molecular features of the distinct TGFBI (human transforming growth factor β-induced,OMIM No.601692) gene-linked corneal ***,five pedigrees and ten unrelated individuals diagnosed as corneal dystrophy were *** venous DNA was extracted,and then amplified by polymerase chain reaction (PCR) and scanned for mutation by single-stranded conformation polymorphism (SSCP).Direct DNA sequencing was used to analyze the mutations of the TGFBI *** our study,thirty patients from five pedigrees and ten sporadic patients were diagnosed as four TGFBI gene-linked corneal dystrophies of granular corneal dystrophy type I (GGCD I),Avellino corneal dystrophy (ACD),lattice corneal dystrophy type I (LCD I),and lattice corneal dystrophy type ⅢA (LCD IIIA),and in total,seven disease-causing mutations,namely R555W,A546D,A546T,and T538P mutations in exon 12,R124H and R124C mutations in exon 4,and P501T mutation in exon 11,were identified,while four polymorphisms of V327V,L472L,F540F,and 1665-1666insC were screened in exons 8,11,and *** study ascertained the tight genotype-phenotype relationship and confirmed the clinical and genetic features of four TGFBI gene-linked corneal dystrophies.

关键词： TGFBI gene Corneal dystrophy Genotype Phenotype Mutation

A highly selective solid-contact electrode for Ag^+ based on a monoazathiacrown ether ionophore

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Chinese Chemical Letters 2012年第4期23卷 488-491页

作者： shun yang Yu Lan Ju Fu Hai Li Yong Ming Liu Jun Feng Fang Key Laboratory of Coastal Zone Environmental Processes Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Zhejiang Textile and Fashion College Ningbo 31521lChina Chemistry and Chemical Engineering College Yantai UniversityYantai 264005China Ningbo Institute of Material Technology&Engineering Chinese Academy of SciencesNingbo 315201China

A new solid-contact Ag~＋-selective electrode was prepared with 9,10,12,13,24,25-hexahydro-5H,15H,23H-dibenzo [b,q][1,7,10,13,19,4,16]-entathiadiazacyclodocosine-6,16（7H,17H）-dione as ionophore,and cc,a-dihexylsexithiophene（DH- 6T） ion-to-electron *** sensor exhibited a working concentration range of 10~8 to 10^（-3） mol/L,with a near-Nernstian slope of 55.1±0.2 mV/dec and detection limit of 1.7×10^（-9） mol/*** fabricated electrodes demonstrated excellent selectivity over the most common monovalent and divalent cations.

关键词： Solid contact Silver Ion-selective electrodes Low detection limit

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致密气连续管完井技术研究及应用

内蒙古石油化工 2024年第7期50卷 73-76页

作者：杨旭东田伟杨顺智赵彬彬肖述琴卫亚明中国石油长庆油田分公司油气工艺研究院低渗透油气田勘探开发国家工程实验室陕西西安710018 中国石油长庆油田分公司苏里格气田开发分公司内蒙古鄂尔多斯017300

针对致密气井常规生产管柱管径大携液困难,后期生产需多种阶段性措施,存在工艺衔接时机难把握、措施费用高、生产组织及管理难度大等问题,通过观念创新、工艺拓展、理论计算,解决了连续管代替常规油管完井存在的“合理管径优选问题、薄... 详细信息

针对致密气井常规生产管柱管径大携液困难,后期生产需多种阶段性措施,存在工艺衔接时机难把握、措施费用高、生产组织及管理难度大等问题,通过观念创新、工艺拓展、理论计算,解决了连续管代替常规油管完井存在的“合理管径优选问题、薄壁管长期悬挂问题、生产各环节工具配套问题”三项技术难题,形成了致密气连续管完井工艺,技术满足了带压下钻、高压期井下节流、低压期速度管柱全通径生产、间歇期柱塞气举的全生命周期生产需求。

关键词：致密气连续管完井一体化井下节流排水采气

无抽搐电休克治疗并发肺炎的临床特点及预警模型

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中国现代医学杂志 2024年第19期34卷 73-79页

作者：王阳顺李伟谭绍霞吴甜甜广州医科大学附属脑科医院重症医学科广东广州510370

目的分析无抽搐电休克治疗(MECT)患者并发肺炎的临床特点,构建并验证预警模型。方法回顾性分析2023年2月-2024例2月广州医科大学附属脑科医院1 802例行MECT的精神疾病患者的临床资料。MECT期间或终止治疗48 h内,根据患者是否并发肺炎... 详细信息

目的分析无抽搐电休克治疗(MECT)患者并发肺炎的临床特点,构建并验证预警模型。方法回顾性分析2023年2月-2024例2月广州医科大学附属脑科医院1 802例行MECT的精神疾病患者的临床资料。MECT期间或终止治疗48 h内,根据患者是否并发肺炎分为并发组与非并发组。对比两组临床资料,多因素逐步Logistic回归模型分析MECT患者并发肺炎的影响因素,构建并验证MECT患者并发肺炎的风险预测模型。结果1 802例MECT患者中,发生肺炎69例,发生率为3.83%(69/1 802),其中46例吸入性肺炎、23例坠积性肺炎。并发组抗精神病药物、呼吸恢复时间、年龄≥60岁、抽搐发作时间、吞咽困难均高于非并发组(P <0.05)。多因素逐步Logistic回归分析结果显示,使用抗精神病药物[OR=5.150(95%CI:2.264,11.715)]、年龄[OR=5.613(95%CI:2.467,12.767)]、抽搐发作时间[OR=3.842(95%CI:1.689,8.740)]、吞咽困难[OR=4.563(95%CI:2.006,10.380)]为MECT患者并发肺炎的危险因素(P <0.05)。列线图模型预测MECT患者并发肺炎的敏感性为79.71%(95%CI:0.680,0.881),特异性为91.06%(95%CI:0.896,0.923),曲线下面积为0.904(95%CI:0.809,0.965)。结论 MECT患者并发吸入性肺炎的风险较高,使用抗精神病药物、较高年龄、较长抽搐发作时间、吞咽困难与MECT患者并发肺炎有关,构建风险预警模型有助于早期筛查MECT患者并发肺炎风险。

关键词：精神疾病肺炎无抽搐电休克治疗临床特点预警模型

Enhanced cycling stability of single-crystal LiNi_(0.83)Co_(0.07)Mn_(0.10)O_(2)by Li-reactive coating with H_(3)BO_(3)

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稀有金属:英文版 2023年第8期42卷 2612-2621页

作者： Wen-Hui Hu Ya Yin Ya Sun Guo-Xue Liu shun-Yi yang You-Yuan Huang Bo Wang BTR New Material Group Co. LtdShenzhen 518000China Key Laboratory of Cluster Science Ministry of EducationSchool of Chemistry and Chemical EngineeringBeijing Instituteof Technology Beijing 100081China BTR Nano Tech Co. LtdShenzhen 518000China College of Chemistry and Environmental Engineering Wuhan Polytechnic UniversityWuhan 430023China

Ni-rich cathode materials will be primarily used as next-generation high-specific energy cathode materials in lithium-ion ***,residual Li formation and cracking considerably restrict the wide application of these *** address the issues related to cracking,micro-sized single-crystal cathode materials without internal grain boundaries are *** this study,we constructed a thin LiBO_(2)layer on the single-crystal LiNi_(0.83)Co_(0.07)Mn_(0.10)O_(2)particles by solvent-free H_(3)BO_(3)*** residual Li on the material surface decreased by 14%through the reaction of LiOH/Li_(2)CO_(3)and H_(3)BO_(3).The coated materials exhibited higher initial Coulombic efficiency(88.44%),higher reversible capacity(213.4 mAh·g^(-1)at 0.1 C),and better cycling performance(91.31%retention over 50 cycles within 3.0-4.3 V at 1.0C)than the unmodified *** the galvanostatic intermittent titration technique,electrochemical impedance spectroscopy(EIS),and inductively coupled plasma-optical emission spectroscopy(ICP-OES),we reveal the mechanism by which the electrochemical properties are improved upon H_(3)BO_(3)*** superior electrochemical performances are associated with increased Li+conductivity,lower charge transfer impedance,and suppressed transition metal ***,this study demonstrates the importance of surface modification in obtaining Ni-rich single-crystal materials with enhanced performance.

关键词： Ni-rich cathode Residual Li Cycling stability Li-reactive coating Single crystal

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超深水液压打桩锤动力传输方式分析

建筑机械 2024年第7期 82-84页

作者：于文太刘顺庆陈太清刘鹏鹏杨顺钦韩才智海洋石油工程股份有限公司天津300461 中机锻压江苏股份有限公司江苏海安226600

文章通过两种动力传输方案的比较分析,阐明电力传输+水下液压系统方案,是超深水液压打桩锤动力传输具有传动效率高、实施最为经济有效的方案。

关键词：超深水液压打桩锤动力传输方式