检索结果-南通市图书馆

Cellular & Molecular Immunology 2021年第8期18卷 2078-2080页

作者： Haoran Wang Sananda Pai shun ishiyama Xin Guo Wei Dong Gao Lakshmi Santhanam Kathy Gabrielson Dolores B.Njoku Department of Anesthesiology and Critical Care Medicine Johns Hopkins UniversityBaltimoreMDUSA Molecular and Comparative Pathobiology Johns Hopkins UniversityBaltimoreMDUSA Department of Pathology Johns Hopkins UniversityBaltimoreMDUSA Department of Pediatrics Johns Hopkins UniversityBaltimoreMDUSA

In our prior publication[1],we elucidated IL-33-dependent mechanisms that regulate drug-induced liver *** this commentary,we mechanistically connected IL-33-dependent drug-induced steatohepatitis with nonalcoholic ***-induced steatohepatitis(DISH)is a rare form of drug-induced liver injury caused by drugs that are capable of inducing metabolic injury,steatosis or steatohepatitis[2].

关键词： drug hepatitis drugs

尼罗河及其流域环境的近期变化:以文献为依据（英文）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Resources and Ecology 2015年第5期6卷 345-352页

作者： Shamik CHAKRABORTY YASUDA Hiroshi Abhik CHAKRABORTY NABETA Hajime KAWAI Takayuki ishiyama shun 独立研究人员日本大分县874-0844别府市松川町4-1寓302室鸟取大学干旱土地研究中心日本鸟取市680-00011390Hamasaka 伊豆半岛地质公园日本Ito414-85552-1-1Ohara 新泻大学自然灾害及灾难恢复研究所日本新泻西区950-2181IkarashiNinomachi8050 人文与自然研究所日本京都市603-8047KamigamoHonyama457-4Kita-ku

尼罗河是地球上最长的河流之一,也是非洲干旱区域重要的淡水补给源,是一条受到人类广泛影响的河流。本文博采以实地研究为支撑的文献,试图解释引起尼罗河流域环境广泛变化的诸多社会驱动力。主要关注点为下尼罗河,这里人类干扰的影响最... 详细信息

尼罗河是地球上最长的河流之一,也是非洲干旱区域重要的淡水补给源,是一条受到人类广泛影响的河流。本文博采以实地研究为支撑的文献,试图解释引起尼罗河流域环境广泛变化的诸多社会驱动力。主要关注点为下尼罗河,这里人类干扰的影响最为突出。我们认为,尼罗河流域的资源管理问题具有既相互关联又相互纠结的特点,若想有效开展流域管理,必须将注意力由与水相关的问题转向整个流域范围的管理规划。这一整体规划在制订时,对环境历史的了解非常重要,并且,"利益共享"理念可以减轻这个极其敏感的干旱流域日益加重的压力。

关键词：尼罗河流域环境变化社会参数利益共享整体研究

Efficacy of Postoperative Adjuvant Chemotherapy According to Prognostic Factor in Patients with Stage III Colon Cancer

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2014年第8期5卷 806-816页

作者： Kiichi Sugimoto Kazuhiro Sakamoto Yuichi Tomiki Michitoshi Goto Yutaka Kojima Hiromitsu Komiyama Makoto Takahashi shun ishiyama Koichiro Niwa Haruna Okubo Department of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan

Background: We retrospectively identified prognostic factors in patients with Stage III colon cancer and considered the effectiveness of postoperative adjuvant chemotherapy based on these prognostic factors. Methods: Two hundred and thirty four patients with lymph node metastases who underwent curative surgery for colon cancer between 1999 and 2005 were enrolled in the present study. Firstly, clinicopathological factors and survival data, were analyzed to determine prognostic factors related to cancer-specific survival. Secondly, we examined the effectiveness of postoperative adjuvant chemotherapy based upon these prognostic factors. Results: The multivariate analysis revealed that differentiation (P = 0.03, Hazard ratio = 2.50), lymphatic invasion (P = 0.02, Hazard ratio = 3.23) and the TNM classification, 7th?edition (P = 0.04, Hazard ratio = 1.94) were found to be significant independent prognostic factors. Among the patients classified as TNM IIIA, the recurrence-free survival rates were extremely good. Among the patients classified as IIIB and IIIC, there was no significant difference between the patients with and without postoperative adjuvant chemotherapy. Conclusion: The present study suggests that the patients with Stage IIIA colon cancer may not require postoperative adjuvant chemotherapy. The addition of oxaliplatin to 5-FU should be considered for the patients with Stage IIIB and IIIC colon cancer, for whom the prognoses are far from satisfactory.

关键词： Colorectal Cancer Postoperative Adjuvant Chemotherapy Prognostic Factor Stage III Colon Cancer TNM Classification 7th Edition

The validity of predicting prognosis by the number of lymph node metastases in node-positive colon cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Gastroenterology 2013年第4期3卷 217-222页

作者： Kiichi Sugimoto Masaya Kawai Kazuhiro Takehara Yoshihiko Tashiro Shinya Munakata Kiichi Nagayasu Koichiro Niwa shun ishiyama Hiromitsu Komiyama Makoto Takahashi Yutaka Kojima Michitoshi Goto Yuichi Tomiki Kazuhiro Sakamoto Department of Coloproctological Surgery Faculty of Medicine Juntendo University Tokyo Japan

Background: We examined the possibility of predicting prognosis by the number of lymph node metastases. Methods: Two hundred and forty nine patients with lymph node metastases who underwent curative surgery for colon cancer were enrolled in this study. We calculated cancer-specific survival according to the number of lymph node metastases. Results: There was a tendency toward better rates of cancer-specific survivals among the patients with 1 LNM, compared with those with 2 LNM (p = 0.07). When comparing cancer-specific survival between the patients with 1, 2-3 and 4 or more lymph node metastases, cancer-specific survival was well stratified (p i.e., the patients with 1, 2 and 3 and 4 or more lymph node metastases. This study was in favor of the TNM classification in which N category is classified by the number of lymph node metastases.

关键词： Colon Cancer Lymph Node Metastasis Stage Classification TNM Classification Prognostic Factors

Prognostic factors after palliative resection for colorectal cancer with incurable synchronous liver metastasis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Gastroenterology 2013年第5期3卷 259-266页

作者： Kiichi Sugimoto Kazuhiro Sakamoto Yuichi Tomiki Michitoshi Goto Yutaka Kojima Hiromitsu Komiyama Makoto Takahashi Yukihiro Yaginuma shun ishiyama Koichiro Niwa Kiichi Nagayasu Shingo Ito Masaya Kawai Kazuhiro Takehara Yoshihiko Tashiro Shinya Munakata Department of Coloproctological Surgery Faculty of Medicine Juntendo University Tokyo Japan

Purpose: With the improvements in newer chemotherapeutic agents, there is currently no consensus regarding the validity of palliative resection of the primary tumor for colorectal cancer with incurable distant metastasis. We retrospectively analyzed prognostic factor in patients with colorectal cancer accompanied by incurable synchronous liver metastasis. Methods: 82 patients with incurable synchronous liver metastases, who underwent primary tumor resection alone, were enrolled. Results: The multivariate analysis revealed that the presence of ascites (P = 0.001, Hazard ratio = 2.96) and differentiation (P = 0.003, Hazard ratio = 3.68) were found to be significant independent prognostic factors. The median survival time among the patients with ascites was 4.8 months and that among the patients with poorly-differentiated or mucinous adenocarcinoma, or signet ring cell carcinoma (high grade differentiation) was 1.4 months, respectively. Conclusion: The presence of ascites and differentiation were prognostic factors in the patients with incurable liver metastases. Therefore, because prognosis is generally poor after primary tumor resection in the patients with ascites or high grade differentiation, the introduction of systemic chemotherapy with alleviation of symptoms related to the primary tumor should be taken into account as one of the therapeutic strategies.

关键词： Colorectal Carcinoma Liver Metastasis Primary Tumor Resection Palliative Resection Systemic Chemotherapy Postoperative Morbidity