检索结果-南通市图书馆

Function and clinical significance of SUMOylation in type Ⅰ endometrial carcinoma

Oncology and Translational Medicine 2017年第6期3卷 249-253页

作者： Xin Cui Caixin Zhang Yunhui Li Yongyun Qi Xiaoyan Ding shumin hei Weiqing Huang Department of Pathology The Third Affiliated Hospital of Qingdao University Qingdao 266000 China Department of Pathology Qingdao Municipal Hospital Qingdao 266000 China Department of Obstetrics and Gynecology The Affiliated Medical College of Qingdao University Qingdao 266100China Department of Pathology The Affiliated medical college of Qingdao University Qingdao 266100 China

Objective This study elucidated the function and role of SUMOylation in type Ⅰ endometrial *** Fifty type Ⅰ endometrial carcinoma cases and para-cancer tissue samples were *** expression levels of ubiquitin-conjugating enzyme E2I(Ube2 i,Ubc9) and small ubiquitin-like modifier 1(SUMO1)/sentrin-specific peptidase 1(SENP1) proteins were examined using immunohistochemistry and the correlation with clinicopathological parameters was *** Ubc9 expression in type Ⅰ endometrial carcinoma tissues was significantly higher than that in the para-cancer tissues;in contrast,the expression of the SENP1 protein was markedly lower than that in the para-cancer ***9 and SENP1 expression levels were negatively correlated and were associated with tumor differentiation,but not age,depth of invasion,tumor stage,and lymph node *** SUMOylation modification plays a major role in the pathogenesis and development of type Ⅰ endometrial ***,it could be a potential target for the treatment of endometrial cancer.

关键词： SUMOylation Ubc9 sentrin-specific peptidase 1 (SENP1) immunohistochemistry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SUMO特异性蛋白酶1和ERα在Ⅰ型子宫内膜癌组织中的表达及其临床意义

引用

临床与病理杂志 2017年第10期37卷 2062-2066页

作者：崔鑫张采欣李云辉亓永云丁晓燕黑淑敏黄维清青岛大学第三附属医院病理科山东青岛266000 青岛市市立医院病理科山东青岛266000 青岛大学附属医院妇产科山东青岛266100 青岛大学附属医院病理科山东青岛266100

目的:探讨小泛素相关修饰物(small ubiquitin-related modifier,SUMO)特异性蛋白酶1(SUMO specific protease 1,SENP1)和ERα在Ⅰ型子宫内膜癌中的表达,并分析两者之间的相互关系。方法:收集Ⅰ型子宫内膜癌组织及其配对癌旁组织各50例,... 详细信息

目的:探讨小泛素相关修饰物(small ubiquitin-related modifier,SUMO)特异性蛋白酶1(SUMO specific protease 1,SENP1)和ERα在Ⅰ型子宫内膜癌中的表达,并分析两者之间的相互关系。方法:收集Ⅰ型子宫内膜癌组织及其配对癌旁组织各50例,采用免疫组织化学法检测SENP1蛋白及雌激素受体(ERα)的表达,分析其表达与患者临床病理参数的关系。结果:Ⅰ型子宫内膜癌中SENP1蛋白在癌旁组织中的表达明显高于肿瘤组织。SENP1蛋白在高分化肿瘤中的表达明显高于低分化肿瘤组织。SENP1阳性表达与ERα表达呈正相关,而与患者的年龄、肿瘤浸润的深度、肿瘤分期及淋巴结转移无关。结论:SENP1在Ⅰ型子宫内膜癌的发生、发展中发挥重要作用,有望成为治疗子宫内膜癌的新靶点。

关键词：子宫内膜癌 SUMO特异性蛋白酶1 雌激素受体免疫组织化学

来源：

维普期刊数据库

同方期刊数据库评论