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过敏性鼻炎与支气管哮喘患儿外周血HMGB1与Th17/Treg的变化及相关性

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发育医学电子杂志 2024年第4期12卷 284-289页

作者：安家李艳阳杜淑玲夏迎龙赵顺英国家儿童医学中心首都医科大学附属北京儿童医院呼吸二科北京100045 解放军总医院第七医学中心儿科医学部门急诊北京100700 解放军总医院第七医学中心检验科北京100700

目的探讨儿童过敏性鼻炎(allergic rhinitis,AR)和支气管哮喘(bronchial asthma,BA)患儿外周血高迁移率族蛋白B1(high mobility group box 1,HMGB1)水平与辅助性T细胞17(T helper 17 cell,Th17)和调节性T细胞(regulatory T cell,Treg)的比例(Th17/Treg)的相关性。方法采用前瞻性研究方法,选取2023年3月至12月在解放军总医院第七医学中心门急诊就诊患儿及健康体检者共113例作为研究对象,按照临床症状分成健康对照组(n=25)、过敏性鼻炎组(AR组,n=28)、支气管哮喘组(BA组,n=31)和两者并有组(AR+BA组,n=29),比较4组肺功能、免疫球蛋白E(immunoglobulin E,IgE)、白细胞介素(interleukin,IL)-17、HMGB1水平和Th17/Treg比例。统计学方法采用t检验、方差分析和Pearson相关性分析。结果各组的第1秒用力呼气容积(forced expiratory volume in the first second,FEV1)的结果显示,健康对照组高于AR组、BA组和AR+BA组[(96.4±2.5)%、(90.7±4.9)%、(88.6±4.1)%、(82.1±5.5)%,F=47.193,P值均<0.001],显示AR和BA患儿肺功能可能变差。AR组、BA组和AR+BA组HMGB1水平高于健康对照组[(30.4±12.4)mg/L、(47.2±17.8)mg/L、(51.4±21.8)mg/L、(4.3±2.1)mg/L,F=48.896,P值均<0.001]。AR组、BA组和AR+BA组Th17/Treg比例高于健康对照组(0.68±0.14、0.71±0.14、1.36±0.40、0.30±0.07,F=105.547,P值均<0.001)。Pearson相关性分析结果显示,HMGB1与Th17(r=0.521,P<0.001)、Th17/Treg(r=0.419,P<0.05)、IgE(r=0.502,P<0.05)、IL-17(r=0.472,P<0.05)呈正相关,与FEV1(r=-0.645,P<0.001)呈负相关。结论在儿童AR合并BA的发病过程中,HMGB1水平及Th17细胞百分比增加,而Treg细胞百分比降低,Th17/Treg比例存在失衡的情形,HMGB1水平与Th17细胞百分比、Th17/Treg比例、IgE、IL-17及FEV1存在一定的相关性,HMGB1和Th17/Treg的动态平衡可能通过影响细胞因子的表达而起到一定的调节作用。

关键词：过敏性鼻炎支气管哮喘高迁移率族蛋白B1 辅助性T细胞17 调节性T细胞

Study of Turing patterns in a SI reaction-diffusion propagation system based on network and non-network environments

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International Journal of Biomathematics 2024年第1期17卷 199-225页

作者： Yuxuan Tang shuling Shen Linhe Zhu School of Mathematical Sciences Jiangsu University Zhenjiang212013P.R.China Department of Stomatology Afiliated Hospital of Jiangsu University Zhenjiang 210008P.R.China

The study of rumor propagation dynamics is of great significance to *** news and ensure the authenticity of news *** this paper,a SI reaction-diffusion rumor propagation model with nonlinear saturation incidence is ***,through stability analysis,we obtain the conditions for the existence and local stability of the positive equilibrium *** selecting suitable variable as the control parameter,the critical value of Turing bifurcation and the existence theorem of Turing bifurcation are ***,using the above theorem and multi-scale standard analysis,the expression of amplitude equation around Turing bifurcation point is *** analyzing the amplitude equation,different types of Turing pattern are divided such as uniform steady-state mode,hexagonal mode,stripe mode and mixed structure ***,in the numerical simulation part,by observing different patterns corresponding to different values of control variable,the correctness of the theory is ***,the effects of different network structures on patterns are *** results show that there are significant differences in the distribution of users on different network structures.

关键词： Reaction-diffusion system rumor propagation amplitude equation Turing pattern

Aerodynamic optimization of an adaptive flap for next-generation green aircraft

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Chinese Journal of Aeronautics 2024年第2期37卷 100-122页

作者： Tianlong LIN Rosario PECORA Danilo CILIBERTI Wei XIA shuling HU State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China Deparment of Industrial Engineering Aerospace DivisionUniversity of Naples"FEDERICO II"Napoli 80125Italy

Adaptive,morphing flaps are taking ever-increasing attention in civil aviation thanks to the expected benefits this technology can bring at the aircraft level in terms of high-lift performance improvement and related fuel burnt reduction per *** upon morphing capabilities,it is possible to fix a unique setting for the flap and adapt the flap shape to match the aerodynamic requirements for take-off or *** proper morphed shapes can assure better high-lift performances than those achievable by referring to a conventional ***,standing the unique flap setting for take-off and landing,a dramatic simplification of the flap deployment systems may be *** a consequence of this simplification,the deployment system can be fully hosted in the wing,thus avoiding under-wing nacelles with significantly better aerodynamics and fuel *** first step for a rational design of an adaptive flap consists in defining the target morphed shapes and the unique optimal flap setting in the take-off and landing *** this work,aerodynamic optimization analyses are carried out to determine the best flap setting and related morphed shapes in compliance with the take-off and landing requirements of a reference civil transport *** different initial conditions are adopted to avoid the optimization falling into local optima,thus obtaining four groups of optimal candidate *** comparing each candidate’s performance through 2D and 3D simulations,the optimal configuration has been selected.2D simulations show that the optimal configuration is characterized by a maximum lift increase of 31.92%in take-off and 9.04%in *** to 3D simulations,the rise in maximum lift equals 22.26%in take-off and 3.50%in *** results are finally verified through wind tunnel tests,and the aerodynamic mechanism behind the obtained improvements is explained by carefully analyzing the flow field around the flap.

关键词： Morphing wings High-lift system Adaptive flap Computational Fluid Dynamics(CFD) Wind tunnel tests

Research on Regulation Method of Energy Storage System Based on Multi-Stage Robust Optimization

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Energy Engineering 2024年第3期121卷 807-820页

作者： Zaihe Yang shuling Wang Runhang Zhu Jiao Cui Ji Su Liling Chen Electrical Dispatching and Control Center Yunnan Power GridKunming650011China Kunming Power Supply Bureau Yunnan Power Grid Co.Ltd.Kunming650011China Yuxi Power Supply Bureau Yunnan Power Grid Co.Ltd.Yuxi653100China

To address the scheduling problem involving energy storage systems and uncertain energy,we propose a method based on multi-stage robust *** approach aims to regulate the energy storage system by using a multi-stage robust optimal control method,which helps overcome the limitations of traditional methods in terms of time *** goal is to effectively utilize the energy storage power station system to address issues caused by unpredictable variations in environmental energy and fluctuating load throughout the *** achieve this,a mathematical model is constructed to represent uncertain energy sources such as photovoltaic and wind *** generalized Benders Decomposition method is then employed to solve the multi-stage objective optimization *** decomposing the problem into a series of sub-objectives,the system scale is effectively reduced,and the algorithm’s convergence ability is *** with other algorithms,the multi-stage robust optimization model has better economy and convergence ability and can be used to guide the power dispatching of uncertain energy and energy storage systems.

关键词： Multi-stage robust optimization energy storage system regulation methods output uncertainty

Investigation of anisotropic strength criteria for layered rock mass

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1289-1304页

作者： shuling Huang Jinxin Zhang Xiuli Ding Chuanqing Zhang Gang Han Guoqi Yu Lulu Qu Key Laboratory of Geotechnical Mechanics and Engineering of the Ministry of Water Resources Changjiang River Scientific Research InstituteWuhan430071China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430000China University of Chinese Academy of Sciences Beijing100049China

Layered rock mass is a type of engineering rock mass with sound mechanical anisotropy,which is generally unfavorable to the stability of underground *** investigate the strength anisotropy of layered rock,the Mohr-Coulomb and Hoek-Brown criteria are introduced to establish the two transverse isotropic strength criteria based on Jaeger's single weak plane theory and maximum axial strain theory,and parameter determination ***,the sensitivity of strength parameters(K 1,K 2,and K 3)that are used to characterize the anisotropy strength of non-sliding failure involved in the strength criteria and confining pressure are *** results demonstrate that strength parameters K 1 and K 2 affect the strength of layered rock samples at all bedding angles except for the bedding angle of 90°and the angle range that can cause the shear sliding failure along the bedding *** strength of samples at any bedding angle decreases with increasing K 1,whereas the opposite is for K *** for bedding angles of 0°and 90°and the bedding angle range that can cause the shear sliding along the bedding plane,K 3 has an impact on the strength of rock samples with other bedding angles that the specimens'strength increases with increase of K *** addition,the strength of the rock sample increases as confining pressure ***,the uniaxial and triaxial tests of chlorite schist samples were carried out to verify and evaluate the strength criteria proposed in the *** shows that the predicted strength is in good agreement with the experimental *** test the applicability of the strength criterion,the strength data of several types of rock in the literature are ***,a comparison is made between the fitting effects of the two strength criteria and other available criteria for layered rocks.

关键词： Layered rock Strength anisotropy Strength criterion Experimental verification

Microdynamic mechanical properties and fracture evolution mechanism of monzogabbro with a true triaxial multilevel disturbance method

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International Journal of Mining Science and Technology 2024年第3期34卷 385-411页

作者： Zhi Zheng Bin Deng Hong Liu Wei Wang shuling Huang Shaojun Li State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Key Laboratory of Disaster Prevention and Structural Safety of Ministry of EducationCollege of Civil Engineering and ArchitectureGuangxi UniversityNanning 530004China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing 210098China Key Laboratory of Geotechnical Mechanics and Engineering of Ministry of Water Resources Changjiang River Scientific Research InstituteWuhan 430015China

The far-field microdynamic disturbance caused by the excavation of deep mineral resources and underground engineering can induce surrounding rock damage in high-stress conditions and even lead to ***,the mechanical properties and damage/fracture evolution mechanisms of deep rock induced by microdynamic disturbance under three-dimensional stress states are ***,a true triaxial multilevel disturbance test method is proposed,which can completely simulate natural geostress,excavation stress redistribution(such as stress unloading,concentration and rotation),and subsequently the microdynamic disturbance triggering damaged rock *** on a dynamic true triaxial test platform,true triaxial microdynamic disturbance tests under different frequency and amplitudes were carried out on *** results show that increasing amplitude or decreasing frequency diminishes the failure strength of *** modulus gradually decreases during disturbance *** frequency and amplitude increase,the degradation rate of deformation modulus decreases slightly,disturbance dissipated energy increases significantly,and disturbance deformation anisotropy strengthens obviously.A damage model has been proposed to quantitatively characterize the disturbance-induced damage evolution at different frequency and amplitude under true triaxial *** disturbance failure,the micro-tensile crack mechanism is dominant,and the micro-shear crack mechanism increases significantly at *** the increase of amplitude and frequency,the micro-shear crack mechanism *** approaching disturbance failure,the acoustic emission fractal dimension changes from a stable value to local large oscillation,and finally increases sharply to a high value at ***,the disturbance-induced failure mechanism of surrounding rock in deep engineering is clearly elucidated.

关键词： True triaxial disturbance test Mechanical properties Fracture evolution mechanism Disturbance-induced damage evolution Failure mechanism and precursor

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莫言作品在韩国的译介问题研究

东北亚外语研究 2022年第3期10卷 105-116页

作者：杜书灵北京外国语大学亚洲学院北京100089

本文梳理了莫言作品目前在韩国的译介情况,指出了其中仍然存在的问题,并从文本内和文本外因素两方面分析了问题存在的原因。文本内因素在于莫言作品本身所具有的时空抗译性、文化抗译性和文学手法抗译性;文本外因素则在于莫言作品在韩... 详细信息

本文梳理了莫言作品目前在韩国的译介情况,指出了其中仍然存在的问题,并从文本内和文本外因素两方面分析了问题存在的原因。文本内因素在于莫言作品本身所具有的时空抗译性、文化抗译性和文学手法抗译性;文本外因素则在于莫言作品在韩国译介传播时遇到的与意识形态、赞助人、主流诗学相关的矛盾。在分析莫言作品在韩国译介传播遇到的问题和原因后,本文据此提出了可能的提升方案,期对今后在韩国译介包括莫言作品在内的中国现当代文学作品有所帮助。

关键词：莫言韩国译介抗译性

Dendritic mesoporous silica nanoparticles for enzyme immobilization

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Green Chemical Engineering 2024年第2期5卷 173-186页

作者： shuling Zhang Jing Bai Weixi Kong Haolei Song Yunting Liu Guanhua Liu Li Ma Liya Zhou Yanjun Jiang School of Chemical Engineering and Technology Hebei University of TechnologyTianjin300130China College of Food Science and Biology Hebei University of Science&TechnologyShijiazhuang050018China Hebei Yanuo Bioscience Co. Ltd.Shijiazhuang052165China

Dendritic mesoporous silica nanoparticles(DMSNs)are a new class of solid porous materials used for enzyme immobilization support due to their intrinsic characteristics,including their unique open central-radial structures with large pore channels and their excellent *** this review,we review the recent progress in research on enzyme immobilization using DMSNs with different structures,namely,flower-like DMSNs and tree-branch-like *** DMSN synthesis methods are briefly compared,and the distinct characteristics of the two DMSN types and their effects on the catalytic performance of immobilized enzymes are comprehensively *** directions for future research on enzyme immobilization using DMSNs are also proposed.

关键词： Dendritic mesoporous silica nanoparticles Enzyme immobilization Flower-like Tree-branch-like Central-radial structure

Analysis of Drug Medical Insurance Access Pricing Based on the Perspective of Binary Equilibrium

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Asian Journal of Social Pharmacy 2024年第2期19卷 117-125页

作者： Zhang Junjun Wang shuling School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China

Objective To study the influencing factors in the process of national medical insurance negotiation and drug pricing from the dualistic equilibrium perspective,and to provide reference for the harmonious management of drug pricing in *** Through the literature analysis and policy review,the pricing subject,pricing basis and price control system in the pricing process of medical-accessed medicines were analyzed from the perspective of binary equilibrium and harmonious *** and Conclusion It is found that four balances in the drug pricing process,two balances in pricing basis and three balances in price control system need to be considered,*** pricing is the key content of national medical insurance access,which is also the hotspot of the policy in the pharmaceutical fields in recent *** pricing not only reflects the value of drugs,but also reflects a lot of top-level designs of binary equilibriums in medical insurance *** the rational design of drug pricing requires the joint efforts of the government,pharmaceutical companies and relevant experts to comprehensively consider many equilibriums,so as to improve the relevant systems.

关键词： medical insurance access drug pricing binary equilibrium