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Adaptive ultra-hypofractionated whole-pelvic radiotherapy in high-risk and very high-risk prostate cancer on 1.5-Tesla MR-Linac:Estimated delivered dose and early toxicity results

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Chronic Diseases and Translational Medicine 2024年第1期10卷 51-61页

作者： Linrui Gao Ran Wei Shirui Qin Yuan Tian Wenlong Xia Yongwen Song shulian wang Hui Fang Yu Tang Hao Jing Yueping Liu Yuan Tang Shunan Qi Bo Chen Yexiong Li Nianzeng Xing Ningning Lu Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina GCP Center/Clinical Research Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Urology State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background: Magnetic resonance(MR)-guided ultra-hypofractionated radiotherapy with whole-pelvic irradiation(UHF-WPRT)is a novel approach to radiotherapy for patients with high-risk(HR)and very high-risk(VHR)prostate cancer(PCa).However,the inherent complexity of adaptive UHF-WPRT might inevitably result in longer on-couch *** aimed to estimate the delivered dose,study the feasibility and safety of adaptive UHF-WPRT on a 1.5-Tesla ***: Ten patients with clinical stage T3a-4N0-1M0-1c PCa,who consecutively received UHF-WPRT,were enrolled *** contours of the target and organ-at-risks on the position verification-MR(PV-MR),beam-on 3D-MR(Bn-MR),and post-MR(after radiotherapy delivery)were derived from the pre-MR data by deformable image *** physician then manually adjusted them,and dose recalculation was performed *** Prism 9(GraphPad Prism Software Inc.)was utilized for conducting statistical ***: In total,we collected 188 MR scans(50 pre-MR,50 PV-MR,44 Bn-MR,and 44 post-MR scans).With median 59 min,the mean prostate clinical target volume(CTV)-V_(100%)was 98.59%±2.74%,and the mean pelvic CTVp-V_(100%)relative percentages of all scans was 99.60%±1.18%.The median V29 Gy change in the rectal wall was−2%(−18%to 20%).With a median follow-up of 9 months,no patient had acute Common Terminology Criteria for Adverse Events(CTCAE)grade 2 or more severe genitourinary(GU)or gastrointestinal(GI)toxicities(0%).Conclusion: UHF-RT to the prostate and the whole pelvis with concomitant boost to positive nodes using an Adapt-To-Shape(ATS)workflow was technically feasible for patients with HR and VHR PCa,presenting only mild GU and GI *** estimated target dose during the beam-on phase was clinically acceptable based on the 3D-MR-based dosimetry *** trial registration Chinese Clinical Trial Registry ChiCTR2000033382.

关键词： dosimetry hypofractionation magnetic resonance imaging prostate cancer radiation dose radiotherapy

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乳腺癌新辅助全身治疗后保留腋窝的研究进展

中华放射肿瘤学杂志 2024年第7期33卷 661-667页

作者：邱子涵王淑莲国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科北京100021

乳腺癌新辅助全身治疗的有效率提高,使患者的腋窝治疗朝着降低治疗强度、保留腋窝的方向发展。尤其对于新辅助治疗后腋窝淋巴结降期的患者,豁免腋窝淋巴结清扫成为可能。但腋窝放疗能否取代腋窝淋巴结清扫仍有待进一步研究。另外,如何... 详细信息

乳腺癌新辅助全身治疗的有效率提高,使患者的腋窝治疗朝着降低治疗强度、保留腋窝的方向发展。尤其对于新辅助治疗后腋窝淋巴结降期的患者,豁免腋窝淋巴结清扫成为可能。但腋窝放疗能否取代腋窝淋巴结清扫仍有待进一步研究。另外,如何对腋窝转移淋巴结能达到病理完全缓解的患者进行预测,以挑选出能够豁免腋窝手术的人群也是临床关注的焦点。本文对乳腺癌新辅助全身治疗后保留腋窝的研究进展进行综述。

关键词：乳腺肿瘤新辅助全身治疗前哨淋巴结活组织检查

Application of artificial hibernation technology in acute brain injury

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Neural Regeneration Research 2024年第9期19卷 1940-1946页

作者： Xiaoni wang shulian Chen Xiaoyu wang Zhen Song Ziqi wang Xiaofei Niu Xiaochu Chen Xuyi Chen Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina

Controlling intracranial pressure,nerve cell regeneration,and microenvironment regulation are the key issues in reducing mortality and disability in acute brain *** is currently a lack of effective treatment *** has the characteristics of low temperature,low metabolism,and hibernation rhythm,as well as protective effects on the nervous,cardiovascular,and motor *** hibernation technology is a new technology that can effectively treat acute brain injury by altering the body’s metabolism,lowering the body’s core temperature,and allowing the body to enter a state similar to *** review introduces artificial hibernation technology,including mild hypothermia treatment technology,central nervous system regulation technology,and artificial hibernation-inducer *** summarizing the relevant research on artificial hibernation technology in acute brain injury,the research results show that artificial hibernation technology has neuroprotective,anti-inflammatory,and oxidative stress-resistance effects,indicating that it has therapeutic significance in acute brain ***,artificial hibernation technology can alleviate the damage of ischemic stroke,traumatic brain injury,cerebral hemorrhage,cerebral infarction,and other diseases,providing new strategies for treating acute brain ***,artificial hibernation technology is currently in its infancy and has some complications,such as electrolyte imbalance and coagulation disorders,which limit its *** research is needed for its clinical application.

关键词： cute brain injury artificial hibernation hypothermia low metabolism mild hypothermia

Degradation of organic pollutants by visible light synergistic electro-Fenton oxidation process

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Science China Chemistry 2013年第6期56卷 813-820页

作者： wang shulian wang Qi FANG YanFen HUANG YingPing Engineering Research Center of Eco-environment in Three Gorges Reservoir Region Ministry of EducationChina Three Gorges University Key Laboratory of Novel Thin Film Solar Cells Institute of Plasma Physics

Visible light irradiation combined with homogeneous iron and/or hydrogen peroxide to degrade organic dye rhodamine B (RhB) and small molecular compound 2,4-dichlorophenol (2,4-DCP) in a home-made bottle reactor was assessed. The concen-tration of oxidize species, Fe3+ and Fe2+ were determined during the degradation process. The results demonstrated that visible light irradiation combined with electro-Fenton improved the degradation efficiency. Moreover, both RhB and 2,4-DCP were mineralized during visible light synergistic electro-Fenton oxidation process. 95.0% TOC (total organic carbon) removal rate of RhB occurred after 90 min and 96.7% of COD (chemical oxygen demand) removal rate after 65 min of irradiation. 91.3% TOC removal rate of 2,4-DCP occurred after 16 h of irradiation and 99.9% COD removal rate occurred after 12 h of illumination. The degradation and oxidation process was dominated by the hydroxyl radical ( · OH) generated in the system. Both the impressed electricity and dye sensitization by visible light facilitated the conversion between Fe3+ and Fe 2+ , thus, improving Fenton reaction efficiency.

关键词：化学 C-C 原理方法实验

新辅助直肠评分在局部晚期直肠癌新辅助短程放疗后巩固化疗模式中的预后及辅助化疗决策作用

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中华肿瘤杂志 2024年第4期46卷 335-343页

作者：曾强唐源周海涛李宁刘文扬陈司霖李帅卢宁宁房辉王淑莲刘跃平宋永文李晔雄金晶国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院、北京协和医学院肿瘤医院放疗科北京100021 国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院、北京协和医学院肿瘤医院结直肠外科北京100021 福建医科大学附属协和医院放疗科、福建省肿瘤智能影像与精准放疗重点实验室福建省消化、血液系统与乳腺恶性肿瘤放射与治疗临床医学研究中心福州350001 血液系统与乳腺恶性肿瘤放射与治疗临床医学研究中心北京100142 北京大学肿瘤医院放疗科、北京市肿瘤防治研究所恶性肿瘤发病机制及转化研究教育部重点实验室北京100142 国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院深圳医院放疗科深圳518116

目的探讨新辅助直肠(NAR)评分在新辅助短程放疗加巩固化疗模式下对局部晚期直肠癌(LARC)预后的影响及对辅助化疗决策的价值。方法选取2015年8月至2018年8月入组STELLARⅢ期试验(NCT02533271)接受新辅助短程放疗加巩固化疗并可计算NAR评... 详细信息

目的探讨新辅助直肠(NAR)评分在新辅助短程放疗加巩固化疗模式下对局部晚期直肠癌(LARC)预后的影响及对辅助化疗决策的价值。方法选取2015年8月至2018年8月入组STELLARⅢ期试验(NCT02533271)接受新辅助短程放疗加巩固化疗并可计算NAR评分的LARC患者。按照NAR评分,分为低(16分)组。生存分析采用Kaplan-Meier法和Log rank检验,影响因素分析采用Cox比例风险回归模型。结果232例LARC患者,低、中和高NAR评分患者分别为56例(24.1%)、113例(48.7%)和63例(27.2%)。中位随访37个月,低、中和高NAR评分患者的3年无病生存(DFS)率分别为87.3%、68.3%和53.4%(P<0.001)。多因素分析显示,NAR评分(中NAR评分:HR=3.10,95%CI:1.30~7.37,P=0.011;高NAR评分:HR=5.44,95%CI:2.26~13.09,P<0.001)、切除状态(HR=3.00,95%CI:1.64~5.52,P<0.001)及辅助化疗(HR=3.25,95%CI:2.01~5.27,P<0.001)为DFS的独立预后因素,高NAR评分者DFS显著较低。R0切除患者中,低、中NAR评分者接受辅助化疗的3年DFS率分别为97.8%、78.0%,高于未接受辅助化疗的患者(分别为43.2%和50.6%,均P<0.05)。高NAR评分者接受或未接受辅助化疗的3年DFS差异无统计学意义(分别为54.2%和53.3%,P=0.214)。结论NAR评分是LARC新辅助短程放疗加巩固化疗策略中的有效预后指标,在后续辅助化疗决策方面具有潜在作用,其值得在更大样本量的研究中进一步验证其价值。

关键词：直肠肿瘤新辅助直肠评分短程放疗巩固化疗预后

Photocatalytic properties of hierarchical BiOXs obtained via an ethanol-assisted solvothermal process

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Journal of Environmental Sciences 2015年第9期27卷 172-180页

作者： Manke Jia Xiaolong Hu shulian wang Yingping Huang Lirong Song Institute of Hydrobiology Chinese Academy of Sciences Engineering Research Center of Eco-environment in Three Gorges Reservoir Region Ministry of Education China Three Gorges University Collaborative Innovation Center for Geo-Hazards and Eco-Environment in Three Gorges Area

In this study, bismuth oxyhalide（Bi OXs（X_Cl, Br, I）） semiconductors were prepared by a simple solvothermal method, with ethanol serving as solvent and a series of tetrabutylammonium halide surfactants as halogen sources. Under identical synthetic conditions, Bi OBr was more readily constructed into regular flower-like hierarchical architectures. The photocatalytic properties of the materials were studied by monitoring the degradation of rhodamine B（Rh B）,with visible light absorption, and colorless salicylic acid（SA）. It was found that both Rh B and SA were rapidly degraded on the surface of Bi OBr. Bi OCl was rather active for the degradation of Rh B,but ineffective toward the degradation of SA. However, neither Rh B nor SA could be degraded effectively in the case of Bi OI. Further experiments such as UV–visible spectroscopy and detection of U OH and O2 Uradicals suggest that the electronic structure of the Bi OX photocatalysts is responsible for the difference in their activities.

关键词： BiOXs(X_Cl Br I) Ethanol-assisted solvothermal process Photocatalytic properties

乳腺癌改良根治术后放疗不同计划靶区外放边界探讨

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国际放射医学核医学杂志 2024年第6期48卷 359-365页

作者：侯露张伟张彦新万宝郇福奎孙超任雯廷王淑莲国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院放疗科北京100021 国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院超声科北京100021

目的探讨乳腺癌改良根治术后放疗患者不同计划靶区的外放边界。方法回顾性分析2022年10月至2023年4月中国医学科学院肿瘤医院收治的38例女性乳腺癌改良根治术后使用颈胸一体架+热塑膜方式固定的放疗患者(中位年龄50岁,范围34~74岁)的33... 详细信息

目的探讨乳腺癌改良根治术后放疗患者不同计划靶区的外放边界。方法回顾性分析2022年10月至2023年4月中国医学科学院肿瘤医院收治的38例女性乳腺癌改良根治术后使用颈胸一体架+热塑膜方式固定的放疗患者(中位年龄50岁,范围34~74岁)的338次锥形束CT(CBCT)图像资料。对所有患者的CBCT图像针对不同的感兴趣区分别进行配准,范围包括胸壁靶区、锁骨上区靶区和整体靶区,并计算出3个靶区在六维方向的摆位误差[平移方向:左右、头脚、腹背,旋转方向:俯仰、翻滚、偏转]。采用公式M=2.5∑+0.7σ计算3个靶区的外放边界。比较3个靶区在六维方向的摆位误差的差异并分析其相关性。摆位误差的组间比较采用非参数检验(Firedman检验),相关性分析采用Spearman法。结果锁骨上区靶区与整体靶区在左右方向的摆位误差的差异有统计学意义[(2.53±2.46)mm对(1.82±2.18)mm,χ^(2)=0.286,P=0.004],胸壁靶区和整体靶区[(1.10±0.95)°对(0.87±0.75)°]、锁骨上区靶区和整体靶区[(1.24±1.05)°对(0.87±0.75)°]在翻滚方向的摆位误差的差异均有统计学意义(χ^(2)=0.265、0.241,P=0.001、0.002)。胸壁靶区在左右、头脚、腹背方向的外放边界分别为6.10、6.21、5.90 mm,锁骨上区靶区外放边界分别为8.06、6.22、6.70 mm,整体靶区外放边界分别为6.09、5.95、5.48 mm。相较于锁骨上区靶区与整体靶区(r=0.35~0.81,均P<0.001),胸壁靶区与整体靶区在六维方向均表现出更强的相关性(r=0.76~0.93,均P<0.001)。结论对于乳腺癌改良根治术后放疗患者,在进行胸壁靶区、锁骨上区靶区计划设计时,应使用不同的外放边界。

关键词：乳腺肿瘤放射疗法计划靶区锥束计算机体层摄影术摆位误差外放边界

Genetic polymorphisms in genes regulating cell death and prognosis of patients with rectal cancer receiving postoperative chemoradiotherapy

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Cancer Biology & Medicine 2023年第4期20卷 297-316页

作者： Hongxia Chen Luxi Yin Jie Yang Ningxin Ren Jinna Chen Qixuan Lu Ying Huang Yanru Feng Weihu wang shulian wang Yueping Liu Yongwen Song Yexiong Li Jing Jin Wen Tan Dongxin Lin State Key Laboratory of Molecular Oncology Department of Etiology and CarcinogenesisBeijing Key Laboratory for Carcinogenesis and Cancer PreventionNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China

Objective:The identification of biomarkers for predicting chemoradiotherapy efficacy is essential to optimize personalized *** study determined the effects of genetic variations in genes involved in apoptosis,pyroptosis,and ferroptosis on the prognosis of patients with locally advanced rectal cancer receiving postoperative chemoradiotherapy(CRT).Methods:The Sequenom MassARRAY was used to detect 217 genetic variations in 40 genes from 300 patients with rectal cancer who received postoperative *** associations between genetic variations and overall survival(OS)were evaluated using hazard ratios(HRs)and 95%confidence intervals(CIs)computed using a Cox proportional regression *** experiments were performed to determine the functions of the arachidonate 5-lipoxygenase(ALOX5)gene and the ALOX5 rs702365 ***:We detected 16 genetic polymorphisms in CASP3,CASP7,TRAILR2,GSDME,CASP4,HO-1,ALOX5,GPX4,and NRF2 that were significantly associated with OS in the additive model(P[C]represses ALOX5 transcription and corollary experiments suggested that ALOX5 may promote colon cancer cell growth by mediating an inflammatory ***:Polymorphisms in genes regulating cell death may play essential roles in the prognosis of patients with rectal cancer who are treated with postoperative CRT and may serve as potential genetic biomarkers for individualized treatment.

关键词： Rectal neoplasms genetic variation regulated cell death overall survival ALOX5

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胃癌术后调强放疗后的复发模式分析

中华放射肿瘤学杂志 2024年第5期33卷 419-425页

作者：史金明唐源李宁王淑莲宋永文刘跃平亓姝楠卢宁宁景灏陈波房辉李晔雄刘文扬金晶国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科北京100021 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院深圳医院放疗科深圳518116

目的探索在调强放疗技术条件下,胃癌术后放疗的失败模式。方法回顾性分析2009年5月至2018年12月就诊于中国医学科学院肿瘤医院,手术病理分期为T_(3-4)N_(0)期或T_(x)N_(1-3)期的胃癌或胃食管结合部癌患者的资料。患者均接受术后放疗,并... 详细信息

目的探索在调强放疗技术条件下,胃癌术后放疗的失败模式。方法回顾性分析2009年5月至2018年12月就诊于中国医学科学院肿瘤医院,手术病理分期为T_(3-4)N_(0)期或T_(x)N_(1-3)期的胃癌或胃食管结合部癌患者的资料。患者均接受术后放疗,并在随诊期间存在影像学、内镜及病理等资料证实肿瘤复发。根据肿瘤复发位置分为局部或区域复发,以及远处转移。使用t检验和χ^(2)检验比较不同组间的复发模式差异,利用Kaplan-Meier法评估患者生存。结果共计入组76例患者,患者中位年龄49(范围为27~67)岁,T_(3)、T_(4)、N_(1-3)期分别为34例(45%)、40例(53%)和75例(99%),病理分期为Ⅲ期者73例(92%),接受D2清扫者占50%(38例)。患者中位随访时间为32.8(范围为7.1~138.5)个月,中位复发时间为17.6(范围为2.9~113.6)个月,复发后中位生存时间为8.19(范围为0.6~91.9)个月。患者局部或区域复发、远处转移分别为13例(17%)、6例(8%)、72例(95%)。远处转移的模式以腹膜转移(33例,43%)和远处淋巴结转移(12例,16%)为主。结论在调强放疗技术条件下,胃癌术后放疗有良好的局部和区域控制,整体的复发模式仍以远处转移为主。

关键词：胃肿瘤,局部晚期术后放射疗法靶区勾画失败模式