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新时代中国职业卫生工作现状及应对策略

职业卫生与应急救援 2024年第3期42卷 407-412页

作者：黄伟乐黄河海许姝丽何剑锋赵鼎甲深圳市宝安区公共卫生服务石岩分中心广东深圳518108

职业健康是健康中国战略的重要组成部分。随着职业卫生专业技术发展,我国逐步建立了较为健全的职业卫生工作体系,极大限度地降低了职业病的发生、发展。然而,随着我国工业化进程不断推进,职业病危害问题日渐突出,造成了接触人员基数大... 详细信息

职业健康是健康中国战略的重要组成部分。随着职业卫生专业技术发展,我国逐步建立了较为健全的职业卫生工作体系,极大限度地降低了职业病的发生、发展。然而,随着我国工业化进程不断推进,职业病危害问题日渐突出,造成了接触人员基数大、职业病危害因素复杂等的现状,职业病防治工作面临的形势依然严峻。基于现有文献、政府文件以及实际工作情况,着重分析了我国现阶段职业卫生工作情况,提出问题,并探讨了新时代背景下的职业卫生工作相关法律体系、工作理论体系与机制、监管机制、职业病防治理念、人才培养、技术服务体系等的应对策略。

关键词：新时代职业卫生职业病健康中国策略

Microfluidic-based isolation of circulating tumor cells with high-efficiency and high-purity

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Chinese Chemical Letters 2024年第8期35卷 101-111页

作者： Feng Wu xuemin Kong Yixuan Liu shuli Wang Zhong Chen xu Hou Fujian Engineering Research Center for Solid-State Lighting Department of Electronic ScienceSchool of Electronic Science and EngineeringXiamen UniversityXiamen 361005China College of Physics and New Energy Xuzhou University of TechnologyXuzhou 221018China State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China College of Physical Science and Technology Xiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361102China

The isolation of circulating tumor cells(CTCs)from complex biological samples is of paramount signifi-cance for advancing cancer diagnosis,prognosis,and ***,the low concentration of CTCs and nonspecific adhesion of white blood cells(WBCs)present challenges that hinder the efficiency and purity of captured ***-based strategies utilize precise fluid control at the micron level to incorporate specific micro/nanostructures or recognition molecules,enabling effective CTCs ***,by employing surface modification designs that exhibit exceptional anti-adhesion properties against WBCs,the purity of isolated CTCs can be further *** review offers an in-depth explo-ration of recent advancements,challenges,and opportunities associated with microfluidic-based CTCs iso-lation from biological ***,we will comprehensively introduce the microfluidic-based strate-gies for achieving high-efficiency CTCs isolation,which includes the morphological design of microchan-nels for physical force-based CTCs isolation and the specific modification of microchannel surfaces for affinity-based CTCs ***,a review of recent research advances in microfluidic-based high-purity CTCs isolation is presented,focusing on strategies that decrease the nonspecific adhesion of WBCs through surface micro-/nanostructure construction or chemical and biological ***,we will summarize the article by providing the prospective opportunities and challenges for the future development of microfluidic-based CTCs isolation.

关键词： Microfluidics Isolation Circulating tumor cells High-efficiency High-purity

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肉桂的组成及其在化妆品中的应用

中国洗涤用品工业 2024年第4期 78-86页

作者：闫永涛李晓敏许树立张红霞贺晓静林燕惜完美(广东)日用品有限公司广东中山528400

介绍了肉桂的基本情况及主要化学组成,肉桂含有挥发油、黄酮、多糖、萜类、木脂素、香豆素、矿物质等多种成分,其中挥发油为其主要成分;总结了肉桂与化妆品行业相关的抗氧化、抑菌、美白、皮肤保护等功效;分析了肉桂在化妆品的应用现状... 详细信息

介绍了肉桂的基本情况及主要化学组成,肉桂含有挥发油、黄酮、多糖、萜类、木脂素、香豆素、矿物质等多种成分,其中挥发油为其主要成分;总结了肉桂与化妆品行业相关的抗氧化、抑菌、美白、皮肤保护等功效;分析了肉桂在化妆品的应用现状及安全性,并提出了肉桂在化妆品中的应用展望。

关键词：肉桂化学组成生物活性化妆品

Noether's Symmetries and Its Inverse for Fractional Logarithmic Lagrangian Systems

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Journal of Systems Science and Information 2019年第1期10卷 90-98页

作者： Jun JIANG Yuqiang FENG shuli xu School of Science Wuhan University of Science and Technology Hubei Province Key Laboratory of Systems Science in Metallurgical Process Wuhan University of Science and Technology

In this paper, Noether's theorem and its inverse theorem are proved for the fractional variational problems based on logarithmic Lagrangian systems. The Hamilton principle of the systems is derived. And the definitions and the criterions of Noether's symmetry and Noether's quasi-symmetry of the systems based on logarithmic Lagrangians are given. The intrinsic relation between Noether's symmetry and the conserved quantity is established. At last an example is given to illustrate the application of the results.

关键词： fractional derivatives nonstandard Lagrangians Hamilton’s principle Noether’s theorem Noether’s inverse theorem

Petrogenesis and Tectonic Implications of the Paleoproterozoic A-Type Granites in the Xiong’ershan Area along the Southern Margin of the North China Craton

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Journal of Earth Science 2024年第2期35卷 416-429页

作者： Jinhong xu Yuping Jiang shuli Hu Zhengwei Zhang Chengquan Wu Chaofei Zheng Xiyao Li Ziru Jin Sensen Zhang Yatao Zhou State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang550081China University of Chinese Academy of Sciences Beijing100049China Henan Province Non-ferrous Metals Geological Mineral Resources Bureau Zhengzhou450053China Jiangmen Land Market Monitoring Center Jiangmen 529000China

Paleoproterozoic A-type granites are widely distributed in the southern margin of the North China Craton(SNCC),providing important information for understanding the Paleoproterozoic tectonic regimes in this *** paper reports newly obtained whole-rock compositions and zircon U-Pb ages for the Tieluping syenogranite porphyry(TLP)and Huoshenmiao alkali granite porphyry(HSM)in the *** from the TLP and HSM have U-Pb ages of 1805±12 and 1792±14 Ma,*** ages are taken to date the emplacement of these *** had high total alkali contents(K_(2)O+Na_(2)O>7.13 wt.%),with high 10000×Ga/Al ratios(3.06–3.41)and Zr+Y+Nb+Ce values(709 ppm–910 ppm)as well as high zircon saturation temperatures(864–970℃),indicative of A-type granite *** Y/Nb(1.75–3.32),Ce/Nb(7.72–9.72),and Yb/Ta(2.89–5.60)ratios suggested that TLP and HSM belonged to the A2-type *** negative whole rockε_(Nd)(t)values(−8.4 to−6.6)and negative zirconε_(Hf)(t)values(−15.9 to−6.3)confirmed that TLP and HSM were likely generated by the partial melting of an ancient continental ***εHf(t)(−7.4 to+4.0)values of inherited zircons in the TLP suggested that they were derived from the partial melting of Archean basement *** the geochemical similarity of the 1.80 Ga A-type granitoids in the SNCC,we propose that the TLP and HSM were formed in a post-collisional regime that was likely associated with the break-off of the Paleoproterozoic subducted *** of the asthenosphere provided huge heat to generate the regional 1.80 Ga A-type granite in the SNCC.

关键词： Paleoproterozoic A-type granite Post-collisional North China Craton tectonic geochemistry

Green Synthesized Liquid-like Dynamic Polymer Chains with Decreased Nonspecific Adhesivity for High-Purity Capture of Circulating Tumor Cells

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CCS Chemistry 2024年第2期6卷 507-517页

作者： Feng Wu Xiaofeng Chen shuli Wang Ruimin Zhou Chunyan Wang Lejian Yu Jing Zheng Chaoyong Yang xu Hou State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujian 361005 College of Physical Science and Technology Xiamen UniversityXiamenFujian 361005 College of Physics and New Energy Xuzhou University of TechnologyXuzhouJiangsu 221018 Fujian Engineering Research Center for Solid-State Lighting Department of Electronic ScienceSchool of Electronic Science and EngineeringXiamen UniversityXiamenFujian 361005 Institute of Artificial Intelligence Xiamen UniversityXiamenFujian 361005 Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) XiamenFujian 361102 State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdaoShandong 266071

The capture of circulating tumor cells(CTCs)is of great significance in reducing cancer mortality and ***,the nonspecific binding of proteins and white blood cells(WBCs)weakens the targeting capabilities of the capture surfaces,which critically hampers the efficiency and purity of the captured ***,we propose a liquid-like interface design strategy that consists of liquid-like polymer chains and anti-EpCAM modification processes for high-purity and high-efficiency capture of *** dynamic flexible feature of the liquid-like chains endows the modified surfaces with excellent antiadhesion property for proteins and blood *** liquid-like surfaces can capture the target CTCs and show high cell viability due to the environmentfriendly surface modification *** liquid-like surface designs were introduced in the deterministic lateral displacement(DLD)-patterned microfluidic chip,the nonspecific adhesion rate of WBCs was reduced by more than fivefold compared to that in the DLD chip without liquid-like interface design,while maintaining comparable capture ***,this strategy provides a novel perspective on surface design for achieving high purity and efficient capture of CTCs.

关键词： green synthesis dynamic polymer chains liquid-like interface nonspecific adsorption capture of circulating tumor cells microfluidics

贝那普利联合厄贝沙坦治疗原发性高血压伴左心室肥厚的临床疗效研究

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中国药物滥用防治杂志 2022年第1期28卷 71-76页

作者：徐淑莉永城市人民医院心血管内科河南永城476600

目的:探讨贝那普利联合厄贝沙坦治疗原发性高血压(essential hypertension,EH)伴左心室肥厚(left ventricular hypertrophy,LVH)的临床疗效研究。方法:选择2019年6月—2021年6月我院就诊的EH伴LVH患者116例,按照随机数表法分成观察组和... 详细信息

目的:探讨贝那普利联合厄贝沙坦治疗原发性高血压(essential hypertension,EH)伴左心室肥厚(left ventricular hypertrophy,LVH)的临床疗效研究。方法:选择2019年6月—2021年6月我院就诊的EH伴LVH患者116例,按照随机数表法分成观察组和对照组,每组58例。对照组采用厄贝沙坦治疗,观察组在对照组基础上联合贝那普利治疗,比较两组临床效果、血压、心率、心室结构以及N-末端脑钠肽前体(NT-proBNP)、超敏C反应蛋白(hs-CRP)水平变化及不良反应发生情况。结果:观察组总有效率为91.38%,高于对照组的75.86%,差异有统计学意义(P0.05);观察组IVST、LVPWT、LVMI及NT-proBNP、hs-CRP水平低于对照组,差异有统计学意义(P0.05)。结论:贝那普利联合厄贝沙坦治疗EH伴LVH患者具有较高的临床效果,能有效降低患者血压,改善其左心室结构,降低NT-proBNP、hs-CRP水平,且具有一定安全性。

关键词：贝那普利厄贝沙坦原发性高血压左心室肥厚心率变异性

Riverine sulfate sources and behaviors in arid environment,Northwest China:Constraints from sulfur and oxygen isotopes

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Journal of Environmental Sciences 2024年第3期137卷 716-731页

作者： Yifu xu Wenjing Liu Bing xu Zhifang xu Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

The fate of riverine sulfate ion (SO_(4)^(2-)) and its environmental effects in arid environment are difficult to evaluate due to its complicated sources and strongly coupled behaviors with water cycle which is significantly modified by *** understand the sulfur cycle in aquatic systems in arid environment,the chemical and sulfur and oxygen isotopic compositions (δ^(34)S_(SO4)and δ^(18)O_(SO4)) of major rivers around the Badain Jaran Desert,northwestern China,were *** rivers had averaged SO_(4)^(2-)content at 1336μmol/L,over 10times higher than the global *** δ^(34)S_(SO4)and δ^(18)O_(SO4)values ranged from-5.3‰to+11.8‰and+1.6‰to+12.8‰,*** end-member analysis and the inverse model showed that riverine sulfate was mainly derived from evaporites dissolution (0-87%),sulfide oxidation (13%-100%) and precipitation (0-33%),indicating heterogeneity in sulfur sources and behaviors along the river drainage with the lithology variations and climate *** isotopic tools combining with hydro-chemistry compositions could be applied to reveal sulfur cycle in arid *** on the calculation,sulfide oxidation plays the primary role in the headwater and upstream in the Qilian-Mountains area,where sulfide is widely *** the proportion of evaporites dissolution contributing to riverine sulfate is much higher in downstream in a drier ***,less precipitation and higher temperature can lead to more intensive evaporation,affecting the process of sulfide oxidation and enhancing the rates of evaporites dissolution and sulfate precipitation in the basin.

关键词： Sulfur and oxygen isotopes Source apportionment Inverse model Arid environment Inland rivers Northwestern China

Laboratory evaluation of high-friction thin overlays for pavement preservation

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Frontiers of Structural and Civil Engineering 2024年第6期18卷 936-948页

作者： Ouming xu Rentao xu Lintong JIN School of Highway Chang’an UniversityXi’an 710064China School of Materials Science and Engineering Chang’an UniversityXi’an 710061China

Traditional asphalt concrete(AC)and stone matrix asphalt(SMA),which are used as thin asphalt overlays,are common maintenance strategies to enhancing ride quality,skid resistance,and ***,several studies have used a novel asphalt mixture known as a high-friction thin overlay(HFTO)to improve surface ***,it remains uncertain whether the laboratory properties of HFTO differ significantly from those of conventional *** study aims to evaluate the laboratory properties of HFTO mixtures and compare them with those of AC and *** mixtures with nominal maximum size of 9.5 mm were produced in the laboratory,and performance tests were conducted,including wheel tracking test,low temperature flexural creep test,moisture susceptibility test,Cantabro Abrasion Test,Marshall Test,sand patch test,British pendulum test,and indoor tire-rollingdown *** results showed that the HFTO exhibited a lower tire/pavement noise than the AC and ***,HFTO had superior high-temperature stability,larger macro texture,and higher skid resistance in comparison to those of AC,but lower than those of ***,HFTO mixtures may be considered a suitable replacement for traditional AC mixtures in regions where skid resistance and noise reduction are concerns.

关键词： road engineering pavement maintenance high friction thin overlay performance skid resistance tire/pavement noise