检索结果-南通市图书馆

METTL9-catalyzed histidine methylation of S100A9 suppresses the anti-Staphylococcus aureus activity of neutrophils

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2024年第3期15卷 223-229页

作者： Dan Cao Mengyue Lv Chi Hu shukai li Siwen Wang Chao Xu Wen Pan Department of Digestive Disease The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technologyof ChinaHefei230001China Division of life Sciences and Medicine The CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesInstitute of ImmunologyUniversity of Science and Technology of ChinaHefei 230027China Division of life Sciences and Medicine MOE Key Laboratory for Cellular DynamicsHefei National Center for Cross-Disciplinary SciencesUniversity of Science and Technology of ChinaHefei 230027China

Dear Editor,Protein histidine methylation has been found to be a widespread post-translational modification(PTM)in mammalian cells and represents more than 13%of all protein methylation events in the human methylome(Ning et al.,2016;Kapell and Jakobsson,2021).Recently,we and other groups independently identified METTL9 as the first broad-specificity histidine N1 methyltransferase in mammals(Davydova et al.,2021;Lv et al.,2021).METTL9 methylates a variety of substrates with a common x-His-x-His motif(His is for histidine;the second x is preferably small amino acids:A/C/G/S)and catalyzes methyl transfer to the last histidine.

关键词： S100A9 specificity

基于物理引导的深度学习的突发公共卫生事件期间城市轨道交通短时OD客流预测（英文）

在线全文

学校读者我要写书评

暂无评论

Engineering 2024年第10期41卷 276-296页

作者： Shuxin Zhang Jinlei Zhang lixing Yang Feng Chen shukai li Ziyou Gao School of Systems Science Beijing Jiaotong University School of Civil Engineering Beijing Jiaotong University

Accurate origin–destination(OD) demand prediction is crucial for the efficient operation and management of urban rail transit(URT) systems, particularly during a pandemic. However, this task faces several limitations, including real-time availability, sparsity, and high-dimensionality issues, and the impact of the pandemic. Consequently, this study proposes a unified framework called the physics-guided adaptive graph spatial–temporal attention network(PAG-STAN) for metro OD demand prediction under pandemic conditions. Specifically, PAG-STAN introduces a real-time OD estimation module to estimate real-time complete OD demand matrices. Subsequently, a novel dynamic OD demand matrix compression module is proposed to generate dense real-time OD demand matrices. Thereafter, PAG-STAN leverages various heterogeneous data to learn the evolutionary trend of future OD ridership during the ***, a masked physics-guided loss function(MPG-loss function) incorporates the physical quantity information between the OD demand and inbound flow into the loss function to enhance model interpretability. PAG-STAN demonstrated favorable performance on two real-world metro OD demand datasets under the pandemic and conventional scenarios, highlighting its robustness and sensitivity for metro OD demand prediction. A series of ablation studies were conducted to verify the indispensability of each module in PAG-STAN.

关键词： OD demand prediction Urban rail transit PAG-STAN Pandemic

面向自动驾驶安全测试的碰撞场景构建与仿真分析

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国安全科学学报 2024年第7期34卷 211-218页

作者：赵尧华陈延展郑亮李树凯中南大学交通运输工程学院湖南长沙410075 北京交通大学轨道交通控制与安全国家重点实验室北京100044

为减少自动驾驶车辆产生的交通事故,提高车辆在仿真环境中的安全测试效率,提出一种基于深度强化学习的自动驾驶碰撞测试场景构建方法。首先,通过设置状态、动作和奖励函数,将车辆的驾驶过程映射为马尔可夫决策过程;然后,基于搭建的仿真... 详细信息

为减少自动驾驶车辆产生的交通事故,提高车辆在仿真环境中的安全测试效率,提出一种基于深度强化学习的自动驾驶碰撞测试场景构建方法。首先,通过设置状态、动作和奖励函数,将车辆的驾驶过程映射为马尔可夫决策过程;然后,基于搭建的仿真平台(CARLA-DRL)训练智能体完成车辆碰撞任务,生成碰撞测试场景;最后,随机进行500次碰撞仿真试验,根据智能体与自动驾驶车辆的相对距离,分析碰撞成功率、碰撞时间和冲突能量。结果表明:智能体生成符合车辆动力学的碰撞轨迹,能够构建精细化、多类型的碰撞测试场景;智能体与自动驾驶车辆的平均碰撞成功率为62.20%,平均碰撞时间为127.25 s,平均冲突能量值为175.98 kJ。该方法能够构建高频、高效和高危的自动驾驶车辆碰撞测试场景,增加仿真场景中偶发高风险场景的发生概率,提高自动驾驶车辆对于碰撞事故的安全测试效率。

关键词：自动驾驶安全测试深度强化学习碰撞测试场景仿真试验

不确定信息下的灾后道路实时抢修鲁棒优化策略

在线全文

学校读者我要写书评

暂无评论

系统工程学报 2024年第3期39卷 360-372页

作者：马倩乾李树凯杨立兴杨凯北京交通大学系统科学学院北京100044

针对突发事件后受损道路的抢修问题,建立了以抢修总成本最小为目标的多阶段道路抢修优化模型.进一步,考虑各个受损点抢修时间的不确定性,构建了基于情景集的灾后道路抢修鲁棒优化模型.为满足受损与抢修信息的预测不准确性和动态变化性,... 详细信息

针对突发事件后受损道路的抢修问题,建立了以抢修总成本最小为目标的多阶段道路抢修优化模型.进一步,考虑各个受损点抢修时间的不确定性,构建了基于情景集的灾后道路抢修鲁棒优化模型.为满足受损与抢修信息的预测不准确性和动态变化性,设计了一种基于多周期滚动优化方法的高效求解策略.最后通过数值实验发现,多阶段鲁棒优化抢修策略可以满足灾后道路抢修的不确定性和实时性要求.此外,决策者可根据实际需求选取合适的风险权衡因子,实现解鲁棒和模型鲁棒之间的权衡.

关键词：道路抢修鲁棒优化滚动优化不确定性

准噶尔盆地东部石钱滩凹陷石炭系石钱滩组烃源岩特征及其生烃潜力分析

在线全文

学校读者我要写书评

暂无评论

西北地质 2024年第2期57卷 34-45页

作者：崔炳富孔令华陈军张大勇梁辉李书凯郭望中国石油新疆油田分公司勘探开发研究院新疆克拉玛依834000 中国石油吐哈油田分公司勘探开发研究院新疆哈密839000 西安西北有色地质研究院有限公司陕西西安710054 中国地质调查局西安地质调查中心陕西西安710119

石钱滩组烃源岩为准噶尔盆地石钱滩凹陷石炭系的主力生烃层位。在充分调研其空间展布的基础上,选取最新发现的双井子地质探槽剖面及石钱1井、石钱2井与钱1井进行系统的烃源岩总有机碳、热解、族组分组成、有机显微组分、镜质体反射率及... 详细信息

石钱滩组烃源岩为准噶尔盆地石钱滩凹陷石炭系的主力生烃层位。在充分调研其空间展布的基础上,选取最新发现的双井子地质探槽剖面及石钱1井、石钱2井与钱1井进行系统的烃源岩总有机碳、热解、族组分组成、有机显微组分、镜质体反射率及饱和烃色质等有机地球化学分析测试。结果表明,石钱滩组烃源岩为一套典型的海湾泻湖相沉积,呈NW–SE向展布于石钱滩凹陷,局部地区厚度巨大,可达370 m,沉积厚度中心位于凹陷东南隅。富有机质层段主要集中在石钱滩组下部,次为上部。整体具有较高的有机质丰度,可达到好等级及以上,有机质类型以Ⅱ2-Ⅲ为主,且已进入到高成熟生气阶段。综合研究认为,石炭系石钱滩组烃源岩具有良好的生烃条件,能够为石钱滩凹陷提供充足的油气源。

关键词：准噶尔盆地石钱滩组烃源岩生烃条件

DATA PROCESSING TECHNOLOGY OF AIRBORNE 3D IMAGE

在线全文

学校读者我要写书评

暂无评论

Geo-Spatial Information Science 2001年第3期4卷 62-67页

作者： YOU Hongjian liU Shaochuang li shukai Institute of Remote Sensing Applications Chinese Academy of Sciences Beijing China

Airborne 3D image which integrates GPS, attitude measurement unit (AMU), scanning laser rangefinder (SLR) and spectra scanner has been developed successfully. The spectral scanner and SLR use the same optical system which ensures laser point to match pixel seamlessly. The distinctive advantage of 3D image is that it can produce geo-referenced images and DSM (digital surface models) images without any ground control points (GCPs). It is no longer necessary to survey GCPs and with some softwares the data can be processed and produce digital surface models (DSM) and geo-referenced images in quasi-real-time, therefore the efficiency of 3D image is 10–100 times higher than that of traditional approaches. The processing procedure involves decomposing and checking the raw data, processing GPS data, calculating the positions of laser sample points, producing geo-referenced image, producing DSM and mosaicing strips. The principle of 3D image is first introduced in this paper, and then we focus on the fast processing technique and algorithms. The flight tests and processed results show that the processing technique is feasible and can meet the requirement of quasi-real-time applications.

关键词： 3D image fast processing DSM geo-referenced images

METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2021年第12期12卷 965-970页

作者： Mengyue Lv Dan Cao liwen Zhang Chi Hu shukai li Panrui Zhang lianbang Zhu Xiao Yi Chaoliang li Alin Yang Zhentao Yang Yi Zhu Kaiguang Zhang Wen Pan Department of Gastroenterology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for Physical Sciences at Microscale the CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Key Laboratory of Structural Biology of Zhejiang Province School of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China

Dear Editor,Histidine methylation has been known for many years(Searle and Westall,1951),but only a few proteins carrying such modifications have been studied(Webb et al.,2010;Al-Hadid et al.,2014;Kwiatkowski et al.,2... 详细信息

关键词： al. Searle tumor

Mg/Fe site-specific dual-doping to boost the performance of cobalt-free nickle-rich layered oxide cathode for high-energy lithium-ion batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第4期91卷 670-679页

作者： Yunting Wang Gaohui Du Di Han Wenhao Shi Jiahao Deng Huayu li Wenqi Zhao shukai Ding Qingmei Su Bingshe Xu Materials Institute of Atomic and Molecular Science Shaanxi University of Science and TechnologyXi'an 710021ShanxiChina Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030024ShanxiChina Key Laboratory of Interface Science and Engineering in Advanced Materials Taiyuan University of TechnologyTaiyuan 030024ShanxiChina

Layer-type liNi0.9Mn0.1O2is promising to be the primary cathode material for lithium-ion batteries(liBs)due to its excellent electrochemical ***,the cathode with high nickel content suffers from severely detrimental structural transformation that causes rapid capacity ***,site-specific dual-doping with Fe and Mg ions is proposed to enhance the structural stability of *** Fe3+dopants are inserted into transition metal sites(3b)and can favorably provide additional redox potential to compensate for charge and enhance the reversibility of anionic *** Mg ions are doped into the li sites(3a)and serve as O_(2)^(-)-Mg^(2+)-O_(2)^(-)pillar to reinforce the electrostatic cohesion between the two adjacent transition-metal layers,which further suppress the cracking and the generation of harmful phase transitions,ultimately improving the *** theoretical calculations,including Bader charge and crystal orbital Hamilton populations(COHP)analyses,confirm that the doped Fe and Mg can form stable bonds with oxygen and the electrostatic repulsion of O_(2)^(-)-O_(2)^(-)can be effectively suppressed,which effectively mitigates oxygen anion loss at the high delithiation *** dual-site doping strategy offers new avenues for understanding and regulating the crystalline oxygen redox and demonstrates significant potential for designing high-performance cobalt-free nickel-rich cathodes.

关键词： Cobalt-free Layered oxide Cathode Dual dopants Density functional theory calculation

在线全文

学校读者我要写书评

暂无评论

辽化乙烯装置裂解气压缩机运行分析

乙烯工业 2010年第1期22卷 43-48页

作者：李树凯中国石油辽阳石化公司烯烃厂辽宁辽阳111003

介绍辽阳石化公司乙烯装置2台裂解气压缩机在2007年装置扩能改造后1年来的运行情况,重点说明了CCC公司的双机并联技术在裂解气压缩机上的应用及通过采用EC3144A型阻聚剂,避免机体及段间系统结焦从而保证压缩机的"安稳长"运行。

关键词：裂解气压缩机双机并联 “安稳长”运行