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Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaemic lesions at 1 month: the ATTUNE study

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Stroke & Vascular Neurology 2024年第1期9卷 30-37,I0034页

作者： Angelos Sharobeam Longting Lin Christina lam Carlos Garcia-Esperon Yash Gawarikar Ronak Patel Matthew Lee-Archer Andrew Wong Michael Roizman Amanda Gilligan Andrew Lee Kee Meng Tan Susan Day Christopher Levi Stephen M Davis Mark Parsons Bernard Yan Melbourne Brain Centre at Royal Melbourne Hospital ParkvilleVictoriaAustralia University of New South Wales South Western Sydney Clinical School LiverpoolNew South WalesAustralia Department of Neurology John Hunter HospitalNewcastleNew South WalesAustralia Department of Neurology Calvary Public HospitalCanberraAustralian Capital TerritoryAustralia Department of Neurology Northern Hospital EppingEppingVictoriaAustralia Department of Neurology Royal Brisbane and Women's HospitalHerstonQueenslandAustralia The University of Queensland School of Medicine HerstonQueenslandAustralia Neurosciences Clinical Institute Epworth HealthcareRichmondVirginiaAustralia Department of Neurology Austin HealthUniversity of MelbourneHeidelbergVictoriaAustralia Flinders University College of Medicine and Public Health AdelaideSouth AustraliaAustralia Department of Neurology Gold Coast University HospitalSouthportQueenslandAustralia The University of Sydney Northern Clinical School St LeonardsNew South WalesAustralia Department of Neurology and Neurophysiology Liverpool HospitalLiverpoolNew South WalesAustralia

Background The optimal time to commence anticoagulation in patients with atrial fibrillation(AF)after ischaemic stroke or transient ischaemic attack(TIA)is unclear,with guidelines differing in recommendations.A limitation of previous studies is the focus on clinically overt stroke,rather than radiologically obvious diffusion-weighted imaging ischaemic *** aimed to quantify silent ischaemic lesions and haemorrhages on MRI at 1month in patients commenced on early(5mL,regardless of anticoagulation *** Commencing anticoagulation<4days after stroke or TIA is associated with fewer ischaemic lesions at 1month in AF *** is no increased rate of haemorrhage with early *** results suggest that early anticoagulation after mild-to-moderate acute ischaemic stroke associated w

关键词： patients lesions ischaemic

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Predicting 3D Radiotherapy Dose-Volume Based on Deep Learning

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Intelligent Automation & Soft Computing 2024年第2期39卷 319-335页

作者： Do Nang Toan lam Thanh Hien Ha Manh Toan Nguyen Trong Vinh Pham Trung Hieu Institute of Information Technology Vietnam Academy of Science and TechnologyHanoi10072Vietnam Faculty of Information Technology Lac Hong UniversityBien HoaDong Nai76120Vietnam

Cancer is one of the most dangerous diseaseswith *** of the principal treatments is radiotherapy by using radiation beams to destroy cancer cells and this workflow requires a lot of experience and skill from doctors and *** our study,we focused on the 3D dose prediction problem in radiotherapy by applying the deeplearning approach to computed tomography(CT)images of cancer *** image data has more complex characteristics than normal image data,and this research aims to explore the effectiveness of data preprocessing and augmentation in the context of the 3D dose prediction *** proposed four strategies to clarify our hypothesis in different aspects of applying data preprocessing and *** strategies,we trained our custom convolutional neural network model which has a structure inspired by the U-net,and residual blocks were also applied to the *** output of the network is added with a rectified linear unit(Re-Lu)function for each pixel to ensure there are no negative values,which are absurd with radiation *** experiments were conducted on the dataset of the Open Knowledge-Based Planning Challenge which was collected from head and neck cancer patients treatedwith radiation *** results of four strategies showthat our hypothesis is rational by evaluating metrics in terms of the Dose-score and the Dose-volume histogram score(DVH-score).In the best training cases,the Dose-score is 3.08 and the DVH-score is *** addition,we also conducted a comparison with the results of another study in the same context of using the loss function.

关键词： CT image 3D dose prediction data preprocessing augmentation

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Tuberculosis Diagnosis and Visualization with a Large Vietnamese X-Ray Image Dataset

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Intelligent Automation & Soft Computing 2024年第2期39卷 281-299页

作者： Nguyen Trong Vinh lam Thanh Hien Ha Manh Toan Ngo Duc Vinh Do Nang Toan Faculty of Information Technology Lac Hong UniversityBien HoaDong Nai76120Vietnam Institute of Information Technology Vietnam Academy of Science and TechnologyHanoi10072Vietnam Faculty of Information Technology Hanoi University of IndustryHanoi11915Vietnam

Tuberculosis is a dangerous disease to human life,and we need a lot of attempts to stop and reverse ***,in theCOVID-19 pandemic,access to medical services for tuberculosis has become very *** late detection of tuberculosis could lead to danger to patient health,even *** one of the countries heavily affected by the COVID-19 pandemic,andmany residential areas as well as hospitals have to be isolated for a long *** demands a fast and effective tuberculosis diagnosis solution to deal with the difficulty of accessingmedical services,such as an automatic tuberculosis diagnosis *** our study,aiming to build that system,we were interested in the tuberculosis diagnosis problem from the chest X-ray images of Vietnamese *** chest X-ray image is an important data type to diagnose tuberculosis,and it has also received a lot of attention from deep learning *** paper proposed a novel method for tuberculosis diagnosis and visualization using the deeplearning approach with a large Vietnamese X-ray image *** detail,we designed our custom convolutional neural network for the X-ray image classification task and then analyzed the predicted result to provide visualization as a *** prove the performance of our network model,we conducted several experiments to compare it to another study and also to evaluate it with the dataset of this *** support the implementation,we built a specific annotation system for tuberculosis under the requirements of radiologists in the Vietnam National Lung Hospital.A large experiment dataset was also from this hospital,and most of this data was for training the convolutional neural network *** experiment results were evaluated regarding sensitivity,specificity,and *** achieved high scores with a training accuracy score of 0.99,and the testing specificity and sensitivity scores were over *** on the X-ray image classification result,we visualize pr

关键词： Tuberculosis classification Vietnamese chest X-ray deep learning

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苏格兰的跨年夜

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中学生英语 2024年第5期 36-39页

作者： Kenny lam 长庚(选译) 不详

"Hogmanay"是苏格兰人所说的新年前夜——12月31日,是标志着新年到来的重要夜晚。它的起源可以追溯到维京人在12月下旬举行的冬至庆祝活动。

关键词：维京人苏格兰人庆祝活动新年

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Caveolin‑1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease

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Military Medical Research 2024年第2期11卷 206-227页

作者： Guang-Hui Deng Chao-Feng Wu Yun-Jia Li Hao Shi Wei-Chao Zhong Mu-Keng Hong Jun-Jie Li Jia-Min Zhao Chang Liu Meng-Chen Qin Zhi-Yun Zeng Wei-Min Zhang Ken Kin lam Yung Zhi-Ping Lv Lei Gao Department of Gastroenterology Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China Department of Hepatology Cancer CenterIntegrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033GuangdongChina Department of Biology Hong Kong Baptist UniversityKowloon TongKowloonHong Kong SAR 999077China

Background:Nonalcoholic fatty liver disease(NAFLD)is associated with disordered lipid and iron *** previous study has substantiated the pivotal role of Caveolin-1(Cav-1)in protecting hepatocytes and mediating iron metabolism in the *** study aimed to explore the specific mechanisms underlying the regulation of iron metabolism by Cav-1 in ***:Hepatocyte-specific Cav-1 overexpression mice and knockout mice were used in this ***-1-knockdown of RAW264.7 cells and mouse primary hepatocytes were performed to verify the changes in ***,a high-fat diet and palmitic acid plus oleic acid treatment were utilized to construct a NAFLD model in vivo and in vitro,respectively,while a high-iron diet was used to construct an in vivo iron overload ***,iron concentration,the expression of Cav-1 and iron metabolism-related proteins in liver tissue or serum were detected using iron assay kit,Prussian blue staining,Western blotting,immunofluorescence staining,immunohistochemical staining and *** related indicators of lipid metabolism and oxidative stress were evaluated by the corresponding reagent kit and ***:Significant disorder of lipid and iron metabolism occurred in *** expression of Cav-1 was decreased in NAFLD hepatocytes(P<0.05),accompanied by iron metabolism ***-1 enhanced the iron storage capacity of hepatocytes by activating the ferritin light chain/ferritin heavy chain pathway in NAFLD,subsequently alleviating the oxidative stress induced by excess ferrous ions in the ***,CD68^(+) CD163^(+) macrophages expressing Cav-1 were found to accelerate iron accumulation in the liver,which was contrary to the effect of Cav-1 in *** correlations were also observed between the serum Cav-1 concentration and the serum iron-related protein levels in NAFLD patients and healthy volunteers(P<0.05).Conclusions:These findings confirm that Cav-1 is an essential target protein that reg

关键词： Caveolin-1 Nonalcoholic fatty liver disease Iron metabolism Ferritin Oxidative stress

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编写诗乐大音乐史的理想与实际困难:我的个人体会

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黄钟（武汉音乐学院学报） 2024年第2期 6-13,167页

作者： [美]林萃青美国密歇根大学音乐学院安娜堡MI48109 中国音乐学院

该文是作者基于在《牛津手册:中国与海外华人音乐》中发表的“中国人为什么、又如何唱《诗经》歌曲?”(Why and How Do Chinese Sing Shijing Songs?),以及正在写作的《孔子之歌:中国诗乐的大历史描述》(Confucius's Songs:A Global His... 详细信息

该文是作者基于在《牛津手册:中国与海外华人音乐》中发表的“中国人为什么、又如何唱《诗经》歌曲?”(Why and How Do Chinese Sing Shijing Songs?),以及正在写作的《孔子之歌:中国诗乐的大历史描述》(Confucius's Songs:A Global History of Chinese Shiyue)一书有关编写诗乐大音乐史的理论建构和相关思考。作者突破了对传统诗乐历史认知的框架,以“大历史”的理念观照诗乐和格里高利圣咏历史发展的异同,为当今理解诗乐提供了新路径。

关键词：诗经诗乐大历史大音乐史格里高利圣咏

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A Framework for Driver DrowsinessMonitoring Using a Convolutional Neural Network and the Internet of Things

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Intelligent Automation & Soft Computing 2024年第2期39卷 157-174页

作者： Muhamad Irsan Rosilah Hassan Anwar Hassan Ibrahim Mohamad Khatim Hasan Meng Chun lam Wan Mohd Hirwani Wan Hussain School of Computing Telkom UniversityBandung40257Indonesia Faculty of Information Science and Technology Universiti Kebangsaan MalaysiaBangi43600Malaysia Department of Electrical Engineering College of EngineeringQassim UniversityAl-Gassim51411Saudi Arabia Graduated School of Business Universiti Kebangsaan MalaysiaBangi43600Malaysia

One of the major causes of road accidents is sleepy *** accidents typically result in fatalities and financial losses and disadvantage other road *** studies have been conducted to identify the driver’s sleepiness and integrate it into a warning *** studies have examined how the mouth and eyelids ***,this limits the system’s ability to identify drowsiness ***,this study designed an Accident Detection Framework(RPK)that could be used to reduce road accidents due to sleepiness and detect the location of *** drowsiness detectionmodel used three facial parameters:Yawning,closed eyes(blinking),and an upright head *** model used a Convolutional Neural Network(CNN)consisting of two *** initial phase involves video processing and facial landmark coordinate *** second phase involves developing the extraction of frame-based features using normalization *** these phases used OpenCV and *** dataset contained 5017 images with 874 open eyes images,850 closed eyes images,723 open-mouth images,725 closed-mouth images,761 sleepy-head images,and 1084 non-sleepy head *** dataset of 5017 images was divided into the training set with 4505 images and the testing set with 512 images,with a ratio of 90:*** results showed that the RPK design could detect sleepiness by using deep learning techniques with high accuracy on all three parameters;namely 98%for eye blinking,96%for mouth yawning,and 97%for head ***,the test results have provided an overview of how the developed RPK prototype can accurately identify drowsy *** findings will have a significant impact on the improvement of road users’safety and mobility.

关键词： Drowsy drivers convolutional neural network openCV microprocessor face detection

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Evaluation of the Living Conditions and Health Perceptions of Waste Electrical and Electronic Equipment Handlers in the Informal Sector in Dakar

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Occupational Diseases and Environmental Medicine 2024年第2期12卷 115-129页

作者： Robert Faomowe Foko Awa Ndong Marius Kedote Fatoumata Bah Absa lam Cheikh Diop Aminata Toure Mathilde Cabral Mamadou Fall Laboratoire de Toxicologie et d’ Hydrologie Facult&#233 de M&#233decine Pharmacie et Odontostomalogie Universit&#233 Cheikh Anta Diop de Dakar Dakar S&#233n&#233gal Unité Mixte de Recherche d&#8217Exploration et de Diagnostic Unit&#233 de Formation et de Recherche des Sciences de la Sant&#233 Universit&#233 Iba Der Thiam de Thi&#232s Thi&#232s S&#233n&#233gal Institut Ré gional de Sant&#233 Publique Universit&#233 d&#8217Abomey-Calavi Ouidah B&#233nin

Electrical and electronic devices are becoming an increasingly important part of our society. In Africa, and in Senegal in particular, the handling and management of electronic and electrical equipment (EEE) that has reached the end of its life is mainly informal. This professional environment is characterized by the disintegration of the sector and the social heterogeneity that can be found there. The objective of this study is to assess the standard of living of electrical and electronic equipment waste handlers in the Dakar region, as well as their perception of their health. A survey was used to obtain information on sociodemographic background, living arrangements, perception of health status, and good practices to be implemented in case of work-related health problems. Life style, perception of general health and health problems were ranged as excellent, very good, good, average and poor. Informal recyclers in the Dakar region lived mainly in rooms and buildings as tenants (49.1%), or in family homes (48.4%) before starting this activity, and 51.2% continue to live in rooms and buildings as tenants compared to 41.4% who still live in a family home. The perception of health status ranged from poor to excellent, and 4.9% believe that they are limited in work due to a disability or health problem. Informal work is a heterogeneous phenomenon that makes research and policymaking particularly complex. There are several external factors within informal WEEE re-cyclers that can cause health problems or functional disability. However, the living conditions and the perception they have of their state of health are contradictory to the working conditions and the social environment to which they belong. A biomedical approach would consolidate these achievements by confirming or invalidating them.

关键词： E-Waste Informal Work Living Arrangements Health Perception Occupational Exposure

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All-sky Guide Star Catalog for CSST

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Research in Astronomy and Astrophysics 2024年第4期24卷 35-59页

作者： Hui-Mei Feng Zi-Huang Cao Man I lam Ran Li Hao Tian Da-Yi Yin Yuan-Yu Yang Xin Zhang Dong-Wei Fan Yi-Qiao Dong Xin-Feng Li Wei Wang Long Li Hugh RAJones Yi-Han Tao Jia-Lu Nie Pei-Pei Wang Mao-Yuan Liu He-jun Yang Chao Liu Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of ChineseAcademy of Sciences Beijing 100049China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai200083China Technology and Engineering Center for Space Utilization.Chinese Academy of Sciences Beijing 100094China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Centre for Astrophysics University of HertfordshireHatfieldUK Beijing University of Technology Beijing 100124China

The China Space Station Telescope(CSST)is a two-meter space telescope with multiple back-end *** Fine Guidance Sensor(FGS)is an essential subsystem of the CSST Precision Image Stability System to ensure the required absolute pointing accuracy and line-of-sight *** this study,we construct the Main Guide Star Catalog for *** accomplish this,we utilize the information about the FGS and object information from the Gaia Data Release *** provide an FGS instrument magnitude and exclude variables,binaries,and high proper motion stars from the catalog to ensure uniform FGS guidance ***,we generate a HEALPix index,which provides a hierarchical tessellation of the celestial sphere,and employ the Voronoi algorithm to achieve a homogeneous distribution of stars across the *** distribution ensures adequate coverage and sampling of the *** performance of the CSST guide star catalog was assessed by simulating the field of view of the FGS according to the CSST mock survey strategy *** analysis of the results indicates that this catalog provides adequate coverage and *** catalog's performance meets the FGS requirements,ensuring the functioning of the FGS and its guidance capabilities.

关键词： catalogs astrometry instrumentation:detectors

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Design and mathematical analysis of activating transcriptional amplifiers that enable modular temporal control in synthetic juxtacrine circuits

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Synthetic and Systems Biotechnology 2023年第4期8卷 654-672页

作者： Calvin lam Department of Biochemistry and Molecular Biology University of Nebraska Medical CenterOmahaNE68198USA.

The ability to control mammalian cells such that they self-organize or enact therapeutic effects as desired has incredible *** only would it further our understanding of native processes such as development and the immune response,but it would also have powerful applications in medical fields such as regenerative medicine and *** control is typically obtained by synthetic circuits that use synthetic receptors,but control remains *** synthetic juxtacrine receptors(SJRs)are widely used as they are fully modular and enable spatial control,but they have limited gene expression amplification and temporal *** these are integral facets to cell control,I therefore designed transcription factor based amplifiers that amplify gene expression and enable unidirectional temporal control by prolonging duration of target gene *** a validated in silico framework for SJR signaling,I combined these amplifiers with SJRs and show that these SJR amplifier circuits can direct spatiotemporal patterning and improve the quality of self-organization.I then show that these circuits can improve chimeric antigen receptor(CAR)T cell tumor killing against various heterogenous antigen expression *** amplifiers are flexible tools that improve control over SJR based circuits with both basic and therapeutic applications.

关键词： Synthetic biology Synthetic development Synthetic immunotherapy synNotch SNIPR Amplifiers Self-organization Temporal control Spatiotemporal control CAR T cell Synthetic receptors

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