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Chinese Chemical Letters 2018年第1期29卷 107-110页

作者： shujun xia Jing Dong Yiying Chen Yiru Wang Xi Chen Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation College of Chemistry and Chemical Engineering Xiamen University State Key Laboratory of Marine Environmental Science Xiamen University

In this work, three dimensional phytic acid-induced graphene coating was prepared by hydrothermal synthesis and fabricated on a stainless-steel wire using physical coating method as a solid phase microextraction （SPME） coating. The graphene coating revealed high specific surface area, extraordinary electrical conductivity and excellent chemical stability. Coupled with gas chromatography-flame ionization detector （GC-FID）, the home-made phytic acid-induced graphene SPME fiber exhibited excellent extraction efficiency for the analysis of nerolidol in tea samples. Under the optimized conditions, the linear range of working curve was found to be 1-1000 ng/g, and the limit of detection of nerolidol was 0.18 ng/g. The coefficient variation of repeatability for each single fiber and reproducibility for fiber to fiber was less than 3.9Yg and 8.3~, respectively.

关键词： Phytic acid-induced grapheneSolid phase microextractionGas chromatographyNerolidolTea

Colloidal CsPbBr3 perovskite nanocrystal films as electrochemiluminescence emitters in aqueous solutions

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Nano Research 2018年第3期11卷 1447-1455页

作者： Zhixiong Cai Feiming Li Wei Xu shujun xia Jingbin Zeng Shaogui He Xi Chen Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China State Key Laboratory of Marine Environmental Science Xiamen University Xiamen 361005 China State Key Laboratory of Heavy Oil Processing & College of Science China University of Petroleum (East China) Qingdao 266555 China xiamen Huaxia University Xiamen 361024 China

Perovskite nanocrystals （NCs）, which have emerged as a new class of phosphors with superb luminescence properties and bandgaps that can be easily tuned using chemical methods, have generated tremendous interest for a wide variety of applications where colloidal quantum dots have been very successful as carrier sources. In this study, self-assembled films of CsPbBr3 NCs were produced via drop casting of colloidal NCs onto glassy carbon electrodes （GCEs） to form an NC film-modified electrode. The possible fabrication process of the CsPbBr3 NCs films was discussed. We further studied the anodic electrochemiluminescence （ECL） behavior of the perovskite CsPbBr3 NCs film using cyclic voltammetry with tripropylamine （TPA） as a coreactant, and a possible ECL mechanism was proposed. Briefly, TPA was oxidized to produce strongly reducing radical spedes, which can react with electrochemically oxidized CsPbBr3 NCs to generate excited CsPbBr3 NCs＊ capable of light emission. The relative stability of the ECL emission of the CsPbBr3 NC films under aqueous conditions was also investigated, and it was found that they showed operational stability over the first three hours, indicating suitable reliability for application as sensing materials. The results suggested that semiconducting perovskite NCs have great potential for application in the ECL field.

关键词： perovskite CsPbBr3 colloidal nanocrystals film aqueous solution

The emerging role of snoRNAs in human disease

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Genes & Diseases 2023年第5期10卷 2064-2081页

作者： Xinhai Zhang Chenglong Wang shujun xia Fei xiao Jianping Peng Yuxuan Gao Fengbin Yu Chuandong Wang xiaodong Chen Department of Orthopedic Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine(SJTUSM)Shanghai 200092China Ultrasound Department Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine(SJTUSM)Shanghai 200025China Department of Orthopaedic Surgery Second Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Orthopaedics The 72nd Group Army Hospital of PLAHuzhouZhejiang 313000China

Small nucleolar RNAs(snoRNAs)play critical roles in various biological *** aberrant expression or depletion of snoRNAs is related to various *** previous research,most of the snoRNAs were categorized as C/D box snoRNAs and H/ACA box snoRNAs,whose typical functions were thought of as regulation of 2′-O-ribose methylation and pseudouridylation of ribosome RNAs,***,in the past two decades,studies have revealed an increasing number of snoRNAs without specific targets or determined cell *** findings indicated that some potential roles of snoRNAs are still *** studies have indicated the correlation of snoRNAs with human *** play various roles in abundant biological processes,and they have great potential in controlling human *** new and rising field could benefit from investigations of the disease pathogenesis,biomarker identification,and the determination of novel therapeutic *** review summarized the reports on snoRNAs and the regulation of different diseases in recent years.

关键词： Cancer Genetic disease Inflammation Metabolism Small nucleolar RNAs

Noninvasive Assessment of Liver Fibrosis and Inflammation in Chronic Hepatitis B:A Dual-task Convolutional Neural Network(DtCNN)Model Based on Ultrasound Shear Wave Elastography

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1077-1085页

作者： Chengyan Wang Lili Zheng Yan Li shujun xia Jun Lv Xumei Hu Weiwei Zhan Fuhua Yan Ruokun Li Xinping Ren Human Phenome Institute Fudan UniversityShanghaiChina Ultrasound Department Ruijin Hospital Wuxi BranchShanghai Jiao Tong University School of MedicineWuxiJiangsuChina Department of Radiology Ruijin HospitalShang-hai Jiao Tong University School of MedicineShanghaiChina Ultrasound Department Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina School of Computer and Control Engineering Yantai UniversityYantaiShandongChina

Background and Aims:Liver stiffness(LS)measured by shear wave elastography(SWE)is often influenced by hepat-ic *** aim was to develop a dual-task convo-lutional neural network(DtCNN)model for the simultaneous staging of liver fibrosis and inflammation activity using ***:A total of 532 patients with chronic hepatitis B(CHB)were included to develop and validate the DtCNN *** additional 180 consecutive patients between De-cember 2019 and April 2021 were prospectively included for further *** patients underwent 2D-SWE examina-tion and serum biomarker assessment.A DtCNN model con-taining two pathways for the staging of fibrosis and inflam-mation was used to improve the classification of significant fibrosis(≥F2),advanced fibrosis(≥F3)as well as cirrhosis(F4).Results:Both fibrosis and inflammation affected LS measurements by *** proposed DtCNN performed the best among all the classification models for fibrosis stage[significant fibrosis AUC=0.89(95%CI:0.87-0.92),ad-vanced fibrosis AUC=0.87(95%CI:0.84-0.90),liver cirrho-sis AUC=0.85(95%CI:0.81-0.89)].The DtCNN-based pre-diction of inflammation activity achieved AUCs of 0.82(95%CI:0.78-0.86)for grade≥A1,0.88(95%CI:0.85-0.90)grade≥A2 and 0.78(95%CI:0.75-0.81)for grade≥A3,which were significantly higher than the AUCs of the single-task *** findings were observed in the prospec-tive ***:The proposed DtCNN improved di-agnostic performance compared with existing fibrosis staging models by including inflammation in the model,which sup-ports its potential clinical application.

关键词： Fibrosis Inflammation Shear wave elastography Chronic hepati-tis B Dual-task convolutional neural network.

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基于数据仓库的远程故障诊断系统研究

计算机工程与应用 2003年第3期39卷 221-223页

作者：单树军夏志澜海军工程大学动力工程学院武汉430033

文章讨论了数据仓库的基本原理,提出了基于数据仓库远程故障诊断系统的体系结构,并结合舰船动力装置远程故障诊断系统的开发阐述了开发的关键技术和过程。

关键词：数据仓库远程故障诊断系统舰船动力装置数据库数据处理

宫缩乏力性产后出血产妇应用康复护理干预的价值

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中国医药指南 2020年第32期18卷 132-133页

作者：夏淑君大连市金州区第二人民医院辽宁大连116105

目的研究宫缩乏力性产后出血产妇应用康复护理干预的价值。方法将我院在2017年1月至2020年1月收治的100例阴道分娩产后出血产妇采取随机数字表法分为两组,分别为研究组和对照组。对照组产妇50例给予常规护理,研究组产妇50例采取康复护... 详细信息

目的研究宫缩乏力性产后出血产妇应用康复护理干预的价值。方法将我院在2017年1月至2020年1月收治的100例阴道分娩产后出血产妇采取随机数字表法分为两组,分别为研究组和对照组。对照组产妇50例给予常规护理,研究组产妇50例采取康复护理干预。对两组产妇施行护理后的效果进行密切观察,比较两组患者的2 h产后出血量、24 h产后出血量以及护理满意。结果护理后,研究组产妇2 h、24 h产后出血量低于对照组(P<0.05);研究组产妇的护理满意度高于对照组(P<0.05),差异均有统计学意义。结论在此次研究中,对宫缩乏力性产后出血产妇予以康复护理,该护理方法效果尤为显著,能有效降低产后出血量,并提高产妇的护理满意度,值得在宫缩乏力性产后出血产妇的护理中推广应用。

关键词：宫缩乏力性产后出血康复护理干预护理效果阴道分娩

分析活跃期采用特殊体位护理对纠正持续性枕横位枕后位分娩的效果

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中国医药指南 2020年第33期18卷 230-231页

作者：夏淑君大连市金州区第二人民医院辽宁大连116105

目的分析研究分析活跃期采用特殊体位护理对纠正持续性枕横位枕后位分娩的方法与效果。方法在我院妇产科2017年3月至2020年3月接收的持续性枕横位枕后位产妇中选择100例随机分为两组,其中50例常规待产护理,设为对照组,另50例在对照组基... 详细信息

目的分析研究分析活跃期采用特殊体位护理对纠正持续性枕横位枕后位分娩的方法与效果。方法在我院妇产科2017年3月至2020年3月接收的持续性枕横位枕后位产妇中选择100例随机分为两组,其中50例常规待产护理,设为对照组,另50例在对照组基础上增加特殊体位护理内容,设为观察组。比较两组产妇的分娩情况。结果观察组第一产程及总产程时间均明显低于对照组,且组间对比具有统计学意义(P0.05),同时观察组顺产率以及胎位矫正率明显高于对照组,且组间对比具有统计学意义(P<0.05)。结论对于持续性枕横位枕后位产妇而言,其活跃期采用特殊体位护理方法可有效矫正胎位,利于顺产,同时还能缩短分娩时间,减轻产妇痛苦,可有效改善分娩结局。

关键词：特殊体位护理活跃期持续性枕横位枕后位

共情护理对艾滋病患者负性情绪及治疗依从性的影响

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国际流行病学传染病学杂志 2018年第5期45卷 353-356页

作者：夏淑钧四川绵阳四0四医院感染科 621000

为探讨共情护理对艾滋病抗病毒治疗的辅助效果，研究选取82名抗病毒治疗艾滋病患者随机分为对照组和观察组，分别给予基础护理和基础护理加共情护理，观察12个月。干预后观察组焦虑（SAS）、抑郁（SDS）评分、HIV载量均显著低于对照组... 详细信息

为探讨共情护理对艾滋病抗病毒治疗的辅助效果，研究选取82名抗病毒治疗艾滋病患者随机分为对照组和观察组，分别给予基础护理和基础护理加共情护理，观察12个月。干预后观察组焦虑（SAS）、抑郁（SDS）评分、HIV载量均显著低于对照组，抗病毒治疗依从率、CD4^＋T细胞计数明显高于对照组，提示共情护理有助于提高艾滋病患者的治疗效果。

关键词：艾滋病抗病毒治疗共情护理负性情绪

胰腺癌早期诊断相关miRNAs的筛选与验证

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中华外科杂志 2014年第3期52卷 198-201页

作者：夏蜀珺郭俊超李建周立赵玉沛中国医学科学院北京协和医学院北京协和医院基本外科 100730

目的寻找具有潜在早期诊断价值的外周血特异性miRNAs；探索胰腺癌发生过程中相关miRNAs水平的动态变化及其对胰腺癌早期诊断的价值.方法通过建立SD大鼠胰腺癌演进模型,利用miRNA芯片技术筛选胰腺癌发生相关的差异miRNA表达谱,并利用... 详细信息

目的寻找具有潜在早期诊断价值的外周血特异性miRNAs；探索胰腺癌发生过程中相关miRNAs水平的动态变化及其对胰腺癌早期诊断的价值.方法通过建立SD大鼠胰腺癌演进模型,利用miRNA芯片技术筛选胰腺癌发生相关的差异miRNA表达谱,并利用生物信息学技术对相关miRNAs进行初步验证分析.结果胰腺、血标本中分别获得有意义的差异表达miRNAs 35条和12条,验证结果发现hsa-let-7c、hsa-miR-122-5p、hsa-miR-142-5p、hsa-miR-199a-3p及hsa-miR-451a在正常胰腺与胰腺癌之间表达差异无统计学意义（P＞0.05）.结论 miRNAs与胰腺癌的发生密切相关,有潜力成为早期胰腺癌血清特异性肿瘤标记物.初步建立的早期胰腺癌差异miRNAs表达谱为进一步研究胰腺癌发生分子机制奠定了基础.

关键词：胰腺肿瘤疾病模型,动物

甲状腺乳头状癌分子标志物与超声特征相关性研究进展

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肿瘤影像学 2022年第5期31卷 457-462页

作者：胡艳夏蜀珺詹维伟上海交通大学医学院附属瑞金医院超声科上海200025

甲状腺乳头状癌(papillary carcinoma of the thyroid,PTC)是最常见的甲状腺分化型肿瘤,其发生主要与BRAF、RAS、RET、TERT等癌基因的突变密切相关。不同癌基因的改变可能会导致PTC出现不同的生物学行为和肿瘤生长模式,呈现出不同的超... 详细信息

甲状腺乳头状癌(papillary carcinoma of the thyroid,PTC)是最常见的甲状腺分化型肿瘤,其发生主要与BRAF、RAS、RET、TERT等癌基因的突变密切相关。不同癌基因的改变可能会导致PTC出现不同的生物学行为和肿瘤生长模式,呈现出不同的超声特征。近年来,随着分子生物学技术的发展,许多研究者尝试探索PTC分子标志物与超声特征的相关性。充分了解PTC分子标志物与超声特征之间的关联,可以在有创操作前更好地评估PTC患者的总体风险和可能存在的分子特征,这将有助于PTC的个性化评估,对于合理制订患者后续的诊疗方案至关重要。

关键词：甲状腺乳头状癌分子标志物超声特征 BRAF基因