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右美托咪定与咪达唑仑在ICU急性呼吸窘迫综合征行俯卧位通气患者中的镇静效果比较

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临床合理用药杂志 2024年第23期17卷 17-20页

作者：胡龙贺蛟龙时淑娟黄聪灵湘西自治州人民医院重症医学科湖南省吉首市416000 吉首大学医学院湖南省吉首市416000

目的比较右美托咪定与咪达唑仑在重症监护室(ICU)急性呼吸窘迫综合征(ARDS)行俯卧位通气患者中的镇静效果。方法选取2022年1—12月湘西自治州人民医院重症医学科收治的ARDS行俯卧通气的患者60例,采用随机数字表法分为试验组(n=30)和对照... 详细信息

目的比较右美托咪定与咪达唑仑在重症监护室(ICU)急性呼吸窘迫综合征(ARDS)行俯卧位通气患者中的镇静效果。方法选取2022年1—12月湘西自治州人民医院重症医学科收治的ARDS行俯卧通气的患者60例,采用随机数字表法分为试验组(n=30)和对照组(n=30)。试验组采用右美托咪定行镇静治疗,对照组采用咪达唑仑行镇静治疗。比较2组镇静效果,镇静前(T_(0))、镇静后2 h(T_(1))、镇静后24 h(T_(2))生命体征,T_(0)、T_(2)时炎性因子水平及不良反应。结果试验组达到目标镇静时间、达到目标镇痛时间、停药后唤醒时间短于对照组,酒石酸布托啡诺用量低于对照组(P0.05);2组T_(2)时的白介素-6、肿瘤坏死因子-α水平均低于T_(0),且试验组低于对照组(P<0.01);试验组低血压、呼吸抑制、谵妄的发生率低于对照组,但心动过缓发生率高于对照组(P<0.05或P<0.01)。结论右美托咪定在ICU中ARDS行俯卧位通气患者中的镇静效果相较于咪达唑仑更好,可有效减轻患者炎性反应,但患者同时面临心动过缓的发生风险,仍需结合患者实际情况综合考量。

关键词：急性呼吸窘迫综合征俯卧位通气右美托咪定咪达唑仑镇静镇痛生命体征

The Inhibitory Effects of PSS-Loaded Nanoparticles on the Dysfunction of Cardiac Microvascular Endothelia in Rats with Diabetic Cardiomyopathy

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Journal of Ocean University of China 2019年第1期18卷 253-259页

作者： AN Nina YU Luyan HU Yi FENG Wenjing shi shujuan CHEN Honghua MAO Yongjun Department of Geriatrics the Affiliated Hospital of Qingdao University

Propylene glycol alginate sodium sulfate-loaded nanoparticles(PSS-NP) has been shown potential to prevent the microvascular endothelial injuries caused by diabetic cardiomyopathy(DCM). In this study, we aimed to investigate the effects of PSS-NP on the dysfunction of cardiac microvascular endothelia in streptozotocin(STZ)-induced DCM rat model. Echocardiographic measurements showed a significant improvement of cardiac function in the PSS-NP-treated group. Our results revealed that the abnormalities of cardiac systolic and diastolic functions were suppressed by the treatments of prostaglandin E1(PGE1), low molecular weight heparin(LMWH), PSS and PSS-NP. Our comparison analysis indicated that PSS-NP showed the strongest inhibitory effects on microvascular endothelial injuries. Transmission electron microscopy analysis demonstrated that PSS-NP protected the cardiac microvascular endothelium and further improved endothelium dysfunction in DCM rats. ELISA and Western blot assays further showed a high efficiency of improving cardiac microvascular endothelial dysfunction with PSS-NP. Our results demonstrated that PSS-NP increased the protein expression of phosphatidylinositol 3-kinase(PI3K)-p85 and vascular endothelial growth factor(VEGF)-A, and the phosphorylation of protein kinase B(Akt) and endothelial nitric oxide synthase(eNOS), which were involved in the amelioration of cardiac microvascular endothelial dysfunction. These data suggest that PSS-NP may be a novel approach to the treatment the coronary microcirculation disorder diseases such as DCM.

关键词： PSS-loaded nanoparticles marine drug DCM microvascular endothelial dysfunction

Ischemic stroke susceptibility gene in a Northern Han Chinese population

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Neural Regeneration Research 2013年第20期8卷 1881-1891页

作者： Haiping Wang shujuan shi Wenjing Yan Yan Song Jingjing Zhan Chen Zhang Haiji Wang Department of Neurology Affiliated Hospital of Qingdao University Medical College Health Care Office Affiliated Hospital of Qingdao University Medical College Department of Gerontology Affiliated Hospital of Qingdao University Medical College Department of Internal Medicine Ward 1 Jiao Nan People's Hospital

Interleukin-18 gene promoter polymorphisms are potential risk factors for ischemic cerebrovascular disease, and the –607C allele may increase ischemic stroke risk in the Han Chinese population. In the present study, we recruited 291 patients with ischemic cerebrovascular disease from the Affiliated Hospital of Qingdao University Medical College, China, and 226 healthy controls. Both patients and controls were from the Han population in northern China. Immunoresonance scattering assays detected increased serum amyloid A protein, C-reactive protein, and interleukin-18 levels in ischemic cerebrovascular disease patients compared with healthy controls. Analysis of the –607C/A （rs1946518） polymorphism in the interleukin-18 gene promoter showed ischemic cerebrovascular disease patients exhibited increased frequencies of the CC genotype and C alleles than healthy controls. Genotype and allele frequencies of the interleukin-18 –137G/C （rs187238） polymorphism and the –13T/C （rs11024595） polymorphism in the 5＇-flanking region of serum amyloid A, showed no significant difference between the two groups. Multivariate logistic regression analysis on the interleukin-18 promoter A/C genetic locus, for correction of age, gender, history of smoking, hypertension, diabetes mellitus, hypercholesteremia, and an ischemic stroke family history, showed ischemic cerebrovascular disease risk in individuals without the A allele （C homozygotes） was 2.2-fold greater than in A allele carriers. Overall, our findings suggest that the –13T/C （rs11024595） polymorphism in the 5′-flanking region of serum amyloid A has no correlation with ischemic cerebrovascular disease, but the C allele of the –607C/A （rs1946518） polymorphism in the interleukin-18 promoter is a high-risk factor for ischemic cerebrovascular disease in the Han population of northern China. In addition, the A allele is likely a protective gene for ischemic cerebrovascular disease.

关键词： neural regeneration brain injury interleukin-18 ischemic cerebrovascular disease atherosclerosis gene polymorphism C-reactive protein serum amyloid A protein inflammation neuroregeneration

Distinct roles of H3K27me3 and H3K36me3 in vernalization response,maintenance,and resetting in winter wheat

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Science China(Life Sciences) 2024年第10期67卷 2251-2266页

作者： Xuemei Liu Min Deng Bingxin shi Kehui Zhu Jinchao Chen shujuan Xu Xiaomin Bie Xiansheng Zhang Xuelei Lin Jun Xiao Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute of Science and Technology Austria(ISTA) Klosterneuburg 3400Austria National Key Laboratory of Wheat Improvement College of Life SciencesShandong Agricultural UniversityTai’an 271018China Centre of Excellence for Plant and Microbial Science(CEPAMS) JIC-CASBeijing 100101China

Winter plants rely on vernalization,a crucial process for adapting to cold conditions and ensuring successful ***,understanding the role of histone modifications in guiding the vernalization process in winter wheat remains *** this study,we investigated the transcriptome and chromatin dynamics in the shoot apex throughout the life cycle of winter wheat in the *** core histone modifications,H3K27me3 and H3K36me3,exhibited opposite patterns on the key vernalization gene VERNALIZATION1(VRN1),correlating with its induction during cold ***,the H3K36me3 level remained high at VRN1 after cold exposure,which may maintain its active *** in FERTILIZATION-INDEPENDENT ENDOSPERM(TaFIE)and SET DOMAIN GROUP 8/EARLY FLOWERING IN SHORT DAYS(TaSDG8/TaEFS),components of the writer complex for H3K27me3 and H3K36me3,respectively,affected flowering ***,VRN1 lost its high expression after the cold exposure memory in the absence of *** embryo development,VRN1 was silenced with the removal of active histone modifications in both winter and spring wheat,with selective restoration of H3K27me3 in winter *** mutant of Tafie-cr-87,a component of H3K27me3“writer”complex,did not influence the silence of VRN1during embryo development,but rather attenuated the cold exposure requirement of winter *** gene expression with H3K27me3 and H3K36me3 patterns identified potential regulators of *** study unveils distinct roles of H3K27me3 and H3K36me3 in controlling vernalization response,maintenance,and resetting in winter wheat.

关键词： vernalization H3K27me3 H3K36me3 winter wheat resetting maintenance

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美国POGO抑制装置的材料工艺

宇航材料工艺 2014年第2期44卷 87-90页

作者：史淑娟谷良贤西北工业大学西安710072 北京宇航系统工程研究所北京100076

综合介绍了美国运载火箭发展历史中所使用的囊式蓄压器、弹簧活塞式蓄压器、金属膜盒式蓄压器和注气式蓄压器等POGO抑制装置的材料和工艺发展。通过对美国POGO抑制装置的材料与工艺的介绍,为我国相关领域的材料和工艺发展提供参考。

关键词： POGO抑制装置材料工艺

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河北省铅锌矿源层与地球化学块体

矿床地质 2010年第2期29卷 276-282页

作者：师淑娟宫进忠张洁中国地质科学院应用地球化学重点开放实验室河北廊坊065000 河北省地球物理勘查院河北廊坊065000 河北省区域地质调查研究所河北廊坊065000

文章以河北省岩石和水系沉积物地球化学调查成果为基础,讨论了省内铅锌矿源层、地球化学块体的空间分布范围以及地球化学块体与矿源层的关系,旨在为研究区内的铅锌矿产勘查提供指导。研究结果表明,以高于该地区表壳岩石铅锌元素丰度的... 详细信息

文章以河北省岩石和水系沉积物地球化学调查成果为基础,讨论了省内铅锌矿源层、地球化学块体的空间分布范围以及地球化学块体与矿源层的关系,旨在为研究区内的铅锌矿产勘查提供指导。研究结果表明,以高于该地区表壳岩石铅锌元素丰度的重要矿床的围岩作为铅锌矿源层的判别标志,侏罗纪、白垩纪火山-沉积岩及燕山期侵入岩、遵化岩群、红旗营子岩群等可确定为铅锌矿源层。以25μg/g为异常下限,圈定出水系沉积物铅地球化学块体7处;以100μg/g为异常下限,圈定出水系沉积物锌地球化学块体4处。在铅锌地球化学块体的内部及边缘,有多处大、中型铅锌矿床产出。在丰宁、围场一带出现大范围的铅元素连续成片的岩石高背景分布,锌元素的岩石高背景分布则位于崇礼和围场地区,铅锌高背景区主要分布于侏罗系-白垩系分布区内。侵入岩铅锌高背景区主要集中在乌龙沟-上黄旗岩浆岩带、军都山岩浆岩带及马兰峪复背斜东、西两端。经研究发现,据水系沉积物所圈定出的异常与铅锌矿床分布的一致性要好于据岩石所圈定的异常。在一个地球化学块体分布范围内,存在着多种地质体,而其中对异常形成贡献最大者可能是矿源层和矿床。矿源层与地球化学块体都强调其在成矿作用中是物质的供应源,不同之处在于,前者与矿床关系更紧密,而后者则与成矿省关系比较密切。

关键词：地球化学铅锌矿源层地球化学块体地球化学异常河北省

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Ni晶界上金属和非金属元素的相互作用

北京航空航天大学学报 2018年第4期44卷 862-867页

作者：方淑娟石松鑫祝令刚周健北京航空航天大学材料科学与工程学院北京100083

采用基于密度泛函理论的第一性原理计算方法,研究了常用合金化元素与非金属元素在晶界(GB)的偏析及其相互作用。选取2种类型的晶界结构进行研究:密排的晶界和较疏松的晶界。溶解能计算表明,金属和非金属元素在Σ5晶界上均有明显的偏析行... 详细信息

采用基于密度泛函理论的第一性原理计算方法,研究了常用合金化元素与非金属元素在晶界(GB)的偏析及其相互作用。选取2种类型的晶界结构进行研究:密排的晶界和较疏松的晶界。溶解能计算表明,金属和非金属元素在Σ5晶界上均有明显的偏析行为,而在Σ3晶界上的偏析现象不明显。通过计算常用过渡族合金化元素与非金属杂质C、H、O、N、B在各自最稳定位置的相互作用能,发现Ru、Re、W和Ta对O有强烈的排斥作用,因此对晶界抗氧化有益处;Ta排斥H,有抗晶界氢脆的效果。通过对金属元素与非金属元素在晶界上相互作用的系统研究,为Ni合金的晶界工程提供有价值的参考。

关键词：晶界(GB)偏析镍基高温合金氢脆点缺陷第一性原理计算

冀北地区火山岩型隐伏铀矿地球化学勘查方法试验研究

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地质科技情报 2018年第2期37卷 103-108页

作者：师淑娟代永刚陈军威李冉河北省地球物理勘查院河北廊坊065000 河北省地质矿产勘查开发局博士后科研工作站石家庄050081

冀北地区是火山岩型铀矿产出有利区,该区发现的460铀钼矿是北方地区典型的火山岩型铀矿床。在460铀钼矿体上方开展了土壤细粒级测量和金属活动态测量2种地球化学勘查方法的试验工作,目的是为该地区铀矿找矿工作提供地球化学方法指导。... 详细信息

冀北地区是火山岩型铀矿产出有利区,该区发现的460铀钼矿是北方地区典型的火山岩型铀矿床。在460铀钼矿体上方开展了土壤细粒级测量和金属活动态测量2种地球化学勘查方法的试验工作,目的是为该地区铀矿找矿工作提供地球化学方法指导。剖面测量结果显示,在铀钼矿体上方,土壤细粒级和金属活动态测量都存在明显的U、Mo异常,其中,土壤细粒级U、Mo异常强度和规模较活动态U、Mo突出。U活动态含量以黏土吸附态最强,表明活动态铀以细粒级黏土吸附为主,Mo活动态含量以水溶态最强,表明钼主要以可溶解的钼酸盐形式存在。土壤细粒级和金属活动态面积性测量圈定的异常分布范围与矿区的分布较为一致,说明这2种方法对圈定隐伏火山岩型铀矿都是有效的。

关键词：火山岩型隐伏铀矿 460铀钼矿土壤细粒级测量金属活动态测量

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护理质量控制体系模式的研究

中国医院管理 2001年第4期21卷 31-32页

作者：杨团真时淑娟徐岩青岛大学医学院附属医院青岛市266003

为建立护理管理质量标准化模式,建立护理质控组织并界定其职责范围,制订护理质量标准,实施护理质量控制体系的运行,以实现病人从来医院候诊、就诊、住院、治疗、护理到出院及出院后追踪随访服务的全过程护理质量监控,使影响护理质量的... 详细信息

为建立护理管理质量标准化模式,建立护理质控组织并界定其职责范围,制订护理质量标准,实施护理质量控制体系的运行,以实现病人从来医院候诊、就诊、住院、治疗、护理到出院及出院后追踪随访服务的全过程护理质量监控,使影响护理质量的全部因素处于受控状态。

关键词：护理质量管理质量控制体系模式标准化