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数字经济、健康产业与生态环境质量

统计与决策 2022年第21期38卷 15-18页

作者：胡淑娟龙佩林别凡长江大学教育与体育学院湖北荆州434023 吉首大学体育科学学院湖南吉首416000 长江大学经济与管理学院湖北荆州434023

文章基于长江经济带2011—2020年11个省份的面板数据,通过LM检验、Hausma检验和LR检验,选择空间杜宾模型和偏微分法,研究数字经济、健康产业对生态环境质量的影响。结果显示:生态环境质量在空间上的溢出效应显著为正,在时间维度上存在... 详细信息

文章基于长江经济带2011—2020年11个省份的面板数据,通过LM检验、Hausma检验和LR检验,选择空间杜宾模型和偏微分法,研究数字经济、健康产业对生态环境质量的影响。结果显示:生态环境质量在空间上的溢出效应显著为正,在时间维度上存在持续性;数字经济能促进本地生态环境质量改善,但溢出效应不明显;健康产业抑制本地和相邻省份的生态环境质量提升;数字经济与健康产业能够协同促进本地区生态环境质量改善。

关键词：数字经济健康产业生态环境质量长江经济带空间杜宾模型

A novel cytochrome P450 gene from Catharanthus roseus cell line C_(20)hi:cloning and characterization of expression

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Acta Pharmaceutica Sinica B 2012年第3期2卷 250-255页

作者： Lihong He shujuan Zhao Zhibi hu The SATCM Key Laboratory for New Resources&Quality Evaluation of Chinese Medicines The Shanghai Key Laboratory for Chinese MedicinesInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Cell Biology Medical College of Soochow UniversitySuzhou 215132China

An expressed sequence tag(EST)obtained from a subtractive-suppression hybridization cDNA library constructed using Catharanthus roseus cell line C_(20)hi and its parental cell line C_(20)D was used to clone a ful-length cytochrome P450 cDNA of cyp71d1.The encoded polypeptide contained 507 amino acids with 39-56% identity to other CYP7ID subfamily members at the.amino acid level.Expression characteristics of cyp71d1 were determined using semi-quantitative RT-PCR.The cyp71d1 transcript was expressed in all three cell lines with the highest level in the cell line C_(20)hi.In the mature C.roseus plant,the cyp71d1 cDNA was highly expressed in petals,roots and stems,but very weakly expressed in young leaves.Its transcription level increased with the development of flowers.2,4-D could down-regulate the transcription of cyp71d1,as did KT,but only to a minor degree.Neither light nor yeast elicitor could induce the transcription of cyp71d1.

关键词： Cytochrome P450 cyp71d1 Transcription Tissue specific expression Full habituated cell line

Prediction of decline in shale gas well production using stable carbon isotope technique

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Frontiers of Earth Science 2021年第4期15卷 849-859页

作者： Shengxian ZHAO shujuan KANG Majia ZHENG Shuangfang LU Yunfeng YANG huanxu ZHANG Yongyang LIU Ziqiang XIA Chenglin ZHANG Haoran hu Di Zhu Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao 266580China School of Geosciences China University of Petroleum(East China)Qingdao 266580China Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Shale Gas Institute of PetroChina Southwest Oil&Gasfield Company Chengdu 610000China Suzhou Grand Energy Technology Ltd. Suzhou 215129China

Prediction of shale gas production is a challenging task because of the complex fracture-pore networks and gas flow mechanisms in shale reservoirs.Empirical methods,which are used in the industry to forecast the future production of shale gas,have not been assessed sufficiently to warrant high confidence in their results.Methane carbon isotopic signals have been used for producing gas wells,and are controlled by physical properties and physics-controlling production;they serve as a unique indicator of the gas production status.Here,a workable process,which is combined with a gas isotope interpretation tool(also known as a numerical simulator),has been implemented in Longrnaxi shale gas wells to predict the production decline curves.The numerical simulator,which takes into account a convection-diffu-sion-adsorption model for the matrix and a convection model for fractures in^(13)CH_(4) and ^(12)CH_(4) isotopologues,was used to stabilize the carbon isotope variation in the produced gas to elucidate gas recovery.Combined with the production rates of the four developing wells,the total reserves ranged from 1.72×10^(8) to 2.02×10^(8) m^(3),which were used to constrain the trend of two-segment produc-tion decline curves that exhibited a transition from a hyperbolic equation to an exponential one within 0.82-0.89 year.Two-segment production decline curves were used to forecast future production and estimate ultimate recovery.

关键词： shale gas production decline Longmaxi formation carbon isotope

益生菌联合奥美拉唑对小儿急性肠胃炎的效果及对CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)水平的影响

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河北医药 2023年第4期45卷 555-557,561页

作者：胡淑娟湖北省武汉市第八医院 430000

目的研究益生菌联合奥美拉唑对小儿急性肠胃炎患儿的综合效果及对CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)水平的影响。方法选择2019年2月至2021年2月收治的急性肠胃炎患儿82例。采用随机双盲对照法分成两药联合组及常规组,每组41例。常规... 详细信息

目的研究益生菌联合奥美拉唑对小儿急性肠胃炎患儿的综合效果及对CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)水平的影响。方法选择2019年2月至2021年2月收治的急性肠胃炎患儿82例。采用随机双盲对照法分成两药联合组及常规组,每组41例。常规组予以奥美拉唑治疗,两药联合组则予以益生菌联合奥美拉唑治疗。分析2组临床治疗疗效,临床症状缓解时间,治疗前后CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)水平变化情况,不良反应发生情况等方面的差异。结果在临床治疗总有效率两药联合组高于常规组(P0.05)。结论益生菌联合奥美拉唑对小儿急性肠胃炎患儿的综合效果显著,可缩短腹痛、腹泻、发热以及呕吐症状缓解时间。同时可改善CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)水平,且不会增加不良反应的发生,值得临床推广应用。

关键词：小儿急性肠胃炎益生菌奥美拉唑 T淋巴细胞亚群不良反应

MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1

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Protein & Cell 2014年第11期5卷 851-861页

作者： Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaling hu Qifeng Wang shujuan Ni Bojian Fei Weili Wang Xiang Du Dong hua Zhaohui huang Wuxi Oncology Institute the Affiliated Hospital of Jiangnan University Wuxi 214062 China Department of Surgical Oncology the Affiliated Hospital of Jiangnan University Wuxi 214062 China Department of Radiation Oncology the Affiliated Hospital of Jiangnan University Wuxi 214062 China Department of Pathology Fudan University Shanghai Cancer Center Shanghai 200032 China

MicroRNAs （miRNAs） that exert function by posttran- scriptional suppression have recently brought insight in our understanding of the role of non.protein-coding RNAs in carcinogenesis and metastasis. In this study, we described the function and molecular mechanism of miR-139-5p in colorectal cancer （CRC） and its potential clinical application in CRC. We found that miR-139-5p was significantly downregulated in 73.8% CRC samples compared with adjacent noncancerous tissues （NCTs）, and decreased miR-139-5p was associated with poor prognosis. Functional analyses demonstrated that ectopic expression of miR-139-5p suppressed CRC cell migration and invasion in vitro and metastasis in vivo. Mechanistic investigations revealed that miR-139-5p suppress CRC cell invasion and metastasis by targeting AMFR and NOTCH1. Knockdown of the two genes phe- nocopied the inhibitory effect of miR-139-5p on CRC metastasis. Furthermore, the protein levels of the two genes were upregulated in CRC samples compared with NCTs, and inversely correlated with the miR-139-5p expression. Increased NOTCH1 protein expression was correlated with poor prognosis of CRC patients. Together, our data indicate that miR-139-5p is a potentialtumor suppressor and prognostic factor for CRC, and targeting miR-139-5p may repress the metastasis of CRC and improve survival.

关键词： miR-139-5p AMFR NOTCH1 colorectalcancer metastasis prognosis

THE INTERACTIVE USE OF VIDEO IN THE ENGLISH CLASSROOM

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Chinese Journal of Applied Linguistics 2000年第2期23卷 45-48页

作者： Duan Shaomin hu shujuan huanggang Normal College

Video in language teaching offers exciting possi-bilities to train learners’communicative competence.This article introduces five different techniques in us-ing video in the language class so as to bring about in-ter... 详细信息

关键词： more THE INTERACTIVE USE OF VIDEO IN THE ENGLISH CLASSROOM than

Correction to:MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1

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Protein & Cell 2021年第8期12卷 667-669页

作者： Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaiing hu Qifeng Wang shujuan Ni Bojian Fei Weiii Wang Xiang Du Dong hua Zhaohui huang Wuxi Oncology Institute the Affiliated Hospital of Jiangnan UniversityWuxi 214062China Department of Surgical Oncology the Affiliated Hospital of Jiangnan UniversityWuxi 214062China Department of Radiation Oncology the Affiliated Hospital of Jiangnan UniversityWuxi 214062China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China

CORRECTION TO:PROTEIN CELL(2014)5(11):851-861 HTTPS://***/10.1007/S13238-014-0093-5 In the original publication the display of Fig.1 is in correct.The correct Fig.1 is available in this correction.

关键词： invasion colorectal cancer

游乐设施乘员加速度对安全性和舒适性影响分析及其设计方法研究

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机械工程学报 2023年第2期59卷 281-290页

作者：肖原胡斌沈功田陈涛刘书娟张勇陈卫卫中国特种设备检测研究院北京100029 广东金马游乐股份有限公司中山528437 中国航天员科研训练中心航天医学基础与应用国家重点实验室北京100094

游乐设施是改善人民群众的精神文化生活质量的重要设施,近年来,乘员人身伤害事故偶有发生。为了减少游乐设施的意外伤害现象,分析游乐设施运行过程中的各种加速度对乘员安全性和舒适性的影响因素,给出针对性的防护和控制措施;在此基础上... 详细信息

游乐设施是改善人民群众的精神文化生活质量的重要设施,近年来,乘员人身伤害事故偶有发生。为了减少游乐设施的意外伤害现象,分析游乐设施运行过程中的各种加速度对乘员安全性和舒适性的影响因素,给出针对性的防护和控制措施;在此基础上,提出适合我国人群生理特征的游乐设施加速度耐受阈值曲线和能够反映乘员舒适程度、加速度耐受能力和加速度风险等级之间量化关系的加速度评价指数,形成基于乘员加速度影响分析的设计方法,初步实现游乐设施设计过程中安全性、刺激性和舒适性的协调统一,为游乐设施设计提供了理论指导。

关键词：游乐设施乘员加速度耐受能力设计风险控制

公立医院绩效考核背景下某三级医院落实功能定位的案例分析

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现代医院 2024年第1期24卷 71-75页

作者：张文张欣欣许莹李汶嘉闫学丽张肖在杨晓雨康娅胡颖辉孔德莹郭艺萍张阳华樊书娟牟怡平李红霞左煌西安交通大学第一附属医院陕西西安710061

公立医院绩效考核,为各级公立医院的发展指明了方向。某三甲医院在医院功能定位落实过程中,总结了现阶段医院发展面临的诸多问题,概括为以下四个方面:①精细化管理程度不足;②学科发展方向不明晰;③医疗运行效率提升遇到瓶颈;④支付方... 详细信息

公立医院绩效考核,为各级公立医院的发展指明了方向。某三甲医院在医院功能定位落实过程中,总结了现阶段医院发展面临的诸多问题,概括为以下四个方面:①精细化管理程度不足;②学科发展方向不明晰;③医疗运行效率提升遇到瓶颈;④支付方式改革给医院带来了新挑战。针对以上问题,医院于2022年5月启动了精细化管理实践。以外科科室为试点,通过信息系统建设为精细化管理提升奠定基础,通过管理流程优化提高医疗运行效率,通过亚专科和学科联盟建设提高学科整体竞争力,通过调整绩效考核指标体系发挥绩效激励作用。以上措施有效提升了医院整体的医疗服务能力及效率,为医院高质量发展提供了助力。

关键词：公立医院绩效考核功能定位精细化管理