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Development of Passive-Type Pressure Intensifier for Tap-Water Drive Systems

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Development of Passive-Type Pressure Intensifier for Tap-Wat...

Detection Capability of the Stool Helicobacter pylori Antigen Kit Using Gastric Juice Collected during Esophagogastroduodenoscopy

第九届全国流体传动与控制学术会议（9th FPTC-2016）

作者： Wataru Kobayashi shujiro dohta Tetsuya Akagi Kazuhisa Ito Okayama University of Science

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Chinese Medical Journal 2018年第18期131卷 2252-2253页

作者： Koichiro Kawano shujiro Yazumi Reiko Kawano Katsuhisa Nishi Division of Gastroenterology and Hepatology Internal Medicine Hyogo Prefectural Awaji Medical Center Hyogo Japan Division of Gastroenterology and Hepatology Digestive Disease Center Kitano Hospital Osaka Japan

To the Editor： Helicohacter pylori （H. pylori） infection plays an important role in the pathogenesis of chronic gastritis and gastric adenocarcinoma Therefore, the accurate diagnosis of H. pylori infection is important. During esopbagogastroduodenoscopy （EGD）, the diagnostic tests for H. pylori infection available are the rapid urease test （RUT）, immunohistopathological examination, and culture. As all of these require gastric mucosal biopsy during EGD.

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Rescue case of low birth weight infant with acute hepatic failure

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World Journal of Gastroenterology 2017年第40期23卷 7337-7342页

作者： Noriki Okada Yukihiro Sanada Taizen Urahashi Yoshiyuki Ihara Naoya Yamada Yuta Hirata Takumi Katano Kentaro Ushijima Shinya Otomo shujiro Fujita Koichi Mizuta Department of Transplant Surgery Jichi Medical University Department of Clinical Pharmacology Jichi Medical University Department of Pharmacy Jichi Medical University Department of Pediatrics Yokohama City University School of Medicine

We report a case involving a rescued low birth weight infant(LBWI) with acute liver failure. Case: The patient was 1594 g and 32^(3/7) gestational wk at birth. At the age of 11 d, she developed acute liver failure due to gestational alloimmune liver disease. Exchange transfusion and high-dose gamma globulin therapy were initiated, and body weight increased with enteral nutrition. Exchange transfusion was performed a total of 33 times prior to living donor liver transplantation(LDLT). Her liver dysfunction could not be treated by medications alone. At 55 d old and a body weight of 2946 g, she underwent LDLT using an S2 monosegment graft from her mother. Three years have passed with no reports of intellectual disability or liver dysfunction. LBWIs with acute liver failure may be rescued by LDLT after body weight has increased to over 2500 g.

关键词： Liver transplantation Acute liver failure Low birth weight infant Transplantable body weight Monosegment graft

Analysis of bacterial growth at various distances from an antimicrobial surface

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Advances in Bioscience and Biotechnology 2013年第4期4卷 563-569页

作者： Shohei Nunose Rie Iwai shujiro Okuda Yuki Tsuchiya Hisao Morisaki College of Life Sciences Ritsumeikan University Kusatsu Japan Faculty of Science and Engineering Ritsumeikan University Kusatsu Japan

Antimicrobial materials have been used in various environments. However, the activity of cells at a distance from the antimicrobial materials has not been elucidated. In the present study, the cell growth of Escherichia coli NBRC 3972 was observed at different distances (0 - 300 μm) from the antimicrobial surface under various nutrient concentrations, from full strength nutrient broth (NB) to 1/40 NB. Under higher nutrient concentrations, NB and 1/2 NB, no antimicrobial effect on cell growth was observed at any distance from the surface. Under lower nutrient concentrations, 1/10 NB and 1/40 NB, the growth of cells directly contacting the antimicrobial surface (at 0 μm from the surface) was blocked immediately after inoculation on the surface. However, at distances of 100 - 300 μm from the surface, the cells grew normally for a while, and then stopped the growth;earlier growth discontinuation was observed for cells closer to the surface. It was suggested that the antimicrobial agent (silver ions) is released from the antimicrobial surface into the medium and that the diffusion of the silver ions may influence the lag in the antimicrobial effects observed at distances away from the antimicrobial surface. The present study reveals the possibility that antimicrobial activity in the environments where the antimicrobial material is used depends on the distance from the surface and the surrounding nutrient concentrations.

关键词： Antimicrobial Surface Escherichia coli Microculture Biofilm

Evaluation of novel slim biopsy forceps for diagnosis of biliary strictures: Single-institutional study of consecutive 360 cases(with video)

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World Journal of Gastroenterology 2017年第35期23卷 6429-6436页

作者： Kenjiro Yamamoto Takayoshi Tsuchiya Takao Itoi shujiro Tsuji Reina Tanaka Ryosuke Tonozuka Mitsuyoshi Honjo Shuntaro Mukai Kentaro Kamada Mitsuru Fujita Yasutsugu Asai Yukitoshi Matsunami Yuichi Nagakawa Hiroshi Yamaguchi Atsushi Sofuni Department of Gastroenterology and Hepatology Tokyo Medical University Third Department of Surgery Tokyo Medical University Department of Pathology Tokyo Medical University

AIM To evaluate the feasibility and reliability of endoscopic transpapillary bile duct biopsy for the diagnosis of biliary *** A total of 360 patients(241 men) who underwent endoscopic retrograde cholangiopancreatography for biliary strictures with biopsy from April 2012 to March 2016 at Tokyo Medical University Hospital were retrospectively reviewed. This study was approved by our Institutional Review Board(No. 3516). Informed consent was obtained from all individual participants included in this study. The biopsy specimens were obtained using a novel slim biopsy forceps(Radial Jaw 4P, Boston Scientific, Boston, MA, United States).RESULTS The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 69.6%, 100%, 100%, 59.1%, and 78.8%, respectively. The sensitivity was 75.6% in bile duct cancer, 64% in pancreatic cancer, 61.1% in gallbladder cancer, and 57.1% in metastasis. In bile duct cancer, a lower sensitivity was observed for perihilar bile duct stricture(68.7%) than for distal bile duct stricture(83.1%). In terms of the stricture lengths of pancreatic cancer, gallbladder cancer, and metastasis, a longer stenosis resulted in a better sensitivity. In particular, there was a significant difference between pancreatic cancer and gallbladder cancer(P < 0.05). One major complication was perforation of the extrahepatic bile duct with bile leakage. CONCLUSION Endoscopic transpapillary biopsy alone using novel slim biopsy forceps is feasible and reliable, but restrictive. Biopsy should be performed in consideration of the stricture level, stricture length, and cancer type.

关键词： Endoscopic transpapillary biopsy Biopsy forceps Biliary stricture Bile duct cancer Endoscopic retrograde cholangiography

Transpapillary incision of refractory circumscript pancreatic duct stricture using wire-guided snare forceps

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World Journal of Gastroenterology 2010年第12期16卷 1541-1544页

作者： Takao Itoi Atsushi Sofuni Fumihide Itokawa Toshio Kurihara Takayoshi Tsuchiya Kentaro Ishii shujiro Tsuji Nobuhito Ikeuchi Fuminori Moriyasu Department of Gastroenterology and Hepatology Tokyo Medical University

Endoscopic therapy of pancreatic duct(PD)strictures using balloon dilation and pancreatic duct stent(PS) placement has been reported to improve the severity of abdominal pain in selected patients with chronic pancreatitis(CP).However,some strictures are refractory and require frequent PS exchange to control *** describe two cases of successful endoscopic PD incision for difficult PD stricture using a wireguided *** snare is partially opened within the strictured pancreatic duct while applying current,thus incising the *** both cases were successful without complications we do not advocate that this method be used routinely because of the potential for severe complications,***,ductal perforation or pancreatic parenchymal *** order to prevent these complications,we developed a wire-guided technique under fluoroscopic *** think this procedure may be useful in patients with short,straight PD *** further study is required,this approach may have potential for selected patients with refractory PD strictures due to CP.

关键词： Chronic pancreatitis Pancreatic duct stricture Pancreatic duct incision

Endoscopic ultrasound-guided choledochoduodenostomy in patients with failed endoscopic retrograde cholangiopancreatography

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World Journal of Gastroenterology 2008年第39期14卷 6078-6082页

作者： Takao Itoi Fumihide Itokawa Atsushi Sofuni Toshio Kurihara Takayoshi Tsuchiya Kentaro Ishii shujiro Tsuji Nobuhito Ikeuchi Fuminori Moriyasu Department of Gastroenterology and Hepatology Tokyo Medical University HospitalTokyo 160-0023Japan

Endoscopic ultrasonography （EUS）-guided biliary drainage was performed for treatment of patients who have obstructive jaundice in cases of failed endoscopic retrograde cholangiopancreatography （ERCP）. In the present study, we introduced the feasibility and outcome of EUS-guided choledochoduodenostomy in four patients who failed in ERCR We performed the procedure in 2 papilla of Vater, including one resectable case, and 2 cases of cancer of the head of pancreas. Using a curved linear array echoendoscope, a 19 G needle or a needle knife was punctured transduodenally into the bile duct under EUS visualization. Using a biliary catheter for dilation, or papillary balloon dilator, a 7-Fr plastic stent was inserted through the choledochoduodenostomy site into the extrahepatic bile duct. In 3 （75%） of 4 cases, an indwelling plastic stent was placed, and in one case in which the stent could not be advanced into the bile duct, a naso-biliary drainage tube was placed instead. In all cases, the obstructive jaundice rapidly improved after the procedure. Focal peritonitis and bleeding not requiring blood transfusion was seen in one case. In this case, pancreatoduodenectomy was performed and the surgical findings revealed severe adhesion around the choledochoduodenostomy site. Although further studies and development of devices are mandatory, EUS-guided choledochoduodenostomy appears to be an effective alternative to ERCP in selected cases.

关键词： Endoscopic ultrasonography-guided fine needle aspiration Biliary drainage Endoscopic retrograde cholangiopancreatography

Endoscopic removal and trimming of distal self-expandable metallic biliary stents

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World Journal of Gastroenterology 2011年第21期17卷 2652-2657页

作者： Kentaro Ishii Takao Itoi Atsushi Sofuni Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara shujiro Tsuji Nobuhito Ikeuchi Junko Umeda Fuminori Moriyasu Akihiko Tsuchida Department of Gastroenterology and Hepatology Tokyo Medical University Third Department of Surgery Tokyo Medical University

AIM:To evaluate the efficacy and safety of endoscopic removal and trimming of self-expandable metallic stents(SEMS).METHODS:All SEMS had been placed for distal biliary ***-seven endoscopic procedures were performed in 19 patients in whom SEMS(one uncovered and 18 covered) removal had been attempted,and 8 patients in whom stent trimming using argon plasma coagulation(APC) had been attempted at Tokyo Medical University *** APC settings were:voltage 60-80 W and gas flow at 1.5 L/***:The mean stent indwelling period for all patients in whom stent removal had been attempted was 113.7 ± 77.6 d(range,8-280 d).Of the 19 patients in whom removal of the SEMS had been attempted,the procedure was successful in 14(73.7%) without procedure-related adverse *** indwelling period in the stent removable group was shorter than that in the unremovable group(94.9 ± 71.5 d vs 166.2 ± 76.2 d,P = 0.08).Stent trimming was successful for all patients with one minor adverse event consisting of self-limited *** time ranged from 11 to 16 ***:Although further investigations on larger numbers of cases are necessary to accumulate evidence,the present data suggested that stent removal and stent trimming is feasible and effective for stent-related complications.

关键词： Self-expandable metallic stent Endoscopic biliary stenting Endoscopic stent removal Endoscopic stent trimming

Prognosis of cancer with branch duct type IPMN of the pancreas

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World Journal of Gastroenterology 2010年第15期16卷 1890-1895页

作者： Nobuhito Ikeuchi Takao Itoi Atsushi Sofuni Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii shujiro Tsuji Junko Umeda Fuminori Moriyasu Akihiko Tsuchida Kazuhiko Kasuya Department of Gastroenterology and Hepatology Tokyo Medical University Department of Surgery Tokyo Medical University

AIM:To examine the coexistence of metachronous and synchronous cancer in branch duct intraductal papillary mucinous neoplasms of the pancreas (IPMN).METHODS: We reviewed the records of 145 patients with branch duct IPMN between January 1991 and April 2008 and assessed the relationship between IPMN and intraor extra-pancreatic carcinoma and the outcome of ***: The mean observation period was 55.9 ± 45.3 mo. Among the 145 patients, the frequency of extra-pancreatic cancer was 29.0%. The frequency of gastric cancer, colon cancer, breast cancer, and pan-creatic cancer were 25.5%, 15.7%, 13.7%, and 9.8%, respectively. Twenty (13.8%) of the patients died. The cause of death was extra-pancreatic carcinoma in 40%,pancreatic cancer in 25%, IPMN per se in 20%, and benign disease in 15% of the ***: The prognosis for IPMN depends not on the IPMN per se, but on the presence of intraor extra-pancreatic cancer.

关键词： Intraductal papillary mucinous neoplasms of the pancreas Long-term follow-up Extra-pancreatic cancer Pancreatic cancer Prognosis