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Chinese emotional words in patients with major depressive disorder during a subliminal Stroop task An event-related potential study

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Neural Regeneration Research 2010年第16期5卷 1274-1280页

作者： Daxing Wu shujing xu Huifang Yin Medical Psychological Research Center Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China

Patients with major depressive disorder （MDD） develop a negative cognitive bias, but how they respond to information in Chinese emotional words is unclear. Here we used a Stroop paradigm with subliminal Chinese emotional words to explore the event-related potential components of abnormal emotional processing Jn patients with MDD. The correct rate was similar in MDD and normal control groups, but MDD reaction time was longer than the normal controls, especially to the negative and neutral stimuli. In N270, repeated-measure analysis of variance demonstrated a significant main effect of the relation electrode and valence on peak amplitude and interactions between valence and electrode site. The peak amplitudes of the three kinds of words were different in the two groups （positive 〉 negative 〉 neutral）. The topography of the difference waves indicated that the difference distributed in the frontal and left parietal-temporal sites across the scalp. In N400, there was a significant main effect of the relation electrode and valence on peak amplitude, and the latency showed a main effect of the electrode and an interaction between electrode and group. The amplitudes induced by type of words were significantly different from each other in both groups （positive 〉 negative 〉 neutral）. The topography of the difference waves indicated that the effect of relation type was primarily at left and right frontal and central and left parietal-temporal regions. Both MDD patients and normal controls exhibited significant emotional Stroop effects during the processing of positive/negative Chinese emotional words. MDD patients showed interference in emotional stimuli in early cognitive processing that induced psychological resource intervention during late emotional information processing.

关键词： Stroop test subliminal stimulations event-related potentials depression Chinese emotional words

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SMIP-30,a potent and selective PPM1A inhibitor with potential to treat tuberculosis

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Acta Pharmaceutica Sinica B 2022年第12期12卷 4519-4521页

作者： shujing xu Xinyong Liu Peng Zhan Department of Medicinal Chemistry Key Laboratory of Chemical BiologyMinistry of EducationSchool of Pharmaceutical SciencesShandong UniversityJi'nan 250012China

Recently,a collaborative research led by Weibo Yang and Jim Sun1 published in Cell Chemical Biology identified a potent and selective small molecule inhibitor(SMIP-30)for human protein phosphatase Mg^(2+)/Mn^(2+)-dependent 1 A(PPM1A).They applied this chemical probe to determine the autophagy receptor p62 as a new substrate of PPM1A.

关键词： PPM1A Tuberculosis Drug discovery Compound library

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Low Thrust Minimum Time Orbit Transfer Nonlinear Optimization Using Impulse Discretization via the Modified Picard–Chebyshev Method

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Computer Modeling in Engineering & Sciences 2016年第1期111卷 1-27页

作者： Darin Koblick shujing xu Joshua Fogel Praveen Shankar California State University-Long Beach CAUSA. Millennium Space Systems Inc. El SegundoCAUSA. Claremont Graduate University CAUSA. University of California-San Diego CAUSA. University of Southern California Los AngelesCAUSA.

The Modified Picard-Chebyshev Method(MPCM)is implemented as an orbit propagation solver for a numerical optimization method that determines minimum time orbit transfer trajectory of a satellite using a series of multiple impulses at intermediate *** waypoints correspond to instantaneous impulses that are determined using a nonlinear constrained optimization routine,SNOPT with numerical force models for both Two-Body and J2 *** is found that using the MPCM increases run-time performance of the discretized lowthrust optimization method when compared to other sequential numerical solvers,such as Adams-Bashforth-Moulton and Gauss-Jackson 8th order methods.

关键词： Low Thrust Picard–Chebyshev Optimization Multi-Impulse Boundary Value Problem.

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The Chinese species of the mealybug genus Neotrionymus Borchsenius(Hemiptera： Coccoidea： Pseudococcidae)

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Zoological Systematics 2018年第1期43卷 52-57页

作者： shujing xu san'an wu Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry University Beijing 100083 China

The genus Neotrionymus Borchsenius comprises five species in China, N. cynodontis, N. guandunensis, N. monstatus, N. yunnanensis and N. chinensis sp. nov., which collected from Beijing, Shanxi and Shandong under the leaf sheath of species of Poaceae. This new species is similar to N. kerzhneri Danzig, but can be distinguished by with a large, quadrate（longer than width） or sometimes hour-glass shaped circulus, presence of tubular ducts in median area of thorax on dorsum and venter, presence of translucent pores on apical part of hind tibia and the distribution of trilocular pores not only in cerarii, but also on lips of ostioles and near spiracles. A key to species of genus Neotrionymus in China is also given.

关键词： Pseudococcidae Neotrionymus new species taxonomy China

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Magnetic records of heavy metal pollution in urban topsoil in Lanzhou,China

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Chinese Science Bulletin 2013年第3期58卷 384-395页

作者： WANG Bo XIA DunSheng YU Ye JIA Jia xu shujing Key Laboratory of West China's Environmental Systems(Ministry of Education) Lanzhou University Key Laboratory of Desert and Desertification Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences

This study is a systematic analysis of the magnetic characteristics and heavy metal elements in soil samples collected from Lanzhou City,*** 117 surface soil samples were measured to study the feasibility and effectiveness of environmental magnetism for evaluating heavy metal pollution in urban *** of the study indicate that low-coercivity magnetite dominates the magnetic properties in the *** high values of the soil magnetic mineral concentration parameters and low values of magnetic particle size parameters are distributed throughout the northern area of Xigu District,the industrial zones of the eastern section of Chengguan District and the districts of the narrow sections connecting Chengguan District and the other three districts;these parameters are fundamentally consistent with the distribution of the high values of the Pollution Load Index and Nemerow Pollution ***-quantitative studies which use the environmental magnetic method to monitor pollution of heavy metals(such as As,Cr,Cu,Ni,Pb,Zn,and Fe) have shown that when xlf≤35×10-8 m 3 kg-1,it is unpolluted;when 35≤xlf <150×10-8 m3 kg-1,it is moderately polluted to unpolluted;when 150≤xlf <365×10-8 m 3 kg-1,it is moderately polluted;when 365≤xlf <750×10-8 m3 kg-1,fd %<2.7 and ARM /SIRM<0.2×10-3m A-1,it is moderately to highly polluted;when xlf ≥750×10-8 m3 kg-1,xfd %<2.7 and xARM/SIRM<0.2×10-3m A-1,it is highly *** region of moderately to highly polluted distribution is caused by industry and vehicles,showing that the change of pollution in Lanzhou City bears the trend of "vehicle emission + industrial".

关键词：土壤重金属污染城市表层土壤环境磁学兰州市中国土壤样品污染指数污染负荷

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Preparation and luminescence properties of monodisperse silica/aminosilane-coated Y_2O_3:Yb,Ho upconversion nanoparticles

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Chinese Science Bulletin 2011年第2期56卷 137-141页

作者： PANG Tao CAO WangHe XING MingMing LUO XiXian xu shujing Optoelectronic Technology Institute Dalian Maritime University Dalian 116026 China

Monodisperse silica/aminosilane-coated Y 2 O 3:Yb,Ho nanoparticles are prepared via homogenous precipitation combined with a polyvinylpyrrolidone-assisted ammoniation *** factors that contribute to the success of the coating are examined,and the procedure is *** with uncoated nanoparticles,coated nanoparticles exhibit an increased ratio of green to red emission intensity,which can mainly be attributed to the decreased number of surface defects induced by the surface coating.

关键词：单分散二氧化硅纳米涂层 Y2O3 氨基硅烷纳米颗粒发光性能制备上转换

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Medicinal chemistry strategies in the discovery and optimization of HBV core protein allosteric modulators(2018-2022 update)

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Chinese Chemical Letters 2023年第11期34卷 20-30页

作者： Xiaoyu Shao shujing xu xufeng Wan Yang Zhou Shuo Wang Shuo Wu Yuhuan Li Xinyong Liu Peng Zhan Department of Medicinal Chemistry Key Laboratory of Chemical BiologyMinistry of EducationSchool of Pharmaceutical SciencesShandong UniversityJi’nan 250012China CAMS Key Laboratory of Antiviral Drug Research Beijing Key Laboratory of Antimicrobial AgentsNHC Key Laboratory of Biotechnology of AntibioticsInstitute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Despite the improving coverage of preventative vaccines,hepatitis B remains a severe global public health problem,with more than 250 million patients living with hepatitis B virus(HBV)*** available therapies,including nucleos(t)ide analogs and peginterferon,can control HBV replication but fail to eliminate covalently closed circular DNA(cccDNA)and achieve a *** HBV core protein(Cp)is a well-conserved structural protein,self-assembling to form the viral *** involves in or modulates almost every stage of the HBV lifecycle,which makes it an attractive target for the development of new anti-HBV *** core protein allosteric modulators(CpAMs)have become a hotspot in recent ***,we provide a concise report focusing on the various medicinal chemistry strategies involved in the latest research(2018-2022)of HBV CpAMs,including high throughput screening(HTS),virtual screening(VS),drug repositioning,natural products,substitution decorating approach,scaffold hopping,molecular hybridization,prodrug strategy and conformational constraint strategy,to provide guidance for further development of new and effective anti-HBV drugs.

关键词： HBV Capsid CpAMs Medicinal chemistry strategies Drug design

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Twice-yearly lenacapavir demonstrated exceptional efficacy for HIV prevention

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The Innovation 2024年第5期5卷 9-10页

作者： shujing xu Peng Zhan Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesShandong UniversityJinan 250012China

Acquired immunodeficiency syndrome(AIDS),a contagious illness arising from the human immunodeficiency virus(HIV),presents significant threats to human health and societal *** on genotypic differences,HIV can be divided into two main subtypes,HIV-1 and HIV-2,of which HIV-1 is the dominant global variant characterized by its heightened transmissibility and *** from 2022 indicate that approximately 39 million people are living with HIV globally,with 1.3 million new cases reported that *** combination antiretroviral therapy(cART)has demonstrated significant effectiveness in combating HIV infection,hurdles such as the emergence of multidrug-resistant HIV strains,potential long-term side effects,limited accessibility in economically underprivileged areas,and obstacles to treatment adherence hinder its widespread implementation.1 This necessitates the development of innovative medications with diverse resistance profiles and new therapeutic *** multifunctional HIV-1 capsid protein(CA)has emerged as a highly promising target in HIV-1 medication *** CA has a fullerene-shaped structure,consisting of 250 hexamers and 12 pentamers,which is crucial for viral ***,CA plays essential roles in multiple events during viral replication,including reverse transcription,nuclear entry,integration site distribution,assembly,and maturation.2 Therefore,CA-targeting small molecules can provide antiviral efficacy in both the early and late stages of the viral life cycle.

关键词： prevention exceptional globally

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Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors

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Acta Pharmaceutica Sinica B 2022年第2期12卷 581-599页

作者： Shenghua Gao Tianguang Huang Letian Song shujing xu Yusen Cheng Srinivasulu Cherukupalli Dongwei Kang Tong Zhao Lin Sun Jian Zhang Peng Zhan Xinyong Liu Department of Medicinal Chemistry Key Laboratory of Chemical BiologyMinistry of EducationSchool of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJi’nan 250012China China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province Ji’nan 250012China

Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 ***,we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors wi... 详细信息

关键词： SARS-CoV-2 COVID-19 Antiviral drugs Drug design Medicinal chemistry strategies

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Spatial-temporal Variation of Extreme Precipitation Events in Northwest China During 1961-2010

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Meteorological and Environmental Research 2014年第1期5卷 12-19,23页

作者： Lian Lishu xu shujing Li Zhifu Sun Xiaoyin College of Geography and Tourism Qufu Normal University Key Laboratory of Western China's Environmental Systems Ministry of EducationLanzhou University Library of Qufu Normal University

Using the daily precipitation data of 118 meteorological stations in Northwest China from January 1, 1961 to December 31,2010, we analyzed extreme precipitation events from prime precipitation data by applying R-language Climate Index （RClimDex）. The spatial-temporal change characteristics in the past 50 years have been examined using the method of trend analysis, Mann-Kendall and the spatial analysis module of Arcgis9.2. The results show that the spatial distribution of the indices for extreme precipitation in Northwest China is greatly influenced by geographic location, atmospheric circulation and topography, and the spatial difference of extreme precipitation events is very evident, while the indices reduce from the southeast to the northwest except Consecutive Dry Days （CDD）. In Xinjiang region, high values appear in Tianshan Mountains and decrease towards the south and north respectively. In the past 50 years, the temporal variation tendency of the indices for extreme precipitation in Northwest China has a great spatial distinction. It shows that the variation tendency is opposite between the east （decrease） and the west （increase）, and CDD has a decreasing tendency while other indices increase. For each region, it is found that the indices for extreme precipitation in Xinjiang and Qinghai Province shows an increasing trend, and it is remarkable in Tianshan Mountains, the north of Xinjiang and the northeast of Qinghai Province. The temporal variation tendency of the indices for extreme precipitation in Ningxia, Shaanxi and Gansu has a large spatial distinction. The stations which have an increasing tend are mainly found in the north of Ningxia, south of Shaanxi and Hexi Corridor of Gansu. However, the south of Ningxia, north of Shaanxi and Longnan of Gansu Province mainly present a decreasing trend. The temporal variation tendency of the indices for extreme precipitation in Inner Mongolia is not obvious. Overall, the east part of Northwest China has a dry tende

关键词： Northwest China Extreme precipitation events Spatial-temporal variation characteristics Mann-Kendall method China

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