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差示扫描量热法测定石蜡熔点的研究

石油炼制与化工 2024年第5期55卷 165-171页

作者：李淑杰王刚李奕睿张立军马丽中国石油石油化工研究院大庆化工研究中心黑龙江大庆163714

采用差示扫描量热(DSC)技术,模拟石蜡熔点(冷却曲线法)测试过程,测定石蜡的熔点。研究了起始温度、终止温度、吹扫气(氮气)流量、升降温速率、试样质量、恒温时间、样品制备方式、升降温次数等对测试结果的影响,确定了DSC法测定石蜡熔... 详细信息

采用差示扫描量热(DSC)技术,模拟石蜡熔点(冷却曲线法)测试过程,测定石蜡的熔点。研究了起始温度、终止温度、吹扫气(氮气)流量、升降温速率、试样质量、恒温时间、样品制备方式、升降温次数等对测试结果的影响,确定了DSC法测定石蜡熔点的适宜条件,考察了DSC法与标准方法(GB/T 2539—2008)的偏倚。结果表明,采用DSC法测定石蜡熔点时的升温速率宜为10℃/min,降温速率宜为5℃/min,试样在高于预估熔点20~30℃下熔融时间不应超过1 h。通过采用6台不同型号的DSC仪器对14个牌号石蜡样品进行测试,计算出DSC法与标准方法的偏倚为-1.14℃。DSC法操作简单、试样用量少、检测速率快、重复性好,可作为控制分析手段,快速准确地测定石蜡的熔点。

关键词：差示扫描量热法熔点石蜡偏倚

基于邮件的科技期刊精准推送实践与策略优化——以《棉纺织技术》为例

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新闻研究导刊 2024年第10期15卷 227-230页

作者：李舒婕杨家密王利陕西棉纺织技术期刊社有限公司陕西西安710048

为有效提升科技期刊传播力,扩大期刊影响力,文章针对目前科技期刊传播力不足的问题,介绍了期刊精准推送方式,包括嵌入式推荐阅读和基于大数据挖掘技术的邮件推送,以精准推送平台对《棉纺织技术》专题论文进行推送实践为例;分析了精准推... 详细信息

为有效提升科技期刊传播力,扩大期刊影响力,文章针对目前科技期刊传播力不足的问题,介绍了期刊精准推送方式,包括嵌入式推荐阅读和基于大数据挖掘技术的邮件推送,以精准推送平台对《棉纺织技术》专题论文进行推送实践为例;分析了精准推送平台的传播效果,提出了精准推送传播的优化策略。研究结果表明,基于邮件的精准推送平台大数据挖掘能力较强,便于传播交叉学科研究内容,推送方式高效便捷,邮件触达率和打开率较高,推送精准度高。但是推送中存在平台提供数据不充分,推送文章的引用周期长,推送效果难以评定和推送反馈较少等问题。文章认为,在科技期刊的推送中应将期刊自有数据库与精准推送平台深度融合,充分挖掘期刊作者库、审稿专家库和编委库,进行推送对象标签化,在采用精准推送平台推送时建立推送白名单,明确推送效果以便进一步优化推送策略。推送中应加强对科技论文的二次加工,顺应读者阅读需求创新推送内容。推送链接中应增加推送反馈调查表,提高推送反馈效率。此外,充足的资金支持和运营人才支持是实现期刊精准传播的必要保障。科技期刊的精准推送还处于起步阶段,未来期刊的推送方式趋于多渠道融合,只有构建科学的期刊推送策略方能推动期刊高质量发展。

关键词：科技期刊精准推送大数据媒体融合

Unified Solution of Conjugate Fluid and Solid Heat Transfer-Part *** Heat Conduction

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Advances in Applied Mathematics and Mechanics 2023年第3期15卷 814-830页

作者： shujie li lili Ju Division of Mechanics Beijing Computational Science Research CenterBeijing 100193China Department of Mathematics University of South CarolinaColumbiaSC 29208USA

A unified solution framework is proposed for efficiently solving conjugate fluid and solid heat transfer *** unified solution is solely governed by the compressible Navier-Stokes(N-S)equations in both fluid and solid *** method not only provides the computational capability for solid heat transfer simulations with existing successful N-S flow solvers,but also can relax time-stepping restrictions often imposed by the interface conditions for conjugate fluid and solid heat *** paper serves as Part I of the proposed unified solution framework and addresses the handling of solid heat conduction with the nondimensional N-S ***,a parallel,adaptive high-order discontinuous Galerkin unified solver has been developed and applied to solve solid heat transfer problems under various boundary conditions.

关键词： Conjugate heat transfer solid heat conduction compressible Navier-Stokes exponential time integration discontinuous Galerkin

Co-delivery of mitochondrial targeted lonidamine and PIN1 inhibitor ATRA by nanoparticulate systems for synergistic metastasis suppression

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Nano Research 2022年第4期15卷 3376-3386页

作者： Cheng Chen Qiuyi li liyun Xing Minglu Zhou Chaohui Luo shujie li lian li Yuan Huang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

Mitochondria are highly involved in the metastasis of cancer ***,tumor cells impede the efficiency of mitochondrial targeted drugs by protecting mitochondria through an intrinsic and adaptive antioxidant *** aim to disturb the redox homeostasis by prolyl-isomerase PIN1 inhibitor all-trans retinoic acid(ATRA)to improve the therapeutic efficacy of mitochondrial targeted lonidamine(TL).The combination of ATRA and TL with a ratio of 2:1 was found to have the best synergistic effect in inhibiting the proliferation and metastasis of metastatic 4T1 breast cancer ***-drug loaded nanoparticles(TL-ATRA NPs)were further developed by self-assembly and were observed to disturb the redox homeostasis drastically and triggered a robust mitochondrial disruption on metastatic 4T1 breast cancer *** molecular mechanism was related to the downregulation of nuclear factor E2-related factor 2(NRF2),a critical transcription factor that regulated antioxidant responses,and its downstream *** a result,TL-ATRA NPs significantly suppressed the growth of primary tumors and the formation of lung metastasis ***,our findings showed that sensitizing mitochondria to anti-cancer drugs by disturbing redox homeostasis achieved a satisfactory therapeutic effect to inhibit tumor growth and metastasis.

关键词： tumor metastasis mitochondrial dysfunction PIN1 inhibition redox homeostasis disruption combinatorial therapy

Increasing stiffness promotes pulmonary retention of ligand-directed dexamethasone-loaded nanoparticle for enhanced acute lung inflammation therapy

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Bioactive Materials 2023年第2期20卷 539-547页

作者： Yinglan Yu shujie li Yuan Yao Xinran Shen lian li Yuan Huang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu610041China

Inhaled nanoparticles(NPs)need to penetrate the bronchial mucosa to deliver drug payloads deeply in the lung for amplified local ***,the bronchial mucociliary barrier eliminates NPs rapidly,which considerably limits their mucosal *** this study,we find that surface ligand modification and stiffness adjustment of NPs contribute to the significantly enhanced bronchial mucosal absorption and pulmonary retention of inhaled *** utilize neonatal Fc receptor ligand(FcBP)to modify the rationally designed low stiffness NPs(Soft-NP)and high stiffness NPs(Stiff-NP)to target bronchial *** an acute lung inflammation rat model,after intranasal administration with dexamethasone-loaded NPs,Stiff-NP endowed with FcBP displays superior therapeutic *** in vitro data demonstrate that the promotion effect of FcBP to bronchial mucosal absorption of Stiff-NP dominates over *** could be attributed to the higher affinity between ligand-receptor when incorporating FcBP on the Stiff-NP ***,high stiffness modulates more actin filaments aggregation to mediate endocytosis,along with strengthened Ca2+signal to enhance ***,we highlight that FcBP-modified NPs with higher stiffness would be a potential pulmonary drug delivery system.

关键词： Pulmonary drug delivery Mucus barrier Epithelial barrier Stiffness ligand modification Acute lung inflammation

Application of micro-seismic facies to coal bed methane exploration

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Mining Science and Technology 2011年第5期21卷 743-747页

作者： li Donghui Dong Shouhua Zhang Cong Deng Shuaiqi li shujie School of Resources and Geoscience China University of Mining ＆ Technolagy Xuzhou 221008 China Huabei Oilfield CBM Branch Company fincheag 048000 China School of Economics and Management Changchun University of Science ＆ Technology Chaagchun 130022 China

A neural network is applied to high-quality 3-D seismic data during micro-seismic facies analysis to perform the waveform analysis and training on single reflection events. Modeled seismic channels are established and the real seismic channels are classified. Thus, a distribution of micro-seismic facies having a high precision over a fiat surface was acquired. This method applied to existing geological data allows the distribution of areas rich in coal bed methane to be clearly defined. A distribution map of the micro-seismic facies in the research area is shown. The data accord well with measured methane con- tents, indicating that the analysis using micro-seismic facies is reliable and effective. This method could be applied to coal bed methane exploration and is of great importance to future exploration work and to an increase in the drilling success rate.

关键词： Micro-seismic faciesCoal bed methaneWaveform classificationGas rich area

益肾降糖饮对糖尿病肾脏病大鼠TGF-β1/SMAD2/3信号通路的调节作用

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中医药通报 2024年第4期23卷 60-64页

作者：张丽香李玉玲李述捷于翔丘余良福建中医药大学附属人民医院福建福州350004 南京中医药大学江苏南京210029 江苏省中医院江苏南京210029 福建医科大学附属协和医院福建福州350004 南京市中医院江苏南京210022

目的:观察益肾降糖饮对糖尿病肾脏病(DKD)大鼠TGF-β1/SMAD2/3信号通路的调节作用。方法:随机将30只大鼠分为对照组、模型组、益肾降糖饮低剂量组、益肾降糖饮高剂量组、达格列净组,以柠檬酸缓冲液溶解的1%链脲佐菌素(STZ)经腹腔注射建... 详细信息

目的:观察益肾降糖饮对糖尿病肾脏病(DKD)大鼠TGF-β1/SMAD2/3信号通路的调节作用。方法:随机将30只大鼠分为对照组、模型组、益肾降糖饮低剂量组、益肾降糖饮高剂量组、达格列净组,以柠檬酸缓冲液溶解的1%链脲佐菌素(STZ)经腹腔注射建立DKD大鼠实验模型。经8w治疗后,检测并比较各实验组大鼠禁食状态下的血糖、24h尿蛋白、肾组织病理的变化,以及转化生长因子-β1(TGF-β1)/SMAD2/3信号通路、纤维粘连蛋白(FN)、α-平滑肌肌动蛋白(α-SMA)的表达情况。结果:与模型组比较,益肾降糖饮低剂量组、益肾降糖饮高剂量组大鼠的肾重指数、空腹血糖、24h尿蛋白、TGF-β1、SMAD2/3、纤维粘连蛋白(FN)、α-平滑肌肌动蛋白(α-SMA)表达及肾纤维化程度均明显降低(P<0.05或P<0.01)。结论:益肾降糖饮可通过干预TGF-β1/SMAD2/3信号传导,从而延缓DKD大鼠肾纤维化的进展。

关键词：益肾降糖饮糖尿病肾脏病 TGF-β1/SMAD2/3信号通路

股权激励对企业创新的影响研究——基于融资约束中介效应的分析

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市场周刊 2024年第7期37卷 42-46页

作者：陈非凡张雨露李淑杰苏州科技大学商学院江苏苏州215009

股权激励在我国呈现“常态化”发展趋势,且激励对象逐渐覆盖核心技术人员。在这一现实背景下,股权激励能否促进企业创新值得进一步探究。文章借助2011—2020年沪深A股上市公司数据,实证检验了股权激励对企业创新的影响及其机制。研究发... 详细信息

股权激励在我国呈现“常态化”发展趋势,且激励对象逐渐覆盖核心技术人员。在这一现实背景下,股权激励能否促进企业创新值得进一步探究。文章借助2011—2020年沪深A股上市公司数据,实证检验了股权激励对企业创新的影响及其机制。研究发现,股权激励能够促进企业创新,融资约束在二者关系中存在中介效应;股权激励对企业创新的促进作用在非国有企业和位于高知识产权保护度地区企业中更为明显。

关键词：股权激励企业创新融资约束中介效应

探讨益肝灵联合甘草酸二铵治疗抗结核药物性肝损伤的疗效

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临床研究 2024年第1期32卷 123-126页

作者：李淑洁孙振华完颜福亮鹿邑县疾病预防控制中心门诊部结防科河南周口477200

目的探讨益肝灵联合甘草酸二铵治疗抗结核药物性肝损伤(ATB-DIli)的疗效,并分析其对肝功能、炎性因子水平、免疫功能的影响。方法选取2021年6月至2023年6月鹿邑县疾病预防控制中心收治的80例ATB-DIli患者为研究对象,随机分为单一组40... 详细信息

目的探讨益肝灵联合甘草酸二铵治疗抗结核药物性肝损伤(ATB-DIli)的疗效,并分析其对肝功能、炎性因子水平、免疫功能的影响。方法选取2021年6月至2023年6月鹿邑县疾病预防控制中心收治的80例ATB-DIli患者为研究对象,随机分为单一组40例、联合组40例。单一组予以甘草酸二铵治疗,联合组予以益肝灵联合甘草酸二铵治疗。统计对比两组临床疗效、不良反应、临床症状积分及治疗前后肝功能[丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、γ-谷氨酰转肽酶(γ-GT)]、炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)]、外周血T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+))水平变化。结果联合组治疗有效率高于单一组,差异有统计学意义(P 0.05)。结论益肝灵联合甘草酸二铵治疗ATB-DIli的疗效确切且具有一定安全性,可改善临床症状,促进免疫功能、肝功能恢复,抑制炎性反应。

关键词：抗结核药物性肝损伤益肝灵甘草酸二铵疗效炎性因子