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Thermal Conductivity and Tensile Properties of Carbon Nanofiber-Reinforced Aluminum-Matrix Composites Fabricated via Powder Metallurgy: Effects of Ball Milling and Extrusion Conditions on Microstructures and Resultant Composite Properties

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Acta Metallurgica Sinica(English Letters) 2019年第5期32卷 573-584页

作者： Fumio Ogawa shuji yamamoto Chitoshi Masuda Department of Mechanical Engineering College of Science and Engineering Ritsumeikan University Kanto Gakuin University Kagami Memorial Institute for Materials Science and Technology Waseda University

Carbon nanofiber(CNF)-reinforced aluminum-matrix composites were fabricated via ball milling and spark plasma sintering(SPS), SPS followed by hot extrusion and powder extrusion. Two mixing conditions of CNF and aluminum powder were adopted: milling at 90 rpm and milling at 200 rpm. After milling at 90 rpm, the mixed powder was sintered using SPS at 560 °C. The composite was then extruded at 500 °C at an extrusion ratio of 9. Composites were also fabricated via powder extrusion of powder milled at 200 rpm and 550 °C with an extrusion ratio of 9(R9) or 16(R16). The thermal conductivity and tensile properties of the resultant composites were evaluated. Anisotropic thermal conductivity was observed even in the sintered products. The anisotropy could be controlled via hot extrusion. The thermal conductivity of composites fabricated via powder extrusion was higher than those fabricated using other methods. However, in the case of specimens with a CNF volume fraction of 4.0%, the thermal conductivity of the composite fabricated via SPS and hot extrusion was the highest. The highest thermal conductivity of 4.0% CNF-reinforced composite is attributable to networking and percolation of CNFs. The effect of the fabrication route on the tensile strength and ductility was also investigated. Tensile strengths of the R9 composites were the highest. By contrast, the R16 composites prepared under long heating duration exhibited high ductility at CNF volume fractions of 2.0% and 5.0%. The microstructures of composites and fracture surfaces were observed in detail, and fracture process was elucidated. The results revealed that controlling the heating and plastic deformation during extrusion will yield strong and ductile composites.

关键词： Al composite Carbon nanofiber Ball milling Hot extrusion Microstructure and performance

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净水用过滤设备及其操作方法

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水处理信息报导 2003年第1期 46-46页

作者： yamamoto,shuji

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IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions

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World Journal of Gastroenterology 2014年第29期20卷 10050-10061页

作者： Takafumi Naito Katsuhiko Nosho Miki Ito Hisayoshi Igarashi Kei Mitsuhashi Shinji Yoshii Hironori Aoki Masafumi Nomura Yasutaka Sukawa Eiichiro yamamoto Yasushi Adachi Hiroaki Takahashi Masao Hosokawa Masahiro Fujita Toshinao Takenouchi Reo Maruyama Hiromu Suzuki Yoshifumi Baba Kohzoh Imai Hiroyuki yamamoto shuji Ogino Yasuhisa Shinomura Department of Gastroenterology Rheumatology and Clinical ImmunologySapporo Medical University School of Medicine Department of Gastroenterology Keiyukai Sapporo Hospital Center for Gastroenterology Teine-Keijinkai Hospital Department of Medical Oncolo-gy Dana-Farber Cancer InstituteBostonMA 02115United States Department of Surgery Keiyukai SapporoHospital Department of Pathology Keiyukai Sapporo Hospital Department of Molecular Biology Sapporo Medical University School of Medicine Department of Gastroenterological Surgery Graduate School of Medical ScienceKumamoto University Division of Cancer Research The Institute of Medical ScienceThe University of Tokyo Division of Gastroenterology and Hepatology Department of Internal MedicineSt.Marianna University School of Medicine

AIM:To investigate insulin-like growth factor 2(IGF2)differentially methylated region(DMR)0 hypomethylation in relation to clinicopathological and molecular features in colorectal serrated lesions.METHODS:To accurately analyze the association between the histological types and molecular features of each type of serrated lesion,we consecutively collected1386 formalin-fixed paraffin-embedded tissue specimens that comprised all histological types[hyperplastic polyps(HPs,n=121),sessile serrated adenomas(SSAs,n=132),traditional serrated adenomas(TSAs,n=111),non-serrated adenomas(n=195),and colorectal cancers(n=827)].We evaluated the methylation levels of IGF2 DMR0 and long interspersed nucleotide element-1(LINE-1)in HPs(n=115),SSAs(n=120),SSAs with cytological dysplasia(n=10),TSAs(n=91),TSAs with high-grade dysplasia(HGD)(n=15),non-serrated adenomas(n=80),non-serrated adenomas with HGD(n=105),and CRCs(n=794).For the accurate quantification of the relative methylation levels(scale 0%-100%)of IGF2 DMR0 and LINE-1,we used bisulfite pyrosequencing method.Tumor specimens were analyzed for microsatellite instability,KRAS(codons 12 and 13),BRAF(V600E),and PIK3CA(exons 9and 20)mutations;MLH1 and MGMT methylation;and IGF2 expression by immunohistochemistry.RESULTS:The distribution of the IGF2 DMR0 methylation level in 351 serrated lesions and 185 non-serrated adenomas(with or without HGD)was as follows:mean61.7,median 62.5,SD 18.0,range 5.0-99.0,interquartile range 49.5-74.4.The IGF2 DMR0 methylation level was divided into quartiles(Q1≥74.5,Q2 62.6-74.4,Q3 49.6-62.5,Q4≤49.5)for further analysis.With regard to the histological type,the IGF2 DMR0 methylation levels of SSAs(mean±SD,73.1±12.3)were significantly higher than those of HPs(61.9±20.5),TSAs(61.6±19.6),and non-serrated adenomas(59.0±15.8)(P<0.0001).The IGF2 DMR0 methylation level was inversely correlated with the IGF2 expression level(r=-0.21,P=0.0051).IGF2 DMR0 hypomethylation was less frequently detected in SSAs compared with HPs,TSAs,and non-serrated adenomas(P<0.0001

关键词： BRAF Colon polyp Colorectal neoplasia Colorectum G

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Alpha-fetoprotein before and after pegylated interferon therapy for predicting hepatocellular carcinoma development

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World Journal of Hepatology 2015年第19期7卷 2220-2228页

作者： Yasuto Takeuchi Fusao Ikeda Toshiya Osawa Yasuyuki Araki Kouichi Takaguchi Youichi Morimoto Noriaki Hashimoto Kousaku Sakaguchi Tatsuro Sakata Masaharu Ando Yasuhiro Makino shuji Matsumura Hiroki Takayama Hiroyuki Seki Shintarou Nanba Yuki Moritou Tetsuya Yasunaka Hideki Ohnishi Akinobu Takaki Kazuhiro Nouso Yoshiaki Iwasaki Kazuhide yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharma- ceutical Sciences Department of Molecular Hepatology Okayama University Graduate School of Medicine Dentistry and Pharma- ceutical Sciences Department of Internal Medicine Okayama Saiseikai General Hospital Department of Internal Medicine Hiroshima City Hospital Department of Internal Medicine Kagawa Prefectural Central Hospital Department of Internal Medicine Kurashiki Central Hospital Department of Internal Medicine Mihara Red Cross hospital Department of Internal Medicine Fukuyama City Hospital Department of Internal Medicine National Hospital Organization Fukuyama Clinical Center Department of Internal Medicine Mitoyo General Hospital Department of Gastroenterology National Hospital Organization Iwakuni Clinical Center Department of Internal Medicine Sumitomo Besshi Hospital Department of Gastroenterology Tsuyama Central Hospital Health Service Center Okayama University

AIM: To investigate factors that accurately predict hepatocellular carcinoma(HCC) development after antiviral therapy in chronic hepatitis C(CHC) patients. METHODS: CHC patients who received pegylated interferon and ribavirin were enrolled in this cohort study that investigated the ability of alpha-fetoprotein(AFP) to predict HCC development after interferon(IFN) therapy. RESULTS: Of 1255 patients enrolled, 665 developed sustained virological response(SVR) during mean follow-up period of 5.4 years. HCC was occurred in 89 patients, and 20 SVR patients were included. Proportional hazard models showed that HCC occurred in SVR patients showing AFP ≥ 5 ng/m L before therapy and in non-SVR patients showing AFP ≥ 5 ng/m L before and 1 year after therapy besides older age, and low platelet counts. SVR patients showing AFP ≥ 5 ng/m L before therapy and no decrease in AFP to < 5 ng/m L 1 year after therapy had significantly higher HCC incidence than non-SVR patients showing AFP ≥ 5 ng/m L before therapy and decreased AFP(P = 0.043). AFP ≥ 5 ng/m L before therapy was significantly associated with low platelet counts and high values of alanine aminotransferase(ALT) in stepwise logistic regression analysis. After age, gender, platelet count, and ALT was matched by propensity score, significantly lower HCC incidence was shown in SVR patients showing AFP < 5 ng/m L before therapy than in those showing AFP ≥ 5 ng/m L.CONCLUSION: The criteria of AFP < 5 ng/m L before and 1 year after IFN therapy is a benefical predictor for HCC development in CHC patients.

关键词： Hepatitis C virus Interferon Hepatocellular carcin

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热时效对X80钢级埋弧焊管变形能力的影响

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钢管 2010年第5期39卷 16-24页

作者：下本豪纪滨田雅彦冈口修治高桥信明山本敬之竹内泉藤田周助张忠秀安立芬陶爱莲徐淑媛住友金属工业有限公司中国石油集团渤海装备华油钢管设计研究院河北青县062658 南京巨龙钢管公司江苏南京250000 乐亭电力局河北乐亭062658

X80钢级管线钢管的应用促进了管线运行压力的提高,因此对基于应变的管线设计(SBD)来说,有必要对X80钢级埋弧焊管的应变能力进行测定。在对应变能力的测定中,热时效对屈服现象的影响便成为其重要因素。本次研究中,进行了全尺寸钢管弯曲... 详细信息

X80钢级管线钢管的应用促进了管线运行压力的提高,因此对基于应变的管线设计(SBD)来说,有必要对X80钢级埋弧焊管的应变能力进行测定。在对应变能力的测定中,热时效对屈服现象的影响便成为其重要因素。本次研究中,进行了全尺寸钢管弯曲试验和有限元分析(FEA),用以弄清热时效对X80钢级UOE直缝焊管应变能力的影响;并采用有限元分析法对应变能力与应变要求之间的关系进行了研究。

关键词： X80钢级埋弧焊管热时效应力-应变曲线有限元分析应变能力

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