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Diagnosis and management of fibromuscular dysplasia and segmental arterial mediolysis in gastroenterology field: A mini-review

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World Journal of Gastroenterology 2018年第32期24卷 3637-3649页

作者： Masayoshi Ko Kenya Kamimura Kohei Ogawa Kentaro Tominaga Akira Sakamaki Hiroteru Kamimura Satoshi Abe Kenichi Mizuno shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

The vascular diseases including aneurysm, occlusion, and thromboses in the mesenteric lesions could cause severe symptoms and appropriate diagnosis and treatment are essential for managing patients. With the development and improvement of imaging modalities, diagnostic frequency of these vascular diseases in abdominal lesions is increasing even with the small changes in the vasculatures. Among various vascular diseases, fibromuscular dysplasia(FMD) and segmental arterial mediolysis(SAM) are noninflammatory, nonatherosclerotic arterial diseases which need to be diagnosed urgently because these diseases could affect various organs and be lethal if the appropriate management is not provided. However, because FMD and SAM are rare, the cause, prevalence, clinical characteristics including the symptoms, findings in the imaging studies, pathological findings, management, and prognoses have not been systematically summarized. Therefore, there have been neither standard diagnostic criteria nor therapeutic methodologies established, to date. To systematically summarize the information and to compare these disease entities, we have summarized the characteristics of FMD and SAM in the gastroenterological regions by reviewing the cases reported thus far. The information summarized will be helpful for physicians treating these patients in an emergency care unit and for the differential diagnosis of other diseases showing severe abdominal pain.

关键词： Fibromuscular dysplasia Segmental arterial mediolysis Mesenteric lesion diagnosis Humans

用药护理中断事件风险评价指标体系的构建及应用研究

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中华急危重症护理杂志 2024年第8期5卷 731-736页

作者：董小倩丁四清曹欢王星星甘港刘敏谢建飞王莎郑树基中南大学湘雅三医院护理部长沙市410013 中南大学湘雅护理学院 School of Health Sciences Western Sydney University

目的构建护士用药护理中断事件风险评价指标体系并临床应用。方法2023年1月—10月,以“基于安全信息流的事故致因概念模型”为理论基础,采用文献分析、质性访谈、德尔菲法及层次分析法,确定用药护理中断事件风险评价指标体系内容及各指... 详细信息

目的构建护士用药护理中断事件风险评价指标体系并临床应用。方法2023年1月—10月,以“基于安全信息流的事故致因概念模型”为理论基础,采用文献分析、质性访谈、德尔菲法及层次分析法,确定用药护理中断事件风险评价指标体系内容及各指标权重。应用该指标体系对湖南省某三级甲等医院440名护士进行评价。结果2轮函询问卷有效回收率为100%,专家权威系数为0.922和0.894,变异系数为0~0.240和0~0.188,肯德尔和谐系数为0.151和0.171。最终确定一级指标6项、二级指标17项、三级指标56项。指标体系的Cronbach'sα系数为0.746,平均内容效度指数为0.969。秩和检验结果显示,不同科室护士总分差异无统计学意义(P>0.05),但在管理和环境因素方面,差异具有统计学意义(P<0.05)。结论用药护理中断事件风险评价指标体系信效度好,指标科学合理、内容全面、专业性强,可为用药安全管理策略提供依据。

关键词：护理中断事件用药安全德尔菲技术护理管理研究

Remaining issues of recommended management in current guidelines for asymptomatic common bile duct stones

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World Journal of Gastroenterology 2021年第18期27卷 2131-2140页

作者： Hirokazu Saito Yoshihiro Kadono Takashi Shono Kentaro Kamikawa Atsushi Urata Jiro Nasu Haruo Imamura Ikuo Matsushita shuji Tada Department of Gastroenterology Kumamoto City HospitalKumamoto City 862-8505Japan Department of Gastroenterology Tsuruta HospitalKumamoto City 862-0925Japan Department of Gastroenterology Kumamoto Chuo HospitalKumamoto City 862-0965Japan Department of Gastroenterology Saiseikai Kumamoto HospitalKumamoto City 861-4193Japan Department of Gastroenterological Surgery Kumamoto Chuo HospitalKumamoto City 862-0965Japan

Current guidelines for treating asymptomatic common bile duct stones(CBDS)recommend stone removal,with endoscopic retrograde cholangiopan-creatography(ERCP)being the first treatment *** deciding on ERCP treatment for asymptomatic CBDS,the risk of ERCP-related complications and outcome of natural history of asymptomatic CBDS should be *** incidence rate of ERCP-related complications,particularly of post-ERCP pancreatitis for asymptomatic CBDS,was reportedly higher than that of symptomatic CBDS,increasing the risk of ERCP-related complications for asymptomatic CBDS compared with that previously reported for biliopancreatic *** studies have reported short-to middle-term outcomes of natural history of asymptomatic CBDS,its long-term natural history is not well *** date,there are no prospective studies that determined whether ERCP has a better outcome than no treatment in patients with asymptomatic CBDS or *** randomized controlled trial has evaluated the risk of early and late ERCP-related complications vs the risk of biliary complications in the wait-and-see approach,suggesting that a change is needed in our perspective on endoscopic treatment for asymptomatic *** studies examining long-term complication risks of ERCP and wait-and-see groups for asymptomatic CBDS are warranted to discuss whether routine endoscopic treatment for asymptomatic CBDS is justified or not.

关键词： Asymptomatic common bile duct stone Endoscopic retrograde cholangiopancreatography Complication Natural history of asymptomatic common bile duct stone Guideline Recommendation

Expression of AID, P53, and Mlh1 proteins in endoscopically resected differentiated-type early gastric cancer

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World Journal of Gastrointestinal Oncology 2012年第6期4卷 131-137页

作者： Yohei Takeda Kazuo Yashima Akihiro Hayashi shuji Sasaki Koichiro Kawaguchi Kenichi Harada Yoshikazu Murawaki Hisao Ito Division of Medicine and Clinical Science Faculty of Medicine Tottori University Division of Organ Pathology Faculty of Medicine Tottori University

AIM: To analyze the expression of the tumor-related proteins in differentiated-type early gastric carcinoma (DEGC) samples. METHODS: Tumor specimens were obtained from 102 patients (75 males and 27 females) who had received an endoscopic tumor resection at Tottori University Hospital between 2007 and 2009. Ninety-one cancer samples corresponded to noninvasive or intramucosal carcinoma according to the Vienna classification system, and 11 samples were submucosal invasive carcinomas. All of the EGCs were histologically differentiated carcinomas. All patients were classified as having Helicobacter pylori (H. pylori) infections by endoscopic atrophic changes or by testing seropositive for H. pylori IgG. All of the samples were histopathologically classified as either tubular or papillary adenocarcinoma according to their structure. The immunohistochemical staining was performed in a blinded manner with respect to the clinical information. Two independent observers evaluated protein expression. All data were statistically analyzed then. RESULTS: The rates of aberrant activation-induced cytidine deaminase (AID) expression and P53 overexpression were both 34.3% in DEGCs. The expression of Mlh1 was lost in 18.6% of DEGCs. Aberrant AID expression was not significantly associated with P53 overexpression in DEGCs. However, AID expression was associated with the severity of mononuclear cell activity in the non-cancerous mucosa adjacent to the tumor (P = 0.064). The rate of P53 expression was significantly greater in flat or depressed tumors than in elevated tumors. The frequency of Mlh1 loss was significantly increased in distal tumors, elevated gross-type tumors, papillary histological-type tumors, and tumors with a severe degree of endoscopic atrophic gastritis (P < 0.05). CONCLUSION: Aberrant AID expression, P53 overexpression, and the loss of Mlh1 were all associated with clinicopathological features and gastric mucosal alterations in DEGCs. The aberrant expression of AID p

关键词： Gastric cancer Activation-induced cytidine deaminase P53 Mlh1 Endoscopic resection

Effects of anti-hypertensive drugs on esophageal body contraction

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World Journal of Gastroenterology 2010年第8期16卷 987-991页

作者： Koichi Yoshida Kenji Furuta Kyoichi Adachi Shunji Ohara Terumi Morita Takashi Tanimura shuji Nakata Masaharu Miki Kenji Koshino Yoshikazu Kinoshita Second Department of Internal Medicine Shimane University Faculty of Medicine Department of Clinical Nursing Shimane University Faculty of Medicine

AIM:To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possi-ble relationship with gastro-esophageal reflux ***:Thirteen healthy male volunteers were enrolled. Esophageal body peristaltic contractions and lower esophageal sphincter (LES) pressure were measured using high resolution manometry. All subjects were randomly examined on four separate occasions following administrations of nifedipine,losartan,and atenolol,as well as without any drug ***:Peristaltic contractions by the esophageal body were separated into three segments by two troughs. The peak peristaltic pressures in the mid and lower segments of the esophageal body under atenolol administration were signifi cantly higher than those without medication in a supine position. On the other hand,peristaltic pressures under nifedipine administration were lower than those observed without drug ad-ministration. Losartan did not change esophageal body peristalsis. Atenolol elevated LES pressure and slowed peristaltic wave transition,while the effects of nifedip-ine were the opposite. CONCLUSION:Among the anti-hypertensive drugs tested,atenolol enhanced esophageal motor activity,which was in contrast to nifedipine.

关键词： Anti-hypertensive drug High-resolution manometry Lower esophageal sphincter Esophageal body contraction Calcium-channel blocker β1 blocker

Present the work condition in Japan 17th

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Present the work condition in Japan

Triple Range Imager and POLarimeter(TRIPOL)——a compact and economical optical imaging polarimeter for small telescopes

第十七届国际工效学大会暨中国人类工效学会成立20周年庆祝大会

作者： shuji Hisamune Department of Economics Takasaki City Univ.of Economics 1300 Kaminamiye

Japan is critical that the country focus not only on responding to declining population,population aging,and low birthrate issues,but also with globalization and an advanced industrial *** is important to develop a society in which each worker is motivated to work and can demonstrate their *** order to achieve this goal,public interest must be raised and proper measures should be *** a society with a declining population,it is also necessary to develop care services for children and the elderly so that the life and work of those caring for the elderly and children becomes more *** members of society,including the young,female,elderly,and the disabled should work and support each *** it is important to stop this acceleration by developing a system to promote the supply of manpower from the elderly,youth,and disabled workforces by ergonomic technology.

关键词： Disabled Persons globalisation Labor Force Workers Manpower CARING aged person Japan acceleration Working Conditions Child

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Research in Astronomy and Astrophysics 2019年第9期19卷 149-158页

作者： shuji Sato Po Chieh Huang Wen Ping Chen Takahiro Zenno Chakali Eswaraiah Bo He Su Shinsuke Abe Daisuke Kinoshita Jia Wei Wang Astrophysics Department Nagoya UniversityNagoya464–8602Japan Graduate Institute of Astronomy NCUTaoyuan32001 Department of Physics and Institute of Astronomy NTHUHsinchu30013

We report the design concept and performance of a compact, lightweight and economical imaging polarimeter, the Triple Range Imager and POLarimeter(TRIPOL), capable of simultaneous optical imagery and polarimetry. TRIPOL splits the beam in wavelengths from 400 to 830 nm into g′-, r′-and i′-bands with two dichroic mirrors, and measures polarization with an achromatic half-waveplate and a wire grid polarizer. The simultaneity makes TRIPOL a useful tool for small telescopes for the photometry and polarimetry of time variable and wavelength dependent phenomena. TRIPOL is designed for a Cassegrain telescope with an aperture of^1 m. This paper presents the engineering considerations of TRIPOL and compares the expected with observed performance. Using the Lulin 1-m telescope and 100 seconds of integration, the limiting magnitudes are g′~19.0 mag, r′~18.5 mag and i′~18.0 mag with a signal-to-noise ratio of 10, in agreement with design expectation. The instrumental polarization is measured to be^0.3% in the three bands. Two applications, one to the star-forming cloud IC 5146 and the other to the young variable GM Cep, are presented as demonstrations.

关键词： instrumentation:photometers instrumentation:polarimeters techniques:photometric techniques:polarimetric methods:observational ISM:magnetic fields

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低压静电场处理对鱿鱼保鲜效果的影响

食品研究与开发 2024年第18期45卷 99-105页

作者：方旭波刘淑集曹蓉露蒋丽萍项德胜陈小娥浙江国际海运职业技术学院浙江舟山316021 福建省水产研究所国家海水鱼类加工技术研发中心福建省海洋生物增养殖与高值化利用重点实验室福建厦门361013 浙江海洋大学食品与药学学院浙江舟山316022 浙江大洋兴和食品有限公司浙江舟山316014

为探究低压静电场(low voltage electrostatic field,LVEF)处理对鱿鱼贮藏品质的影响,采用pH值、蒸煮损失率、挥发性盐基氮(total volatile basicnitrogen,TVB⁃N)和硫代巴比妥酸(thiobarbituric acid,TBA)等评价指标,以无电场处理的样品为对照组,研究比较低压静电场贮藏条件下的鱿鱼品质变化情况。结果表明,低压静电场处理能够改善鱿鱼的贮藏品质。随着贮藏时间的延长,LVEF组的样品pH值增加缓慢;贮藏期间对照组的蒸煮损失率、TVB⁃N值始终低于LVEF组,且当贮藏至15 d时LVEF组的TBA值远低于对照组的1.24 mg/kg;低压静电场对微生物繁殖有明显的抑制作用,贮藏15 d内LVEF组菌落总数均低于6 lg(CFU/g);在硬度、弹性、感官评价和蒸煮损失率上LVEF组均优于对照组。此外,十二烷基硫酸钠⁃聚丙烯酰胺凝胶电泳分析显示LVEF组条带未发生明显变化,故低压静电场处理能更好地保持鱿鱼品质。

关键词：鱿鱼低压静电场保鲜品质十二烷基硫酸钠⁃聚丙烯酰胺凝胶电泳

Liver-targeted hydrodynamic gene therapy: Recent advances in the technique

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World Journal of Gastroenterology 2016年第40期22卷 8862-8868页

作者： Takeshi Yokoo Kenya Kamimura Hiroyuki Abe Yuji Kobayashi Tsutomu Kanefuji Kohei Ogawa Ryo Goto Masafumi Oda Takeshi Suda shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University Institute for Research Collaboration and Promotion Niigata University

One of the major research focuses in the field of gene therapy is the development of clinically applicable, safe, and effective gene-delivery methods. Since the first case of human gene therapy was performed in 1990, a number of gene-delivery methods have been developed, evaluated for efficacy and safety, and modified for human application. To date, viral-vectormediated deliveries have shown effective therapeutic results. However, the risk of lethal immune response and carcinogenesis have been reported, and it is still controversial to be applied as a standard therapeutic option. On the other hand, delivery methods for nonviral vector systems have been developed, extensively studied, and utilized in in vivo gene-transfer studies. Compared to viral-vector mediated gene transfer, nonviral systems have less risk of biological reactions. However, the lower gene-transfer efficiency was a critical hurdle for applying them to human gene therapy. Among a number of nonviral vector systems, our studies focus on hydrodynamic gene delivery to utilize physical force to deliver naked DNA into the cells in the living animals. This method achieves a high gene-transfer level by DNA solution injections into the tail vein of rodents, especially in the liver. With the development of genome editing methods, in vivo gene-transfer therapy using this method is currently the focus in this research field. This review explains the method principle, efficiency, safety, and procedural modifications to achieve a high level of reproducibility in large-animal models.

关键词： Gene therapy liver Hydrodynamic gene delivery Non-viral image-guided