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Molecular evolution of Toll-like receptors in rodents

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Integrative Zoology 2024年第3期19卷 371-386页

作者： Qianqian SU Yi CheN Hongxuan he College of Forestry Central South University of Forestry and TechnologyChangshaChina National Research Center for Wildlife-Borne Diseases Institute of ZoologyChinese Academy of SciencesBeijingChina

Toll-like receptors(TLRs),the key sensor molecules in vertebrates,trigger the innate immunity and prime the adaptive immune *** TLR family of rodents,the largest order of mammals,typically contains 13 TLR ***,a clear picture of the evolution of the rodent TLR family has not yet emerged and the TLR evolutionary patterns are unclear in rodent ***,we analyzed the natural variation and the evolutionary processes acting on the TLR family in rodents at both the interspecific and population *** results showed that rodent TLRs were dominated by purifying selection,but a series of positively selected sites(PSSs)primarily located in the ligand-binding domain was also *** numbers of PSSs differed among TLRs,and nonviralsensing TLRs had more PSSs than those in viral-sensing ***-conversion events were found between TLR1 and TLR6 in most rodent *** genetic analyses showed that TLR2,TLR8,and TLR12 were under positive selection in Rattus norvegicus and ***,whereas positive selection also acted on TLR5 and TLR9 in the former species,as well as TLR1 and TLR7 in the latter ***,we found that the proportion of polymorphisms with potentially functional change was much lower in viral-sensing TLRs than in nonviral-sensing TLRs in both of these rat *** findings revealed the first thorough insight into the evolution of the rodent TLR genetic variability and provided important novel insights into the evolutionary history of TLRs over long and short timescales.

关键词： adaptive evolution gene conversion positive selection rodents Toll-like receptors

Underwater inertial error rectification with limited acoustic observations

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Satellite Navigation 2024年第1期5卷 207-223页

作者： Hongqiong Tang Hongyang he Fangneng Li Jiangning Xu Department of Navigation Engineering Naval University of EngineeringWuhan430000China

Underwater inertial navigation is particularly difficult for the long-durance operations as many navigation systems such global satellite navigation systems are *** acoustic signal is a marvelous choice for underwater inertial error rectification due to its underwater penetration ***,the traditional Acoustic Positioning Systems(APS)are expensive and incapable of positioning with limited acoustic *** novel underwater inertial error rectification algorithms with limited acoustic observations are *** first one is the single acoustic-beacon Range-only Matching Aided Navigation(RMAN)method,which is inspired by matching navigation without reference maps and presented for the first *** second is the improved single acoustic-beacon Virtual Long Baseline(VLBL)method,which considers the impact of indicated relative position increments on virtual beacon *** RMAN and improved VLBL are further developed when multi acoustic-beacons are available,named mAB-RMAN and *** comprehensive simulations and field investigations were *** results demonstrated that the proposed methods achieved excellent accuracy and stability compared to the baseline,specifically,the mAB-RMAN and mAB-VLBL can reduce the inertial error by more than 90%and 98%when using single and double acoustic-beacons,*** proposed techniques will provide new perspectives for underwater positioning,navigation,and timing.

关键词： Underwater PNT Range-only matching aided navigation Virtual long baseline Inertial error rectification

Gravitational wave footprints from Higgs-portal scalegenesis with multiple dark chiral scalars

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Chinese Physics C 2024年第4期48卷 209-221页

作者： he-Xu Zhang Shinya Matsuzaki Hiroyuki Ishida Center for Theoretical Physics and College of Physics Jilin UniversityChangchun 130012China Center for Liberal Arts and Sciences Toyama Prefectural UniversityToyama 939-0398Japan

We discuss the gravitational wave(GW)spectra predicted from the electroweak scalegenesis of the Higgs portal type with a large number of dark chiral flavors,which many flavor QCD would underlie and give the dynamical explanation of the negative Higgs portal coupling required to trigger the electroweak symmetry *** employ the linear-sigma model as the low-energy description of dark many flavor QCD and show that the model undergoes ultra-supercooling due to the produced strong first-order thermal phase transition along the(approximately realized)flat direction based on the Gildener-Weinberg *** through evaluation of the bubble nucleation/percolation,we address the reheating and relaxation processes,which are generically non-thermal and *** the reheating epoch in terms of the e-folding number,we propose proper formulae for the redshift effects on the GW frequencies and signal *** then turns out that the ultra-supercooling predicted from the Higgs-portal scalegenesis generically yields none of GW signals with the frequencies as low as nano Hz,unless the released latent heat is transported into another sector other than reheating the ***,models of this class prefer to give the higher frequency signals and still keeps the future prospected detection sensitivity,like at LISA,BBO,and DECIGO,*** also find that with large flavors in the dark sector,the GW signals are made further smaller and the peak frequencies *** phenomenological consequences related to the multiple chiral scalars include the prediction of dark pions with the mass much less than TeV scale,which is also briefly addressed.

关键词： gravitational wave electroweak scalegenesis many flavor QCD

Distributed generalized Nash equilibrium seeking:event-triggered coding-decoding-based secure communication

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Science China(Information Sciences) 2024年第7期67卷 271-284页

作者： Shaofu YANG Wenying XU Wangli he Jinde CAO School of Computer Science and Engineering Southeast University School of Mathematics Southeast University Key Laboratory of Advanced Control and Optimization for Chemical Processes East China University of Science and Technology

In this paper, we consider the distributed generalized Nash equilibrium(GNE) seeking problem in strongly monotone games. The transmission among players is implemented through a digital communication network with limited bandwidth. For improving communication efficiency or/and security, an event-triggered coding-decoding-based communication is first proposed, where the data(decision variable) are first mapped to a series of finite-level codewords and, only when an event condition is satisfied, then sent to the neighboring agents. Moreover, a distributed communication-efficient GNE seeking algorithm is constructed accordingly,and the overrelaxation scheme is further taken into consideration. Through primal-dual analysis, the proposed algorithm is proven to converge to a variational GNE with fixed step-sizes by recasting it as an inexact forward-backward iteration. Finally, numerical simulations illustrate the benefit of the proposed algorithms in terms of saving communication resources.

关键词： noncooperative games event-triggered communication coding-decoding quantization

Recycling the spent electronic materials to construct a highperformance Cu_(1.94)S/ZnS heterostructure anode of sodium-ion batteries

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Nano Research 2024年第5期17卷 4006-4015页

作者： Xiaowei he Tianshuai Wang Lidong Tian Qiuyu Zhang School of Chemistry and Chemical Engineering Xi’an Key Laboratory of Functional Organic Porous MaterialsKey Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information TechnologyNorthwestern Polytechnical UniversityXi’an 710072China Chongqing Science and Technology Innovation Center of Northwestern Polytechnical University Chongqing 401135China College of Materials Science and Engineering Xi’an University Science and TechnologyXi’an 710054China

heterostructure engineering by coupling different nanocrystals has received extensive attention because it can enhance the reaction kinetics of the anode of sodium-ion batteries(SIBs).However,constructing high-quality heterostructure anode materials through green and environmentally friendly methods remains a ***,we have proposed a simple one-step method by recycling the electronic waste metal materials to synthesize the Cu_(1.94)S/ZnS heterostructure *** with the experimental analysis and first principle calculations,we find that the synergistic effect of different components in heterostructure structures can significantly enhance the reversible capacity and rate performance of anode *** on the constructed Cu_(1.94)S/ZnS anode,we obtain a superior reversible capacity of 440 mAh·g^(-1) at 100 mA·g^(-1) and 335 mAh·g^(-1) after 3000 cycles at 2000 mA·g^(-1).Our work sheds new light on designing high-rate and capacity anodes for SIBs through the greenness synthesis method.

关键词： sodium-ion batteries heterostructure reversible capacity environmentally synthesis process

A novel and promising engineering application of carbon dots:Enhancing the chloride binding performance of cement

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Chinese Chemical Letters 2024年第6期35卷 409-416页

作者： Wu-Jian Long Yang Yu Chuang he Guangdong Provincial Key Laboratory of Durability for Marine Civil Engineering Key Lab of Coastal Urban Resilient InfrastructureMOECollege of Civil and Transportation EngineeringShenzhen UniversityShenzhen 518060China

Corrosion of reinforcement induced by chloride invasion is extensively considered as the dominating deterioration mechanism of reinforced concrete(RC)structures,leading to serious safety hazards and tremendous economic ***,it still lacks well dispersive and cost-efficient nanomaterials to improve the anti-chloride-corrosion ability of RC ***,specific carbon dots(CDs)with high dispersity and low cost are deliberately designed,successfully prepared by hydrothermal processing,and then firstly applied to immensely enhance chloride binding performance of cement,thereby contributing to suppressing the corrosion of ***,the tailored CDs are composed of the carbon core with highly crystalline sp^(2)C structures and oxygen-containing groups connecting on the carbon core;The typical equilibrium test confirms that with respect to that of the blank cement paste,the chloride binding capacity of cement paste involving 0.2 wt%(by weight of cement)CDs is increased by 109% after 14-day exposure to 3 mol/L Na Cl solution;according to comprehensive analyses of phase compositions,the chloride binding mechanism of CDs-modified cement is rationally attributed to the fact that the incorporation of CDs advances the formation of calcium silicate hydrate(C-S-H)gels and Friedel's salt(Fs),thus enormously enhancing the physically adsorbed and chemically bound chloride ions of cement *** work not only firstly provides a novel high-dispersity and low-cost nanomaterial toward the durability enhancement of RC structures,but also broadens the application of CDs in the field of engineering,conducing to stimulating their industrialization development.

关键词： Carbon dots Chloride binding Cement Chloride binding mechanism Friedel’s salt

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辣椒Arf GAP基因的克隆与表达分析

中国农学通报 2012年第34期28卷 184-189页

作者：冯冬林赖燕何水林福建农林大学园艺学院福州350002 福建农业职业技术学院福州350007 福建农林大学生命科学学院福州350002

ADP核糖基化因子(Arf)GTP酶激活蛋白(GAPs)能够促使束缚于Arfs的GTP水解为GDP,通过转化具有活性的GTP束缚型为非活性的GDP束缚型从而达到调节Arfs的作用。本研究从辣椒幼苗叶片cDNA文库中筛选获得1个阳性克隆。核苷酸序列分析表明,该基... 详细信息

ADP核糖基化因子(Arf)GTP酶激活蛋白(GAPs)能够促使束缚于Arfs的GTP水解为GDP,通过转化具有活性的GTP束缚型为非活性的GDP束缚型从而达到调节Arfs的作用。本研究从辣椒幼苗叶片cDNA文库中筛选获得1个阳性克隆。核苷酸序列分析表明,该基因编码含有1个408个氨基酸残基,分子量约为43.98kD,含有1个保守的Arf GAP结构域,与葡萄、大豆中的AGD8-Like基因的同源性分别为73%和71%,与拟南芥AtAGD8同源性为65%,命名为CaAGD8。实时荧光定量PCR检测表明,与对照相比,CaAGD8基因的相对表达量在辣椒茎、叶、花及果实中表达量升高。

关键词：辣椒 Arf GAP 表达

“Blocking and rebalance” mechanism-guided design strategies of bimetallic doped 2D a-phosphorus carbide as efficient catalysts for N2 electroreduction

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Journal of Energy Chemistry 2024年第10期97卷 68-78页

作者： Cheng he Jianglong Ma Shen Xi Wenxue Zhang State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and Engineering Xi'an Jiaotong University School of Materials Science and Engineering Chang'an University

Compared to single atom catalysts（SACs）,the introduction of dual atom catalysts（DACs） has a significantly positive effect on improving the efficiency in the electrocatalytic nitrogen reduction reaction（NRR） which provides an environmental alternative to the Haber-Bosch ***,the research on the mechanism and strategy of designing bimetallic combinations for better performance is still in its early ***,based on "blocking and rebalance" mechanism,45 combinations of bimetallic pair doped α-phosphorus carbide（TMATMB@PC） are investigated as efficient NRR catalysts through density functional theory and machine learning *** a multi-step screening,the combinations of TiV,TiFe,MnMo,and FeW exhibit highly efficient catalytic performance with significantly lower limiting potentials（-0.17,-0.18,-0.14,and-0.30 V,respectively）.Excitingly,the limiting potential for CrMo and CrW combinations is 0 V,which are considered to be extremely suitable for the NRR *** mechanism of "blocking and rebalance" is revealed by the exploration of charge transfer for phosphorus atoms in electron blocking ***,the descriptor φ is proposed with machine learning,which provides design strategies and accurate prediction for finding efficient *** work not only offers promising catalysts TMATMB@PC for NRR process but also provides design strategies by presenting the descriptor φ.

关键词： 2D α-phosphorus carbide DACs Inherent attributes Machine learning Nitrogen reduction reaction

Imaging of human parafoveal area with large field of view in adaptive optics line scanning ophthalmoscope

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Journal of Innovative Optical health Sciences 2024年第6期17卷 41-51页

作者： Wen Kong Yiwei Chen Guohua Shi Yi he Department of Biomedical Engineering University of Science and Technology of ChinaHefei 230041P.R.China Jiangsu Key Laboratory of Medical Optics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163P.R.China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031P.R.China Key Laboratory of Myopia of State health Ministry and Key Laboratory of Visual Impairment and Restoration of ShanghaiShanghai 200003P.R.China

The parafoveal area,with its high concentration of photoreceptors andfine retinal capillaries,is crucial for central vision and often exhibits early signs of pathological *** current adaptive optics scanning laser ophthalmoscope(AOSLO)provides an excellent tool to acquire accurate and detailed information about the parafoveal area with cellular ***,limited by the scanning speed of two-dimensional scanning,thefield of view(FOV)in the AOSLO system was usually less than or equal to 2,and the stitching for the parafoveal area required dozens of images,which was time-consuming and ***,almost half of patients are unable to obtain stitched images because of their *** solve this problem,we integrate AO technology with the line-scan imaging method to build an adaptive optics line scanning ophthalmoscope(AOLSO)system with a larger *** the AOLSO,afocal spherical mirrors in pairs are nonplanar arranged and the distance and angle between optical elements are optimized to minimize the aberrations,two cylinder lenses are orthogonally placed before the imaging sensor to stretch the point spread function(PSF)for su±ciently digitizing light *** human retinal images show the whole parafoveal area with 55FOV,60 Hz frame rate and cellular *** advantage of the 5FOV of the AOLSO,only 9 frames of the retina are captured with several minutes to stitch a montage image with an FOV of 99,in which photoreceptor counting is performed within approximately 5*** AOLSO system not only provides cellular resolution but also has the capability to capture the parafoveal region in a single frame,which offers great potential for noninvasive studying of the parafoveal area.

关键词： Adaptive optics line scanning retinal imaging system parafoveal capillary vasculature.