检索结果-南通市图书馆

Induction of Cytochrome P450 2A6 by Bilirubin in Human Hepatocytes

Pharmacology & Pharmacy 2013年第2期4卷 182-190页

作者： Hiromi Tanii Yoshihisa Shitara Mikako Torii shuichi sekine Hiroshi Iwata Toshiharu Horie Department of Biopharmaceutics Chiba University Chiba Japan Drug Metabolism and Analysis Department Mitsubishi Chemical Medience Corporation Ibaraki Japan Oncology Development Department Novartis Pharma K.K. Tokyo Japan

The influence of bilirubin on mRNA expression of cytochrome P450 (CYP), UDP-glucuronosyltransferase (UGT) and nuclear receptors in human hepatocytes was investigated. The treatment of the hepatocytes with 40 μg/mL bilirubin, which corresponds to hyperbilirubinemia, resulted in 1.7-fold increase of CYP2A6 mRNA compared to the vehicle control while CYP2A6 mRNA did not change after treatment with 1 μg/mL bilirubin, corresponding to physiologically normal level. No significant change of mRNA expression by 40 μg/mL bilirubin treatment was observed for CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4 and CYP3A5, UGT1A1, UGT1A3, UGT1A6, UGT2B4, UGT2B7, UGT2B10 and UGT2B15, constitutive androstane receptor (CAR), pregnane X receptor (PXR), retinoid X receptor α (RXRα) and hepatocyte nuclear factor-4α (HNF-4α). The induction profile of bilirubin was different from that of rifampicin, a typical PXR activator. This study demonstrated that CYP2A6 can be induced by bilirubin in a concentration dependent manner.

关键词： CYP2A6 Hepatocytes Hyperbilirubinemia RT-PCR

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Measurement Method of Internal Residual Stress in Plastic Parts Using Terahertz Spectroscopy

引用

Nanomanufacturing and Metrology 2021年第1期4卷 46-52页

作者： Yusuke Kajihara Rio Takahashi Ichiro Yoshida Shingo Saito Norihiko sekine shuichi Nowatari Shigeo Miyake Institute of Industrial Science The University of TokyoKomaba 4-6-K Meguro-kuTokyoJapan Hosei University Kajino 3-7-2.KoganeiTokyoJapan National Institute of Information and Communications Technology Nukui-Kitamachi 4-2-1KoganeiTokyoJapan Iida Co. LtdNukazawa Mizukami 21-2MotomiyiaFukushimaJapan

Since internal residual stress in polymers causes dimension errors over time,a measurement method for residual stress in polymers,especially in opaque engineering plastics,is strongly *** this study,we propose to utilize terahertz(THz)spectroscopy to non-destructively measure internal residual stress in *** verify the validity of the proposed method,we manufactured polytetrafluoroethylene ring samples with and without residual stress,and studied them with THz time domain spectroscopy *** spectra of samples without residual stress showed almost no polarization difference,whereas spectra of samples with residual stress showed clear polarization *** changes between the samples with and without residual stress were also estimated and it was found that the change had a correlation with THz polarization *** experimental analyses confirm the validity for the proposed non-destructive measurement of residual stress in polymer.

关键词： Engineering plastics Residual stress Polarization Terahertz spectroscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：