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Non-ossifying fibromas: Case series, including in uncommon upper extremity sites

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World Journal of Orthopedics 2017年第7期8卷 561-566页

作者： Akio Sakamoto Ryuzo Arai Takeshi Okamoto shuichi matsuda Department of Orthopaedic Surgery Graduate School of Medicine Kyoto University

AIM To investigate non-ossifying fibromas(NOFs) common fibrous bone lesions in children that occur in bones of the lower *** We analyzed 44 cases of NOF including 47 lesions, which were referred with a working diagnosis of neoplastic lesions. Lesions were located in the upper extremities(1 proximal humerus, 1 distal radius) and the lower extremities(25 distal femurs, 12 proximal and 4 distal tibias, and 4 proximal fibulas).RESULTS Three cases had NOFs in multiple anatomical locations(femur and fibula in 1 case, femur and tibia in 2 cases). Overall, larger lesions > 4 cm and lesion expansion at the cortex were seen in 21% and 32% of cases, respectively. Multiple lesions with bilateral symmetry in the lower extremities suggest that these NOFs were developmental bone defects. Two patients suffered from fracture and were treated without surgery, one in the radius and one in the femur. Lesions in the upper extremities(i.e., humerus of a 4-year-old female and radius of a 9-year-old male) expanded at the cortex and lesion size increased with slow *** NOFs in the lower extremity had fewer clinical problems, regardless of their size and expansiveness. In these two upper extremity cases, the NOFs had aggressive biological features. It seems that there is a site specific difference, especially between the upper extremity and the lower extremity. Furthermore, NOFs in the radius are predisposed to fracture because of the slender structure of the radius and the susceptibility to stress.

关键词： Non-ossifying fibroma Humerus Radius Fibula Upper extremity

Myelin protein zero (P0)- and Wnt1-Cre marked muscle resident neural crest-derived mesenchymal progenitor cells give rise to heterotopic ossification in mouse models

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Genes & Diseases 2023年第3期10卷 731-734页

作者： Chengzhu Zhao Yoshiko Inada Kazuya Sekiguchi Kyosuke Hino Megumi Nishio Yasuhiro Yamada shuichi matsuda Junya Toguchida Makoto Ikeya Department of Clinical Application Center for iPS Cell Research and Application(CiRA)Kyoto UniversitySakyo-kuKyoto 606-8507Japan Laboratory of Skeletal Development and Regeneration Institute of Life SciencesChongqing Medical UniversityChongqing 400016China Department of Cell Growth and Differentiation Center for iPS Cell Research and Application(CiRA)Kyoto UniversitySakyo-kuKyoto 606-8507Japan Department of Orthopaedic Surgery Graduate School of MedicineKyoto UniversitySakyo-kuKyoto 606-8507Japan Regenerative&Cellular Medicine Kobe Center Sumitomo Pharma Co.Ltd.Konohana-kuOsaka 554-0022Japan Division of Stem Cell Pathology Center for Experimental Medicine and Systems BiologyInstitute of Medical ScienceUniversity of TokyoMinato-kuTokyo 108-8639Japan Department of Regeneration Sciences and Engineering Institute for Frontier Life and Medical SciencesKyoto UniversitySakyo-kuKyoto 606-8507Japan

Heterotopic ossification(HO)describes bone formation at non-skeletal sites and results from traumatic injury,surgery,or genetic disease such as fibrodysplasia ossificans progressiva(FOP).1,2 Although it is known that BMP signaling regulates HO,knowledge about the developmental origin of the osteogenic progenitors responsible for the BMP-associated metamorphosis is comparably *** the use of transgenic mice and labelled neural crest-derived cell,3 we found myelin protein zero(P0,or MPZ)-and Wnt1-lineage cells give rise to BMP-7 induced adult ectopic cartilage and bone.

关键词： progenitor ossification neural

System describing surgical field extension associated with flap reconstruction after resection of a superficial malignant soft tissue tumor

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World Journal of Clinical Oncology 2023年第11期14卷 471-478页

作者： Akio Sakamoto Takashi Noguchi shuichi matsuda Department of Orthopaedic Surgery Graduate School of MedicineKyoto UniversityKyoto 606-8507Japan

BACKGROUND Flap reconstruction after resection of a superficial malignant soft tissue tumor extends the surgical field and is an indicator for potential recurrence *** To describe a grading system for surgical field extension of soft tissue *** Grading system:CD-grading is a description system consisting of C and D values in the surgical field extension,which are related to the compartmental position of the flap beyond the nearby large joint and deeper extension for the pedicle,respectively.C1/D1 are positive values and C0/D0 are *** a known location,1/0 values can be"p"(proximal),"d"(distal),and"b"(in the tumor bed),and the description method is as follows:flap type,CxDx[x=0,1,p,d or b].RESULTS Four representative patients with subcutaneous sarcomas who underwent reconstruction using fasciocutaneous flaps are *** cases involved a distal upper arm(elbow)synovial sarcoma reconstructed using a pedicled latissimus dorsi(pedicled flap:CpDp);a distal upper arm(elbow)pleomorphic rhabdomyosarcoma reconstructed using a transpositional flap from the forearm(transpositional flap:CdD0);an undifferentiated pleomorphic sarcoma in the buttocks reconstructed using a transpositional flap(transpositional flap:C0D0);and a myxofibrosarcoma in the buttocks reconstructed using a propeller flap from the thigh(pedicled flap:CdDd).CONCLUSION The reconstruction method is chosen by the surgeon based on size,location,and other tumor characteristics;however,the final surgical field cannot be determined based on preoperative images ***-grading is a description system consisting of C and D values in the surgical field extension that are related to the compartmental position of the flap beyond the nearby large joint and deeper extension for the pedicle,*** CD-grading system gives a new perspective to the flap reconstruction *** CD-grading system also provides important information for follow-up imaging of a possible recurrenc

关键词： Soft tissue Sarcoma Surgery Sarcoma Grading system Surgical flap

Rice Stomatal Closure Requires Guard Cell Plasma Membrane ATP-Binding Cassette Transporter RCN1/OsABCG5

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Molecular Plant 2016年第3期9卷 417-427页

作者： shuichi matsuda Sho Takano Moeko Sato Kaoru Furukawa Hidetaka Nagasawa Shoko Yoshikawa Jun Kasuga Yoshihiko Tokuji Kazufumi Yazaki Mikio Nakazono Itsuro Takamure Kiyoaki Kato Department of Agro-environmental Science Obihiro University of Agricultural and Veterinary Medicine 2-11 Nishi Inada Obihiro Hokkaido 080-0834 Japan Department of Food Science Obihiro University of Agricultural and Veterinary Medicine 2-11 Nishi Inada Obihiro Hokkaido 080-0834 Japan Research Institute for Sustainable Humanosphere Kyoto University Gokasho Uji Kyoto 611-0011 Japan Graduate School of Bioagricultural Sciences Nagoya University Furo-cho Chikusa Nagoya Aichi 464-8601 Japan Graduate School of Agriculture Hokkaido University Kita 9 Nishi 9 Kita-ku Sapporo Hokkaido 060-8589 Japan

Water stress is one of the major environmental stresses that affect agricultural production worldwide. Water loss from plants occurs primarily through stomatal pores. Here, we report that an Oryza sativa half-size ATP-binding cassette （ABC） subfamily G protein, RCN 1/OsABCG5, is involved in stomatal closure mediated by phytohormone abscisic acid （ABA） accumulation in guard cells. We found that the GFP-RCN1/ OsABCG5-fusion protein was localized at the plasma membrane in guard cells. The percentage of guard cell pairs containing both ABA and GFP-RCN1/OsABCG5 increased after exogenous ABA treatment, whereas they were co-localized in guard cell pairs regardless of whether exogenous ABA was applied. ABA application resulted in a smaller increase in the percentage of guard cell pairs containing ABA in rcnl mutant （A684P） and RCN1-RNAi than in wild-type plants. Furthermore, polyethylene glycol （drought stress）-inducible ABA accumulation in guard cells did not occur in rcnl mutants. Stomata closure mediated by exogenous ABA application was strongly reduced in rcnl mutants. Finally, rcnl mutant plants had more rapid water loss from detached leaves than the wild-type plants. These results indicate that in response to drought stress, RCN1/OsABCG5 is involved in accumulation of ABA in guard cells, which is indispensable for stomatal closure.

关键词： stomatal closure abscisic acid ABC transporter rice drought stress

The 45-Degree Arthroscope Improves Visualization of the Femoral Attachment of the Anterior Cruciate Ligament

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Surgical Science 2012年第1期3卷 43-46页

作者： Ken Okazaki shuichi matsuda Yasutaka Tashiro Yukihide Iwamoto Department of Orthopaedic Surgery Graduate School of Medical Sciences Kyushu University Fukuoka Japan

Background: Exposure of the insertion site of the anterior cruciate ligament (ACL) is important for appropriate tunnel placement in ACL reconstruction surgery. However, observing the femoral ACL insertion site via the standard anterolateral portal is sometimes difficult. In this study, we compared views of the femoral ACL insertion site between 30-degree and the 45-degree arthroscopes. Methods: We first inserted the 30-degree and the 45-degree arthroscope into the anterolateral portal of a knee simulator in which we had drawn a lattice pattern on the lateral intercondylar notch based on the quadrant method. Next, we compared the arthroscopic views provided by the 30-degree and 45-degree arthroscopes during ACL reconstruction surgery by measuring the area of the lateral intercondylar notch visible through each of the arthroscopes. Results: In the knee simulator, the 45-degree arthroscope showed the entire area of the lateral intercondylar notch, whereas the 30-degree arthroscope had to be introduced more deeply to show the most superior and posterior quadrant, where the attachment of the anteromedial bundle of ACL is located. During the ACL reconstruction, the area of the lateral intercondylar notch in the field of view was larger through the 45-degree arthroscope than through the 30-degree arthroscope. Conclusion: The 45-degree arthroscope provides a better view of the femoral ACL insertion site via the anterolateral portal, which may be helpful during ACL reconstruction.

关键词： Arthroscope Knee Anterior Cruciate Ligament (ACL) Surgical Device

CT-guided radiofrequency ablation of osteoid osteoma in the long bones of the lower extremity

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World Journal of Radiology 2012年第6期4卷 278-282页

作者： Yoshiki Asayama Akihiro Nishie Kousei Ishigami Daisuke Kakihara Yasuhiro Ushijima Yukihisa Takayama Nobuhiro Fujita Tsuyoshi Tajima Kengo Yoshimitsu shuichi matsuda Yukihide Iwamoto Hiroshi Honda Department of Clinical Radiology Graduate School of Medical SciencesKyushu University3-1-1 MaidashiHigashikuFukuoka 812-8582Japan Department of Molecular Imaging and Diagnosis Kyushu University3-1-1 MaidashiHigashi-kuFukuoka 812-8582Japan Department of Diagnostic Imaging and Nuclear Medicine Tokyo Women’s Medical University8-1 KawadachoShinjuku-kuTokyo 162-8666Japan Department of Radiology Fukuoka University7-45-1 NanakumaJonan-kuFukuoka 814-0180Japan Department of Orthopaedic Surgery Kyushu University3-1-1 MaidashiHigashi-kuFukuoka 812-8582Japan

AIM:To present our initial experience with computed tomography guided radiofrequency ablation(RFA) of osteoid osteoma(OO) in our ***:RFA was performed on eight patients(5 males and 3 females) with clinically and radiologically diagnosed OO(femoral neck,n = 4;femoral diaphysis,n = 2;tibial diaphysis,n = 1;fibular diaphysis,n = 1).Ablation was performed using an electrode with a 10-mm exposed tip for a total of 4-6 min at a targeted temperature of 90 degrees *** cooling system was *** intervention was accepted as technically successful if the tip of the electrode could be placed within the center of the *** defined clinical success as a disappearance within 2 wk after treatment of symptoms that had manifested at ***:All procedures were technically *** major or immediate complications were *** success was achieved in six of eight patients in the first procedure.A second procedure was performed for two patients who had recurrent or continued pain,and one of these cases was successfully *** overall rate of success was 87.5%(7/8).No complication was ***:Our preliminary results indicate a favorable success rate and no complications and are compatible with the previous reports of RFA of OO.

关键词： Ablation Osteoid osteoma Computed tomography

The 45-Degree Arthroscope Improves Visualization of the Femoral Attachment of the Anterior Cruciate Ligament

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Japanese Perspectives on Nutrition for New Millenium

Surgical Science 2012年第1期

作者： Ken Okazaki shuichi matsuda Yasutaka Tashiro Yukihide Iwamoto

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Biomedical and Environmental Sciences 2001年第1期14卷 82-86页

作者： shuichi KIMURA ShowaWomen’sUniversity ILSI1_7TaishdoSetaguyaku

The Japanese are the longest living people in the world. According to Japan's Ministry of Health and Welfare, the average life expectancy at birth for male born in 1997 was 77.10 years, and the figure for female was 83.99 years.　　Our country is ranked first in the Healthy Life Expectancy as shown in Table 1. The total Disability Adjusted Life Expectancy (DALE) is 74.5 years.

关键词： Nutrition Nutrition Policy Public Health Demography Humans Japan Life Expectancy Public Policy Social Conditions

Dissipative structure for symmetric hyperbolic systems with memory

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Science China Mathematics 2018年第11期61卷 2053-2064页

作者： shuichi Kawashima Shogo Taniue Faculty of Mathematics Kyushu University Graduate School of Mathematics Kyushu University

We study symmetric hyperbolic systems with memory-type dissipation and investigate their dissipative *** treat two cases:memory-type diffusion and memory-type relaxation,and observe that the dissipative structures of these two cases are essentially ***,we show that the dissipative structure of the system with memory-type diffusion is of the standard type,while that of the system with memory-type relaxation is of the regularity-loss type.

关键词： hyperbolic systems memory-type dissipation dissipative structure