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Efficacy and safety of sofosbuvir and ledipasvir in Japanese patients aged 75 years or over with hepatitis C genotype 1

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World Journal of Hepatology 2017年第36期9卷 1340-1345页

作者： Yoshinori Ozono Kenji Nagata Satoru Hasuike Hisayoshi Iwakiri Kenichi Nakamura Mai Tsuchimochi Yuri Yamada Yuka Takaishi Mitsue Sueta Tadashi Miike Yoshihiro Tahara Shojiro Yamamoto Kotaro Shide Tomonori Hidaka Yoko Kubuki Kazunori Kusumoto Toshimasa Ochiai Junya Kato Naoto Komada shuichi hirono Kazuo Kuroki Masafumi Shigehira Kazuya Shimoda Department of Gastoroenterology and Hematology Faculty of Medicine University of Miyazaki Department of Liver Disease University of Miyazaki Hospital Department of Internal Medicine Koga General Hospital Department of Internal Medicine National Hospital Organization Miyakonojo Medical Center Department of Internal Medicine Hirono Naika Clinic Department of Internal Medicine Kushima Municipal Hospital Department of Internal Medicine Shigehira Clinic

AIM To evaluate the efficacy and safety of a regimen containing sofosbuvir(SOF) and ledipasvir(LDV) in Japanese patients aged ≥ 75 years with hepatitis C genotype *** This multicenter, retrospective study consisted of 246 Japanese patients with HCV genotype 1 at nine centers in Miyazaki prefecture in Japan. Demographic, clinical, virological, and adverse effects(AE)-related data obtained during and after SOF/LDV therapy were collected from medical records. These patients were divided into two groups, younger(aged < 75 years) and elderly(aged ≥ 75 years). Virological data and AEs were analyzed by age *** The sustained virological response(SVR) rates at 12 wk after treatment were 99.2%, 99.4%, and 98.7% in the overall population and in patients aged < 75 and ≥ 75 years, respectively. Common AEs during therapy were headache, pruritus, constipation, and insomnia. These occurred in fewer than 10% of patients, and their incidence was not significantly different between the younger and elderly groups. Two patients discontinued treatment, one due to a skin eruption and the other due to cerebral bleeding. CONCLUSION Compared with younger patients, elderly patients had a similar virological response and tolerance to SOF/LDV therapy.

关键词： Chronic hepatitis C Sofosbuvir Ledipasvir Sustained virological response Direct acting antivirals

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Japanese Perspectives on Nutrition for New Millenium

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Biomedical and Environmental Sciences 2001年第1期14卷 82-86页

作者： shuichi KIMURA ShowaWomen’sUniversity ILSI1_7TaishdoSetaguyaku

The Japanese are the longest living people in the world. According to Japan's Ministry of Health and Welfare, the average life expectancy at birth for male born in 1997 was 77.10 years, and the figure for female was 83.99 years.　　Our country is ranked first in the Healthy Life Expectancy as shown in Table 1. The total Disability Adjusted Life Expectancy (DALE) is 74.5 years.

关键词： Nutrition Nutrition Policy Public Health Demography Humans Japan Life Expectancy Public Policy Social Conditions

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Dissipative structure for symmetric hyperbolic systems with memory

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Science China Mathematics 2018年第11期61卷 2053-2064页

作者： shuichi Kawashima Shogo Taniue Faculty of Mathematics Kyushu University Graduate School of Mathematics Kyushu University

We study symmetric hyperbolic systems with memory-type dissipation and investigate their dissipative *** treat two cases:memory-type diffusion and memory-type relaxation,and observe that the dissipative structures of these two cases are essentially ***,we show that the dissipative structure of the system with memory-type diffusion is of the standard type,while that of the system with memory-type relaxation is of the regularity-loss type.

关键词： hyperbolic systems memory-type dissipation dissipative structure

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Experimental Study on Load Characteristics in a Floating Type Pendulum Wave Energy Converter

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Journal of Thermal Science 2014年第5期23卷 465-471页

作者： Tengen Murakami Yasutaka Imai shuichi Nagata Institute of Ocean Energy Saga University

A floating type pendulum wave energy converter(FPWEC) with a rotary vane pump as the power take-off system was proposed by Watabe et *** *** showed that this device had high energy conversion *** the previous research,the authors conducted 2D wave tank tests in regular waves to evaluate the generating efficiency of FPWEC with a power take-off system composed of pulleys,belts and a *** a result,the influence of the electrical load on the generating efficiency was ***,the load characteristics of FPWEC are pursued experimentally by using the servo motors to change the damping coefficient in this *** a later part of this paper,the motions of the model with the servo motors are compared with that of the case with the same power take-off system as the previous *** the above experiment,it may be concluded that the maximum primary conversion efficiency is achieved as high as 98%at the optimal load.

关键词： pendulum wave energy converter floating type load characteristics primary conversion efficiency

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Origami Folding by Multifingered Hands with Motion Primitives

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Cyborg and Bionic Systems 2021年第1期2021卷 169-183页

作者： Akio Namiki shuichi Yokosawa Graduate School of Engineering Chiba UniversityChibaJapan

Origami,a traditional Japanese art,is an example of superior handwork produced by human *** such extreme dexterity is one of the goals of robotic *** the work described in this paper,we developed a new general-purpose robot system with sufficient capabilities for performing *** decomposed the complex folding motions into simple primitives and generated the overall motion as a combination of these ***,to measure the paper deformation in real-time,we built an estimator using a physical simulator and a depth *** a result,our experimental system achieved consecutive valley folds and a squash fold.

关键词： robot primitive system

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Electron Temperature Measurement by Floating Probe Method Using AC Voltage

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Plasma Science and Technology 2016年第11期18卷 1089-1094页

作者： Satoshi NODOMI shuichi SATO Mikio OHUCHI Department of Electrical and Electronic Engineering Tokyo Denki University

This study presents a novel floating probe method to measure electron temperatures using a hollow cathode-type discharge tube. The proposed method detects a shift in the floating potential when an AC voltage is applied to a probe through an intermediary blocking capacitor. The shift in the floating potential is described as a function of the electron temperature and the applied AC voltage. The floating probe method is simpler than the Langmuir probe method because it does not require the measurement of volt-ampere characteristics. As the input AC voltage increases, the electron temperature converges. The electron temperature measured using the floating probe method with an applied sinusoidal voltage shows a value close to the first （tail） electron temperature in the range of the floating potential.

关键词： electrostatic probe Langmuir probe floating potential electron temperature sheath

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Nonlinear Magnetic Response of Superconducting Flux Arrays with Random Pinning

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Chinese Physics Letters 1997年第3期14卷 217-220页

作者： NI Jun GU Bing-lin shuichi Iwata Department of Physics Tsinghua UniversityBeijing 100084 Research into Artifacts Center for EngineeringThe University of TokyoKamaba 4-6-1Meguro-kuTokyo 153Japan

The static nonlinear magnetic response of randomly pinned flux-line lattice in a type-Ⅱ super-conductor has been investigated using variational replica-symmetry-broken method.A peak in the curve of susceptibility as a function of external magnetic field is *** the magnetic field is low,there is a softening in the susceptibility as an effect of pinning potential with nonzero correlation *** some critical magnetic field,the softening changes into *** reaching the maximum in hardening,the susceptibility decreases to its value of piire states with the increase of magnetic field.

关键词： method. field. susceptibility

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Recovery of Tungsten Surface with Fiber-Form Nanostructure by Plasmas Exposures

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Plasma Science and Technology 2013年第2期15卷 161-165页

作者： Takanori MIYAMOTO shuichi TAKAMURA Hiroaki KURISHITA Department of Electrical Engineering Faculty of EngineeringAichi Institute of TechnologyToyota 470-0392Japan International Research Center for Nuclear Materials Science IMRTohoku UniversityOaraiIbaraki 311-1313 Japan

One of the serious concerns for tungsten materials in fusion devices is the radiation defects caused by helium plasma irradiation since helium is a fusion product. The fiber-formed nanostructure is thought to have a possible weakness against the plasma heat flux on the plasma- facing component and also may destroy the reflectivity of optical mirrors. In this paper an inter- esting method for the recovery of such tungsten surfaces is shown. The recovery process depends on the grade and manufacturing process of tungsten materials.

关键词： helium defects tungsten plasma-surface interaction fiber-form nanostruc-ture surface recovery

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First-principles calculation of phase equilibria and phase separation of the Fe-Ni alloy system

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Rare Metals 2006年第5期25卷 437-440页

作者： Ying Chen shuichi Iwata Tetsuo Mohri Department of Quantum Engineering and System Science School of Engineering The University of Tokyo Hongo 7-3-1 Bunkyo-ku Tokyo113-8656 Japan Graduate School of Frontier Sciences The University of Tokyo Hongo 7-3-1 Bunkyo-ku Tokyo 113-8656 Japan Division of Materials Science and Engineering Graduate School of Engineering Hokkaido University Kita-13 Nishi-8 Kita-ku Sapporo060-8628 Japan

Theoretical investigation of the phase equilibria of the Fe-Ni alloy has been performed by combining the FLAPW total energy calculations and the Cluster Variation Method through the Cluster Expansion Method. The calculations have proved the stabilization of the LIE phase at 1：3 stoichiometry, which is in agreement with the experimental result, and predicted the existence of L1 0 as a stable phase below 550 K; this L1 0 phase has been missing in the conventional phase diagram. The calculations are extended to the Fe-rich region that is characterized by a wide range phase separation and has drawn considerable attention because of the intriguing Invar property associated with a Fe concentration of 65%. To reveal the origin of the phase separation, a P-V curve in an entire concentration range is derived by the second derivative of free energy functional of the disordered phase with respect to the volume. The calculation confirmed that the phase separation is caused by the breakdown of the mechanical-stability criterion. The newly calculated phase separation line combined with the L1 0 and L12Eorder-disordered phase boundaries provides phase equilibria in the wider concentration range of the system. Furthermore, a coefficient of thermal expansion （CTE） is attempted by incorporating the thermal vibration effect through harmonic approximation of the Debye-Gruneisen model. The Invar behavior has been reproduced, and the origin of this anomalous volume change has been discussed.

关键词： Fe-Ni alloy system order-disorder separation magnetism first-principles calculations cluster variation method cluster expansion method Debye-Gruneisen model

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Frequency dependence of electron temperature in hollow cathode-type discharge as measured by several different floating probe methods

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Plasma Science and Technology 2018年第8期20卷 50-57页

作者： shuichi SATO Hiromu KAWANA Tatsushi FUJIMINE Mikio OHUCHI Department of Electronic Engineering Tokyo Denki University

We measured electron temperatures through a hollow cathode-type discharge tube using several different floating probe methods. This method detected a shift in the floating potential when an AC voltage was applied to a probe through an intermediary blocking capacitor. The shift in the floating potential is described as a function of the electron temperature and the applied AC voltage. In this study, the effects of the frequency and waveform on the electron temperatures were systematically investigated. The electron temperature measured when using the floating probe method with applied sinusoidal and triangular voltages was lower than that measured with an applied rectangular *** value in the high frequency range was close to that of the tail electron temperature.

关键词： electrostatic probe Langmuir probe floating potential electron temperature sheath

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