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Identification of Dysregulated microRNAs in Glioma Using RNA sequencing

Current Medical Science 2021年第2期41卷 356-367页

作者： Chang LIU Ying-ying GE Xiao-xun XIE bin LUO Ning SHEN Xing-sheng LIAO shui-qing bi Tao XU Shao-wen XIAO qing-mei ZHANG Department of Neurosurgery the First Affiliated HospitalGuangxi Medical UniversityNanning 530021China School of Pre-clinical Medicine Guangxi Medical UniversiryNanning 530021China Department of Stomatology the People's Hospital of Guangxi Zhuang Atutonomous RegionNanning 530021China

Glioma is the most common malignant brain tumor in central nervous *** advances in the treatment of glioma such as surgery and chemoradiotherapy,most patients are easy to relapse,resulting in adverse clinical ***,effective molecular=targeting treatment may be one of attractive strategies for glioma *** dysregulated microRNAs(miRNAs),one of the candidates of therapeutic targets,are believed to play an important role in the progression of *** this study,we aimed to examine the expression profile of miRNAs in glioma and provide a reference for glioma ***,expression profile of miRNAs in 5 normal brain tissues,5 low-grade glioma(LGG)tissues and 5 glioblastoma(GBM)tissues was detected by RNA sequencing(RNA-seq).Next,the target genes of differentially expressed miRNAs(DEmiRNAs)were predicted and then GO enrichment and KEGG pathway analysis performed by ***,10 miRNAs which were significantly up-or down-regulated both in GBM and LGG were validated by real-time quantitative PCR(qRT-PCR).RNA-seq results indicated a number of DEmiRNAs in *** were 64 up-regulated miRNAs and 17 down-regulated miRNAs n LGG,and 181 up-regulated miRNAs and 124 down-regulated miRNAs in GBM,*** analysis showed that the target genes of these DEmiRNAs were enriched in various biological processes and signaling pathways such as cell metabolic and developmental *** DEmiRNAs were further confirmed by ***-10b-5p,miRNA-92b-3p and miRNA-455-5p were significantly up-regulated in both GBM and LGG;while miRNA-542-3p was significantly up-regulated in LGG;miRNA-184 and miRNA-206 were significantly down-regulated in both GBM and LGG;miRNA-766-5p and miRNA-1-3p were significantly down-regulated in *** subject of our study demonstrated several dysregulated miRNAs may serve as a potential therapeutic target for gl ioma.

关键词： glioma microRNA RNA-sequencing

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FMR1NB Involved in Glioma Tumorigenesis Is a Promising Target for Prognosis and Therapy

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Current Medical Science 2022年第4期42卷 803-816页

作者： shui-qing bi Ya PENG Zong-dang WEI Sheng-zhong YAO bin LUO Ying-ying GE Xiao-xun XIE Wei-xia NONG Chang LIU Shao-wen XIAO qing-mei ZHANG Department of Neurosurgery the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Department of Histology and Embryology School of Pre-Clinical MedicineGuangxi Medical UniversityNanning 530021China Central Laboratory School of Pre-Clinical MedicineGuangxi Medical UniversityNanning 530021China

Objective:Cancer/testis antigen FMR1NB is aberrantly expressed in various types of cancer,but not in normal tissues except for *** study aimed to investigate the expression and functional role of FMR1NB in ***:The expression of FMR1NB mRNA and protein was determined using RT-PCR and immunohistochemistry,respectively,in glioma specimens from 83 patients at *** effects of siRNA-mediated FMR1NB silencing on malignant biological behaviors were evaluated in glioma cell lines Al 72 and ***:FMR1NB mRNA and protein expression was detected in 58.8%(77/131)and 46.34%(57/123)of glioma tissues,***1NB protein was positively correlated with World Health Organization grade and found to be an independent prognostic marker for poor *** of FMR1NB induced apoptosis and suppressed proliferation,adhesion,migration,and invasion by modulating the expression of cyclin A,CDK2,caspase-3,E-cadherin,and N-cadherin in A172 and U251 ***:Our findings suggest that FMR1NB contributes to the tumorigenesis of glioma cells and may represent a potential prognostic biomarker and an attractive therapeutic target in glioma.

关键词： cancer/testis antigen FMR1NB glioma

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Cancer-testis Antigen OY-TES-1 Expression and Immunogenicity in Hepatocellular Carcinoma

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Current Medical Science 2020年第4期40卷 719-728页

作者： bin LUO Xiang YUN Jing LI Rong FAN Wen-wen GUO Chang LIU Yong-da LIN Ying-ying GE Xia ZENG shui-qing bi Wei-xia NONG qing-mei ZHANG Xiao-xun XIE School of Basic Medical Sciences Guangxi Medical UniversityNanning 530021China Department of Surgery the First Affiliated HospitalGuangxi Medical UniversityNanning 530021China Clinical Laboratory Chinese Medicine HospitalQuanzhou 362000China School of Basic Medical Sciences Guangxi University of Chinese MedicineNanning 530021China Department of Pathology the People's Hospital of Guangxi Zhuang Autonomous RegionNanning 530021China Guangxi Key Laboratory of Early Prevention and Treatmentfor Regional High Frequency Tumor Guangxi Medical UniversityNanning 530021China Key Laboratory Research on Preclinical Medicine Guangxi Medical UniversityNanning 530021China

Summary:Cancer testis(CT)antigens have received particular attention in cancer ***-TES-1 is a member of CT *** study was to evaluate OY-TES-1 expression and immunogenicity in hepatocelluar carcinoma(HCC).OY-TES-1 mRNA expression was detected in 56 HCC tissues and 5 normal liver tissues by reverse transcriptase PCR(RT-PCR).Of the 56 cases of HCC tissues tested,37 cases had tumor and matched adjacent non-cancer tissues and were subjected to both RT-PCR and quantitative real-time ***-TES-1 protein was subsequently observed on a panel of tissue *** from patients were tested for OY-TES-1 antibody by *** identify OY-TES-1 capable of inducing cellular immune response,OY-TES-1 protein was used to sensitize dentritic cells and the cytotoxicity effect was measured in *** results showed that OY-TES-1 mRNA was highly expressed in 41 of the 56(73.21%)HCC tissues,whereas none in 5 normal liver ***-TES-1 mRNA was frequently expressed not only in HCC tissues(72.97%,27/37),but also in paired adjacent non-cancer tissues(64.86%,24/37).But the mean expression level of OY-TES-1 mRNA in HCC tissues was significantly higher than that in adjacent non-cancer tissues(0.76854 vs.0.09834,P=0.021).Immunohistochemistry showed that OY-TES-1 protein expression was detected in 6 of the 49 cases of HCC tissues,and absent in 9 cases of normal liver and 6 cases of cirrhosis *** was detected in 10 of the 45 HCC patients,but not detected in 17 cirrhosis patients and 76 healthy *** specific cytotoxic T cells elicited by OY-TES-1 could kill HLA-A2^+HCC cell line which expressed *** target lysis was mainly HLA class I-dependent and could be blocked by antibodies against monomorphic HLA class I but not HLA class II *** summary,OY-TES-1 expression is upregulated in HCC tissues and can be recognized by humoral and cellular responses,which suggests that OY-TES-1 is an attractive target for tumor immunotherapy in

关键词： cancer testis antigen hepatocelluar cancer tumor immunotherapy

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SUPG finite element method based on penalty function for lid-driven cavity flow up to Re = 27500

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Acta Mechanica Sinica 2016年第1期32卷 54-63页

作者： Da-Guo Wang qing-Xiang shui School of Environment and Resources Southwest University of Science and Technology

A streamline upwind/Petrov-Galerkin （SUPG） finite element method based on a penalty function is pro- posed for steady incompressible Navier-Stokes equations. The SUPG stabilization technique is employed for the for- mulation of momentum equations. Using the penalty function method, the continuity equation is simplified and the pres- sure of the momentum equations is eliminated. The lid-driven cavity flow problem is solved using the present model. It is shown that steady flow simulations are computable up to Re = 27500, and the present results agree well with previous solutions. Tabulated results for the properties of the primary vortex are also provided for benchmarking purposes.

关键词： Streamline upwind/Petrov-Galerkin (SUPG)finite element method Lid-driven cavity flow Penaltyfunction method High Reynolds number

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Two properties of sequence of vector measures on effect algebras

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Applied Mathematics(A Journal of Chinese Universities) 2010年第4期25卷 475-480页

作者： LIN qing-shui LI Rong-lu Department of Mathematics Harbin Institute of Technology Harbin 150006 China

Let （L, ,0, 1） be an effect algebra and let X be a Banach space. A function ： L→ X is called a vector measure if μ（a b） =μ（a）＋ μ（b） whenever a⊥b in L. The function μ is said to be 8-bounded if limn→∞μ（an） = 0 in X for any orthogonal sequence （an）n∈N in L. In this paper, we introduce two properties of sequence of s-bounded vector measures and give some results on these properties.

关键词： Effect algebra s-bounded vector measure.

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Effect of Nano-anatase TiO_2 on Spectral Characterization of PhotosystemⅡParticles from Spinach

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Chemical Research in Chinese Universities 2005年第2期21卷 196-200页

作者： HONGFa-shui YANGPing GAOFeng-qing LIUChao ZHENGLei YANGFan ZHOUJuan CollegeofLifeSciences CollegeofChemistryandChemicalEngineering SuzhouUniversitySuzhou215006P.R.China

The photosystem Ⅱ(PSⅡ) particles were purified by means of nano-anatase TiO_2 treatment of spinach and studied by spectroscopy. The results show that the electron transport and the oxygen-evolving rate of PSⅡ are accelerated after it has been treated with nano-anatase TiO_2; the UV-Vis absorption spectrum of PSⅡ particles is increased; the red shift of fluorescence emission peak of PSⅡ is 2 nm; the peak intensity is decreased; the PSⅡ signal Ⅱs of low temperature electron paramagnetic resonanace(EPR) spectrum is intensified under light, and the PSⅡ circular dichroism(CD) spectrum is similar to that of control. It is suggested that nano-anatase TiO_2 might bind to the PSⅡ reaction center complex and intensify the function of the PSⅡ electron donor, however, nano-anatase TiO_2 treatment does not change the configuration of the PSⅡ reaction center complex.

关键词： Nano-anatase TiO_2 Spinach PhotosystemⅡ Spectral characterization

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An efficient and coordinated mapping algorithm in virtualized SDN networks

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Frontiers of Information Technology & Electronic Engineering 2016年第7期17卷 701-716页

作者： shui-qing GONG Jing CHEN Qiao-yan KANG qing-wei MENG qing-chao ZHU Si-yi ZHAO College of Information and Navigation Air Force Engineering University

Software-defined networking(SDN) enables the network virtualization through SDN hypervisors to share the underlying physical SDN network among multiple logically isolated virtual SDN networks(v SDNs),each with its own *** v SDN embedding,which refers to mapping a number of v SDNs to the same substrate SDN network,is a key problem in the SDN virtualization ***,due to the distinctions of the SDN,such as the logically centralized controller and different virtualization technologies,most of the existing embedding algorithms cannot be applied directly to SDN *** this paper,we consider controller placement and virtual network embedding as a joint vS DN embedding problem,and formulate it into an integer linear programming with objectives of minimizing the embedding cost and the controller-to-switch delay for each v ***,we propose a novel online vS DN embedding algorithm called CO-v SDNE,which consists of a node mapping stage and a link mapping *** the node mapping stage,CO-vS DNE maps the controller and the virtual nodes to the substrate nodes on the basis of the controller-to-switch delay and takes into account the subsequent link mapping at the same *** the link mapping stage,CO-v SDNE adopts the k-shortest path algorithm to map the virtual *** evaluation results with simulation and Mininet emulation show that the proposed CO-v SDNE not only significantly increases the long-term revenue to the cost ratio and acceptance ratio while guaranteeing low average and maximum controller-to-switch delay,but also achieves good v SDN performance in terms of end-to-end delay and throughput.

关键词： Software-defined networking(SDN) Network virtualization Controller placement Virtual network embedding Coordination

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Least Square Finite Element Method for Viscous Splitting of Unsteady Incompressible Navier–Stokes Equations

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China Ocean Engineering 2018年第4期32卷 490-500页

作者： shui qing-xiang WANG Da-guo HE Zhi-liang HUANG Jin School of Human Settlement and Civil Engineering Xi'an Jiaotong University School of Environmental and Resources Southwest University of Science and Technology

In order to solve unsteady incompressible Navier–Stokes(N–S) equations, a new stabilized finite element method,called the viscous-splitting least square FEM, is proposed. In the model, the N–S equations are split into diffusive and convective parts in each time step. The diffusive part is discretized by the backward difference method in time and discretized by the standard Galerkin method in space. The convective part is a first-order nonlinear *** the linearization of the nonlinear part by Newton’s method, the convective part is also discretized by the backward difference method in time and discretized by least square scheme in space. C0-type element can be used for interpolation of the velocity and pressure in the present model. Driven cavity flow and flow past a circular cylinder are conducted to validate the present model. Numerical results agree with previous numerical results, and the model has high accuracy and can be used to simulate problems with complex geometry.

关键词： unsteady incompressible N–S equations viscous splitting Newton's method least square finite element method driven cavity flow flow past a circular cylinder

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Recent advances in asymmetric synthesis of 2-substituted indoline derivatives

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Chinese Chemical Letters 2020年第2期31卷 311-323页

作者： Ting-bi Hua Cong Xiao qing-qing Yang Jia-Rong Chen College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China CCNU-uOttawa Joint Research Centre Key Laboratory of Pesticides&Chemical Biology Ministry of Education.College of ChemistryCentral China Normal UniversityWuhan 430079China

Enantiomerically pure 2-substituted indolines are an important class of nitrogen heterocycles that occur frequently in many alkaloid natural products and biologically active ***,the synthesis of such skeletons is of great *** past years have witnessed a number of remarkable advances in the development of efficient strategies to construct this class of chiral *** review summarizes the recent advances in asymmetric synthesis of 2-substituted indoline *** to the limitation of the length,this review only summarizes those works published from January of 2012 to January of ***,methods towards synthesis of fu sed and spirocyclic indolines will not be discussed in this review.

关键词： Indolines Asymmetric synthesis Enantioselectivity Nitrogen heterocycles Synthetic methods

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MicroRNA negatively regulates NF-κB-mediated immune responses by targeting NOD1 in the teleost fish Miichthys miiuy

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Science China(Life Sciences) 2021年第5期64卷 803-815页

作者： qing Chu Dekun bi Weiwei Zheng Tianjun Xu Laboratory of Fish Molecular Immunology College of Fisheries and Life ScienceShanghai Ocean UniversityShanghai 201306China Laboratory of Marine biology and biotechnology Qingdao Pilot National Laboratory for Marine Science and TechnologyQingdao 266071China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministry of EducationShanghai Ocean UniversityShanghai 201306China National Pathogen Collection Center for Aquatic Animals Shanghai Ocean UniversityShanghai 201306China

Inflammation is a self-protection mechanism that can be triggered when innate immune cells detect *** of pathogen infection requires appropriate immune and inflammatory responses,but excessive inflammatory responses can cause uncontrolled inflammation,autoimmune diseases,or pathogen *** evidence has shown that microRNAs(miRNAs)in mammals act as important and versatile regulators of innate immunity and ***,miRNAmediated regulation networks are largely unknown in inflammatory responses in lower ***,miR-144 and miR-217 are identified as negative regulators in teleost inflammatory *** find that Vibrio harveyi and lipopolysaccharide(LPS)treatment significantly upregulate the expression of fish miR-144 and *** miR-144 and miR-217 suppress LPS-induced inflammatory cytokine expression by targeting nucleotide-binding oligomerization domain-containing protein 1(NOD1),thereby avoiding excessive inflammatory *** addition,miR-144 and miR-217 regulate inflammatory responses through NOD1-induced nuclear factor kappa(NF-κB)signaling *** findings demonstrate that miR-144 and miR-217 play regulatory roles in inflammatory responses by modulating the NOD1-induced NF-κB signaling pathway.

关键词： microRNA negative regulation NF-κB NOD1 Miichthys miiuy

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