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Yangfei Kongliu Formula, a compound Chinese herbal medicine, combined with cisplatin, inhibits growth of lung cancer cells through transforming growth factor-β1 signaling pathway

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Journal of Integrative Medicine 2017年第3期15卷 242-251页

作者： shui-jie Shen Yong-hong Zhang Xiao-xia Gu shui-ju jiang Ling-jun Xu The First Clinical Medical College Nanjing University of Chinese Medicine Department of Oncology Nantong Hospital of Traditional Chinese MedicineNanjing University of Chinese Medicine Department of Respiratory Medicine Nantong Third People's Hospital

OBJECTIVE： To investigate the tumor inhibition effect of Yangfei Kongliu Formula （YKF）, a compound Chinese herbal medicine, combined with cisplatin （DDP） and its action mechanisms. METHODS： C57BL/6 mice with Lewis lung carcinoma were divided into six groups： control group （C）, DDP group （2 mg/kg, DDP）, low-dose YKF group （2.43 g/kg, L）, high-dose YKF group （24.3 g/kg, H）, low- dose YKF combined with DDP group （L ＋ DDP） and high-dose YKF combined with DDP group （H ＋ DDP）. Transforming growth factor-β1 （TGF-β1）, mothers against decapentaplegic homolog 3 （Smad3） and Smad7 levels were measured with quantitative real-time polymerase chain reaction （qPCR）, Western blotting and immunohistochemistry. An enzyme-linked immunosorbent assay was used to analyze the expressions of interleukin-2 （IL-2） and tumor necrosis factor-α （TNF-α）. RESULTS： YKF combined with DDP significantly inhibited the growth and metastasis of tumors relative to the control group, and YKF groups （P 〈 0.05）. There was no significant difference between high-dose YKF group and low-dose YKF group （P 〉 0.05）. We also found that the expression levels of TGF-β1 and Smad3 were both significantly decreased by YKF relative to the control group （P 〈 0.05）. Furthermore, after treatment with YKF combined with DDP, the expression levels of TGF-β1 and Smad3 were decreased but the expression level of Smad7 was increased relative to the DDP group （P 〈 0.05）. Compared to the DDP group, the combination of YKF and DDP enhanced the effect of tumor inhibition （P 〈 0.05）, showing obvious synergy between YKF and DDP. Treatment with DDP or YKF decreased serum levels of IL-2 and TNF-α relative to the control group （P 〈 0.05）. Furthermore, the expression levels of IL-2 and TNF-α were significantly decreased when treated with YKF in combination with DDP. Co-treatment with YKF and DDP significantly inhibited tumor growth, decreased the expressions of TGF-β1, Smad3, IL-2 and TNF-α and increased the expression of Smad7; these differe

关键词： cisplatin transforming growth factor-β1 Smad3 Smad7 lung cancer drugs, Chinese herbal

Volatile profile and multivariant analysis of Sanhuang chicken breast in combination with Chinese 5-spice blend and garam masala

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Food Science and Human Wellness 2023年第1期12卷 57-68页

作者： Rani Andaleeb Danni Zhang shui jiang Yin Zhang Yuan Liu Department of Food Science&Technology School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Meat Processing of Sichuan Chengdu UniversityChengdu 610106China

Sanhuang chicken is a popular native breed in China and well-known for delicious *** could enhance the chicken meat flavour and work well in *** 5-spice blend(CS)and garam masala(GM)are routinely using spices in China and Pakistan,*** flavour profiles of Sanhuang chicken breast(CB)and its blends with CS and GM were obtained by electronic nose(E-nose),solid-phase microextraction gas chromatography-mass spectrometry(SPME GC-MS)and GC-ion mobility spectrometry(GC-IMS).Principal component analysis(PCA)efficiently discriminated the aroma profiles of three chicken *** GC-chromatographs revealed the significant aroma alterations of chicken breast meat after marination with *** were the major contributors of chicken aroma,while most of the aromatic hydrocarbons were generated by *** all chicken key-compounds produced by oxidation reaction were either reduced or eliminated by marination,showing the antioxidation capacity of spices leading to meat ***-IMS is not only a rapid and comprehensive detection method,but also proved to be more sensitive than *** substantial role of both traditional spices in enhancing flavour quality of chicken meat,and their exposure as functional ingredients in Chinese and Pakistan cuisines could lead to the cross-cultural meat trade opportunities.

关键词： Chicken breast Chinese 5-spice blend Garam masala Volatile compounds Qualitative techniques Multivariant analysis

XMM-Newton observations of H_2O maser galaxy NGC 7479

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Research in Astronomy and Astrophysics 2010年第9期10卷 915-926页

作者： Jin Wang jiang-shui Zhang Jun-Hui Fan Center for Astrophysics Guangzhou University Guangzhou 510006 China

The XMM-Newton observations of H2O megamaser galaxy NGC 7479 are presented. Its smoothed X-ray image clearly shows spiral morphology, which matches well with its optical asymmetric spiral structure. One prominent source can be found at the tip of its northern spiral arm, which is much brighter than its nuclear X-ray source （about a 50% higher count rate）. For the nuclear source （a circular region with a radius of 20 ″）, the spectra show soft excess below 2 keV and a strong iron Kα emission line. The best fitting model includes a partially absorbed model for the hard continuum and one thermal plasma model for the soft scatter component. Both the high column density （NH - 6.88 × 10^23 cm^-2） and strong fluorescent iron line （with an equivalent width of - 1.5 keV） support the existence of one heavily obscured AGN. For the bright prominent source, its radial profile is consistent with that of a single point-like source. Its spectra are extracted from the circular region around its peak, with a radius of 20″ and 6″ respectively and both spectra show models for the ultra-luminous X-ray source no significant difference. Four alternative （ULXs） can reproduce the spectra well： an absorbed power law, thermal bremsstrahlung, multicolor blackbody disk plus another blackbody or power law. Further observations （e.g., the tremendous improvement in the spatial resolution of the Chandra X-ray observations） and studies are desirable for probing the nature of this prominent source. In addition, we also estimate the mass of its central engine to be 1.18 × 10^7 M⊙ and maser disk parameters： the disk radius of -0.7 pc and the dimensionless accretion rate （L2-10kev/LEdd） of 1.2 × 10^-4.

关键词： masers -- galaxies active -- galaxies nuclei --- galaxies individual (NGC 7479) -- X-rays galaxies

Treatment of extracranial internal carotid artery dissecting aneurysm with SUPERA stent implantation:Two case reports

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World Journal of Clinical Cases 2022年第5期10卷 1602-1608页

作者： Min-Jian Qiu Bao-Rong Zhang shui-jiang Song Department of Neurology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina

BACKGROUND There is no standard endovascular treatment for extracranial internal carotid artery dissecting *** the past,stent-graft isolation and stent-assisted coil embolization were commonly used for wide-necked and fusiform ***,we present two cases of extracranial internal carotid artery dissecting aneurysms treated successfully using the SUPERA *** SUMMARY Case 1 was a 57-year-old male patient with sudden right limb weakness and vague speech and diagnosed with cerebral infarction in February *** computed tomographic angiography(CTA)revealed left internal carotid artery dissection with *** at 2 mo showed an eccentric wide-necked dissecting aneurysm(5 mm×5 mm×12 mm,10-mm neck)that was enlarged at 4 mo(7 mm×6 mm×12 mm,11-mm neck).The patient underwent SUPERA stent *** condition was stable in July *** 2 was a 57-year-old man who suddenly felt dizzy and developed unsteady walking in November *** CTA suggested right internal carotid artery dissecting aneurysm(11 mm×9 mm×31 mm)complicated with severe lumen stenosis(95%).The patient underwent SUPERA stent *** patient had no residual symptoms and was stable in December *** SUPERA stent implantation might achieve good results in treating wide-necked or long fusiform internal carotid artery dissecting aneurysms.

关键词： Extracranial Internal carotid artery Dissecting aneurysm Stent Case report

Editorial for advances in slope deformation and failure analysis methods

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第10期16卷 3867-3869页

作者： Jingjing Meng Luca Piciullo Clarence Choi shui-Hua jiang School of Infrastructure Engineering Nanchang UniversityNanchangChina Norwegian Geotechnical Institute Norway The University of Hong Kong Hong KongChina

We are privileged to be invited by the Honorary Editor-in-Chief,Professor Qihu Qian,Editor-in-Chief,Professor Xia-Ting Feng,and the editorial staff of the Journal of Rock Mechanics and Geotechnical Engineering(JRMGE),to serve as Guest Editors for this Special Issue(SI).In literature there have been new advancements in monitoring techniques,advanced numerical modelling,optimization algorithms,artificial intelligence and data science introduced for slope *** newly proposed approaches show great potential for improving slope design,construction,and risk assessment.

关键词： engineering. advances artificial

Effect of different drying methods on the taste and volatile compounds,sensory characteristics of Takifugu obscurus

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Food Science and Human Wellness 2023年第1期12卷 223-232页

作者： Youyou Li shui jiang Yiwen Zhu Wenzheng Shi Yin Zhang Yuan Liu College of Food Science and Technology Shanghai Ocean UniversityShanghai 201306China Department of Food Science&Technology School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Meat Processing of Sichuan Chengdu UniversityChengdu 610106China

Pufferfish is prone to deterioration due to abundant nutrients and high moisture *** technology can extend the shelf life and enhance the flavor quality of aquatic *** study investigated the effect of hot air drying(HAD),microwave vacuum drying(MVD)and hot air assisted radio frequency drying(HARFD)on the taste and volatile profiles of Takifugu *** drying methods had significant influence on the color,rehydration,5’-nucleotides,free amino acids and volatile components(P<0.05).The results showed that HAD and HARFD could promote the flavor of *** by producing higher equivalent umami concentration(EUC)values,which were about two times of MVD group,and more pronounced pleasant odor according to sensory *** is more appropriate for industrial application than HARFD and MVD considering the economic *** study could provide a reference for the industrial application of drying ***.

关键词： Hot air drying Microwave vacuum drying Hot air-assisted radio frequency drying Takifugu obscurus Quantitative descriptive analysis

Spectral Indices of Core and Extended Components of Extragalactic Radio Sources

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Chinese Journal of Astronomy and Astrophysics 2003年第5期3卷 415-422页

作者： jiang-shui Zhang and Jun-Hui FanCenter for Astrophysics, Guangzhou University, Guangzhou 510400 zjshui Center for Astrophysics Guangzhou University Guangzhou 510400

We use observed peak and total flux densities at 6cm and 20cm to determine the spectral indices separately for the core and extended components of QSOs and galaxies, as well as their core-dominance parameters. Our results indicate that 1) Nine QSOs show both greater than 1.0 core-dominance parameters (those objects should be blazars) and greater than 0.5 spectral indices. The average core spectral index is αCore = 0.85±0.21 for the nine blazars, which implies that it is not reliable to use αradio = 0.0 for blazars. For the different subclasses, the core and extended spectral indices are as follows: for the blazars, αCore = 0.22±0.06 and αExt =0.77±0.12; the galaxies,αCore = 1.01±0.13 and αExt =0.83±0.21, and for the QSOs, αCore = 0.28±0.10 and αExt =0.68±0.08. 2) The core spectral index and core dominance parameter (R) show an anti-correlation, αC = (-1.28±0.26) log R+ (0.65 ± 0.11); 3) R is approximately linearly correlated with redshift (z).

关键词： galaxies: active - radio continuum: galaxies

Probabilistic back-analysis of rainfall-induced landslides for slope reliability prediction with multi-source information

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3575-3594页

作者： shui-Hua jiang Hong-Hu Jie Jiawei Xie Jinsong Huang Chuang-Bing Zhou School of Infrastructure Engineering Nanchang UniversityXuefu Road 999Nanchang330031China Discipline of Civil Surveying and Environmental EngineeringFaculty of Engineering and Built EnvironmentThe University of NewcastleCallaghanNSW2308Australia

Probabilistic back-analysis is an important means to infer the statistics of uncertain soil parameters,making the slope reliability assessment closer to the engineering ***,multi-source information(including test data,monitored data,field observation and slope survival records)is rarely used in current probabilistic *** the probabilistic back-analysis of spatially varying soil parameters and slope reliability prediction under rainfalls by integrating multi-source information is a challenging task since thousands of random variables and high-dimensional likelihood function are usually *** this paper,a framework by integrating a modified Bayesian Updating with Subset simulation(mBUS)method with adaptive Conditional Sampling(aCS)algorithm is established for the probabilistic back-analysis of spatially varying soil parameters and slope reliability *** this framework,the high-dimensional probabilistic back-analysis problem can be easily tackled,and the multi-source information(*** pressure heads and slope survival records)can be fully used in the back-analysis.A real Taoyuan landslide case in Taiwan,China is investigated to illustrate the effectiveness and performance of the established *** findings show that the posterior knowledge of soil parameters obtained from the established framework is in good agreement with the field ***,the updated knowledge of soil parameters can be utilized to reliably predict the occurrence probability of a landslide caused by the heavy rainfall event on September 12,2004 or forecast the potential landslides under future rainfalls in the Fuhsing District of Taoyuan City,Taiwan,China.

关键词： Rainfall-induced landslide Spatial variability Probabilistic back-analysis Slope reliability analysis Bayesian updating

Solvent Effect of DMSO-d_6 on 1,2-Diols in ~1H NMR

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Chemical Research in Chinese Universities 2005年第6期21卷 761-762页

作者： LI Ting-you jiang shui-shi WANG Zong-mu College of Chemistry Jilin University Changchun 130021 P. R. China Department of Medicinal Pharmacology Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University Okayama 700-8530 Japan College of Life Sciences Jilin University Changchun 130021 P. R. China

There is a classic experiential rule about 1,2-diol RCR^1 （OH） CR^1 （OH） R（ R^1 = H or methyl）, that is, the proton chemical shift of the α-R^1 group at the hydroxvl group in the all-isomer, in general, aPPears... 详细信息

关键词： 1,2-Diol, ^1H NMR α-H atom X-ray crystallography