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Multi-omic Analyses Shed Light on The Genetic Control of High-altitude Adaptation in Sheep

Genomics, Proteomics & Bioinformatics 2024年第2期22卷 43-56页

作者： Chao Li Bingchun Chen Suo Langda Peng Pu Xiaojia Zhu Shiwei Zhou Peter Kalds Ke Zhang Meenu Bhati Alexander Leonard shuhong huang Ran Li Awang Cuoji Xiran Wang Haolin Zhu Yujiang Wu Renqin Cuomu Ba Gui Ming Li Yutao Wang Yan Li Wenwen Fang Ting Jia Tianchun Pu Xiangyu Pan Yudong Cai Chong He Liming Wang Yu Jiang Jian-Lin Han Yulin Chen Ping Zhou Hubert Pausch Xiaolong Wang International Joint Agriculture Research Center for Animal Bio-Breeding Ministry of Agriculture and Rural Affairs/Key Laboratory of Animal GeneticsBreeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Animal Genomics ETH ZürichZürich 8092Switzerland Institute of Animal Science Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China School of Biological and Pharmaceutical Engineering Lanzhou Jiaotong UniversityLanzhou 730070China College of Life Sciences Shaanxi Normal UniversityXi’an 710119China Zoology and Evolutionary Biology Department of BiologyUniversity of Konstanz78457 KonstanzGermany College of Life and Geographic Sciences Kashi UniversityKashi 844000China Beijing Key Laboratory of Captive Wildlife Technologies Beijing ZooBeijing 100044China Department of Medical Research Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Key Laboratory of Agricultural Internet of Things Ministry of Agriculture and Rural Affairs/Shaanxi Key Laboratory of Agricultural Information Perception and Intelligent ServiceCollege of Information EngineeringNorthwest A&F UniversityYangling 712100China Institute of Animal Husbandry and Veterinary Medicine Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China State Key Laboratory of Sheep Genetic Improvement and Healthy Production Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China Livestock Genetics Program International Livestock Research InstituteNairobi 00100Kenya

Sheep were domesticated in the Fertile Crescent and then spread globally,where they have been encountering various environmental *** Tibetan sheep has adapted to high altitudes on the Qinghai-Tibet Plateau over the past 3000 *** explore genomic variants associated with high-altitude adaptation in Tibetan sheep,we analyzed Illumina short-reads of 994 whole genomes representing∼60 sheep breeds/populations at varied altitudes,PacBio High fidelity(HiFi)reads of 13 breeds,and 96 transcriptomes from 12 sheep *** testing between the inhabited altitudes and 34,298,967 variants was conducted to investigate the genetic architecture of altitude *** accurate HiFi reads were used to complement the current ovine reference assembly at the most significantly associatedβ-globin locus and to validate the presence of two haplotypes A and B among 13 sheep *** haplotype A carried two homologous gene clusters:(1)HBE1,HBE2,HBB-like,and HBBC,and(2)HBE1-like,HBE2-like,HBB-like,and HBB;while the haplotype B lacked the first *** high-altitude sheep showed highly frequent or nearly fixed haplotype A,while the low-altitude sheep dominated by haplotype *** further demonstrated that sheep with haplotype A had an increased hemoglobin–O2 affinity compared with those carrying haplotype *** highly associated genomic region contained the EGLN1 gene which showed varied expression between high-altitude and low-altitude *** results provide evidence that the rapid adaptive evolution of advantageous alleles play an important role in facilitating the environmental adaptation of Tibetan sheep.

关键词： Environmental adaptation High altitude Hypoxia Selection signature Sheep

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Optimal Preview Control for Automatic Carrier Landing System of Carrier-Based Aircraft with Air Wake

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Transactions of Nanjing University of Aeronautics and Astronautics 2017年第6期34卷 659-668页

作者： Li Meng Zhen Ziyang Gong Huajun Hou Min huang shuhong College of Automation Engineering Naniing University of Aeronautics and AstronauticsNanjing 211106P.R.China

Carrier-based aircraft carrier landing is a special kind of tracking control problem and not suitable for classical control methods,which may miss the desired performance or result in ***,we present an optimal preview control for automatic carrier landing system(ACLS)by using state information of system,as well as future reference information,which can avoid the shortcomings of classical control *** the flight performance of carrier-based aircraft is disturbed by air wake when the aircraft flies near the area of carrier stern,we design a disturbance rejection strategy to ensure that aircraft track the glide path with high precision and ***,carrier-based aircraft is a complex nonlinear ***,the nonlinear model of carrier-based aircraft can be linearized at equilibrium landing state and decoupled into the longitudinal model and the lateral ***,an optimal preview control system is *** simulation results of a carrier-based aircraft show that the optimal preview control system can effectively suppress air *** accuracy of optimal preview controller is higher than that of the proportional integral differential(PID)control system.

关键词： carrier-based aircraft carrier landing optimal control preview control nonlinear model

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Gut microbiota-derived metabolites contribute negatively to hindgut barrier function development at the early weaning goat model

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Animal Nutrition 2022年第3期10卷 111-123页

作者： Ke Zhang Yangbin Xu Yuxin Yang Mengmeng Guo Ting Zhang Bo Zong shuhong huang Langda Suo Baohua Ma Xiaolong Wang Yujiang Wu Daniel Brugger Yulin Chen Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling712100China College of Veterinary Medicine Northwest A&F UniversityYangling712100China Institute of Animal Sciences Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa850009China Institute of Animal Nutrition and Dietetics Vetsuisse-FacultyUniversity of Zurich8057ZurichSwitzerland

Early weaning induces intestinal injury,leading to a series of long-term symptoms such as inflammation,malabsorption and *** this study,we hypothesized that microbes and theirmetabolitesmodulate the host's inflammatory response to early weaning stress in a goatmodel.A total of 18 female Tibetan goat kids(n?9)wereweaned fromtheirmothers at 28 d(D28)and 60 d(D60)postpartum.D60 and D28 groupswere fed the same solid diet ad libitum fromweaning to 75 d of *** colonic epithelium was subject to RNAsequencing,the caecal digesta metabolomics were assessed by liquid chromatographyetandem mass spectrometry(LC-MS/MS),and the caecal microbiota composition was analysed by 16S ribosomal RNA gene *** foundthatearlyweaningsubstantially increased the colonic pro-apoptotic gene expressionof B-cell lymphoma associated X(Bax),caspase-9,and caspase-3,and decreased the expression of zonula occludens-1(ZO-1)and claudin-1(P<0.01).In addition,a significant Bacteroides acidifaciens enrichmentwas observed in the hindgut of early-weaned goats(P<0.01),which negatively correlated with lysophosphatidylcholine ***,the chemokine signaling,IL-17 signaling,and peroxisome proliferatorsactivated receptor(PPAR)signaling pathways were upregulated in the colonic mucosa of the early-weaned *** applying caecal microbiota transplantation from goats to defaunated C57/6J mice,we confirmed that caecalmicrobiota of D28 goat kids increased the relative abundance of *** and significantly upregulated the genes of Bax,G proteinecoupled receptor(GPR)109A,GPR 43,fatty acid binding protein 6,nuclear receptor subfamily 1 group H member 3,angiotensin converting enzyme 2,and IL-6 expression(P<0.05),and decreased ZO-1,and claudin-1 protein expression in the mice jejunum and colon(P<0.001).These results proposed that the hindgut microbiota andmetabolites mediate the barrier functionweakening duringearlyweaning,and the relative abundance of *** negatively corr

关键词： Hindgut microbiome Ruminant Dysbiosis Inflammation Colon

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改进灰色模型在变压器故障预测中的应用

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华中科技大学学报（自然科学版） 2008年第5期36卷 100-102页

作者：李建兰黄树红华中科技大学能源与动力工程学院湖北武汉430074

针对传统的灰色GM(1,1)预测模型只适用于对较强指数规律序列进行预测的局限,对传统的GM(1,1)模型进行了改进,通过引入一个m点均值算子,将波动的原始序列生成一个近似指数变化的新序列,并建立等维新息模型,缩小灰平面,从而实现对具有波... 详细信息

针对传统的灰色GM(1,1)预测模型只适用于对较强指数规律序列进行预测的局限,对传统的GM(1,1)模型进行了改进,通过引入一个m点均值算子,将波动的原始序列生成一个近似指数变化的新序列,并建立等维新息模型,缩小灰平面,从而实现对具有波动性质的序列进行有效的预测.通过对变压器油液的C2H2体积分数预测结果表明,改进GM(1,1)模型对波动的变压器油色谱液数据有良好的逼近效果,且预测精度高于传统的GM(1,1)模型.

关键词：变压器 GM(1,1)模型故障预测波动序列油液

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High-resolution mid-infrared single-photon upconversion ranging

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Photonics Research 2024年第6期12卷 1294-1302页

作者： shuhong JIANG KUN huang TINGTING YU JIANAN FANG BEN SUN YAN LIANG QIANG HAO E.WU MING YAN HEPING ZENG State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200062China Chongqing Key Laboratory of Precision Optics Chongqing Institute of East China Normal UniversityChongqing 401121China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China School of Optical Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Research Center for Quantum Sciences Shanghai 201315China Guangyang Bay Laboratory Chongqing Institute for Brain and IntelligenceChongqing 400064China

Single-photon laser ranging has widespread applications in remote sensing and target ***,highly sensitive light detection and ranging(lidar)has long been restricted in the visible or near-infrared *** appealing quest is to extend the operation wavelength into the mid-infrared(MIR)region,which calls for an infrared photon-counting system at high detection sensitivity and precise temporal ***,we devise and demonstrate an MIR upconversion lidar based on nonlinear asynchronous optical ***,the infrared probe is interrogated in a nonlinear crystal by a train of pump pulses at a slightly different repetition rate,which favors temporal optical scanning at a picosecond timing resolution and a kilohertz refreshing rate ***,the cross-correlation upconversion trace is temporally stretched by a factor of 2×10^(4),which can thus be recorded by a low-bandwidth silicon *** combination with the time-correlated photon-counting technique,the achieved effective resolution is about two orders of magnitude better than the timing jitter of the detector itself,which facilitates a ranging precision of 4μm under a low detected flux of 8×10^(−5) photons per *** presented MIR time-of-flight range finder is featured with single-photon sensitivity and high positioning resolution,which would be particularly useful in infrared sensing and imaging in photon-starved scenarios.

关键词： resolution lidar repetition

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Expression of thymosin-β4, RACK1 and HMGB in adult amphioxus: implication for the evolutionary conservation of organ related functional molecules

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Progress in Natural Science:Materials International 2007年第1期17卷 49-53页

作者： ZHANG Wei, LI Baojun, LI Xinyi, WANG Lifeng, huang Xiangwei, huang shuhong, YANG Ling and ZHANG Hongwei (Institute of Developmental Biology, College of Life Science, Shandong University, Jinan 250100, China The Key Laboratory of Experimental Teratology, Ministry of Education, Jinan 250100, China) Institute of Developmental Biology College of Life Science Shandong University Jinan 250100 China Key Laboratory of Experimental Teratology Jinan 250100 China

Vertebrate thymosin-β4, RACK1 and HMGB are important molecules functioning in embryonic development and adult life. Here we report the expression patterns of amphioxus thymosin-β4, RACK1 and HMGB genes in tissues of adult amphioxus as revealed by RT-PCR and in situ hybridization. These three genes are all strongly expressed in the central nervous system and ovary, but differently expressed in other tissues including gut, testis, wheel organ, gill and endostyle.

关键词： amphioxus expression Thymosin-β4 RACK1 HMGB conservation.

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Prevention and Treatment of Chinese Herbal Preparation Yinqiaotiangan against Pathologic Model of Streptococcus suis Serotype II in Kunming Mice

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Agricultural Biotechnology 2013年第1期2卷 48-51页

作者： Hong JIANG shuhong huang Hongjun WANG Tiezhong ZHOU Zhuohui MA Liaoning Medical University 93263 Troops of PLA Station Hospital Animal Health Authority of Zhangwu County

[ Objectlve] This study aimed to investigate the antimicrobial effect of Chinese herbal preparation Yinqiaotiangan against Streptococcus suis serotype II in vivo. [ Method ] The prevention and treatment tests were conducted with Kunming mice weighing about 18 -22 g. In the prevention test, Kunming mice were inocu- lated with Streptococcus suis serotype II and simultaneously taken orally 0.5, 1.0 and 2.0 g/ml Chinese herbal preparation Yinqiaotiangan respectively for continu- ous 3 d, once a day; the incidence rate, mortality rate and protective rate were detected after 7 d. In the treatment test, Kunming mice were inoculated with Strepto- coccus suis serotype II to establish the Streptococcus suis serotype II pathogenic model, and then taken orally 0.5, 1.0 and 2.0 g/ml Chinese herbal preparation Yin- qiaotiangan respectively for continuous 3 d, twice a day; the mortality rate, cure rate and effective rate were detected after 7 d. [ Result ] Results of the prevention test showed that the protective rate in experimental groups was extremely significantly higher than that in control group （P 〈0.01 ）, while the incidence rate and mortality rate were extremely significantly lower than that in control group （P 〈0.01 ）. Results of the treatment test showed that the incidence rate in experimental groups was extremely significantly lower than that in control group （P 〈0.01 ）, the cure rate in 0.5 g/ml group was extremely significantly higher than that in 1.0 g/ml group and 2.0 g/ml group （P 〈 0.01 ）, the effective rate in 0.5 g/ml group was significantly higher than that in 1.0 g/ml group and 2.0 g/ml group （ P 〈 0.05 ）, with no significant difference from the positive group （P 〉 0.05 ）. [ Conclusion ] The pathologic model of Streptococcus su/s serotype II could be effec- tively prevented and treated by oral intake of low dose of Chinese herbal preparation Yinqiaotiangan in Kunming mice.

关键词： Yinqiaotiangan Streptococcus suis serotype II Pathogenic model Kunming mice

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汽轮机组振动波形数据高效实时无损压缩算法

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华中科技大学学报（自然科学版） 2008年第9期36卷 86-89页

作者：汪勇杨涛高伟黄树红华中科技大学能源与动力工程学院湖北武汉430074

针对汽轮机组故障诊断系统中振动波形数据的形态特性，设计并实现了一套基于多次差分的压缩算法VWID．该算法先对原始波形进行多次差分以缩减其数据有效位，完成一次压缩．之后与通用压缩算法Zlib结合，对经过一次压缩后的数据流进行二... 详细信息

针对汽轮机组故障诊断系统中振动波形数据的形态特性，设计并实现了一套基于多次差分的压缩算法VWID．该算法先对原始波形进行多次差分以缩减其数据有效位，完成一次压缩．之后与通用压缩算法Zlib结合，对经过一次压缩后的数据流进行二次压缩，从而大大提高压缩比．针对汽轮机组等旋转机械振动波形数据的对比实验结果表明：以高压缩比著称的商用无损压缩软件Winrar压缩比为2．7～4．4，而VWID压缩算法压缩比达3．9～5．2，VWID-Zlib压缩算法压缩比可达5．3～6．4，同时具有无损压缩和实时高效的特点．

关键词：汽轮机组故障诊断振动波形无损压缩算法实时压缩多次差分

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大型火电机组引风机的状态检修

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华中科技大学学报（自然科学版） 2007年第1期35卷 63-66页

作者：陈刚李冰陈非黄树红华中科技大学煤燃烧国家重点实验室湖北武汉430074

针对国内大型火电厂检修现状,提出一套完整的引风机状态检修平台设计方案.平台在对引风机运行数据分类整理的基础上,充分挖掘数据信息,运用模糊数学的理论对所有参数进行加权综合评判,得出设备的运行状态;依据设备的运行状态信息,运用... 详细信息

针对国内大型火电厂检修现状,提出一套完整的引风机状态检修平台设计方案.平台在对引风机运行数据分类整理的基础上,充分挖掘数据信息,运用模糊数学的理论对所有参数进行加权综合评判,得出设备的运行状态;依据设备的运行状态信息,运用模糊识别的方法进行故障诊断,从而得出设备运行的风险评判;运行人员参照设备的风险评判,结合人工现场经验判断,给出引风机最优的检修策略.广东沙角C电厂660 MW机组引风机实际运用情况表明,该平台界面友好,维护方便,模型推理可靠,为电厂动力设备实现检修优化提供一种可行性方案.

关键词：引风机状态评价风险评估状态检修检修优化

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Catastrophe Model of Steam Flow Excitation Vibration in Steam Turbine Governing Stage

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中国电机工程学报 2013年第11期33卷 I0006-I0006,8页

作者： LI Jianlan GUO Xuhong YU Chen huang shuhong Huazhong University of Science & Technology

汽流激振是影响大型汽轮机组安全运行的主要故障之一。根据突变理论、非线性振动理论以及流体动力学，从机理分析的角度出发，对汽轮机调节级在部分进汽下导致的汽流激振突变性能进行了定量分析。建立了部分进汽情况下调节级气流激振力... 详细信息

汽流激振是影响大型汽轮机组安全运行的主要故障之一。根据突变理论、非线性振动理论以及流体动力学，从机理分析的角度出发，对汽轮机调节级在部分进汽下导致的汽流激振突变性能进行了定量分析。建立了部分进汽情况下调节级气流激振力模型，以及考虑汽流激振力的调节级非线性动力学模型，通过基于突变理论的推导，得到了调节级汽流激振的尖点突变流形和分岔集，确定了系统汽流激振突变的影响因子，讨论了振幅突变与影响因子的相关性，划分了系统工作的突变区域。最后，利用数值计算方法对汽流激振的幅值响应进行了分析，分析结果验证了基于突变理论的汽流激振突变分析方法的正确性。研究成果为汽轮机汽流激振突变性能的研究提供了一条新的途径。

关键词：流激振动大型汽轮机突变理论模型管理汽流激振非线性振动理论蒸汽流量流体动力学

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