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Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer

World Journal of Gastroenterology 2015年第4期21卷 1275-1283页

作者： Shigenori Kadowaki Miho Kakuta shuhei takahashi Akemi takahashi Yoshiko Arai Yoji Nishimura Toshimasa Yatsuoka Akira Ooki Kensei Yamaguchi Keitaro Matsuo Kei Muro Kiwamu Akagi Division of Gastroenterology Saitama Cancer CenterSaitama 362-0806Japan Department of Clinical Oncology Aichi Cancer Center HospitalAichi 464-8681Japan Division of Molecular Diagnosis and Cancer Prevention Saitama Cancer Center Saitama 362-0806Japan Division of Gastroenterological Surgery Saitama Cancer CenterSaitama 362-0806Japan Department of Preventive Medicine Kyushu University Faculty of Medical Sciences Fukuoka 812-8582Japan

AIM: To investigate the prognostic role of KRAS and BRAF mutations after adjustment for microsatellite instability(MSI) status in Japanese colorectal cancer(CRC) ***: We assessed KRAS and BRAF mutations and MSI status in 813 Japanese patients with curatively resected, stage Ⅰ-Ⅲ CRC and examined associations of these mutations with disease-free survival(DFS) and overall survival(OS) using uni- and multivariate Cox proportional hazards ***: KRAS and BRAF mutations were detected in 312(38%) of 812 and 40(5%) of 811 tumors, respectively. KRAS mutations occurred more frequently in females than in males(P = 0.02), while the presence of BRAF mutations was significantly associated with the female gender(P = 0.006), proximal tumor location(P < 0.001), mucinous or poorly differentiated histology(P < 0.001), and MSI-high tumors(P < 0.001). After adjusting for relevant variables, including MSI status, KRAS mutations were associated with poorer DFS(HR = 1.35; 95%CI: 1.03-1.75) and OS(HR = 1.46; 95%CI: 1.09-1.97). BRAF mutations were poor prognostic factors for DFS(HR = 2.20; 95%CI: 1.19-4.06) and OS(HR = 2.30; 95%CI: 1.15-4.71). Neither the BRAF by MSI interaction test nor the KRAS by MSI interaction test yielded statistically significant results for DFS and ***: KRAS and BRAF mutations are associated with inferior survival, independent of MSI status, inJapanese patients with curatively resected CRC.

关键词： Colorectal cancer KRAS BRAF Microsatellite instabi

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Influence of cognitive impairment on cardiac mortality after percutaneous coronary intervention in very elderly patients: a retrospective observational study

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Journal of Geriatric Cardiology 2019年第10期16卷 733-740页

作者： Tomoko Tomioka Ryokichi takahashi Yosuke Ikumi shuhei Tanaka Yoshitaka Ito Hiroki Shioiri Jiro Koyama Kanichi Inoue Department of Cardiology South-Miyagi Medical Center

Background Cognitive impairment (CI) increases cardiac mortality among very elderly patients. Percutaneous coronary intervention (PCI) for ischemic heart disease (IHD) patients is considered a favorable strategy for decreasing cardiac mortality. Here, we investigated the influence of CI on cardiac mortality after PCI in very elderly patients. Methods We performed a retrospective observational analysis of patients who received PCI between 2012 and 2014 at the South Miyagi Medical Center, Japan. IHD patients over 80 years old who underwent the Mini-Mental State Examination for CI screening during hospitalization and/or who had been diagnosed with CI were included. Participants were divided into CI and non-CI groups, and cardiac mortality and incidence of adverse cardiac events in a 3-year follow-up period were compared between groups. Statistical analyses were performed using the t-test,χ^2 test, and multivariable Cox regression analysis, with major comorbid illness and conventional cardiac risk factors as confounders. Results Of 565 patients, 95 were included (41 CI, 54 non-CI). Cardiac mortality during the follow-up period was significantly higher in the CI group (36%) compared with the non-CI group (13%)(OR = 4.3, 95% CI: 1.56–11.82, P < 0.05). CI was an independent cardiac prognostic factor after PCI and, for CI patients, living only with a CI partner was an independent predictor of cardiac death within three years. Conclusions CI significantly affected cardiac prognosis after PCI in very elderly patients, particularly those living with a CI partner. To improve patients’ prognoses, social background should be considered alongside conventional medical measures.

关键词： Cognitive impairments Family background Mortality Octogenarians Percutaneous coronary intervention

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Fabrication of MoSi_2-SiC Composites by a Spark Plasma Sintering Method

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International Journal of Minerals,Metallurgy and Materials 1999年第2期13卷 116-118页

作者： Kurokawa, Kazuya Ube, Makoto takahashi, Hideaki takahashi, Heishichiro Division of Molecular Chemistry Graduate School of Engineering Hokkaido University Kita-ku Sapporo 060-8628 Kita-13 Nishi-8 Japan Center for Advanced Research of Energy Technology Hokkaido University Japan

MolybdenUmdisilicidepeoSi,)hashighmeltingpoint（2293K）,relativelylowdensity（6.249/cm3）,abrittle-to-ductiletemper;tabout1173K[l]andoutstandingoxidationresistance[2M].Forthisreason,thedisilicidematrixcompositesarebei... 详细信息

关键词： MoSi2-SiC composite spark plasma sintering in-siam Synthesis sintering behavior

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Ultrasonic echo signal fetures of dissimilar material bonding joints

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中国有色金属学会会刊：英文版 2004年第6期14卷 1050-1054页

作者：刚铁 Yasuo takahashi State Key Lab of Advanced Welding Production Technology Harbin Institute of Technology Harbin 150001 China JWRI Osaka University Japan

An ultrasonic evaluation method of echo feature of diffusion bond joint between two dissimilar materials is presented. The echo signal was acquired by an automatic ultrasonic C-scan test system. It is found that the intensity of echo and its phase can be used to evaluate the joint quality, and interface products of dissimilar materials bonding can be evaluated by ultrasonic method.

关键词：超声波测试异金属扩散结合非破坏性演化

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Creep and creep-fatigue behavior of high chromium steel weldment

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Acta Metallurgica Sinica(English Letters) 2011年第3期24卷 175-182页

作者： Yukio takahashi Masaaki TABUCHI Materials Science Laboratory Central Research Institute of Electric Power Industry National Institute of Material Sciences

Strength of welded joints of high chromium steels is one of the important concerns for fabricators and operators of ultra supercritical thermal power plants. A number of creep as well as creep-fatigue tests with tensile hold have been carried out on the welded joints of two types of high chromium steels widely used in Japan, i.e. Grade 91 and 122 steels. It was found that failure occurred in fine grain heat-affected zone in all the creep-fatigue tests, even at a relatively low temperature and fairly short time where failure occurred in plain base metal region in simple creep testing. Four procedures were used to predict failure lives and their results were compared with the test results. A newly proposed energy-based approach gave the best estimation of failure life, without respect of the material and temperature.

关键词： Creep Creep-fatigue High chromium steel Life prediction Welded joint

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Preface of the Special Issue: Queueing Systems and Engineering Applications

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Journal of Systems Science and Systems Engineering 2019年第2期28卷 129-131页

作者： Wuyi Yue Yutaka takahashi Department of Intelligence and Informatics Konan University Kobe 658-8501 Japan Graduate School of Informatics Kyoto University Kyoto 606-8501 Japan

This volume of the Journal of Systems Science and Systems Engineering is devoted to the extended versions of papers selected and presented at the 12th International Conference on Queueing Theory and Network Applicatio... 详细信息

关键词： Systems 12th Applications

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Short-fetch high waves during the passage of 2019 Typhoon Faxai over Tokyo Bay

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Frontiers of Earth Science 2022年第1期16卷 206-219页

作者： Hiroshi TAKAGI Atsuhei takahashi School of Environment and Society Tokyo Institute of TechnologyTokyo 152-8550Japan

The risk of wind waves in a bay is often overlooked,owing to the belief that peninsulas and islands will inhibit high ***,during the passage of a tropical cyclone,a semi-enclosed bay is exposed to twodirectional waves:one generated inside the bay and the other propagated from the outer *** Faxai in 2019 resulted in the worst coastal disaster in Tokyo Bay in the last few *** authors conducted a post-disaster survey immediately after this *** modeling was also performed to reveal the mechanisms of unusual high *** significant high-wave damage occurred on coasts facing the Pacific *** contrast,Fukuura-Yokohama,which faces Tokyo Bay,suffered overtopping waves that collapsed *** precisely reproduce multi-directional waves,the authors developed an extended parametric typhoon model,which was embedded in the JMA mesoscale meteorological model(JMA-MSM).The peak wave height was estimated to be 3.4 m off the coast of Fukuura,in which the contribution of the outer-sea waves was as low as 10%–20%.A fetchlimited wave developed over a short distance in the bay is considered the primary mechanism of the high *** maximum wave occurred on the left-hand side of the typhoon track in the bay,which appears to be contrary to the common understanding that it is safer within the semicircle of a storm than on the opposite *** Faxai was a small typhoon;however,if the radius was tripled,it is estimated that the wave height would exceed 3 m over the entire bay and surpass 4 m off the coasts of Yokohama and Chiba.

关键词： Typhoon Faxai Tokyo Bay high waves short fetch overtopping wave hindcasting parametric typhoon JMA-MSM storm surge

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A Patient with Spinal Arteriovenous Malformation Treated with Lumbar Vertebral Surgery Due to Misdiagnosis

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Open Journal of Orthopedics 2020年第9期10卷 193-202页

作者： shuhei Matsuoka Shintaro Tsuge Kazumasa Nakamura Keiji Hasegawa Akihito Wada Hiroshi takahashi Department of Orthopaedic Surgery Toho University School of Medicine Tokyo Japan

Spinal arteriovenous malformation (AVM) is a rare disease that arises more commonly from the lower thoracic and upper lumbar spine. It is classified based on the development pattern and the shunt location. The developmental mechanism of the symptoms is thought to be as follows. Spinal venous return is impaired by high-pressure arterial blood flowing into the coronary sinus via a shunt and venous pressure is promoted, which causes spinal cord symptoms to progress gradually. Listlessness, pain, and an abnormal sensation of the lower limb are possible initial symptoms. Spinal AVM may cause intermittent claudication and bladder and rectal disturbance, and differentiation from lumbar degenerative diseases and arteriosclerosis obliterans is required, which may cause difficulty with diagnosis. We encountered a patient in whom intermittent claudication was treated with lumbar decompression and fixation at another hospital, but symptoms did not improve. The patient was diagnosed with spinal AVM at our hospital and symptoms were improved by surgery. Because the symptoms did not improve despite being treated with surgery for spinal canal stenosis, we strongly suspected spinal intermittent claudication, and we performed a spinal CT and MRI after myelography for the entire spinal cord, and identified the lesion in the thoracic spinal cord. Regarding the postoperative outcome and prognosis of spinal dural AVF, early diagnosis and early treatment have been proposed as prognostic factors because the postoperative outcome is poor in patients with high preoperative severity and a long duration of illness. In our patient, the preoperative JOA score was 6, showing high preoperative severity, and the duration of illness was 1.5 years before diagnosis, which may explain the limited improvement of the JOA score to 20 at final follow-up. In a case with these characteristics, we suggest that close examination of the entire spinal cord is needed for effective treatment.

关键词： Spinal Arteriovenous Malformation Intermittent Claudication

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Challenges for beyond 5G:ultra-densification of radio access network

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通信学报 2020年第11期41卷 1-11页

作者： Fumiyuki Adachi Ryo takahashi Hidenori Matsuo Research Organization of Electrical Communication Tohoku UniversitySendai 980-8577Japan

Ultra-densification of radio access network(RAN)is a key to efficiently support the exponentially growing mobile data traffic in 5 G ***,extremely high frequency band like mm Wave band was utilized to solve the bandwidth shortage ***,untra-dense reusing the same radio resource produced severe *** the mm Wave link was very harsh due to frequent blockage by *** a new RAN architecture needed to be introduced to realize ultra-reliable communications in such a severe radio propagation *** architecture of distributed MIMO based RAN was ***,enhanced interference coordination(e IC)was ***,the effectiveness of distributed MIMO based RAN with e IC by computer simulation was showed.

关键词： 5G advanced systems distributed MIMO radio access network interference coordination cooperative signal transmission

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Recent advances in prostate cancer: WNT signaling, chromatin regulation, and transcriptional coregulators

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Asian Journal of Andrology 2023年第2期25卷 158-165页

作者： Sayuri takahashi Ichiro Takada Department of Urology The Institute of Medical ScienceThe University of TokyoShirokanedaiMinato-kuTokyo 108-8639Japan Department of Urology The Faculty of MedicineThe University of TokyoHongoBunkyo-kuTokyo 113-8655Japan

Prostate cancer is one of the most common diseases in men ***,radiation therapy,and hormonal therapy are effective treatments for early-stage prostate ***,the development of castration-resistant prostate cancer has increased the mortality rate of prostate *** develop novel drugs for castration-resistant prostate cancer,the molecular mechanisms of prostate cancer progression must be *** the signaling pathways regulating prostate cancer development,recent studies have revealed the importance of noncanonical wingless-type MMTV integration site family(WNT)signaling pathways,mainly that involving WNT5A,in prostate cancer progression and metastasis;however,its role remains ***,chromatin remodelers such as the switch/sucrose nonfermentable(SWI/SNF)complex and chromodomain helicase DNA-binding proteins 1 also play important roles in prostate cancer progression through genome-wide gene expression ***,we review the roles of noncanonical WNT signaling pathways,chromatin remodelers,and epigenetic enzymes in the development and progression of prostate cancer.

关键词： chromatin remodeling histone-modifying enzymes prostate cancer WNT5A

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