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垂体促甲状腺激素腺瘤合并桥本甲状腺炎1例并文献复习

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疑难病杂志 2023年第7期22卷 753-754页

作者：姚佳佳刘维徐书杭谢绍锋南京中医药大学附属中西医结合医院内分泌科 210028

报道1例垂体促甲状腺激素腺瘤合并桥本甲状腺炎患者的临床资料,并进行文献复习。

关键词：垂体促甲状腺激素腺瘤桥本氏病甲状腺功能亢进病例报道

Research on buffer structure and flow field simulation of swash plate plunger type hydraulic transformer

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High Technology Letters 2022年第4期28卷 425-433页

作者：王晓晶 HUO shuhang LI Wenjie Beijing Key Laboratory of Performance Guarantee on Urban Rail Transit Vehicle Beijing University of Civil Engineering and ArchitectureBeijing 102616P.R.China Beijing Engineering Research Center of Monitoring for Construction Safety Beijing University of Civil Engineering and ArchitectureBeijing 102616P.R.China School of Mechanical and Power Engineering Harbin University of Science and TechnologyHarbin 150080P.R.China

In order to solve the problem of excessive noise and vibration during the operation of the hydraulic transformer,an optimization method of valve plate damping hole structure is proposed to alleviate the phenomenon of pressure shock.Firstly,the mathematical model of oil pressure gradient in the plunger cavity is established,and the incremental equation of pressure change is derived.Secondly,a kind of buffering structure is proposed,the corresponding relationship between the pressure change and the envelopment angle of the buffering hole and the aperture size is determined by analyzing the oil pressure change curve in the plunger cavity.Finally,the flow field models with buffering holes are established,and the transient simulation of the pressure change process under the optimal solution is carried out with ANSYS software and the flow field pressure distribution contours are obtained.Through the analysis of simulation results,it is concluded that the optimal envelope angle of the three buffer holes ofA-T-B-Ais 5°,and the optimal aperture is 1.8 mm,1.6 mm,and 1.7 mm,respectively.The buffer hole can achieve a better-buffering effect in the range of variable pressure angle[0°,101°].The buffer hole structure can effectively alleviate the pressure shock and reduce the noise level,which lays a foundation for the design and theoretical research of hydraulic transformers.

关键词： hydraulic transformer pressure shock buffer structure flow field simulation dynamic grid

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基于动态贝叶斯网络的轨道机动接近意图预测

Transactions of Nanjing University of Aeronautics and Astronautics 2023年第4期40卷 460-471页

作者：陈士博李军谢亚恩吴限德冷淑航杨若楚哈尔滨工程大学航空航天与建筑工程学院哈尔滨150001 中国船舶及海洋工程设计研究院上海210110

在信息化条件下,现代空间环境的复杂性急剧增加,地面操作人员难以在短时间内处理大量信息并识别未知目标的接近意图。本文将模糊理论与专家经验相结合,设计了一种可以帮助操作者快速、系统地识别接近意图的动态贝叶斯网络模型。与静态... 详细信息

在信息化条件下,现代空间环境的复杂性急剧增加,地面操作人员难以在短时间内处理大量信息并识别未知目标的接近意图。本文将模糊理论与专家经验相结合,设计了一种可以帮助操作者快速、系统地识别接近意图的动态贝叶斯网络模型。与静态贝叶斯网络(Static Bayesian network,SBN)相比,动态贝叶斯网络在识别多个时间片内意图和通过连续计算概率预测未来趋势两方面更加实用,适用于快速变化的空间环境。众多算例表明,本文所提出的意图预测方法可行有效。

关键词：动态贝叶斯网络轨道机动模糊集意图预测卫星

Distr ibution, risk and bioavailability of metals in sediments of Lake Yamdrok Basin on the Tibetan Plateau, China

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Journal of Environmental Sciences 2020年第11期32卷 169-179页

作者： Feifei Che Junyi Chen Bo Zhang Xia Jiang shuhang Wang National Engineering Laboratory for Lake Pollution Control and Ecological Restoration Chinese Research Academy of Environmental SciencesBeijing l00012China

Total contents of metals in soil and sediments on the Tibetan Plateau of China have been widely analyzed,but existing information is insufficient to effectively evaluate metal ecological risk because of a lack of metal bioavailability data.In this study,distribution,potential risk,mobility and bioavailability of metals in sediments of Lake Yamdrok Basin in Tibet of China were explored by combined use of total digestion,sequential extraction and the diffusive gradient in thin-films(DGT).Average concentrations of Cr,Ni,Cu,Zn,As,Cd and Pb in surface sediments were 31.25,30.31,22.00,45.04,31.32,0.13 and 13.39 mg/kg,respectively.Higher levels of metals were found near the inflowing rivers.Residual form was dominant in Cr,Ni,Zn,Cd and Pb,and reducible form was dominant in As and Cd.Metals in surface sediments showed a low enrichment degree overall,but Cd and As had higher ecological risk levels than the other metals.Furthermore,there was a larger average proportion of exchangeable form of As(20.4%)and Cd(9.0%)than the other metals(1.7%-3.3%),implying their higher mobility and release risk.Average DGT-labile concentrations of Cr,Ni,Cu,Zn,As,Cd and Pb were 0.5,4.5,0.7,25.1,60.0,0.22 and 1.0μg/L,respectively.The DGT-labile As was significantly correlated with extractable As forms(p<0.01),suggesting that extractable As in sediments acts as a"mobile pool"for bioavailable As.These results suggest potential risks of As and Cd,especially As,deserve further attention in Lake Yamdrok Basin.

关键词： Sequential extraction the Diffusive gradients in thin films(DGT) Mobility Geochemical baseline Tibet

Approaching the upper boundary of driver-response relationships:identifying factors using a novel framework integrating quantile regression with interpretable machine learning

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Frontiers of Environmental Science & Engineering 2023年第6期17卷 153-163页

作者： Zhongyao Liang Yaoyang Xu Gang Zhao Wentao Lu Zhenghui Fu shuhang Wang Tyler Wagner National Engineering Laboratory for Lake Pollution Control and Ecological Restoration State Environment Protection Key Laboratory for Lake Pollution ControlChinese Research Academy of Environmental SciencesBeijing 100012China Fujian Provincial Key Laboratory for Coastal Ecology and Environmental Studies Xiamen UniversityXiamen 361102China College of the Environment&Ecology Xiamen UniversityXiamen 361102China Key Laboratory of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Department of Global Ecology Carnegie Institution for ScienceStanfordCA 94305USA Institute of Strategic Planning Chinese Academy of Environmental PlanningBeijing 100012China The Center for Beautiful China Chinese Academy of Environmental PlanningBeijing 100012China U.S.Geological Survey Pennsylvania Cooperative Fish and Wildlife Research UnitPennsylvania State UniversityUniversity ParkPA 16802USA

The identification of factors that may be forcing ecological observations to approach the upper boundary provides insight into potential mechanisms affecting driver-response relationships,and can help inform ecosystem management,but has rarely been explored.In this study,we propose a novel framework integrating quantile regression with interpretable machine learning.In the first stage of the framework,we estimate the upper boundary of a driver-response relationship using quantile regression.Next,we calculate“potentials”of the response variable depending on the driver,which are defined as vertical distances from the estimated upper boundary of the relationship to observations in the driver-response variable scatter plot.Finally,we identify key factors impacting the potential using a machine learning model.We illustrate the necessary steps to implement the framework using the total phosphorus(TP)-Chlorophyll a(CHL)relationship in lakes across the continental US.We found that the nitrogen to phosphorus ratio(N:P),annual average precipitation,total nitrogen(TN),and summer average air temperature were key factors impacting the potential of CHL depending on TP.We further revealed important implications of our findings for lake eutrophication management.The important role of N:P and TN on the potential highlights the co-limitation of phosphorus and nitrogen and indicates the need for dual nutrient criteria.Future wetter and/or warmer climate scenarios can decrease the potential which may reduce the efficacy of lake eutrophication management.The novel framework advances the application of quantile regression to identify factors driving observations to approach the upper boundary of driver-response relationships.

关键词： Driver-response Upper boundary of relationship Interpretable machine learning Quantile regression Total phosphorus Chlorophyll a

Visualizing veins from color skin images using convolutional neural networks

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Journal of Innovative Optical Health Sciences 2020年第4期3卷 80-92页

作者： Chaoying Tang Yimin Yuan shuhang Xia Gehua Ma Biao Wang Nanjing University of Aeronautics and Astronautics Nanjing Jiangsu 211106P.R.China

Intravenous cannulation is the most important phase in medical practices.Currently,limited literature is available about visibility of veins and the characteristics of patients associated with difficult intravenous access.In modern medical treatment,a major challenge is locating veins for patients who have difficult venous access.Presently,some products of vein locators are available in the market to improve vein access,but they need auxiliary equipment such as near infrared(NIR)illumination and camera,which add weight and cost to the devices,and cause inconveniences to daily medical care.In this paper,a vein visualization algorithm based on the deep learning method was proposed.Based on a group of synchronous RGB/NIR arm images,a convolutional neural network(CNN)model was designed to implement the mapping from RGB to NIR images,where veins can be detected from skin.The model has a simple structure and less optimization parameters.A color transfer scheme was also proposed to make the network adaptive to the images taken by smartphone in daily medical treatments.Comprehensive experiments were conducted on three datasets to evaluate the proposed method.Subjective and objective evaluations showed the effec-tiveness of the proposed method.These results indicated that the deep learning-based method can be used for visualizing veins in medical care applications.

关键词： Intravenous cannulation vein visualization convolutional neural network

Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

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Frontiers of Medicine 2016年第4期10卷 383-388页

作者： shuhang Wang Yongping Song Feifei Yan Delong Liu The Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital Beijing 100142 China Henan Cancer Hospital and the Affiliated Cancer Hospital of Zhengzhou University Zhengzhou 450008 China

The tyrosine kinase inhibitors （TKI） of the epidermal growth factor receptor （EGFR） are becoming the first line of therapy for advanced non-small cell lung cancer （NSCLC）. Acquired mutations in EGFR account for one of the major mechanisms of resistance to the TKIs. Three generations of EGFR TKIs have been used in clinical applications. AZD9291 （osimertinib; Tagrisso） is the first and only FDA approved third-generation EGFR TKI for T790M-positive advanced NSCLC patients. However, resistance to AZD9291 arises after 9-13 months of therapy. The mechanisms of resistance to third-generation inhibitors reported to date include the EGFR C797S mutation, EGFR L718Q mutation, and amplifications of HER-2, MET, or ERBB2. To overcome the acquired resistance to AZD9291, EAI045 was discovered and recently reported to be an allosteric EGFR inhibitor that overcomes T790M- and C797S-mediated resistance. This review summarizes recent investigations on the mechanisms of resistance to the EGFR TKIs, as well as the latest development of EAI045 as a fourth-generation EGFR inhibitor.

关键词： EGFR tyrosine kinase inhibitor AZD9291 EAI045

Highly efficient separation of benzene+cyclohexane mixtures by extraction combined extractive distillation using imidazolium-based dicationic ionic liquids

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Green Chemical Engineering 2023年第3期4卷 312-323页

作者： Wanxiang Zhang Wuji Zhao shuhang Ren Yucui Hou Weize Wu State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China Department of Chemistry Taiyuan Normal UniversityShanxi030619China

Benzene(BEN)and cyclohexane(CYH),which have very close boiling points and a binary azeotrope,are the most difficult binary components in the separation of aromatic and non-aromatic hydrocarbons.This study further explored the separation mechanism and industrial application prospects of BEN+CYH mixtures separated by a dicationic ionic liquid(DIL)[C_(5)(MIM)_(2)][NTf_(2)]_(2) based on experimental research.The calculation results of the Conductor-like Screening model Segment Activity Coefficient(COSMO-SAC)model show that selectivity and solvent capacity of the DIL are significantly improved.The effects of different anions and cations on the micro-structure distribution and diffusion behavior of BEN+CYH system were investigated by quantum chemistry(QC)calculations and molecular dynamics(MD)simulations.The results indicate that the anion[NTf_(2)]_(2)has low polarity,uniform charge distribution,and a dual role of hydrogen bonding andπ-πbonding,and the cation[C_(5)(MIM)_(2)]^(2+) has stronger interaction with BEN and higher selectivity than conventional cations.The liquid-liquid extraction and extractive distillation(LLE-ED)process using an optimized 65 mol/mol DIL+35 mol/mol H_(2)O mixed solution as the extractant was proposed,which solved the problem of low product purity in the LLE process and high energy consumption in the ED process.Under the best operating conditions,the purity of CYH product was 99.9%,the purity of BEN product was 99.6%,the recovery rate of BEN reached 99.9%,and the recovery rate of DIL reached 99.9%.The heat-integrated LLE-ED process reduced total annual cost by 21.6%,and reduced CO_(2) emissions by 48.0%,which has broad industrial application prospects.

关键词： Dicationic ionic liquids Benzeneþcyclohexane mixture LLE-ED process Quantum chemical calculation Molecular dynamics simulation

Ionic liquids:Functionalization and absorption of SO_2

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Green Energy & Environment 2018年第3期3卷 179-190页

作者： shuhang Ren Yucui Hou Kai Zhang Weize Wu State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Department of Chemistry Taiyuan Normal University

Room-temperature ionic liquids(ILs), which have excellent properties, such as high gas absorption abilities, extremely low volatility and tunable structures, are regarded as environmentally-friendly absorbents and widely used in SO_2 absorption and separation. As a result, a large number of ILs have been synthesized to capture SO_2 from flue gas or simulated gas, but a part of them just have physical interaction with SO_2 and can hardly absorb SO_2 when the content of SO_2 is very low. Hence, functional ILs, which can chemically absorb a large amount of SO_2 with low contents, have been designed and synthesized for SO_2 capture. Up to now, many kinds of functional ILs were investigated for SO_2 absorption from flue gas. In this review, the functional ILs are classified into guanidinium based ILs, hydroxyl ammonium based ILs, imidazolium/pyridinium based ILs, quaternary ammonium based ILs, phosphonium based ILs, and other kinds of ILs according to their cations. The capacities of SO_2 absorption in these ILs, the mechanism of the absorption, and the ways to enhance the absorption are briefly introduced. The prospect of functional ILs for their application in SO_2 removal is presented. The present problems and the further studies are also discussed.

关键词： Ionic liquid SO2 Absorption Functionalization