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Mannogalactoglucan from mushrooms protects pancreatic islets via restoring UPR and promotes insulin secretion in TIDM mice

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Food Science and Human Wellness 2024年第3期13卷 1390-1401页

作者： Ting Liu Si Chen Yunhe Qu Lujuan Zheng Xiaoxuan yang shuhan Men Yuanning Wang Hanrui Ma Yifa Zhou Yuying Fan Engineering Research Center of Glycoconjugates Ministry of EducationJilin Provincial Key Laboratory of Chemistry and Biology of Changbai Mountain Natural DrugsSchool of Life SciencesNortheast Normal UniversityChangchun 130024China

Type 1 diabetes mellitus(T1DM) lacks insulin secretion due to autoimmune deficiency of pancreaticβ-*** pancreatic islets and enhancing insulin secretion has been therapeutic *** is the main type of polysaccharide from natural mushroom,which has potential medicinal ***,the antidiabetic property of mannogalactoglucan in T1DM has not been fully *** this study,we obtained the neutral fraction of alkali-soluble Armillaria mellea polysaccharide(AAMP-N) with the structure of mannogalactoglucan from the fruiting body of *** and investigated the potential therapeutic value of AAMP-N in *** demonstrated that AAMP-N lowered blood glucose and improved diabetes symptoms in T1DM ***-N activated unfolded protein response(UPR) signaling pathway to maintain ER protein folding homeostasis and promote insulin secretion in *** that,AAMP-N promoted insulin synthesis via upregulating the expression of transcription factors,increased Ca^(2+) signals to stimulate intracellular insulin secretory vesicle transport via activating calcium/calmodulin-dependent kinase Ⅱ(CamkⅡ) and cAMP/PKA signals,and enhanced insulin secretory vesicle fusion with the plasma membrane via vesicle-associated membrane protein 2(VAMP2).Collectively,these studies demonstrated that the therapeutic potential of AAMP-N on pancreatic islets function,indicating that mannogalactoglucan could be natural nutraceutical used for the treatment of T1DM.

关键词： Mannogalactoglucan Mushroom Pancreatic islets Insulin secretion Insulin synthesis Unfolded protein response(UPR) Type 1 diabetes mellitus(T1DM)

IFN-γ induced LSK(Lin-Sca-1+c-Kit+) cells negatively regulate T cell response in Con A-induced liver injury model

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IFN-γ induced LSK(Lin-Sca-1+c-Kit+) cells negatively regula...

Channel modeling for MI-based wireless underground sensor networks with conductive objects

第十届全国免疫学学术大会

作者： shuhan yang Liang Li Yuan Yao Zhexiong Lian Institute of Immunology and School of Life Sciences University of Science and Technology of China

Background and Objective:Clinical researches have shown that many diseases such as autoimmune liver disease are often accompanied by hematopoiesis *** our research,we used Con A-induced acute liver injury model to inv... 详细信息

关键词： Con A Liver injury LSK cells IFN-γ

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Science China(Information Sciences) 2024年第7期67卷 333-334页

作者： shuhan DENG Guanghua LIU Ziwei CHEN Huaijin ZHANG Tao JIANG Research Center of 6G Mobile Communications School of Cyber Science and EngineeringHuazhong University of Science and Technology School of Electronic Information and Communications Huazhong University of Science and Technology

Wireless underground sensor networks (WUSNs) are an emerging research field with promising applications. However, WUSNs links suffer from significant attenuation as the propagation of the signal needs to pass through soil, rock,and water. Magnetic induction (MI)-based transmission is proposed to overcome these issues as MI signal can penetrate most substances similarly without experiencing high path loss, which ensures the robustness of WUSNs links [1].

关键词： Wireless sensor networks

卵巢癌患者生辰五运六气特点与罹患率相关性分析

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山东中医杂志 2024年第9期43卷 965-969页

作者：杨舒涵冯婧丽谢伊刘苏颖王妍方宇航房立源王润兮隋白鹭张英中国中医科学院广安门医院北京100053 北京中医药大学北京100029 北京中医药大学东直门医院北京100007

目的:分析卵巢癌患者先天五运六气特点与分布差异,并研究其与后天发病的相关性。方法:选取2018年至2022年在中国中医科学院广安门医院就诊的卵巢癌患者共6 129例作为研究对象,分析卵巢癌患者出生日期运气学特征的分布差异,探讨其与卵巢... 详细信息

目的:分析卵巢癌患者先天五运六气特点与分布差异,并研究其与后天发病的相关性。方法:选取2018年至2022年在中国中医科学院广安门医院就诊的卵巢癌患者共6 129例作为研究对象,分析卵巢癌患者出生日期运气学特征的分布差异,探讨其与卵巢癌罹患率的关系。结果:卵巢癌患者的出生日期在不同天干、主运、主气、客气、司天在泉分布方面存在显著差异性(P<0.05)。出生日期天干为癸年、主运为金运、主气为阳明燥金、客气为阳明燥金、司天在泉为阳明燥金司天-少阴君火在泉的人群更易罹患卵巢癌;出生日期天干为丁年、主运为火运、主气为少阴君火、客气为太阴湿土、司天在泉为太阴湿土司天-太阳寒水在泉的人群不易罹患卵巢癌。结论:卵巢癌的后天发病与先天运气学禀赋有一定相关性。

关键词：五运六气卵巢癌出生日期癸年金运阳明燥金阳明燥金司天-少阴君火在泉

Chemical simulation teaching system based on virtual reality and gesture interaction

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虚拟现实与智能硬件（中英文） 2024年第2期6卷 148-168页

作者： Dengzhen LU Hengyi LI Boyu QIU Siyuan LIU shuhan QI School of Computer Science and Technology Harbin Institute of TechnologyShenzhen 518055China Pengcheng Laboratory Shenzhen 518052China

Background Most existing chemical experiment teaching systems lack solid immersive experiences,making it difficult to engage *** address these challenges,we propose a chemical simulation teaching system based on virtual reality and gesture *** The parameters of the models were obtained through actual investigation,whereby Blender and 3DS MAX were used to model and import these parameters into a physics *** establishing an interface for the physics engine,gesture interaction hardware,and virtual reality(VR)helmet,a highly realistic chemical experiment environment was *** code script logic,particle systems,as well as other systems,chemical phenomena were ***,we created an online teaching platform using streaming media and databases to address the problems of distance *** The proposed system was evaluated against two mainstream products in the *** the experiments,the proposed system outperformed the other products in terms of fidelity and *** The proposed system which offers realistic simulations and practicability,can help improve the high school chemistry experimental education.

关键词： Chemical experiment simulation Gesture interaction Virtual reality Model establishment Process control Streaming media Database

Bioorthognal Equipping CAR-T Cells with Hyaluronidase and Checkpoint Blocking Antibody for Enhanced Solid Tumor Immunotherapy

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Bioorthognal Equipping CAR-T Cells with Hyaluronidase and Ch...

Modulating perovskite crystallization and band alignment using coplanar molecules for high-performance indoor photovoltaics

第十四届全国免疫学学术大会

作者： yangyang Zhao Yansong Dong shuhan yang Youyong Yuan Zhexiong Lian South China University of Technology

Adoptive cellular therapy utilizing Chimeric antigen receptor-redirected T(CAR-T) cells has shown striking therapeutic effects on hematological malignancies. In contrast, the efficacy of treating solid tumors with CAR-T cell therapies is still poor, which is largely due to inefficient penetration into solid tumors and immunosuppressive tumor microenvironment. Herein, we engineered hyaluronidase(HAase) and the checkpoint blocking antibody α-PDL1 on the surface of CAR-T cells via highly efficient and biocompatible bioorthogonal click chemistry to improve the therapeutic effects of CAR-T cells on solid tumors. The modified HAase degrades hyaluronic acid and destroys the tumor extracellular matrix, allowing CAR-T cells penetrate deeply into solid tumors, as evidenced by in vitro infiltration experiments and in vivo biodistribution studies. In addition, in vitro cytotoxicity studies showed stronger antitumor activity of α-PDL1-decorated CAR-T cells than traditional CAR-T cells. Importantly, HAase-and α-PDL1-engineered CAR-T cells showed better therapeutic efficacy on A20 solid tumors, and did not cause significant systemic toxicity. In this work, we provided a simple, efficient, and biologically safe chemical strategy to engineer traditional CAR-T cells for enhanced therapeutic efficacy on solid tumors, which can be extended to other adoptive cellular immunotherapies and holds great potential for clinical application.

关键词： Bioorthogonal reaction Chimeric antigen receptor T cell Immunotherapy Solid tumor

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Journal of Energy Chemistry 2024年第11期 383-390页

作者： Qu yang shuhan Fan Haozhe Zhang Zhenhuang Su Xingyu Gao Hui Shen Mingkui Wang Xiu Gong College of Physics & Guizhou Province Key Laboratory for Photoelectrics Technology and Application Guizhou University State Key Laboratory of Public Big Data Guizhou University Shanghai Synchrotron Radiation Facility (SSRF) Shanghai Advanced Research Institute Chinese Academy of Sciences Wuhan National Laboratory for Optoelectronics School of Optical and Electronic Information Huazhong University of Science and Technology

The proper bandgap and exceptional photostability enable CsPbI3as a potential candidate for indoor photovoltaics（IPVs）,but indoor power conversion efficiency（PCE） is impeded by serious nonradiative recombination stemming from challenges in incomplete DMAPbI3conversion and lattice structure ***,the coplanar symmetric structu re of hexyl sulfide（HS） is employed to functionalize the CsPbI3layer for fabricating highly efficient *** hydrogen bond between HS and DMAI promotes the conversion of DMAPbI3to CsPbI3,while the copianar symmetric structure enhances crystalline ***,surface sulfidation during HS-induced growth results in the in situ formation of PbS,spontaneously creating a CsPbI3N-P homojunction to enhance band alignment and carrier *** a result,the CsPbI3&HS devices achieve an impressive indoor PCE of 39.90%(Pin:334.6 μW cm-2,Pout:133.5 μW cm-2) under LED@2968 K,1062 lux,and maintain over 90% initial PCE for 800 h at ～30% air ambient humidity.

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Structural characterization and prebiotic potential of polysaccharides from Polygonatum sibiricum

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Food Science and Human Wellness 2024年第4期13卷 2208-2220页

作者： Zihan Qi Tiexiang Gao Jingjing Li shuhan Zhou Zhigang Zhang Mingzhu Yin Haiming Hu Hongtao Liu College of Basic Medical Sciences Hubei University of Chinese MedicineWuhan 430065China College of Pharmacy Hubei University of Chinese MedicineWuhan 430065China

Polygonatum sibiricum has been widely used due to its excellent biological *** prepared a novel polysaccharide from ***(PSP)in this *** a monosaccharide composition analysis,PSP was mainly composed of fructose and glucose with a molar percentage of 93.81:*** main linkage types were identified asα-D-Glcp-1→and→2-β-D-Fruf-1→.The molecular weight of PSP showed no significant change after simulated salivary and gastrointestinal ***,PSP could be broken down by intestinal *** findings revealed that PSP administration increased the abundance of probiotics such as ***,the results showed that gut microbes could utilize PSP to produce short-chain fatty acids including acetic acid,propionic acid,and butyric ***,the PSP fermentation broth displayed an excellent scavenging effect on free radicals,including 2,2-diphenyl-1-picrylhydrazyl radical,superoxide radical,and hydroxyl *** summary,this study will help to promote the application of PSP as prebiotics in functional food and the medical industry.

关键词： Dietary polysaccharides Prebiotic Gut microbiota Short-chain fatty acids

Enhanced remediation of chlorpyrifos-contaminated soil by immobilized strain Bacillus H27

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Journal of Environmental Sciences 2024年第10期144卷 172-184页

作者： Changrui Liu Shengfang Wen shuhan Li Yu Tian Lanjun Wang Lusheng Zhu Jun Wang Young Mo Kim Jinhua Wang National Engineering Research Center for Efficient Utilization of Soil and Fertilizer Resources Key Laboratory of Agricultural Environment in Universities of ShandongCollege of Resources and EnvironmentShandong Agricultural UniversityTaian 271018China Department of Civil and Environmental Engineering Hanyang UniversitySeongdong-guSeoul 04763Korea

Chlorpyrifos is a pesticide widely used in agricultural production with a relatively long residual half-life in *** the problem of residual chlorpyrifos is of universal *** this study,rice hull biochar was used as an immobilized carrier to prepare the immobilized strain H27 for the remediation of chlorpyrifos-contamination *** microorganisms after remediation were investigated by ecotoxicological *** immobilized strain H27 had the highest removal rate of chlorpyrifos when 10%bacterial solution was added to the liquid medium containing 0.075-0.109 mm diameter biochar cultured for 22 *** study on the removal of chlorpyrifos by immobilized strain H27 showed that the initial concentration of chlorpyrifos in solution was 25mg/L,and the removal rate reached 97.4%after 7 days of *** the soil,the removal rate of the immobilized bacteria group increased throughout the experiment,which was significantly higher than that of the free bacteria and biochar treatment *** Biolog-ECO test,T-RFLP and RT-RCR were used to study the effects of the soil microbial community and nitrogen cycling functional genes during chlorpyrifos *** was found that ICP group had the highest diversity index among the four treatment *** microflora of segment containing 114 bp was the dominant bacterial community,and the dominant microflora of the immobilized bacteria group was more evenly *** influence of each treatment group on ammonia-oxidizing bacteria(AOB)was greater than on ammonia-oxidizing archaea(AOA).This study offers a sound scientific basis for the practical application of immobilized bacteria to reduce residual soil pesticides.

关键词： Chlorpyrifos Immobilized microorganisms Soil remediation Soil microorganism