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Unveiling non-radiative center control in CsPbBr_(3) nanocrystals:A comprehensive comparative analysis of hot injection and ligandassisted reprecipitation approaches

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Nano Research 2024年第5期17卷 4525-4534页

作者： Daocheng Hong Yuchen Zhang shuhan Pan Hanyu Liu Wei Mao Wanli Zhang Yuhui Ye Zhihong Wei Xuxing Lu Xiaoyong wang Zhenda Lu Yuxi Tian Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province Yancheng Institute of TechnologyYancheng 224051China Laboratory of Mesoscopic Chemistry of MOE School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China College of Engineering and Applied Sciences Nanjing UniversityNanjing 210023China National Laboratory of Solid State Microstructures School of PhysicsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China School of Electronic Electrical Engineering and PhysicsFujian University of TechnologyFuzhou 350118China

Metal-halide perovskite nanocrystals(NCs)have gained significant attention in the field of optoelectronic and photonic devices due to their promising *** their exceptional optical properties,the impact of different synthetic strategies on the fundamental nature of NCs,such as nonradiative recombination centers,remains poorly *** this study,we investigated the photophysical properties of CsPbBr_(3) NCs synthesized using two distinct methods,hot injection and ligand-assisted reprecipitation,at the individual particle *** observed different blinking behaviors under specific photoexcitation power densities and proposed,through intensity-lifetime analysis and Monte-Carlo simulations,that these different synthetic strategies can fabricate NCs with similar crystal structures but distinct surface quenchers with varying energy levels,which significantly affected the photo-induced blinking-down and blinking-up behaviors in individual *** findings indicate a practical and feasible approach for controlling defect engineering in perovskite NCs,with significant implications for their use in optoelectronic and other technological applications.

关键词： metal-halide perovskite nanocrystals photophysical properties nonradiative recombination centers hot injection method ligand-assisted reprecipitation

p53 exerts anticancer effects by regulating enhancer formation and activity

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The Journal of Biomedical Research 2024年第04期 334-347页

作者： shuhan Chen Xuchun wang Nan Yang Yuechi Song He Cheng Yujie Sun Key Laboratory of Human Functional Genomics of Jiangsu Province School of Basic Medical Sciences Nanjing Medical University Department of Cell Biology School of Basic Medical Sciences Nanjing Medical University Jiangsu Key Lab of Cancer Biomarkers Prevention and Treatment Collaborative Innovation Center for Personalized Cancer Medicine Nanjing Medical University

The abnormality of the p53 tumor suppressor is crucial in lung cancer development, because p53 regulates target gene promoters to combat cancer. Recent studies have shown extensive p53 binding to enhancer ***, whether p53 exerts a tumor suppressor role by shaping the enhancer landscape remains poorly understood. In the current study, we employed several functional genomics approaches to assess the enhancer activity at p53 binding sites throughout the genome based on our established TP53 knockout(KO) human bronchial epithelial cells(BEAS-2B). A total of 943 active regular enhancers and 370 super-enhancers(SEs)disappeared upon the deletion of p53, indicating that p53 modulates the activity of hundreds of enhancer *** found that one p53-dependent SE, located on chromosome 9 and designated as KLF4-SE, regulated the expression of the Krüppel-like factor 4(KLF4) gene. Furthermore, the deletion of p53 significantly decreased the KLF4-SE enhancer activity and the KLF4 expression, but increased colony formation ability in the nitrosamines4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced cell transformation model. Subsequently, in TP53 KO cells, the overexpression of KLF4 partially reversed the increased clonogenic capacity caused by p53 ***, KLF4 expression also decreased in lung cancer tissues and cell lines. It appeared that overexpression of KLF4 significantly suppressed the proliferation and migration of lung cancer cells. Collectively, our results suggest that the regulation of enhancer formation and activity by p53 is an integral component of the p53 tumor suppressor function. Therefore, our findings offer some novel insights into the regulation mechanism of p53 in lung oncogenesis and introduce a new strategy for screening therapeutic targets.

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TWIP钢不同温度变形的力学性能变化规律及机理研究

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金属学报 2009年第5期45卷 573-578页

作者：王书晗刘振宇张维娜王国栋东北大学轧制技术与连轧自动化国家重点实验室沈阳110004

通过控温拉伸实验分析了在298,373,473和673 K温度下变形时,TWIP钢(Fe-25Mn-3Si-3Al)力学性能和显微组织的变化规律.结果表明,TWIP钢的强度和延伸率均随温度的升高而降低.通过热力学公式对不同温度下TWIP钢层错能Γ的估算可以推断,温度T... 详细信息

通过控温拉伸实验分析了在298,373,473和673 K温度下变形时,TWIP钢(Fe-25Mn-3Si-3Al)力学性能和显微组织的变化规律.结果表明,TWIP钢的强度和延伸率均随温度的升高而降低.通过热力学公式对不同温度下TWIP钢层错能Γ的估算可以推断,温度T≥673 K时,Γ≥76 mJ/m^2,滑移为TWIP钢主要的变形机制;298 K≤T≤373 K时, 21 mJ/m^2≤Γ≤34 mJ/m^2,孪生为TWIP钢主要的变形方式,此时产生"TWIP"效应,可获得较高的加工硬化速率,从而获得高强度及高塑性.

关键词：形变孪晶高温变形变形机制层错能

Sliding Mode Control for Continuous Stirred Tank Reactor with Mismatched Disturbances:A Genetic-Algorithm-Optimized GESO Approach

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Sliding Mode Control for Continuous Stirred Tank Reactor wit...

第40届中国控制会议

作者： Sai Zhou shuhan wang Shumin Ma Qi Lu Jun Song Xiangyun Qing Key Laboratory of Smart Manufacturing in Energy Chemical Process（East China University of Science and Technology） Ministry of Education

The paper develops a generalized-extended-state-observer-based sliding mode control（GESO-SMC） approach for temperature stabilization of continuous stirred tank reactor（CSTR） with mismatched *** generalized extended state observer（GESO） is proposed to generate the estimates of both unmeasured states and *** on the estimated variables,the parameters of sliding mode function are designed for controller to counteract the effect of disturbances on the temperature of ***,the optimized switching gain of controller is found via using genetic algorithm（GA）.Finally,the simulation results show that the proposed method exhibits satisfied disturbance rejection performance even when additional matched disturbances are also considered.

关键词： Generalized Extended State Observer(GESO) Sliding Mode Control(SMC) Continuous Stirred Tank Reactor(CSTR) Mismatched Disturbances Genetic Algorithm(GA)

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自行式高空作业平台的动态稳定性分析

中南大学学报（自然科学版） 2017年第10期48卷 2838-2844页

作者：高旭宏徐向阳王书翰王增全北京航空航天大学交通科学与工程学院北京100191 北京航天发射技术研究所北京100076

为了分析自行式高空作业平台作业过程中的动态稳定性,以数学模型为基础,采用ADAMS软件建立整车的动力学仿真模型,对6种最危险的作业工况进行仿真计算,得到不同工况下各轮胎承载的载荷特性曲线及整车动态稳定性的安全系数。最后,进行场... 详细信息

为了分析自行式高空作业平台作业过程中的动态稳定性,以数学模型为基础,采用ADAMS软件建立整车的动力学仿真模型,对6种最危险的作业工况进行仿真计算,得到不同工况下各轮胎承载的载荷特性曲线及整车动态稳定性的安全系数。最后,进行场地试验测试。研究结果表明:测试数据与仿真计算数值间的极值相对误差最大为13.4%,试验测得动态稳定性的最小安全系数为0.123,验证了整车在作业过程中具有良好的动态稳定性,也验证了对自行式高空作业平台使用动力学仿真和试验测试相结合的分析方法的正确性和准确性。

关键词：自行式高空作业平台动态稳定性安全系数 ADAMS软件

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自动变速器换挡控制参数自整定策略应用

农业工程学报 2015年第12期31卷 83-91页

作者：鲁曦郭伟王书翰徐向阳北京航空航天大学交通科学与工程学院北京100191 国家乘用车自动变速器工程技术研究中心潍坊261205

为了满足量产车辆的自动变速器控制单元(transmission control unit,TCU)软件需求,研究了离合器换挡控制参数自整定控制方法,对自整定控制软件的结构和控制框图进行了介绍。针对换挡过程中,速度阶段和转矩阶段的特点,区别于传统方法对... 详细信息

为了满足量产车辆的自动变速器控制单元(transmission control unit,TCU)软件需求,研究了离合器换挡控制参数自整定控制方法,对自整定控制软件的结构和控制框图进行了介绍。针对换挡过程中,速度阶段和转矩阶段的特点,区别于传统方法对压力传感器、纵向加速度传感器和发动机转矩精度的依赖,分别提出了基于换挡时间的有动力升挡和基于涡轮失速问题的有动力降挡自整定策略。在实车测试过程中,通过软件的自整定参数调整,学习后的换挡时间能够逐步逼近设定的目标值,同时发动机飞车、涡轮失速现象能够逐步消减,换挡品质得到明显提升,保证了不同整车、不同发动机、不同变速器集成之后的换挡品质一致性,以及整车在产品生命周期内的驾驶性能一致性。实车采用该控制方法,在若干次相同工况的重复驾驶后,冲击点能明显弱化直至消除,冲击度逐步消减到低于5 m/s3,达到量产车辆水平,满足了某自主品牌车型投放上市要求。该研究对自动变速器换挡控制参数自整定策略研究和软件开发提供了参考。

关键词：车辆控制变速器换挡控制参数自整定实车测试

Paleontology Knowledge Graph for Data-Driven Discovery

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Journal of Earth Science 2024年第3期35卷 1024-1034页

作者： Yiying Deng Sicun Song Junxuan Fan Mao Luo Le Yao Shaochun Dong Yukun Shi Linna Zhang Yue wang Haipeng Xu Huiqing Xu Yingying Zhao Zhaohui Pan Zhangshuai Hou Xiaoming Li Boheng Shen Xinran Chen shuhan Zhang Xuejin Wu Lida Xing Qingqing Liang Enze wang School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008China School of Earth Sciences and Engineering and Frontiers Science Center for Critical Earth Material Cycling Nanjing UniversityNanjing 210023China State Key Laboratory for Mineral Deposits Research Nanjing UniversityNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China Centre for Research and Education on Biological Evolution and Environment Nanjing UniversityNanjing 210023China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesBeijing 100083China School of the Earth Sciences and Resources China University of GeosciencesBeijing 100083China

A knowledge graph(KG)is a knowledge base that integrates and represents data based on a graph-structured data model or *** have made efforts to construct geosciencerelated KGs to overcome semantic heterogeneity and facilitate knowledge representation,data integration,and text ***,there is currently no comprehensive paleontology KG or data-driven discovery based on *** this study,we constructed a two-layer model to represent the ordinal hierarchical structure of the paleontology KG following a top-down construction *** ontology containing 19365 concepts has been defined up to *** this basis,we derived the synonymy list based on the paleontology KG and designed corresponding online functions in the OneStratigraphy database to showcase the use of the KG in paleontological research.

关键词： paleontology knowledge graph ontology synonymy list OneStratigraphy big data ge-ology.

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多目标组合运输物流量预测建模算法

北京航空航天大学学报 2006年第10期32卷 1209-1214页

作者：徐向阳王书翰汤鹏翔石刚北京航空航天大学汽车工程系北京100083

提出了一种新的多目标组合运输物流量预测建模算法.以时间、领域、影响以及组合运输为基准,运用系统工程理论思想设计出一种四维的物流量影响因素模型,并运用结构方程模型对所建模型做了优化,提取出组合运输物流量的核心影响因素.在改... 详细信息

提出了一种新的多目标组合运输物流量预测建模算法.以时间、领域、影响以及组合运输为基准,运用系统工程理论思想设计出一种四维的物流量影响因素模型,并运用结构方程模型对所建模型做了优化,提取出组合运输物流量的核心影响因素.在改进的神经网络算法的基础上结合遗传算法,提出了一种结合遗传算法的改进的神经网络新算法,弥补了改进的神经网络算法上的缺陷,在多目标组合运输物流量预测的实例应用中,该算法不仅有很高的预测精度,而且具有收敛速度快、运行稳定的特点.

关键词：多目标预测组合运输物流量结构方程模型遗传算法神经网络

Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people

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Journal of Genetics and Genomics 2024年第5期51卷 517-530页

作者： Yuntao Sun Mengge wang Qiuxia Sun Yan Liu shuhan Duan Zhiyong wang Yunyu Zhou Jun Zhong Yuguo Huang Xinyu Huang Qingxin Yang Xiangping Li Haoran Su Yan Cai Xiucheng Jiang Jing Chen Jiangwei Yan Shengjie Nie Liping Hu Junbao Yang Renkuan Tang Chuan-Chao wang Chao Liu Xiaohui Deng Libing Yun Guanglin He West China School of Basic Science&Forensic Medicine Sichuan UniversityChengduSichuan 610041China Institute of Rare Diseases West China Hospital of Sichuan UniversitySichuan UniversityChengduSichuan 610000China Center for Archaeological Science Sichuan UniversityChengduSichuan 610000China Faculty of Forensic Medicine Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510275China Guangzhou Forensic Science Institute GuangzhouGuangdong 510055China Department of Forensic Medicine College of Basic MedicineChongqing Medical UniversityChongqing 400331China School of Clinical Medical Sciences North Sichuan Medical CollegeNanchongSichuan 637100China School of Basic Medical Sciences North Sichuan Medical CollegeNanchongSichuan 637100China School of Forensic Medicine Kunming Medical UniversityKunmingYunnan 650500China School of Stomatology North Sichuan Medical CollegeNanchongSichuan 637100China Department of Medical Laboratory North Sichuan Medical CollegeNanchongSichuan 637007China School of Life Sciences Xiamen UniversityXiamenFujian 361005China Anti-Drug Technology Center of Guangdong Province GuangzhouGuangdong 510230China School of Forensic Medicine Shanxi Medical UniversityJinzhongShanxi030600China

Tibeto-Burman(TB)people have endeavored to adapt to the hypoxic,cold,and high-UV high-altitude environments in the Tibetan Plateau and complex disease exposures in lowland rainforests since the late Paleolithic ***,the full landscape of genetic history and biological adaptation of geographically diverse TB-speaking people,as well as their interaction mechanism,remain ***,we generate a whole-genome meta-database of 500 individuals from 39 TB-speaking populations and present a comprehensive landscape of genetic diversity,admixture history,and differentiated adaptative features of geographically different TB-speaking *** identify genetic differentiation related to geography and language among TB-speaking people,consistent with their differentiated admixture process with incoming or indigenous ancestral source populations.A robust genetic connection between the Tibetan-Yi corridor and the ancient Yellow River people supports their Northern China origin *** finally report substructure-related differentiated biological adaptative signatures between highland Tibetans and Loloish *** signatures associated with the physical pigmentation(EDAR and SLC24A5)and metabolism(ALDH9A1)are identified in Loloish people,which differed from the high-altitude adaptative genetic architecture in ***-related genomic resources provide new insights into the genetic basis of biological adaptation and better reference for the anthropologically informed sampling design in biomedical and genomic cohort research.

关键词： Tibeto-Burman people Genetic profile Natural selection Genetic diversity Biological adaptation