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Surface defect engineered-Mg-based implants enable the dual functions of superhydrophobic and synergetic photothermal/chemodynamic therapy

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Bioactive Materials 2023年第12期30卷 15-28页

作者： Dongdong Zhang Ru Xu shuhan chen Huihui Du Shi Qian Feng Peng Xuanyong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen HospitalShenzhenChina Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of ScienceShenzhen518055PR China Medical Research Institute Department of OrthopedicsGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern MedicalUniversityGuangzhou510080China GuangDong Engineering Technology Research Center of Functional Repair of Bone Defects and Biomaterials Guangzhou510080China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences1 Sub-lane XiangshanHangzhou310024China

Promoting metallic magnesium(Mg)-based implants to treat bone diseases in clinics,such as osteosarcoma and bacterial infection,remains a challenging topic.Herein,an iron hydroxide-based composite coating with a twostage nanosheet-like structure was fabricated on Mg alloy,and this was followed by a thermal reduction treatment to break some of the surface Fe–OH bonds.The coating demonstrated three positive changes in properties due to the defects.First,the removal of–OH made the coating superhydrophobic,and it had self-cleaning and antifouling properties.This is beneficial for keeping the implants clean and for anti-corrosion before implantation into the human body.Furthermore,the superhydrophobicity could be removed by immersing the implant in a 75%ethanol solution,to further facilitate biological action during service.Second,the color of the coating changed from yellow to brown-black,leading to an increase in the light absorption,which resulted in an excellent photothermal effect.Third,the defects increased the Fe2+content in the coating and highly improved peroxidase activity.Thus,the defect coating exhibited synergistic photothermal/chemodynamic therapeutic effects for bacteria and tumors.Moreover,the coating substantially enhanced the anti-corrosion and biocompatibility of the Mg alloys.Therefore,this study offers a novel multi-functional Mg-based implant for osteosarcoma therapy.

关键词： Magnesium-based implants Surface defects Superhydrophobic Anti-bacterial Anti-tumor

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Ferric oxide nanosheet-engineered Mg alloy for synergetic osteosarcoma photothermal/chemodynamic therapy

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Journal of Materials Science & Technology 2023年第7期138卷 203-213页

作者： Huihui Du Dongdong Zhang Ru Xu Juning Xie Shiwei Guan shuhan chen Feng Peng Shi Qian Xuanyong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Medical Research Center Department of OrthopedicsGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Cixi Center of Biomaterials Surface Engineering Ningbo 315300China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences1 Sub-lane XiangshanHangzhou 310024China

Osteosarcoma(OS)is a malignant tumor with a high rate of recurrence.Recently,biodegradable Mg-based implants have become a new therapeutic platform for bone-related diseases.However,poor biosafety and deficient intelligent tumor-killing ability of Mg-based implants are still the main challenges for the pre-cise treatment of OS.Herein,based on the excellent catalytic and photothermal conversion properties of nanozyme ferric oxide(Fe_(3)O_(4)),a novel two-step hydrothermal method for in situ preparation of Fe_(3)O_(4)nanosheets on the surface of plasma electrolytic oxidation(PEO)-treated Mg alloy using Mg-Fe layered double hydroxides(Mg-Fe LDH)as precursor was proposed.Compared with Mg alloy,there were no obvious corrosion cracks on the surface of Fe_(3)O_(4)nanosheets-coated Mg alloy(Fe_(3)O_(4)-NS)immersed in 0.9 wt.%NaCl for 14 days,which demonstrated the corrosion resistance of Mg alloy was significantly enhanced.Cytocompatibility experiments and hemolysis assay confirmed the great biocompatibility of Fe_(3)O_(4)-NS,especially,hemolysis ratio was lower than 1%.Meanwhile,Fe_(3)O_(4)-NS presented excellent cat-alytic oxidation capacity in the presence of H_(2)O_(2),and its temperature can significantly increase from 27℃to approximately 56℃under NIR irradiation.Therefore,intelligent responsive Fe_(3)O_(4)nanosheets-engineered Mg-based implants demonstrated excellent antitumor properties in vivo and in vitro due to their photothermal and chemodynamic synergetic effects.This study provides a novel approach for the preparation of Fe_(3)O_(4)coatings on the surface of Mg alloys and a new strategy for the treatment of OS.

关键词： Mg alloy Fe_(3)O_(4)nanosheets Photothermal effect Chemodynamic therapy Antitumor

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Black Mn-containing layered double hydroxide coated magnesium alloy for osteosarcoma therapy, bacteria killing, and bone regeneration

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Bioactive Materials 2022年第11期7卷 394-405页

作者： Dongdong Zhang Shi cheng Ji Tan Juning Xie Yu Zhang shuhan chen Huihui Du Shi Qian Yuqing Qiao Feng Peng Xuanyong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Medical Research Center Department of OrthopedicsGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong510080China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences1 Sub-lane XiangshanHangzhou310024China Cixi Center of Biomaterials Surface Engineering Ningbo315300China

Osteosarcoma (OS) tissue resection with distinctive bactericidal activity, followed by regeneration of bone de-fects, is a highly demanded clinical treatment. Biodegradable Mg-based implants with desirable osteopromotive and superior mechanical properties to polymers and ceramics are promising new platforms for treating bone-related diseases. Integration of biodegradation control, osteosarcoma destruction, anti-bacteria, and bone defect regeneration abilities on Mg-based implants by applying biosafe and facile strategy is a promising and challenging topic. Here, a black Mn-containing layered double hydroxide (LDH) nanosheet-modified Mg-based implants was developed. Benefiting from the distinctive capabilities of the constructed black LDH film, including near-infrared optical absorption and reactive oxygen species (ROS) generation in a tumor-specific microenvi-ronment, the tumor cells and tissue could be effectively eliminated. Concomitant bacteria could be killed by localized hyperthermia. Furthermore, the enhanced corrosion resistance and synergistic biofunctions of Mn and Mg ions of the constructed black LDH-modified Mg implants significantly facilitated cell adhesion, spreading and proliferation and osteogenic differentiation in vitro, and accelerated bone regeneration in vivo. This work offers a new platform and feasible strategy for OS therapeutics and bone defect regeneration, which broadens the biomedical application of Mg-based alloys.

关键词： Biodegradable magnesium Layered double hydroxides Anti-tumor Anti-bacterial Bone regeneration

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FeeNeC single atom nanozymes with dual enzyme-mimicking activities for colorimetric detection of hydrogen peroxide and glutathione

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Journal of Materiomics 2022年第6期8卷 1251-1259页

作者： Wei Lu shuhan chen Haifeng Zhang Jiajun Qiu Xuanyong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou310024China

H_(2)O_(2) and glutathione(GSH)are critical redox molecules in the organism.Abnormal levels of cellular H_(2)O_(2) and GSH are closely related to some diseases.Thus,it is imperative to detect H_(2)O_(2) and GSH effi-ciently.In this work,FeeNeC single atom nanozymes(SANs)with both peroxidase and oxidasemimicking activities were successfully prepared with the help of formamide condensation by one-step hydrothermal method.The FeeNeC SANs show excellent peroxidase-like activity,which possess a higher affinity for H_(2)O_(2) and 3,30,5,50-tetramethylbenzidine(TMB)than horseradish peroxidase(HRP).Then,based on the chromogenic reaction of TMB,a colorimetric biosensor to detect H_(2)O_(2) and GSH was developed.This biosensor has the linear ranges of 10-600 mmol/L for H_(2)O_(2) with a low detection limit of 4.360 mmol/L and 100-400 mmol/L for GSH with a low detection limit of 78.33 mmol/L.Besides,this colorimetric biosensor exhibited a good recovery of H_(2)O_(2) and GSH in diluted human serum.Finally,the FeeNeC SANs were encapsulated into agar gel to self-quantitatively detect GSH by naked eyes.This work provides a non-pyrolytic way to prepare SANs,which broadens the synthetic method of SANs and may promote the development of SANs for biosensor application.

关键词： Single atom nanozymes Biosensor Peroxidase mimicking Hydrogen peroxide Glutathione

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基于Pockels电光效应的电压方向测量

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激光技术 2024年第3期48卷 352-356页

作者：钟远聪邓定南罗劲明陈书汉嘉应学院物理与电子工程学院梅州514015

为了实现在光学电压互感器中电压方向的测量,利用Pockels效应和偏振光理论进行理论分析和实验验证,提出了一种基于Pockels效应的电压方向测量方法,得到不同方向的电压与出射光偏振态、光传播方向之间的关系。结果表明,当施加的电压值为1... 详细信息

为了实现在光学电压互感器中电压方向的测量,利用Pockels效应和偏振光理论进行理论分析和实验验证,提出了一种基于Pockels效应的电压方向测量方法,得到不同方向的电压与出射光偏振态、光传播方向之间的关系。结果表明,当施加的电压值为100 V时,迎着光观测,透射光的长轴和短轴分别位于空间角度20°和110°,再通过λ/4波片后的光偏振方向位于坐标的二、四象限,可判断透射光是右旋椭圆偏振光,电压方向沿光传播方向;长轴和短轴分别位于角度130°和40°的透射光通过λ/4波片后的光偏振方向位于一、三象限,则透射光是左旋椭圆偏振光,电压方向则沿光传播的相反方向。实验结果与理论分析相符,可指导设计既能测量电压大小又能判断其方向的光学电压互感器。

关键词：光电子学电压方向 Pockels效应椭圆偏振光偏振态

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Intelligent Orchestrating of IoT Microservices Based on Reinforcement Learning

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Chinese Journal of Electronics 2022年第5期31卷 930-937页

作者： WU Yuqin SHEN Congqi chen shuhan WU Chunming LI Shunbin WEI Ruan College of Computer Science and Technology Zhejiang University College of Information and Electrical Engineering Ningde Normal University Zhejiang Lab College of Control Science and Engineering Zhejiang University

With the recent increase in the number of Internet of things(IoT) services, an intelligent scheduling strategy is needed to manage these services. In this paper, the problem of automatic choreography of microservices in IoT is explored. A type of reinforcement learning(RL) algorithm called TD3 is used to generate the optimal choreography policy under the framework of a softwaredefined network. The optimal policy is gradually reached during the learning procedure to achieve the goal, despite the dynamic characteristics of the network environment. The simulation results show that compared with other methods, the TD3 algorithm converges faster after a certain number of iterations, and it performs better than other non-RL algorithms by obtaining the highest reward. The TD3 algorithm can effciently adjust the traffic transmission path and provide qualified IoT services.

关键词： Internet of things Microservice Traffc scheduling Reinforcement learning

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Channel modeling for MI-based wireless underground sensor networks with conductive objects

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Science China(Information Sciences) 2024年第7期67卷 333-334页

作者： shuhan DENG Guanghua LIU Ziwei chen Huaijin ZHANG Tao JIANG Research Center of 6G Mobile Communications School of Cyber Science and EngineeringHuazhong University of Science and Technology School of Electronic Information and Communications Huazhong University of Science and Technology

Wireless underground sensor networks (WUSNs) are an emerging research field with promising applications. However, WUSNs links suffer from significant attenuation as the propagation of the signal needs to pass through soil, rock,and water. Magnetic induction (MI)-based transmission is proposed to overcome these issues as MI signal can penetrate most substances similarly without experiencing high path loss, which ensures the robustness of WUSNs links [1].

关键词： Wireless sensor networks

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Solid-state synthesis and ion transport characteristics of theβ-KSbF_(4)for all-solid-state fluoride-ion batteries

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Journal of Energy Chemistry 2024年第7期94卷 758-767页

作者： Jiali Liu Huahui Zhao Jingcheng Xia Lingguang Yi Xiaoyi chen Dongdu Li shuhan Ni Xinyi Su Yixuan chen Min Liu Xianyou Wang National Base for International Science&Technology Cooperation National Local Joint Engineering Laboratory for Key Materials of New Energy Storage BatteryHunan Province Key Laboratory of Electrochemical Energy Storage&ConversionSchool of ChemistryXiangtan UniversityXiangtan 411105HunanChina College of New Energy Ningbo University of TechnologyNingbo 315336ZhejiangChina

All-solid-state fluoride ion batteries(FIBs)have been recently considered as a post-lithium-ion battery system due to their high safety and high energy density.Just like all solid-state lithium batteries,the key to the development of FIBs lies in room-temperature electrolytes with high ionic conductivity.β-KSbF_(4)is a kind of promising solid-state electrolyte for FIBs owing to its rational ionic conductivity and relatively wide electrochemical stability window at room temperature.However,the previous synthesis routes ofβ-KSbF_(4)required the use of highly toxic hydrofluoric acid and the ionic conductivity of as-prepared product needs to be further improved.Herein,the β-KSbF_(4)sample with an ionic conductivity of 1.04×10^(-4)s cm^(-1)(30°C)is synthesized through the simple solid-state route.In order to account for the high ionic conductivity of the as-synthesizedβ-KSbF_(4),X-ray diffraction(XRD),scanning electron microscopy(SEM),and energy dispersive X-ray spectroscopy(EDS)are used to characterize the physic-ochemical properties.The results show that the as-synthesizedβ-KSbF_(4)exhibits higher carrier concentra-tion of 1.0×10^(-6)S cm-Hz^(-1)K and hopping frequency of 1.31×10^(6)Hz at 30°C due to the formation of the fluorine vacancies.Meanwhile,the hopping frequency shows the same trend as the changes of ionic conductivity with the changes of temperature,while the carrier concentration is found to be almost con-stant.The two different trends indicate the hopping frequency is mainly responsible for the ionic conduc-tion behavior withinβ-KSbF_(4).Furthermore,the all-solid-state FIBs,in which Ag and Pb+PbF_(2)are adopted as cathode and anode,andβ-KSbF_(4)as fluoride ion conductor,are capable of reversible charge and discharge.The assembled FIBs show a discharge capacity of 108.4 mA h g^(-1)at 1st cycle and 74.2 mA h g^(-1)at 50th cycle.Based on an examination of the capacity decay mechanism,it has been found that deterioration of the electrolyte/electrode interface is an important reason for hindering the commer-c

关键词： Solid-state electrolyte Carrier concentration Hopping frequency β-KSbF_(4) All-solid-state fluoride ion batteries

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Mannogalactoglucan from mushrooms protects pancreatic islets via restoring UPR and promotes insulin secretion in TIDM mice

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Food Science and Human Wellness 2024年第3期13卷 1390-1401页

作者： Ting Liu Si chen Yunhe Qu Lujuan Zheng Xiaoxuan Yang shuhan Men Yuanning Wang Hanrui Ma Yifa Zhou Yuying Fan Engineering Research Center of Glycoconjugates Ministry of EducationJilin Provincial Key Laboratory of Chemistry and Biology of Changbai Mountain Natural DrugsSchool of Life SciencesNortheast Normal UniversityChangchun 130024China

Type 1 diabetes mellitus(T1DM) lacks insulin secretion due to autoimmune deficiency of pancreaticβ-cells.Protecting pancreatic islets and enhancing insulin secretion has been therapeutic approaches.Mannogalactoglucan is the main type of polysaccharide from natural mushroom,which has potential medicinal prospects.Nevertheless,the antidiabetic property of mannogalactoglucan in T1DM has not been fully elucidated.In this study,we obtained the neutral fraction of alkali-soluble Armillaria mellea polysaccharide(AAMP-N) with the structure of mannogalactoglucan from the fruiting body of A.mellea and investigated the potential therapeutic value of AAMP-N in T1DM.We demonstrated that AAMP-N lowered blood glucose and improved diabetes symptoms in T1DM mice.AAMP-N activated unfolded protein response(UPR) signaling pathway to maintain ER protein folding homeostasis and promote insulin secretion in vivo.Besides that,AAMP-N promoted insulin synthesis via upregulating the expression of transcription factors,increased Ca^(2+) signals to stimulate intracellular insulin secretory vesicle transport via activating calcium/calmodulin-dependent kinase Ⅱ(CamkⅡ) and cAMP/PKA signals,and enhanced insulin secretory vesicle fusion with the plasma membrane via vesicle-associated membrane protein 2(VAMP2).Collectively,these studies demonstrated that the therapeutic potential of AAMP-N on pancreatic islets function,indicating that mannogalactoglucan could be natural nutraceutical used for the treatment of T1DM.

关键词： Mannogalactoglucan Mushroom Pancreatic islets Insulin secretion Insulin synthesis Unfolded protein response(UPR) Type 1 diabetes mellitus(T1DM)

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Ag超薄膜生长的动力学蒙特卡罗模拟

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真空科学与技术学报 2014年第6期34卷 625-630页

作者：陈书汉嘉应学院物理与光信息科技学院梅州514015

用动力学蒙特卡罗的方法对Ag原子在Pt(111)基底上的生长过程进行模拟,研究了温度对金属超薄膜初始生长形貌的影响。结果表明,随着温度的升高岛从分形状向凝聚状的转变过程,模拟结果能与相关实验现象相吻合。本文进一步讨论了原子扩散能... 详细信息

用动力学蒙特卡罗的方法对Ag原子在Pt(111)基底上的生长过程进行模拟,研究了温度对金属超薄膜初始生长形貌的影响。结果表明,随着温度的升高岛从分形状向凝聚状的转变过程,模拟结果能与相关实验现象相吻合。本文进一步讨论了原子扩散能力对岛形貌的影响,预测了Ag岛从分形状向凝聚状转变的转折温度区域。并且通过改变沉积速率论证了转折温度区域随着沉积速率的增加而提高。

关键词：超薄膜蒙特卡罗方法分形凝聚

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