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FeeNeC single atom nanozymes with dual enzyme-mimicking activities for colorimetric detection of hydrogen peroxide and glutathione

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Journal of Materiomics 2022年第6期8卷 1251-1259页

作者： Wei Lu shuhan chen Haifeng Zhang Jiajun Qiu Xuanyong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou310024China

H_(2)O_(2) and glutathione(GSH)are critical redox molecules in the *** levels of cellular H_(2)O_(2) and GSH are closely related to some ***,it is imperative to detect H_(2)O_(2) and GSH *** this work,FeeNeC single atom nanozymes(SANs)with both peroxidase and oxidasemimicking activities were successfully prepared with the help of formamide condensation by one-step hydrothermal *** FeeNeC SANs show excellent peroxidase-like activity,which possess a higher affinity for H_(2)O_(2) and 3,30,5,50-tetramethylbenzidine(TMB)than horseradish peroxidase(HRP).Then,based on the chromogenic reaction of TMB,a colorimetric biosensor to detect H_(2)O_(2) and GSH was *** biosensor has the linear ranges of 10-600 mmol/L for H_(2)O_(2) with a low detection limit of 4.360 mmol/L and 100-400 mmol/L for GSH with a low detection limit of 78.33 mmol/***,this colorimetric biosensor exhibited a good recovery of H_(2)O_(2) and GSH in diluted human ***,the FeeNeC SANs were encapsulated into agar gel to self-quantitatively detect GSH by naked *** work provides a non-pyrolytic way to prepare SANs,which broadens the synthetic method of SANs and may promote the development of SANs for biosensor application.

关键词： Single atom nanozymes Biosensor Peroxidase mimicking Hydrogen peroxide Glutathione

Surface defect engineered-Mg-based implants enable the dual functions of superhydrophobic and synergetic photothermal/chemodynamic therapy

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Bioactive Materials 2023年第12期30卷 15-28页

作者： Dongdong Zhang Ru Xu shuhan chen Huihui Du Shi Qian Feng Peng Xuanyong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen HospitalShenzhenChina Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of ScienceShenzhen518055PR China Medical Research Institute Department of OrthopedicsGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern MedicalUniversityGuangzhou510080China GuangDong Engineering Technology Research Center of Functional Repair of Bone Defects and Biomaterials Guangzhou510080China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences1 Sub-lane XiangshanHangzhou310024China

Promoting metallic magnesium(Mg)-based implants to treat bone diseases in clinics,such as osteosarcoma and bacterial infection,remains a challenging ***,an iron hydroxide-based composite coating with a twostage nanosheet-like structure was fabricated on Mg alloy,and this was followed by a thermal reduction treatment to break some of the surface Fe–OH *** coating demonstrated three positive changes in properties due to the ***,the removal of–OH made the coating superhydrophobic,and it had self-cleaning and antifouling *** is beneficial for keeping the implants clean and for anti-corrosion before implantation into the human ***,the superhydrophobicity could be removed by immersing the implant in a 75%ethanol solution,to further facilitate biological action during ***,the color of the coating changed from yellow to brown-black,leading to an increase in the light absorption,which resulted in an excellent photothermal ***,the defects increased the Fe2+content in the coating and highly improved peroxidase ***,the defect coating exhibited synergistic photothermal/chemodynamic therapeutic effects for bacteria and ***,the coating substantially enhanced the anti-corrosion and biocompatibility of the Mg ***,this study offers a novel multi-functional Mg-based implant for osteosarcoma therapy.

关键词： Magnesium-based implants Surface defects Superhydrophobic Anti-bacterial Anti-tumor

Ferric oxide nanosheet-engineered Mg alloy for synergetic osteosarcoma photothermal/chemodynamic therapy

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Journal of Materials Science & Technology 2023年第7期138卷 203-213页

作者： Huihui Du Dongdong Zhang Ru Xu Juning Xie Shiwei Guan shuhan chen Feng Peng Shi Qian Xuanyong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Medical Research Center Department of OrthopedicsGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Cixi Center of Biomaterials Surface Engineering Ningbo 315300China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences1 Sub-lane XiangshanHangzhou 310024China

Osteosarcoma(OS)is a malignant tumor with a high rate of ***,biodegradable Mg-based implants have become a new therapeutic platform for bone-related ***,poor biosafety and deficient intelligent tumor-killing ability of Mg-based implants are still the main challenges for the pre-cise treatment of ***,based on the excellent catalytic and photothermal conversion properties of nanozyme ferric oxide(Fe_(3)O_(4)),a novel two-step hydrothermal method for in situ preparation of Fe_(3)O_(4)nanosheets on the surface of plasma electrolytic oxidation(PEO)-treated Mg alloy using Mg-Fe layered double hydroxides(Mg-Fe LDH)as precursor was *** with Mg alloy,there were no obvious corrosion cracks on the surface of Fe_(3)O_(4)nanosheets-coated Mg alloy(Fe_(3)O_(4)-NS)immersed in 0.9 wt.%NaCl for 14 days,which demonstrated the corrosion resistance of Mg alloy was significantly *** experiments and hemolysis assay confirmed the great biocompatibility of Fe_(3)O_(4)-NS,especially,hemolysis ratio was lower than 1%.Meanwhile,Fe_(3)O_(4)-NS presented excellent cat-alytic oxidation capacity in the presence of H_(2)O_(2),and its temperature can significantly increase from 27℃to approximately 56℃under NIR ***,intelligent responsive Fe_(3)O_(4)nanosheets-engineered Mg-based implants demonstrated excellent antitumor properties in vivo and in vitro due to their photothermal and chemodynamic synergetic *** study provides a novel approach for the preparation of Fe_(3)O_(4)coatings on the surface of Mg alloys and a new strategy for the treatment of OS.

关键词： Mg alloy Fe_(3)O_(4)nanosheets Photothermal effect Chemodynamic therapy Antitumor

p53 exerts anticancer effects by regulating enhancer formation and activity

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Journal of Biomedical Research 2024年第4期38卷 334-347页

作者： shuhan chen Xuchun Wang Nan Yang Yuechi Song He cheng Yujie Sun Key Laboratory of Human Functional Genomics of Jiangsu Province School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Department of Cell Biology School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineNanjing Medical UniversityNanjingJiangsu 211166China

The abnormality of the p53 tumor suppressor is crucial in lung cancer development,because p53 regulates target gene promoters to combat *** studies have shown extensive p53 binding to enhancer ***,whether p53 exerts a tumor suppressor role by shaping the enhancer landscape remains poorly *** the current study,we employed several functional genomics approaches to assess the enhancer activity at p53 binding sites throughout the genome based on our established TP53 knockout(KO)human bronchial epithelial cells(BEAS-2B).A total of 943 active regular enhancers and 370 super-enhancers(SEs)disappeared upon the deletion of p53,indicating that p53 modulates the activity of hundreds of enhancer *** found that one p53-dependent SE,located on chromosome 9 and designated as KLF4-SE,regulated the expression of the Krüppel-like factor 4(KLF4)***,the deletion of p53 significantly decreased the KLF4-SE enhancer activity and the KLF4 expression,but increased colony formation ability in the nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced cell transformation ***,in TP53 KO cells,the overexpression of KLF4 partially reversed the increased clonogenic capacity caused by p53 ***,KLF4 expression also decreased in lung cancer tissues and cell *** appeared that overexpression of KLF4 significantly suppressed the proliferation and migration of lung cancer ***,our results suggest that the regulation of enhancer formation and activity by p53 is an integral component of the p53 tumor suppressor ***,our findings offer some novel insights into the regulation mechanism of p53 in lung oncogenesis and introduce a new strategy for screening therapeutic targets.

关键词： p53 enhancer tumor malignant transformation

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Ag超薄膜生长的动力学蒙特卡罗模拟

真空科学与技术学报 2014年第6期34卷 625-630页

作者：陈书汉嘉应学院物理与光信息科技学院梅州514015

用动力学蒙特卡罗的方法对Ag原子在Pt(111)基底上的生长过程进行模拟,研究了温度对金属超薄膜初始生长形貌的影响。结果表明,随着温度的升高岛从分形状向凝聚状的转变过程,模拟结果能与相关实验现象相吻合。本文进一步讨论了原子扩散能... 详细信息

用动力学蒙特卡罗的方法对Ag原子在Pt(111)基底上的生长过程进行模拟,研究了温度对金属超薄膜初始生长形貌的影响。结果表明,随着温度的升高岛从分形状向凝聚状的转变过程,模拟结果能与相关实验现象相吻合。本文进一步讨论了原子扩散能力对岛形貌的影响,预测了Ag岛从分形状向凝聚状转变的转折温度区域。并且通过改变沉积速率论证了转折温度区域随着沉积速率的增加而提高。

关键词：超薄膜蒙特卡罗方法分形凝聚

Black Mn-containing layered double hydroxide coated magnesium alloy for osteosarcoma therapy, bacteria killing, and bone regeneration

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Bioactive Materials 2022年第11期7卷 394-405页

作者： Dongdong Zhang Shi cheng Ji Tan Juning Xie Yu Zhang shuhan chen Huihui Du Shi Qian Yuqing Qiao Feng Peng Xuanyong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Medical Research Center Department of OrthopedicsGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong510080China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences1 Sub-lane XiangshanHangzhou310024China Cixi Center of Biomaterials Surface Engineering Ningbo315300China

Osteosarcoma (OS) tissue resection with distinctive bactericidal activity, followed by regeneration of bone de-fects, is a highly demanded clinical treatment. Biodegradable Mg-based implants with desirable osteopromotive and superior mechanical properties to polymers and ceramics are promising new platforms for treating bone-related diseases. Integration of biodegradation control, osteosarcoma destruction, anti-bacteria, and bone defect regeneration abilities on Mg-based implants by applying biosafe and facile strategy is a promising and challenging topic. Here, a black Mn-containing layered double hydroxide (LDH) nanosheet-modified Mg-based implants was developed. Benefiting from the distinctive capabilities of the constructed black LDH film, including near-infrared optical absorption and reactive oxygen species (ROS) generation in a tumor-specific microenvi-ronment, the tumor cells and tissue could be effectively eliminated. Concomitant bacteria could be killed by localized hyperthermia. Furthermore, the enhanced corrosion resistance and synergistic biofunctions of Mn and Mg ions of the constructed black LDH-modified Mg implants significantly facilitated cell adhesion, spreading and proliferation and osteogenic differentiation in vitro, and accelerated bone regeneration in vivo. This work offers a new platform and feasible strategy for OS therapeutics and bone defect regeneration, which broadens the biomedical application of Mg-based alloys.

关键词： Biodegradable magnesium Layered double hydroxides Anti-tumor Anti-bacterial Bone regeneration

透明导电电极对聚合物太阳能电池光学性能的影响

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光学技术 2020年第6期46卷 660-663页

作者：陈书汉嘉应学院物理与电子工程学院广东梅州514015

采用传输矩阵法研究了基于MoO3/Ag/MoO3(MAM)透明导电电极和ITO电极的聚合物太阳能电池的光学性能。分别对电池耦合层厚度、活化层厚度和金属电极进行了优化,得到了优良效率的结构。结果表明,MAM与ITO有机太阳能电池在不同活性层厚度和... 详细信息

采用传输矩阵法研究了基于MoO3/Ag/MoO3(MAM)透明导电电极和ITO电极的聚合物太阳能电池的光学性能。分别对电池耦合层厚度、活化层厚度和金属电极进行了优化,得到了优良效率的结构。结果表明,MAM与ITO有机太阳能电池在不同活性层厚度和不同光学间隔层厚度条件下有明显的光学性能差异;对于薄活性层MAM电极器件(100nm),最大短路电流密度可达到16.85mA/cm^2,比ITO器件提高了7.3mA/cm^2,而对于厚活性层MAM电极(270nm),ITO电极器件的光学性能明显优于MAM器件;还通过改变光学间隔层LiF的厚度进行计算,得出本仿真条件下两种结构性能差异的临界光学间隔层厚度为30nm。

关键词：传输矩阵法透明导电电极有机太阳能电池光学性能

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一种高光谱图像高精度配准波段选择方法

光学学报 2018年第9期38卷 129-135页

作者：杨韩厉小润赵辽英陈淑涵浙江大学电气工程学院浙江杭州310027

针对高光谱图像和高空间分辨率图像配准过程中,各波段之间差异较大难以选择高精度配准波段的问题,提出一种基于Cram′er-Rao下限(CRLB)理论的高光谱图像高精度匹配波段选择算法。利用波段选择的方法选出高光谱图像中若干信息量大、相关... 详细信息

针对高光谱图像和高空间分辨率图像配准过程中,各波段之间差异较大难以选择高精度配准波段的问题,提出一种基于Cram′er-Rao下限(CRLB)理论的高光谱图像高精度匹配波段选择算法。利用波段选择的方法选出高光谱图像中若干信息量大、相关性小的波段;将其分别与高空间分辨率图像做配准,并计算配准结果相应的CRLB;根据CRLB选择高精度配准波段。通过比较配准后的CRLB和均方根误差,验证CRLB具有较好配准质量评价性能。通过CRLB与其他方法的选择波段配准结果比较可知,本文算法选择的波段配准精度较高。上述波段为高光谱图像和高空间分辨率图像的配准提供更好的数据。

关键词：图像处理高光谱图像高空间分辨率图像配准 Cram’er-Rao下限理论波段选择

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螺旋锥齿轮啮合热特性分析

农业机械学报 2007年第11期38卷 161-166页

作者：明兴祖严宏志陈书涵中南大学机电工程学院

在对螺旋锥齿轮啮合方程进行分析的基础上,采用"自底向上"的实体建模方法和八节点六面体等参元,建立其三齿的有限元分析3-D模型,并基于热传导理论,建立了螺旋锥齿轮啮合的本体稳态温度场;由此,对热和结构两个物理场进行耦合,仿真分析了... 详细信息

在对螺旋锥齿轮啮合方程进行分析的基础上,采用"自底向上"的实体建模方法和八节点六面体等参元,建立其三齿的有限元分析3-D模型,并基于热传导理论,建立了螺旋锥齿轮啮合的本体稳态温度场;由此,对热和结构两个物理场进行耦合,仿真分析了螺旋锥齿轮啮合过程热应力和热变形。结果表明,螺旋锥齿轮副多齿啮合时,其中一个齿的啮合中心处稳态温度较高;最大热应力与热变形不在啮合中心,而是分别在靠近啮合中心的齿根和齿顶部位。

关键词：螺旋锥齿轮啮合热特性有限元分析