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Hippo(YAP)-autophagy axis protects against hepatic ischemia-reperfusion injury through JNK signaling

Chinese Medical Journal 2024年第6期137卷 657-668页

作者： shuguang zhu Xiaowen Wang Haoqi Chen Wenfeng zhu Xuejiao Li Ruiwen Cui Xiaomeng Yi Xiaolong Chen Hua Li Genshu Wang Department of Hepatic Surgery Liver TransplantationThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Hepatology lab The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of General Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Organ Transplantation The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Renal Transplantation Guangdong Provincial Hospital of Chinese MedicineGuangzhouGuangdong 510630China Department of Surgical Intensive Care Unit The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Hepatic Surgery Liver TransplantationGuangdong Provincial Hospital of Chinese MedicineGuangzhouGuangdong 510630China

Background:Hepatic ischemia-reperfusion injury(HIRI)remains a common complication during liver transplantation(LT)in *** a key downstream effector of the Hippo pathway,Yes-associated protein(YAP)has been reported to be involved in various physiological and pathological ***,it remains elusive whether and how YAP may control autophagy activation during ***:Human liver tissues from patients who had undergone LT were obtained to evaluate the correlation between YAP and autophagy *** an in vitro hepatocyte cell line and in vivo liver-specific YAP knockdown mice were used to establish the hepatic ischemia-reperfusion models to determine the role of YAP in the activation of autophagy and the mechanism of ***:Autophagy was activated in the post-perfusion liver grafts during LT in patients,and the expression of YAP positively correlated with the autophagic level of ***-specific knockdown of YAP inhibited hepatocytes autophagy upon hypoxia-reoxygenation and HIRI(P<0.05).YAP deficiency aggravated HIRI by promoting the apoptosis of hepatocytes both in the in vitro and in vivo models(P<0.05).Attenuated HIRI by overexpression of YAP was diminished after the inhibition of autophagy with *** addition,inhibiting autophagy activation by YAP knockdown exacerbated mitochondrial damage through increasing reactive oxygen species(P<0.05).Moreover,the regulation of autophagy by YAP during HIRI was mediated by AP1(c-Jun)N-terminal kinase(JNK)signaling through binding to the transcriptional enhanced associate domain(TEAD).Conclusions:YAP protects against HIRI by inducing autophagy via JNK signaling that suppresses the apoptosis of *** Hippo(YAP)-JNK-autophagy axis may provide a novel strategy for the prevention and treatment of HIRI.

关键词： YAP-signaling proteins Autophagy c-Jun N-terminal kinase Ischemia-reperfusion injury Liver transplantation

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藻-菌颗粒污泥的污染物去除和微生物群落演替研究

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环境科学学报 2024年第1期44卷 184-192页

作者：刘炎坤朱曙光鲍立宁王莉王健于祥冲胡昊安徽建筑大学环境与能源工程学院合肥230601 安徽省绿色建筑先进技术研究院合肥230601 安徽建筑大学节能研究院合肥230601

通过比较好氧颗粒污泥(AGS)与藻-菌颗粒污泥(ABGS)两组SBR反应器,旨在评价微藻的加入对污染物去除和微生物群落的影响.结果表明,微藻的生物强化作用会加速活性污泥颗粒化.同时,ABGS对PO_(4)^(3-)P和总无机氮的平均去除率比AGS分别高5.3%... 详细信息

通过比较好氧颗粒污泥(AGS)与藻-菌颗粒污泥(ABGS)两组SBR反应器,旨在评价微藻的加入对污染物去除和微生物群落的影响.结果表明,微藻的生物强化作用会加速活性污泥颗粒化.同时,ABGS对PO_(4)^(3-)P和总无机氮的平均去除率比AGS分别高5.3%和16.3%,这可归因于微藻对污染物的同化作用.16S rRNA结果进一步发现,变形菌门(Proteobacteria)和拟杆菌门(Bacteroidetes)是主要两个生物反应器中的优势菌,然而,由于微藻的增殖和代谢作用,绿弯菌门(Chloroflexi)、浮霉菌门(Planctomycetes)和疣微菌门(Verrucomicrobia)在藻-菌颗粒污泥中的丰度被发现远高于好氧颗粒污泥中.此外,18S rRNA结果显示,初始接种的蛋白核小球藻(Chlorella pyrenoidesa)被快速生长的四孢藻属(Tetraspora)所取代,致使藻-菌颗粒污泥比好氧颗粒污泥展现了更好的氮、磷去除率.

关键词：藻-菌颗粒污泥好氧颗粒污泥胞外聚合物微生物群落

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麦冬皂苷D调节cAMP/PKA/CREB信号通路对炎症性肠病大鼠炎性损伤的影响

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河北医学 2024年第5期30卷 781-787页

作者：朱曙光李曙晖陈鹏徐大恒山东省滕州市中心人民医院消化内科山东滕州277500

目的:探究麦冬皂苷D调节cAMP/PKA/CREB信号通路对炎症性肠病(IBD)大鼠炎性损伤的影响。方法:将大鼠分为对照组、模型组、麦冬皂苷D低剂量组、麦冬皂苷D高剂量组和麦冬皂苷D高剂量+H-89(cAMP抑制剂)组。检测大鼠质量和大鼠结肠长度;酶联... 详细信息

目的:探究麦冬皂苷D调节cAMP/PKA/CREB信号通路对炎症性肠病(IBD)大鼠炎性损伤的影响。方法:将大鼠分为对照组、模型组、麦冬皂苷D低剂量组、麦冬皂苷D高剂量组和麦冬皂苷D高剂量+H-89(cAMP抑制剂)组。检测大鼠质量和大鼠结肠长度;酶联免疫吸附法检测血清IL-17、IL-6、IL-10、TNF-α、cAMP水平;流式细胞术检测大鼠外周血中Th17、Treg细胞比例;HE染色检测结肠组织病理损伤;Western blot检测大鼠结肠组织中Bax、Bcl-2以及cAMP/PKA/CREB信号通路相关蛋白表达。结果:治疗结束后,与对照组相比,模型组大鼠结肠组织显著损伤,体质量、结肠长度、血清IL-10、cAMP水平、外周血Treg细胞比例、结肠组织Bcl-2、p-PKA/PKA、p-CREB/CREB蛋白表达显著降低,血清IL-17、IL-6、TNF-α水平、外周血中Th17比例和Th17/Treg比值、Bax蛋白表达显著升高(P<0.05);与模型组相比,麦冬皂苷D低、高剂量组大鼠结肠组织显著减轻,体质量、结肠长度、血清IL-10、cAMP水平、外周血Treg细胞比例、结肠组织Bcl-2、p-PKA/PKA、p-CREB/CREB蛋白表达显著升高,血清IL-17、IL-6、TNF-α水平、外周血中Th17比例和Th17/Treg比值、Bax蛋白表达显著降低(P<0.05);H-89可部分逆转麦冬皂苷D对炎症性肠病大鼠的治疗作用(P<0.05)。结论:麦冬皂苷D可降低IBD大鼠炎症反应和结肠组织损伤,可能是通过激活cAMP/PKA/CREB信号通路实现的。

关键词：麦冬皂苷D cAMP/PKA/CREB信号通路炎症性肠病炎性损伤

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波长色散X射线荧光光谱法测定进口八氧化三铀中的铀

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湿法冶金 2024年第2期43卷 206-213页

作者：柳金良张鑫刘朝宋茂生鄢飞燕朱曙光王龙刘悦杨立远核工业二三〇研究所湖南长沙410007 湖南省伴生放射性矿产资源评价与综合利用工程技术研究中心湖南长沙410007 湖北三〇三库湖北武汉430000 中核铀业有限公司北京100013 中国原子能工业有限公司北京100032

为满足天然铀贸易复检对准确性和时效性的要求,对采用波长散射X射线荧光光谱法测定进口八氧化三铀中的铀工作条件进行了优化研究,对消解方式、消解器皿、消解时间和温度、麦拉膜、测定用样品质量等样品前处理条件进行了优化选择,确定了... 详细信息

为满足天然铀贸易复检对准确性和时效性的要求,对采用波长散射X射线荧光光谱法测定进口八氧化三铀中的铀工作条件进行了优化研究,对消解方式、消解器皿、消解时间和温度、麦拉膜、测定用样品质量等样品前处理条件进行了优化选择,确定了X光管电压电流、分光晶体、波峰和背景角度(2θ)、测定时间等仪器测定条件,并对方法的精密度、准确度、可靠性等进行了评估。结果表明:该法工作曲线的线性相关系数为0.9996,相对标准偏差(RSD)在0.029%~0.056%之间;测定结果与标准物质推荐值之间相对偏差≤0.027%;与滴定法相比,该法绝对偏差在0.003%~0.093%之间,结果准确可靠,工作效率是滴定法的5倍。该法可满足进口八氧化三铀样品快速批量分析的要求。

关键词：波长色散X射线荧光光谱法八氧化三铀测定铀消解

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现代光纤通信技术在广播电视网络传输中的应用

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通信电源技术 2024年第4期41卷 203-205页

作者：毛目华朱曙光王海君郝允领鄂托克前旗长城五号矿业有限公司内蒙古鄂尔多斯016299 中国矿业大学江苏徐州221000 华洋通信科技股份有限公司江苏徐州221000

为全面优化现代通信工程传输质量水平,共建稳定、科学及合理的信息传输通道,根据现代通信工程规范管理部署要求,全面分析光纤通信传输技术,有效发挥光纤接入、光交换以及长波单模光纤等技术的应用优势,配合发光二极管(Light Emitting Di... 详细信息

为全面优化现代通信工程传输质量水平,共建稳定、科学及合理的信息传输通道,根据现代通信工程规范管理部署要求,全面分析光纤通信传输技术,有效发挥光纤接入、光交换以及长波单模光纤等技术的应用优势,配合发光二极管(Light Emitting Diode,LED)发射器建立更加可控的信息传输模式,利用加装光放大器的方式优化光纤通信过程的稳定性。通过完善光纤通信传输技术的应用结构,促进现代通信工程的可持续发展。因此,研究现代光纤通信技术在广播电视网络传输中的应用具有重要的实践意义。

关键词：光纤通信传输技术现代通信工程光放大器发光二极管(LED)发射器

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安徽省居住建筑终端能耗及碳排放达峰研究

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建筑节能（中英文） 2024年第5期52卷 24-30页

作者：胡浩威章昱斌叶长青梁倩朱曙光方潜生安徽建筑大学合肥巴230601 安徽省建设领域碳达峰碳中和战略研究院合肥230022 安徽省建筑科学研究设计院合肥230031 安徽省建筑节能与科技协会合肥230091

以安徽省既有居住建筑运行阶段为研究对象,采用能源平衡表法、LEAP模型、碳排放因子法和STIRPAT模型等工具和方法,预测碳排放峰值及影响因素,并提出技术路径和政策建议。研究结果表明:安徽省居住建筑实现碳达峰的最佳实施路径应采取蓝... 详细信息

以安徽省既有居住建筑运行阶段为研究对象,采用能源平衡表法、LEAP模型、碳排放因子法和STIRPAT模型等工具和方法,预测碳排放峰值及影响因素,并提出技术路径和政策建议。研究结果表明:安徽省居住建筑实现碳达峰的最佳实施路径应采取蓝图情景。该情景下居住建筑运行阶段碳排放2025年达到峰值3429.29万t, 2060年回落至918.69万t。在影响因素方面,常住人口是居住建筑碳排放的主导因素,大小为-2.646;能源结构也对居住建筑碳排放产生了不小的影响,大小为-1.465,这得益于安徽省建筑消费能源结构的持续优化。因此,开展建筑电气化、发展可再生能源、限制一次能源的使用、优化能源结构至关重要。

关键词：能源平衡表法 LEAP模型 STIRPAT模型情景分析建筑节能

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Mapping out the reaction network of humin formation at the initial stage of fructose dehydration in water

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Green Energy & Environment 2024年第6期9卷 1016-1026页

作者： Xing Fu Yexin Hu Ping Hu Hui Li shuguang Xu Liangfang zhu Changwei Hu Key Laboratory of Green Chemistry and Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengduSichuan610064China State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengduSichuan611137China

The formation of humins hampers the large-scale production of 5-hydroxymethylfurfural(HMF)in ***,a detailed reaction network of humin formation at the initial stage of fructose-to-HMF dehydration in water is delineated by combined experimental,spectroscopic,and theoretical *** bimolecular reaction pathways to build up soluble humins are *** is,the intermolecular etherification of β-furanose at room temperature initiates the C12 path,whereas the C-C cleavage of a-furanose at 130-150℃ leads to C11 path,and that of open-chain fructose at 180℃ to C11' *** successive intramolecular dehydrations and condensations of the as-formed bimolecular intermediates lead to three types of soluble *** show that the C12 path could be restrained by using HCl or AlCl_(3) catalyst,and both the C12 and C110 paths could be effectively inhibited by adding THF as a co-solvent or accelerating heating rate via microwave heating.

关键词： Carbohydrates 5-hydroxymethylfurfural Reaction network Soluble humins Tautomer

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Aboveground carbon sequestration of Cunninghamia lanceolata forests:Magnitude and drivers

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Forest Ecosystems 2024年第1期11卷 32-41页

作者： Chen Wang shuguang Liu Yu zhu Andrew R.Smith Ying Ning Deming Deng National Engineering Laboratory for Applied Technology of Forestry&Ecology in South China Central South University of Forestry and TechnologyChangsha 410004China Technology Innovation Center for Ecological Conservation and Restoration in Dongting Lake Basin Ministry of Natural ResourcesChangsha 410007China College of Life Science and Technology Central South University of Forestry and TechnologyChangsha 410004China School of Ecology and Environment Hainan UniversityHaikou 570228China School of Natural Sciences Bangor UniversityGwyneddLL572UWUK College of Forestry Central South University of Forestry and TechnologyChangsha 410004China Hunan Prospecting Designing&Research General Institute for Agriculture Forestry&IndustryChangsha 410007China

Understanding the spatial variation,temporal changes,and their underlying driving forces of carbon sequestration in various forests is of great importance for understanding the carbon cycle and carbon management *** carbon density and sequestration in various Cunninghamia lanceolata forests,extensively cultivated for timber production in subtropical China,vary with biodiversity,forest structure,environment,and cultural factors remain poorly explored,presenting a critical knowledge gap for realizing carbon sequestration supply potential through *** on a large-scale database of 449 permanent forest inventory plots,we quantified the spatial-temporal heterogeneity of aboveground carbon densities and carbon accumulation rates in Cunninghamia lanceolate forests in Hunan Province,China,and attributed the contributions of stand structure,environmental,and management factors to the heterogeneity using quantile age-sequence analysis,partial least squares path modeling(PLS-PM),and hot-spot *** results showed lower values of carbon density and sequestration on average,in comparison with other forests in the same climate zone(i.e.,subtropics),with pronounced spatial and temporal ***,quantile regression analysis using carbon accumulation rates along an age sequence showed large differences in carbon sequestration rates among underperformed and outperformed forests(0.50 and 1.80 Mg·ha^(-1)·yr^(-1)).PLS-PM demonstrated that maximum DBH and stand density were the main crucial drivers of aboveground carbon density from young to mature ***,species diversity and geotopographic factors were the significant factors causing the large discrepancy in aboveground carbon density change between low-and high-carbon-bearing *** analysis revealed the importance of culture attributes in shaping the geospatial patterns of carbon *** work highlighted that retaining largesized DBH trees and increasing shade-t

关键词： Carbon density Carbon accumulation rate Forest age Spatial variation Cultural influence

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A data-derived soft-sensor method for monitoring effluent total phosphorus

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Chinese Journal of Chemical Engineering 2017年第12期25卷 1791-1797页

作者： shuguang zhu Honggui Han Min Guo Junfei Qiao College of Electronic Information & Control Engineering Beijing University of Technology Beijing 100124 China Beijing Key Laboratory of Computational Intelligence and Intelligent System Beijing 100124 China Engineering Research Center of Digital Community Ministry of Education Beijing 100124 China Beijing Laboratory for Urban Mass Transit Beijing 100124 China

The effluent total phosphorus(ETP) is an important parameter to evaluate the performance of wastewater treatment process(WWTP). In this study, a novel method, using a data-derived soft-sensor method, is proposed to obtain the reliable values of ETP online. First, a partial least square(PLS) method is introduced to select the related secondary variables of ETP based on the experimental data. Second, a radial basis function neural network(RBFNN) is developed to identify the relationship between the related secondary variables and ETP. This RBFNN easily optimizes the model parameters to improve the generalization ability of the soft-sensor. Finally, a monitoring system, based on the above PLS and RBFNN, named PLS-RBFNN-based soft-sensor system, is developed and tested in a real WWTP. Experimental results show that the proposed monitoring system can obtain the values of ETP online and own better predicting performance than some existing methods.

关键词：导出数据软传感器自河全部的磷废水处理过程光线的基础功能神经网络部分最不方形的方法

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Data-driven intelligent monitoring system for key variables in wastewater treatment process

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Chinese Journal of Chemical Engineering 2018年第10期26卷 2093-2101页

作者： Honggui Han shuguang zhu Junfei Qiao Min Guo College of Electronic Information & Control Engineering Beijing University of Technology Beijing 100124 China Beijing Key Laboratory of Computational Intelligence and Intelligent System Beijing 100124 China Engineering Research Center of Digital Community Ministry of Education Beijing 100124 China Beijing Laboratory for Urban Mass Transit Beijing 100124 China

In wastewater treatment process(WWTP), the accurate and real-time monitoring values of key variables are crucial for the operational strategies. However, most of the existing methods have difficulty in obtaining the real-time values of some key variables in the process. In order to handle this issue, a data-driven intelligent monitoring system, using the soft sensor technique and data distribution service, is developed to monitor the concentrations of effluent total phosphorous(TP) and ammonia nitrogen(NH_4-N). In this intelligent monitoring system, a fuzzy neural network(FNN) is applied for designing the soft sensor model, and a principal component analysis(PCA) method is used to select the input variables of the soft sensor model. Moreover, data transfer software is exploited to insert the soft sensor technique to the supervisory control and data acquisition(SCADA) system. Finally, this proposed intelligent monitoring system is tested in several real plants to demonstrate the reliability and effectiveness of the monitoring performance.

关键词：监视系统水处理过程数据驱动传感器技术传感器模型模糊神经网络分发服务主要部件

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