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Polo-like kinase 1 as a biomarker predicts the prognosis and immunotherapy of breast invasive carcinoma patients

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Oncology Research 2024年第2期32卷 339-351页

作者： JUAN SHEN WEIYU ZHANG QINQIN JIN FUYU GONG HEPING ZHANG HONGLIANG XU JIEJIE LI HUI YAO XIYA JIANG YINTING YANG LIN HONG JIE MEI YANG SONG shuguang zhou School of Big Data and Artificial Intelligence Anhui Xinhua UniversityHefei230088China Department of Gynecology and Obstetrics Maternity and Child Healthcare Hospital Affiliated to Anhui Medical UniversityAnhui Province Maternity and Child Healthcare HospitalHefei230001China Department of Gynecology and Obstetrics The Fifth Clinical College of Anhui Medical UniversityHefei230032China Departments of Breast Surgery Fuyang Women and Children’s HospitalFuyang236000China Departments of Pathology Anhui Province Maternity and Child Health HospitalHefei230001China Department of Pain The First Affiliated Hospital of Anhui Medical UniversityHefei230032China Department of Gynecology and Obstetrics Linquan Maternity and Child Healthcare HospitalFuyang236400China

Invasive breast carcinoma(BRCA)is associated with poor prognosis and high risk of ***,it is critical to identify novel biomarkers for the prognostic assessment of ***:The expression data of polo-like kinase 1(PLK1)in BRCA and the corresponding clinical information were extracted from TCGA and GEO ***1 expression was validated in diverse breast cancer cell lines by quantitative real-time polymerase chain reaction(qRT-PCR)and western *** sample gene set enrichment analysis(ssGSEA)was performed to evaluate immune infiltration in the BRCA microenvironment,and the random forest(RF)and support vector machine(SVM)algorithms were used to screen for the hub infiltrating cells and calculate the immunophenoscore(IPS).The RF algorithm and COX regression model were applied to calculate survival risk scores based on the PLK1 expression and immune cell ***,a prognostic nomogram was constructed with the risk score and pathological stage,and its clinical potential was evaluated by plotting calibration charts and DCA *** application of the nomogram was further validated in an immunotherapy ***:PLK1 expression was significantly higher in the tumor samples in TCGA-BRCA ***,PLK1 expression level,age and stage were identified as independent prognostic factors of *** the IPS was unaffected by PLK1 expression,the TMB and MATH scores were higher in the PLK1-high group,and the TIDE scores were higher for the PLK1-low *** also identified 6 immune cell types with high infiltration,along with 11 immune cell types with low infiltration in the PLK1-high tumors.A risk score was devised using PLK1 expression and hub immune cells,which predicted the prognosis of BRCA *** addition,a nomogram was constructed based on the risk score and pathological staging,and showed good predictive ***:PLK1 expression and immune cell infiltration can predict post-immunotherapy pr

关键词： Breast invasive carcinoma(BRCA) Polo-like kinase 1(PLK 1) Random forest(RF) Support vector machine(SVM) Immune infiltration

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数字经济时代智能会计的角色定位与实现策略

重庆三峡学院学报 2024年第1期40卷 57-66页

作者：周曙光魏丹璐重庆三峡学院财经学院重庆404020 重庆市万州港口(集团)有限责任公司重庆404000

随着数字经济的快速发展,以及以人工智能为代表的新一代信息技术在会计领域的深度应用,智能会计作为一种新型会计模式应运而生。智能会计是“会计与智能”深度融合的产物,其基本特征是人工智能技术在会计系统中的匹配应用。智能会计不... 详细信息

随着数字经济的快速发展,以及以人工智能为代表的新一代信息技术在会计领域的深度应用,智能会计作为一种新型会计模式应运而生。智能会计是“会计与智能”深度融合的产物,其基本特征是人工智能技术在会计系统中的匹配应用。智能会计不仅延承了传统会计的角色,保留了会计作为反映和管理工具的本质特征,也拓展了会计的角色。智能会计在企业中可以承担智能反映者、智能管理者、智能价值创造者的角色。从会计环境的内环境和外环境两个维度,提出促进智能会计角色得以实现的潜在策略:在会计内环境维度,应注重会计组织的智能化建设、提升会计人员的角色认知与角色实践能力;在会计外环境维度,应注重智能会计规则体系建设、智能会计软件的开发。

关键词：智能会计角色理论会计角色数字经济会计环境

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地质聚合物混凝土抗氯离子渗透性能研究进展

硅酸盐通报 2024年第7期43卷 2503-2513页

作者：余金虎李强刘学应周曙光王超安徽建筑大学土木工程学院合肥230601 浙江水利水电学院建筑工程学院杭州310018

地质聚合物混凝土是一种新型绿色建筑材料,氯离子传输是影响其服役寿命的关键因素。本文在介绍地质聚合物混凝土氯离子传输机理的基础上,归纳总结了地质聚合物混凝土抗氯离子渗透性能试验方法的特点和局限性,介绍了地质聚合物混凝土抗... 详细信息

地质聚合物混凝土是一种新型绿色建筑材料,氯离子传输是影响其服役寿命的关键因素。本文在介绍地质聚合物混凝土氯离子传输机理的基础上,归纳总结了地质聚合物混凝土抗氯离子渗透性能试验方法的特点和局限性,介绍了地质聚合物混凝土抗氯离子渗透性能的影响因素,并对比了其与普通混凝土氯离子传输机理的区别。文章最后指出高温、冻融等单一因素影响下的地质聚合物混凝土氯离子传输模型、碱掺量和水玻璃模数对地质聚合物混凝土抗氯离子渗透性能的影响,以及氯离子的显色边界浓度的准确性等还有待进一步深入研究。

关键词：地质聚合物混凝土氯离子渗透性能传输机理试验方法影响因素

Application of cluster analysis to geochemical compositional data for identifying ore-related geochemical anomalies

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Frontiers of Earth Science 2018年第3期12卷 491-505页

作者： shuguang zhou Kefa zhou Jinlin WANG Genfang YANG Shanshan WANG Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Urumqi 830011 China Xinjiang Laboratory of Mineral Resources and Digital Geology Ummqi 830011 China Laboratory of Desert Environment & Engineering Ummqi 830011 China

Cluster analysis is a well-known technique that is used to analyze various types of data. In this study, cluster analysis is applied to geochemical data that describe 1444 stream sediment samples collected in northwestern Xinjiang with a sample spacing of approximately 2 km. Three algorithms （the hierarchical, k-means, and fuzzy cmeans algorithms） and six data transformation methods （the z-score standardization, ZST; the logarithmic transformation, LT; the additive log-ratio transformation, ALT; the centered log-ratio transformation, CLT; the isometric log-ratio transformation, ILT; and no transformation, NT） are compared in terms of their effects on the cluster analysis of the geochemical compositional data. The study shows that, on the one hand, the ZST does not affect the results of columnor variable-based （R-type） cluster analysis, whereas the other methods, including the LT, the ALT, and the CLT, have substantial effects on the results. On the other hand, the results of the row- or observation-based （Q-type） cluster analysis obtained from the geochemical data after applying NT and the ZST are relatively poor. However, we derive some improved results from the geochemical data after applying the CLT, the ILT, the LT, and the ALT. Moreover, the k-means and fuzzy cmeans clustering algorithms are more reliable than the hierarchical algorithm when they are used to cluster the geochemical data. We apply cluster analysis to the geochemical data to explore for Au deposits within the study area, and we obtain a good correlation between the results retrieved by combining the CLT or the ILT with the k-means or fuzzy c-means algorithms and the potential zones of Au mineralization. Therefore, we suggest that the combination of the CLT or the ILT with the k-means or fuzzy c-means algorithms is an effective tool to identify potential zones of mineralization from geochemical data.

关键词： cluster analysis compositional data geochemical anomaly mineral exploration

县域城镇化视角下欠发达地区县城发展路径探索——以河南省宁陵县为例

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中国名城 2024年第3期38卷 11-16页

作者：张洋周曙光刘军民高磊北京林业大学经济管理学院上海长业控股(集团)有限公司中国建筑节能协会绿色城市研究中心防灾科技学院

随着我国城镇化建设进入中后期,县域的城镇化在新经济形势下的价值与作用愈发显现。欠发达地区的城镇化作为其发展的重要任务与依托,正面临着一系列重要挑战。作为该类城镇化的典型地区之一,河南省宁陵县创新性地采用了初期多元融资、... 详细信息

随着我国城镇化建设进入中后期,县域的城镇化在新经济形势下的价值与作用愈发显现。欠发达地区的城镇化作为其发展的重要任务与依托,正面临着一系列重要挑战。作为该类城镇化的典型地区之一,河南省宁陵县创新性地采用了初期多元融资、建设中期引进多方力量参与的方式,以县城为载体,以核心区基础设施为带动,为实现当地历史传承、生态人居改善、产业系统升级进行了有益的探索。宁陵的新型城镇化有效带动了宁陵县的整体发展,同时也为我国其他欠发达地区县城及县域的发展提供了有效参考。

关键词：欠发达地区县域城镇化高质量发展路径探索

High order semi-implicit weighted compact nonlinear scheme for the all-Mach isentropic Euler system

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Advances in Aerodynamics 2020年第1期2卷 555-578页

作者： Yanqun Jiang Xun Chen Xu Zhang Tao Xiong shuguang zhou Department of Mathematics Southwest University of Science and Technology621010 MianyangChina School of Mathematical Sciences Fujian Provincial Key Laboratory of Mathematical Modeling and High-Performance Scientific ComputingXiamen University361005 XiamenChina Computational Aerodynamics Institute China Aerodynamics Research and Development Center621000 MianyangChina

The computation of compressible flows at all Mach numbers is a very challenging *** efficient numerical method for solving this problem needs to have shock-capturing capability in the high Mach number regime,while it can deal with stiffness and accuracy in the low Mach number *** paper designs a high order semi-implicit weighted compact nonlinear scheme(WCNS)for the all-Mach isentropic Euler system of compressible gas *** avoid severe Courant-Friedrichs-Levy(CFL)restrictions for low Mach flows,the nonlinear fluxes in the Euler equations are split into stiff and non-stiff components.A third-order implicit-explicit(IMEX)method is used for the time discretization of the split components and a fifth-order WCNS is used for the spatial discretization of flux *** high order IMEX method is asymptotic preserving and asymptotically accurate in the zero Mach number ***-and two-dimensional numerical examples in both compressible and incompressible regimes are given to demonstrate the advantages of the designed IMEX WCNS.

关键词： High order scheme IMEX time discretization WCNS Asymptotic-preserving property Low Mach number Isentropic Euler equations

CFD-based hull optimization in calm water using adaptive grid deformation method

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Journal of Hydrodynamics 2024年第2期36卷 241-262页

作者： shuguang Wang Yonghwan Kim Department of Naval Architecture and Ocean Engineering Seoul National UniversitySeoulKorea

This paper presents an adaptive grid deformation technique for optimizing ship hull forms using computational fluid dynamics(CFD).The proposed method enables accurate and smooth updates of the hull surface and 3-D CFD grids in response to design *** technique incorporates a two-level point-transformation approach to move the grid points by a few design ***,generic B-splines are utilized to transform grid points according to the displacements of the control points within a defined control *** ensures surface modification accuracy and smoothness,similar to those provided by non-uniform rational ***,radial basis functions are used to interpolate the movements of the control points with a limited set of design *** developed method effectively maintains the mesh quality and simulation *** applying this method to surface and grid adaptation,a regression model is proposed in the form of a second-order polynomial to represent the relationship between the geometric parameters and design *** polynomial is then used to introduce geometric ***,a radial basis function surrogate model for the calm-water resistance is constructed to approximate the objective *** enhanced optimization framework is proposed for CFD–based hull optimization and applied to KVLCC2 to validate its feasibility and efficiency.

关键词： Hull-form optimization adaptive grid deformation ship resistance OpenFOAM radial basis function(RBF)surrogate model

Optimal bandwidth selection for retrieving Cu content in rock based on hyperspectral remote sensing

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Journal of Arid Land 2022年第1期14卷 102-114页

作者： MA Xiumei zhou Kefa WANG Jinlin CUI Shichao zhou shuguang WANG Shanshan ZHANG Guanbin State Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China Xinjiang Key Laboratory of Mineral Resources and Digital Geology Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China Xinjiang Research Centre for Mineral Resources Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Xinjiang Academy of Science and Technology for Development Strategy Urumqi 830011China

Hyperspectral remote sensing technology is widely used to detect element contents because of its multiple bands,high resolution,and abundant *** researchers have paid considerable attention to selecting the optimal bandwidth for the hyperspectral inversion of metal element contents in rocks,the influence of bandwidth on the inversion accuracy are *** this study,we collected 258 rock samples in and near the Kalatage polymetallic ore concentration area in the southwestern part of Hami City,Xinjiang Uygur Autonomous Region,China and measured the ground spectra of these *** original spectra were resampled with different bandwidths.A Partial Least Squares Regression(PLSR)model was used to invert Cu contents of rock samples and then the influence of different bandwidths on Cu content inversion accuracy was *** to the results,the PLSR model obtains the highest Cu content inversion accuracy at a bandwidth of 35 nm,with the model determination coefficient(R^(2))of *** PLSR inversion accuracy is relatively unaffected by the bandwidth within 5-80 nm,but the accuracy decreases significantly at 85 nm bandwidth(R^(2)=0.5473),and the accuracy gradually decreased at bandwidths beyond 85 ***,bandwidth has a certain impact on the inversion accuracy of Cu content in rocks using the PLSR *** study provides an indicator argument and theoretical basis for the future design of hyperspectral sensors for rock geochemistry.

关键词： hyperspectral remote sensing Cu element bandwidth Partial Least Squares Regression inversion accuracy Kalatage polymetallic ore concentration area

高性能混凝土结构(HPCS)中的ASR及抑制措施评价

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西北工业大学学报 2009年第1期27卷 137-143页

作者：周述光张洵安西北工业大学力学与土木建筑学院陕西西安710072 武警工程学院建筑工程系陕西西安710086

对ASR发生的化学机理进行了回顾。ASR发生的化学反应机理可以分为2步:1骨料颗粒外部OH-离子入侵活性颗粒,断开活性颗粒≡Si-O-Si≡的链接,形成分散的Si2+;2外界离子(K+,Na+,OH-)和≡Si-O-结合形成水化石灰石-Na-Si-复合物,该复合物吸水... 详细信息

对ASR发生的化学机理进行了回顾。ASR发生的化学反应机理可以分为2步:1骨料颗粒外部OH-离子入侵活性颗粒,断开活性颗粒≡Si-O-Si≡的链接,形成分散的Si2+;2外界离子(K+,Na+,OH-)和≡Si-O-结合形成水化石灰石-Na-Si-复合物,该复合物吸水膨胀产生压力。利用ASR的化学反应机理分析和评价了普通混凝土中单种抑制材料抑制ASR的效果。由于HPC配合比设计时组成材料众多,根据ASR化学反应机理,研究HPC结构中用来抑制ASR的措施,必须考虑各种材料的相互影响和叠加效应。结论认为要保证HPC结构中抑制ASR的效果,关键是降低HPC结构中活性颗粒周围孔溶液中离子的浓度,防止合适浓度的OH-出现。

关键词： HPC ASR 抑制措施