检索结果-南通市图书馆

Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2024年第1期16卷 33-53页

作者： Hong-Shuo Shi Xin Yuan fang-fang Wu Xiao-Yu Li Wei-Jing fan Xiao Yang Xiao-Ming Hu Guo-Bin Liu Department of Peripheral Vascular Surgery Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 250021China

BACKGROUND Stem cell therapy has shown great potential for treating diabetic foot(DF).AIM To conduct a bibliometric analysis of studies on the use of stem cell therapy for DF over the past two decades,with the aim of depicting the current global research landscape,identifying the most influential research hotspots,and providing insights for future research *** We searched the Web of Science Core Collection database for all relevant studies on the use of stem cell therapy in *** analysis was carried out using CiteSpace,VOSviewer,and R(4.3.1)to identify the most notable *** A search was conducted to identify publications related to the use of stem cells for DF treatment.A total of 542 articles published from 2000 to 2023 were *** United States had published the most papers on this *** this field,Iran’s Shahid Beheshti University Medical Sciences demonstrated the highest ***,*** from the same university has been an outstanding researcher in this *** Cell Research&Therapy is the journal with the highest number of publications in this *** main keywords were“diabetic foot ulcers,”“wound healing,”and“angiogenesis.”CONCLUSION This study systematically illustrated the advances in the use of stem cell therapy to treat DF over the past 23 *** research findings suggested that the hotspots in this field include stem cell dressings,exosomes,wound healing,and adipose-derived stem *** research should also focus on the clinical translation of stem cell therapies for DF.

关键词： Stem cells Diabetic foot Bibliometric CiteSpace VOSviewer R-bibliometrix

Endoscopic features and treatments of gastric cystica profunda

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第7期30卷 673-684页

作者： Zi-Han Geng Yan Zhu Pei-Yao Fu Yi-fan Qu Wei-Feng Chen Xia Yang Ping-Hong Zhou Quan-Lin Li Endoscopy Center and Endoscopy Research Institute Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND Gastric cystica profunda(GCP)represents a rare condition characterized by cystic dilation of gastric glands within the mucosal and/or submucosal *** is often linked to,or may progress into,early gastric cancer(EGC).AIM To provide a comprehensive evaluation of the endoscopic features of GCP while assessing the efficacy of endoscopic treatment,thereby offering guidance for diagnosis and *** This retrospective study involved 104 patients with GCP who underwent endoscopic *** demographic and clinical data,regular patient followups were conducted to assess local *** Among the 104 patients diagnosed with GCP who underwent endoscopic resection,12.5%had a history of previous gastric *** primary site predominantly affected was the cardia(38.5%,n=40).GCP commonly exhibited intraluminal growth(99%),regular presentation(74.0%),and ulcerative mucosa(61.5%).The leading endoscopic feature was the mucosal lesion type(59.6%,n=62).The average maximum diameter was 20.9±15.3 mm,with mucosal involvement in 60.6%(n=63).Procedures lasted 73.9±57.5 min,achieving complete resection in 91.3%(n=95).Recurrence(4.8%)was managed via either surgical intervention(n=1)or through endoscopic resection(n=4).Final pathology confirmed that 59.6%of GCP cases were associated with *** analysis indicated that elderly males were more susceptible to GCP associated with ***,multivariate analysis identified lesion morphology and endoscopic features as significant risk *** analysis demonstrated no statistically significant difference in recurrence between GCP with and without EGC(P=0.72).CONCLUSION The findings suggested that endoscopic resection might serve as an effective and minimally invasive treatment for GCP with or without EGC.

关键词： Gastric cystica profunda Early gastric cancer Endoscopic features Endoscopic resection Endoscopy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

稀酸快速浸提大米中镉方法的响应面优化研究

现代食品 2024年第17期30卷 109-115页

作者：苏祖俭蔡文华吴绒陈明周瑞妮范建彬邢海涛蒋定国胡曙光广东省生物制品与药物研究所广东广州510440 广东省疾病预防控制中心重金属参比实验室广东广州511430 国家食品安全风险评估中心北京100022

本研究采用稀酸提取法,通过单因素实验和响应曲面实验确定大米中镉的最佳提取条件,为大批量、高通量的大米中镉元素提取和检测提供技术支持,更好地保护人们的健康。结果表明,确定的最佳提取条件为采用0.5%硝酸溶液以4∶1液料比对粒径小... 详细信息

本研究采用稀酸提取法,通过单因素实验和响应曲面实验确定大米中镉的最佳提取条件,为大批量、高通量的大米中镉元素提取和检测提供技术支持,更好地保护人们的健康。结果表明,确定的最佳提取条件为采用0.5%硝酸溶液以4∶1液料比对粒径小于300μm的大米粉提取10min。方法对比结果显示,该方法准确、可靠,与《食品安全国家标准食品中多元素的测定》(GB 5009.268—2016)中的微波消解法相比在统计学上差异不显著,适用于大米中镉的快速提取和检测,能够为食品安全监测提供技术支持。

关键词：响应面优化稀酸快速浸提大米镉

双层斜腿刚构连续梁桥人致振动分析及减振设计

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

中国市政工程 2024年第4期 40-45,151,152页

作者：李扬帆同济大学建筑设计研究院(集团)有限公司上海200092

文章以安吉曙光桥为例,研究了这座双层桥面斜腿刚构连续梁桥的人致振动及减振设计。计算了桥梁的行人荷载及动力特性,分析了该桥的人致振动响应并进行舒适度评价。针对桥梁双层布置的特点,提出了应用连杆提高刚度、应用调谐质量阻尼器(T... 详细信息

文章以安吉曙光桥为例,研究了这座双层桥面斜腿刚构连续梁桥的人致振动及减振设计。计算了桥梁的行人荷载及动力特性,分析了该桥的人致振动响应并进行舒适度评价。针对桥梁双层布置的特点,提出了应用连杆提高刚度、应用调谐质量阻尼器(Tuned Mass Damper,TMD)增强阻尼的减振设计思路,比较分析了3种不同的减振设计:单独设置TMD、单独设置连杆、联合设置连杆-TMD。研究结果表明:安吉曙光桥振动频率低、人致振动响应较大,需对其进行减振控制;单独布置TMD,可有效控制桥梁的振动响应;单独设置2组连杆,可显著提高桥梁的自振频率;同时设置连杆和TMD,可采用较小的TMD实现减振目标。3种减振设计均能满足舒适度要求,工程中应根据实际情况选用。

关键词：人致振动舒适性评价减振设计调谐质量阻尼器连杆双层布置

中药熏洗结合针刺治疗糖尿病血管病变临床观察

在线全文

学校读者我要写书评

暂无评论

中华中医药学刊 2024年第6期42卷 248-251页

作者：卢慧敏樊炜静柳国斌上海中医药大学附属曙光医院上海200021

目的观察中药熏洗结合针刺治疗糖尿病血管病变临床效果。方法研究纳入合计151例糖尿病血管病变患者(2020年1月—2023年2月收治)进行分组研究,分组方法为随机数字表法,将患者分为观察组(76例)与对照组(75例),对照组患者采取西医常规治... 详细信息

目的观察中药熏洗结合针刺治疗糖尿病血管病变临床效果。方法研究纳入合计151例糖尿病血管病变患者(2020年1月—2023年2月收治)进行分组研究,分组方法为随机数字表法,将患者分为观察组(76例)与对照组(75例),对照组患者采取西医常规治疗,观察组患者西医常规治疗结合中药熏洗及针刺治疗,各组数据观察:治疗效果、治疗前后患者血糖指标变化空腹血糖(Fasting blood glucose, FPG);餐后2 h血糖(2 hour postprandial plasma glucose, 2hFPG);糖化血红蛋白(glycosylated hemoglobin, HbAlc)、中医证候积分(下肢麻木疼痛、疮面肉芽不新鲜、面色无华、心悸气短、神疲乏力等)变化、足背温度变化及踝/肱指数(ankle brachial index, ABI)变化、下肢动静脉彩超相关指标(血管内径、血管狭窄程度以及血流速度)变化、耐受疼痛最大行走距离变化及血液流变学指标(红细胞比容、血浆黏度值、全血高切黏度及全血低切黏度)变化、不良反应。结果观察组与对照组治疗总有效率分别为96.05%、86.67%,前者更高,P0.05,治疗后各组患者血糖指标(FPG、2hFPG、HbAlc)、中医证候积分(下肢麻木疼痛、疮面肉芽不新鲜、面色无华、心悸气短、神疲乏力等)、足背温度、ABI、下肢动静脉彩超相关指标(血管内径、血管狭窄程度以及血流速度)、耐受疼痛最大行走距离、血液流变学指标(红细胞比容、血浆黏度值、全血高切黏度及全血低切黏度)等指标均改善,观察组患者治疗后血糖指标(FPG、2hFPG、HbAlc)、中医证候积分(下肢麻木疼痛、疮面肉芽不新鲜、面色无华、心悸气短、神疲乏力等)、足背温度、ABI、下肢动静脉彩超相关指标(血管内径、血管狭窄程度以及血流速度)、耐受疼痛最大行走距离、血液流变学指标(红细胞比容、血浆黏度值、全血高切黏度及全血低切黏度)等指标均优于对照组,P<0.05;对照组与观察组不良反应率分别为2.66%、2.64%,均较低。结论中药熏洗结合针刺治疗糖尿病血管病变效果显著,患者症状缓解,安全可靠,值得应用。

关键词：糖尿病血管病变中药熏洗针刺治疗效果中医证候不良反应

维普期刊数据库博看期刊

益心方调控SIRT1/Nrf2/HO-1信号通路改善大鼠心肌缺血再灌注后损伤

在线全文

学校读者我要写书评

暂无评论

中国中西医结合杂志 2024年第3期44卷 316-323页

作者：董莉杨燕玲郑钰凡戎靖枫上海中医药大学附属曙光医院心血管内科上海201203 上海中医药大学附属曙光医院心血管研究所上海201203

目的探讨中药复方益心方改善心肌缺血再灌注后损伤的作用及其机制。方法将75只清洁级大鼠分为5组:假手术组(Sham),缺血再灌注组(IR),益心方+缺血再灌注组(YXF+IR),益心方+缺血再灌注+SIRT1抑制剂组(YXF+IR+EX527),益心方+缺血再灌注+SI... 详细信息

目的探讨中药复方益心方改善心肌缺血再灌注后损伤的作用及其机制。方法将75只清洁级大鼠分为5组:假手术组(Sham),缺血再灌注组(IR),益心方+缺血再灌注组(YXF+IR),益心方+缺血再灌注+SIRT1抑制剂组(YXF+IR+EX527),益心方+缺血再灌注+SIRT1激动剂组(YXF+IR+SRT1720),每组各15只。再灌注7 d后超声心动图检测心功能;免疫荧光法检测心肌细胞凋亡率和组织活性氧(ROS)的活性;ELISA检测血清中的心肌酶水平;Western Blot检测相关蛋白表达。结果与Sham组比较,IR组大鼠的左室射血分数(LVEF)、左室短轴缩短率(LVFS)降低,心肌凋亡指数和ROS活性升高,血清中肌酸激酶(CK)、乳酸脱氢酶(LDH)、丙二醛(MDA)、过氧化氢(H2O2)、琥珀酸脱氢酶(SDH)水平升高,超氧化物歧化酶(SOD)水平降低,沉默信息调节因子1(SIRT1)、核因子E2相关因子2(Nrf2)、血红素氧合酶1(HO-1)、B淋巴细胞瘤-2(Bcl-2)蛋白表达下降,B淋巴细胞瘤-2相关蛋白X(Bax)、胱天蛋白酶3(Caspase 3)表达增加,差异均有统计学意义(P<0.01,P<0.05)。与IR组比较,YXF+IR和YXF+IR+SRT1720组LVEF、LVFS升高,心肌凋亡指数和ROS活性降低,血清中CK、LDH、MDA、H2O2、SDH水平降低,SOD水平升高,SIRT1、Nrf2、HO-1 BCL-2蛋白表达升高,Bax、Caspase 3蛋白表达降低,差异均有统计学意义(P<0.01,P<0.05)。与YXF+IR组比较,YXF+IR+EX527组CK、LDH、MDA、H2O2、SDH升高,SOD水平下降,SIRT1、Nrf2、HO-1、Bcl-2表达降低,Bax、Caspase 3表达升高,差异均有统计学意义(P<0.01,P<0.05)。结论益心方可以通过上调SIRT1/Nrf2/HO-1信号通路改善心肌缺血再灌注损伤大鼠心功能,减轻心肌缺血再灌注后氧化应激损伤。

关键词：益心方心肌缺血再灌注后损伤沉默信息调节因子1 核因子E2相关因子2 血红素氧合酶1 氧化应激细胞凋亡中药复方

组蛋白乳酸化调控巨噬细胞功能促进炎症微环境修复的研究进展

在线全文

学校读者我要写书评

暂无评论

海南医学院学报 2024年第15期30卷 1180-1186页

作者：袁鑫史宏硕樊炜静柳国斌上海中医药大学附属曙光医院上海200120

组蛋白乳酸化修饰是一种快速动态的转录后修饰形式,在巨噬细胞极化和功能性转换中发挥着重要作用。巨噬细胞是免疫系统中最重要的细胞类型之一,其功能的改变可以影响整个免疫系统的活动,是炎症微环境中的重要细胞之一。炎症微环境是许... 详细信息

组蛋白乳酸化修饰是一种快速动态的转录后修饰形式,在巨噬细胞极化和功能性转换中发挥着重要作用。巨噬细胞是免疫系统中最重要的细胞类型之一,其功能的改变可以影响整个免疫系统的活动,是炎症微环境中的重要细胞之一。炎症微环境是许多疾病发生、发展所必需的,而抗炎状态的持续存在以及在肿瘤微环境中的免疫逃逸都阻碍了疾病的好转和愈合,如何调节炎症微环境已成为治疗许多疾病的重要研究方向之一。本文回顾了组蛋白乳酸化的生化途径,对组蛋白乳酸化调控巨噬细胞功能来改善炎症微环境的机制进行综述,强调组蛋白乳酸化在维持生物体内环境稳态中的重要性及在疾病中的应用作用;讨论未来研究方向,旨在为基于组蛋白乳酸化的治疗策略提供科学方向。

关键词：组蛋白乳酸化巨噬细胞功能炎症微环境修复疾病

Experimental study on f-ω regulation model under abnormal methane emission

在线全文

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2016年第6期26卷 1153-1159页

作者： Wu Zhengyan Jiang shuguang Wang Kai Shao Hao Zhou Song He Xinjian Han Jing Cui Chuanbo Pei Xiaodong Key Laboratory of Coal Methane and Fire Control Ministry of Education China University of Mining and Technology Xuzhou 221116 China School of Safety Engineering China University of Mining and Technology Xuzhou 221116 China State Key Laboratory of Cool Resources and Safe Mining China University of Mining and Technology Xuzhou 221116 China Department of Chemical Engineering Engineering Faculty Monash University Melbourne Victoria 3800 Australia Department of Industrial Management and Systems Engineering Statler College of Engineering and Mineral Resources West Virginia University Morgantown WV 26506 USA School of Mining and Safety Engineering Anhui University of Science and Technology Huainan 232001 China

In view of the difficulty of automatic adjustment, the recovery lag and the major accident potential of the mine ventilation system, an experimental model of the pipe net was established according to the typical one mine and one working face ventilation system of Daliuta coal mine. Using the best uniform approximation method of Chebyshev interpolation to fit the fan performance curve, we experimentally determined fan characteristics with different frequencies and establish the data base for the curves. Based on ventilation network monitoring theory, we designed a monitoring system for ventilation network parameter monitoring and fan operating frequency automatic control. Using the absolute methane emission quantity to predict the air quantity requirement of branch and fan frequency, we established a f-ω regulation model based on fan frequency and absolute methane emission quantity. After analysing methane emission and distribution characteristics, using CO_2 to simulate the methane emission characteristics from a working face, we verified the correctness and rationality of the f-ω regulation model. The fan operation frequency is adjusted by the method of air adjustment change with methane emission quantity and the curve searching method after determining air quantity requirements. The results show that the air quantity in a branch strictly changes according to the f-ω regulation model, in the airincreasing dilution by fan frequency regulation, the CO_2 concentration is limited to the set threshold value. The paper verifies the practicability of a frequency regulation system and the feasibility of the frequency adjustment scheme and provides guidance for the construction of automatic frequency conversion control system in coal mine ventilation networks.

关键词： Pipe network model Frequency regulation f-ω regulation model Prediction of air quantity requirement Air-increasing dilution

Association between short-term exposure to ambient fine particulate matter and lung function among children

在线全文

学校读者我要写书评

暂无评论

Association between short-term exposure to ambient fine part...