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新型冠状病毒肺炎放射诊断检查场所的感染控制与辐射安全监测和分析

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中华放射医学与防护杂志 2020年第4期40卷 253-258页

作者：唐利军周文珊刘盛杨想军霍细香谢曙光李静刘安生唐诗迪雷子乔陈为民牛延涛湖北省疾病预防控制中心应用毒理湖北省重点实验室武汉430079 武汉市职业病防治院 430015 华中科技大学同济医学院附属协和医院放射科武汉430022 武汉大学中南医院科研处 430071 首都医科大学附属北京同仁医院放射科北京100730

目的对新型冠状病毒肺炎放射诊断场所存在的感染控制和辐射安全风险进行调查和监测,为放射技师及相关工作人员的安全防护提供数据支持。方法根据国家标准(WS 519-2019和GBZ 130-2013)对湖北省4所未启用的应急医院(“小汤山式”甲、乙医... 详细信息

目的对新型冠状病毒肺炎放射诊断场所存在的感染控制和辐射安全风险进行调查和监测,为放射技师及相关工作人员的安全防护提供数据支持。方法根据国家标准(WS 519-2019和GBZ 130-2013)对湖北省4所未启用的应急医院(“小汤山式”甲、乙医院及方舱医院、砖混模式医院)中新安装的8台CT及其场所进行成像性能和放射防护检测并评价。对机房布局等感染控制安全的因素实施了监测与调查。选择定点医院2所(综合医院和传染病专科医院),通过现场调查和对4个CT机房环境生物样本进行新型冠状病毒核酸检测,对放射场所的布局、感染防控和核酸检测结果的分布进行分析,评价其生物安全的可靠性和风险点。结果应急医院的8台CT设备的成像性能和放射防护指标均能满足国家标准的要求。甲、乙医院各有3个CT机房,面积均为38.8 m^2和4 mm Pb当量的屏蔽防护;方舱医院和砖混建筑医院的CT机房面积和屏蔽防护分别为20.0 m^2、4 mm Pb当量和35.8 m^2、3 mm Pb当量。8个放射诊断场所符合感染防控“三区两通道”的设计要求。新型冠状病毒核酸检测结果显示,CT机房内患者触碰到的多个位点如检查床、机架内侧、地面等多处发现核酸阳性。放射技师通过手部、足底沾染造成操作间内操作台和地面的病毒污染风险。此外,机房内患者未触及的区域如观察窗和排风口等处也出现类似阳性。结论4所应急医院的8台CT设备和机房基本满足成像性能和放射防护要求。新型冠状病毒肺炎放射诊断检查场所需加强消毒的规范化。

关键词：新型冠状病毒肺炎放射诊断场所辐射安全感染控制方舱CT

1728例皮肌炎患者抗特异性肌炎谱抗体结果分析

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检验医学与临床 2021年第21期18卷 3124-3127,3131页

作者：谢曙光李玲李云珍苏坤华李莲莲张玲刘勇广州金域医学检验中心有限公司广东广州510005

目的探讨抗特异性肌炎谱抗体在皮肌炎患者中的临床意义,为临床提供辅助诊断依据。方法随机选取2019年10月至2020年10月送检该单位进行血清抗特异性肌炎谱抗体检测的1728例皮肌炎患者为研究对象,采用免疫印记法进行抗体(抗EJ抗体、抗Fibr... 详细信息

目的探讨抗特异性肌炎谱抗体在皮肌炎患者中的临床意义,为临床提供辅助诊断依据。方法随机选取2019年10月至2020年10月送检该单位进行血清抗特异性肌炎谱抗体检测的1728例皮肌炎患者为研究对象,采用免疫印记法进行抗体(抗EJ抗体、抗Fibrillarin抗体、抗HA抗体、抗JO-1抗体、抗KS抗体、抗KU抗体、抗MDA5抗体、抗Mi-2抗体、抗NOR-90抗体、抗NXP2抗体、抗OJ抗体、抗PL-12抗体、抗PL-7抗体、抗PM-SCL100抗体、抗PM-SCL75抗体、抗RNA-PⅢ抗体、抗Ro-52抗体、抗SAE1抗体、抗SAE2抗体、抗Scl-70抗体、抗SRP抗体、抗Th/To抗体、抗TIF1γ抗体、抗ZO抗体)检测并分析结果。结果1728例皮肌炎患者中抗特异性肌炎谱抗体阳性总例数为907例,总阳性率为52.49%。41~<51岁阳性率最高,为62.58%;其次是61~<71岁,为57.80%;1~<18岁最低,为30.82%。男性抗特异性肌炎谱抗体阳性率为42.58%,女性阳性率为58.93%,组间比较差异有统计学意义(P<0.05)。抗Ro-52抗体总阳性率为24.83%,女性阳性率为18.17%,男性阳性率为6.66%;抗JO-1抗体总阳性率为7.29%,女性阳性率为5.27%,男性阳性率为2.03%;抗RNA-PⅢ抗体总阳性率为6.25%,女性阳性率为4.34%,男性阳性率为1.91%。单独1种抗体阳性有475例,阳性率为52.37%;其次是2种抗体阳性323例,阳性率为35.61%;3种抗体阳性80例,阳性率为8.82%。结论抗特异性肌炎谱抗体检测可为皮肌炎的早期诊断、治疗及预后判断等提供依据。

关键词：抗特异性肌炎谱抗体皮肌炎阳性率

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正交试验优化黄芪消渴汤水提工艺

今日药学 2017年第9期27卷 616-619页

作者：曹丽萍梁奇李曙光谢月张子龙冯晓婷深圳市宝安区中医院广东深圳518133 深圳市中医院广东深圳518033

目的研究黄芪消渴汤的最佳提取工艺。方法采用正交试验设计,以黄芪甲苷含量及干膏量为指标,考察水的用量、煎煮时间及煎煮次数3个因素对黄芪消渴汤提取效果的影响,优选提取工艺。结果黄芪消渴汤的最佳工艺条件为煎煮1 h,煎煮3次,加6倍... 详细信息

目的研究黄芪消渴汤的最佳提取工艺。方法采用正交试验设计,以黄芪甲苷含量及干膏量为指标,考察水的用量、煎煮时间及煎煮次数3个因素对黄芪消渴汤提取效果的影响,优选提取工艺。结果黄芪消渴汤的最佳工艺条件为煎煮1 h,煎煮3次,加6倍量水。结论该提取工艺合理可行,能较好的保证制剂质量。

关键词：黄芪消渴汤黄芪甲苷干膏量正交试验提取工艺

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin xie Yuanhui Guo Yun Chen Hao Zhang Jiawei Xiao Maoxiang Hou Huilong Liu Li Ma Xin Chen Chingping Wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang Wu Xueshun xie Pengfei Xia Jinxin Lu Jiale Liu Lei Bai Xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

Actively tunable electromagnetically induced transparency in hybrid Dirac-VO2 metamaterials

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Optoelectronics Letters 2025年第1期21卷 13-20页

作者： DI Ke xie Meng XIA Huarong CHENG Anyu LIU Yu DU Jiajia Department of Optoelectronic Engineering Chongqing University of Post and Telecommunications Chongqing Key Laboratory of Autonomous Navigation and Microsystem Chongqing University of Posts and Telecommunications Department of Automation Chongqing University of Post and Telecommunications

In this paper, we present a metamaterial structure of Dirac and vanadium dioxide（VO2） and investigate its optical properties using the finite-difference time-domain（FDTD） technique. Using the phase transition feature of VO2, the design can realize active tuning of the plasmon induced transparency（PIT） effect at terahertz frequency, thereby converting from a single PIT to a double-PIT. When VO2is in the insulating state, the structure is symmetric to obtain a single-band PIT effect. When VO2is in the metallic state, the structure turns asymmetric to realize a dual-band PIT effect. This design provides a reference direction for the design of actively tunable metamaterials. Additionally, it is discovered that the transparent window's resonant frequency and the Fermi level in this structure have a somewhat linear relationship. In addition, the structure achieves superior refractive index sensitivity in the terahertz band, surpassing 1 THz/RIU. Consequently, the design exhibits encouraging potential for application in refractive index sensors and optical switches.

关键词： Transparency

Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： Yao Yuan Lingqi Yu Xudong Zhuang Dongjing Wen Jin He Jingmei Hong Jiayu xie Shengan Ling Xiaoyue Du Wenfeng Chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

神农架林区低浓度PM2.5暴露对儿童肺功能的影响

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公共卫生与预防医学 2019年第5期30卷 54-57页

作者：范传刚王津津王婧史廷明崔秀青刘暑霞冯安慧谢曙光湖北省疾病预防控制中心卫生监测与检验防护所武汉430079 湖北省神农架林区疾病预防控制中心

目的探索低浓度细颗粒物(PM2.5)对学龄期儿童肺功能的影响。方法在2016年和2017年对神农架林区松柏镇实验小学3~5年级学生开展3次肺功能检测,同时通过调查问卷收集学生个人和家庭环境暴露信息;获取每日气象信息和距学校最近的博物馆路... 详细信息

目的探索低浓度细颗粒物(PM2.5)对学龄期儿童肺功能的影响。方法在2016年和2017年对神农架林区松柏镇实验小学3~5年级学生开展3次肺功能检测,同时通过调查问卷收集学生个人和家庭环境暴露信息;获取每日气象信息和距学校最近的博物馆路空气监测站的PM2.5暴露数据。采用线性混合模型将小学生肺功能检测结果与每日PM2.5暴露水平进行关联分析。结果2016年和2017年分别检测123名和73名小学生肺功能,其中11名小学生重复测量了2次,共计185名小学生完成了196次肺功能检测。2016年和2017年PM2.5平均浓度为38.82±21.49μg/m^3和24.94±18.68μg/m^3,2017年浓度有显著降低(P<0.05)。在模型校正个人信息等混杂因素后,发现PM2.5暴露与FVC和FEV1有显著性的滞后效应关系(P<0.05)。效应关系在lag0d(当天)最强,PM2.5浓度每上升10μg/m^3,FVC和PEV1分别下降78.7mL(95%CI:-149.9^-7.4)和117.6mL(95%CI:-198^-37.2)。PM2.5暴露与PEF和FEV1P没有显著关联。结论在低浓度暴露时,PM2.5与小学生的肺功能有显著关联,提示PM2.5浓度升高引起肺功能主要指标下降,建议加强对学龄期儿童的空气污染防护。

关键词：细颗粒物 PM2.5 神农架肺功能儿童

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血浆溶血磷脂酸与抑郁症的相关性研究

现代实用医学 2013年第4期25卷 374-375,381页

作者：李再忠胡珍玉罗贤海高树贵杨红英谢曙光宁波市康宁医院宁波315201

目的探讨血浆溶血磷脂酸浓度与抑郁症的关系。方法对对照组和抑郁症组进行基线比较;用抗抑郁药物西酞普兰片治疗抑郁症患者,同时采用抽提法测量血浆溶血磷脂酸浓度;并于治疗前后做脑诱发电位P300、抑郁量表、焦虑量表及认知量表抑郁评... 详细信息

目的探讨血浆溶血磷脂酸浓度与抑郁症的关系。方法对对照组和抑郁症组进行基线比较;用抗抑郁药物西酞普兰片治疗抑郁症患者,同时采用抽提法测量血浆溶血磷脂酸浓度;并于治疗前后做脑诱发电位P300、抑郁量表、焦虑量表及认知量表抑郁评定与临床疗效观察。结果治疗前抑郁症组抑郁量表总分和脑诱发电位P300异常率均比对照组高(均<0.01);抑郁症患者治疗4、8周后抑郁相关量表及脑诱发电位P300检查证明病情显著改善,血浆溶血磷脂酸浓度比治疗前明显降低(均<0.01)。结论血浆溶血磷脂酸浓度与抑郁症的有着密切的关系,为抑郁症的疗效监测提供理论指导。

关键词：溶血磷脂素类抑郁症药物疗法西酞普兰片