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Listeria monocytogenes following orthotopic liver transplantation:Central nervous system involvement and review of the literature

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World Journal of Gastroenterology 2007年第32期13卷 4391-4393页

作者： shugo mizuno Ivan R Zendejas Alan I Reed Robin D Kim Richard J Howard Alan W Hemming Denise C Schain Consuelo Soldevila-Pico Roberto J Firpi Shiro Fujita Division of Transplantation and Hepatobiliary Surgery Department of SurgeryUniversity of Florida College of MedicineGainesvilleFL 32610-0286United States Division of Infectious Disease Department of MedicineUniversity of Florida College of MedicineGainesvilleFL 32610-0286United States Division of Gastroenterology Department of MedicineUniversity of Florida College of MedicineGainesvilleFL 32610-0286United States

Listeria monocytogene is a well-recognized cause of bacteremia in immunocompromised individuals, including solid organ transplant recipients, but has been rarely reported following orthotopic liver transplantation. We describe a case of listeria meningitis that occurred within a week after liver transplantation. The patient developed a severe headache that mimicked tacrolimus encephalopathy, and was subsequently diagnosed with listeria meningitis by cerebrospinal fluid culture. The infection was successfully treated with three-week course of intravenous arnpicillin. Recurrent hepatitis C followed and was successfully treated with interferon alfa and ribavirin. Fourteen cases of listeriosis after orthotopic liver transplantation have been reported in the English literature. Most reported cases were successfully treated with intravenous ampicillin. There were four cases of listeria meningitis, and the mortality of them was 50%. Early detection and treatment of listeria meningitis are the key to obtaining a better prognosis.

关键词： Listeria monocytogene Meningitis Liver transplantation

A standardized technique for safe pancreaticojejunostomy:Pair-Watch suturing technique

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World Journal of Gastrointestinal Surgery 2010年第8期2卷 260-264页

作者： Yoshinori Azumi Shuji Isaji Hiroyuki Kato Yuu Nobuoka Naohisa Kuriyama Masashi Kishiwada Takashi Hamada shugo mizuno Masanobu Usui Hiroyuki Sakurai Masami Tabata Department of Hepatobiliary Pancreatic and Transplant Surgery Mie University Graduate School of Medicine

AIM:To prevent pancreatic leakage after pancreaticoje-junostomy,we designed a new standardized technique that we term the "Pair-Watch suturing technique".METHODS:Before anastomosis,we imagine the faces of a pair of watches on the jejunal hole and pancreatic *** first stitch was put between 9 o'clock of the pancreatic side and 3 o'clock of the jejunal side,and a total of 7 stitches were put on the posterior wall,followed by the 5 stitches on the anterior *** this technique,twelve stitches can be sutured on the first layer anastomosis regardless of the caliber of the pancreatic *** all cases the amylase activity of the drain were measured.A postoperative pancreatic fistula was diagnosed using postoperative pancreatic fistula ***:From March 2007 to July 2008,29 consecutive cases underwent pancreaticojejunostomy using this *** examination results showed pancreatic carcinoma(n=14),intraductal papillary-mucinous neoplasm(n=10),intraductal papillary-mucinous carcinoma(n=1),carcinoma of ampulla of Vater(n=1),carcinoma of extrahepatic bile duct(n=1),metastasis of renal cell carcinoma(n=1),and duodenal carcinoma(n=1).Pancreaticojejunal anastomoses using this technique were all watertight during the surgical *** mean diameter of main pancreatic duct was 3.4 mm(range 2-7 mm).Three patients were recognized as having an amylase level greater than 3 times the serum amylase level,but all of them were diagnosed as grade A postoperative pancreatic fistula grading and required no *** of the cases developed complications such as hemorrhage,abdominal abscess,and pulmonary *** was no postoperative ***:Our technique is less complicated than other methods and very secure,providing reliable anastomosis for any size of pancreatic duct.

关键词： Pancreaticoduodenectomy Pancreaticoje-junostomy Suturing technique

Activation of Trifluoromethylthio Moiety by Appending Iodonium Ylide under Copper Catalysis for Electrophilic Trifluoromethylation Reaction

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Chinese Journal of Chemistry 2016年第5期34卷 485-489页

作者： Ibrayim Saidalimu shugo Suzuki Etsuko Tokunaga Norio Shibata Department of Frontier Materials Nagoya Institute of Technology Gokiso Showa-ku Nagoya 466-8555 Japan Department of Nanopharmaceutical Sciences Nagoya Institute oF Technology Gokiso Showa-ku Nagoya 466-8555 Japan

A novel iodonium-ylide compound 2 that appends a trifluoromethylthio （SCF3） group is disclosed as a new, shelf-stable electrophilic trifluoromethylation reagent. Unlike known shelf-stable electrophilic trifluoromethylation reagents, 2 has a stable SCF3 group which is activated by appending iodonium ylide under copper catalysis via sul- fonium ylide to generate a cationic trifluoromethyl （CF3） species. Reagent 2 was found to be an efficient electro- philic trifluoromethylation reagent for a wide range of silyl enol ethers 3 under copper catalysis. Cyclic and acyclic a-trifiuoromethyl ketones 4 were obtained by reagent 2 in moderate to good yields. On the other hand, a difluoro- methylthio analogue 5 did not affect intermolecular transfer difluoromethylation to substrates. Instead, intramolecu- lar 1,4-migration proceeded similar to the Stevens rearrangement to provide 6 in 21% yield, independent of the presence of nucleophiles 3.

关键词： trifluoromethylation difluoromethylation iodine sulfur ylide

The Pre-rRNA Processing Complex in Arabidopsis Includes Two WD40-Domain-Containing Proteins Encoded by Glucose-Inducible Genes and Plant-Specific Proteins

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Molecular Plant 2016年第2期9卷 312-315页

作者： Tetsuya Ishida shugo Maekawa Shuichi Yanagisawa Laboratory of Plant Functional Biotechnology Biotechnology Research Center The University of Tokyo Yayoi 1-1-1 Bunkyo-ku Tokyo 113-8657 Japan

Dear Editor,In plants, sugars not only serve as energy and metabolic resources but they also exhibit hormone-like activity. Sugars modulate several fundamental processes throughout a plant＇s life cycle, including embryogenesis, germination, vegetative growth, development, reproduction, and senescence （Eveland and Jackson, 2012; Lastdrager et al., 2014; Ruan, 2014）. Previous studies have revealed that various pathways and molecular mechanisms are involved in plant sugar responses,

关键词： glucose component embryo

Omics in marine biotechnology

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Chinese Science Bulletin 2012年第25期57卷 3251-3252页

作者： Qin Song WATABE shugo Lin HanZhi Yantai Institute of Coastal Zone Research Chinese Academy of SciencesYantai 264003China Department of Aquatic Bioscience Graduate School of Agricultural and Life SciencesThe University of TokyoBunkyo-kuTokyo 113-8657Japan Kitasato University School of Marine Biosciences Minami-kuSagamiharaKanagawa 252-0373Japan Key Laboratory of Experimental Marine Biology Institute of OceanologyChinese Academy of SciencesQingdao 266071China

Marine biotechnology emerged in the 1980s, and since then it has been gradually gaining momentum to meet growing demands that cannot be satisfied by terrestrial sources alone.

关键词：海洋生物技术生物多样性可持续发展年代陆源

Experimental investigation of the degradation mechanism of silicone rubber exposed to heat and gamma rays

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High Voltage 2017年第2期2卷 92-101页

作者： shugo Hanada Maki Miyamoto Naoshi Hirai Liuqing Yang Yoshimichi Ohki Department of Electrical Engineering and Bioscience Waseda University3-4-1 OhkuboShinjuku-kuTokyoJapan Research Institute for Materials Science and Technology Waseda University2-8-26 Nishi-WasedaShinjuku-kuTokyoJapan State Key Laboratory for Electrical Insulation and Power Equipment Xi'an Jiaotong UniversityXi'anPeople's Republic of China Cooperative Major in Nuclear Energy Waseda University3-4-1 OhkuboShinjuku-kuTokyoJapan

Cable-grade silicone rubber was aged thermally or by combining heat and gamma-ray radiation,and resultant changes in chemical,thermal,mechanical and electrical properties were *** experimental results obtained in these analyses are clearly consistent with the mechanism that silicone rubber is degraded by forming cross-linked structures via formation of abundant siloxane *** further progress of degradation,decomposition becomes *** these mechanisms,mechanical properties deteriorate dramatically by losing *** the real and imaginary parts of complex permittivity decrease,which is a contrastive difference from typical ageing behaviour of organic insulating *** addition,both the elongation at break and indenter modulus are good indicators of degradation of silicone rubber.

关键词： rubber mechanism modulus

Spinous process plate fixation for cervical spinal fusion after spinal trauma:two case reports

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第9期14卷 855-858页

作者： Hiroki HIRABAYASHI Jun TAKAHASHI Hiroyuki HASHIDATE Nobuhide OGIHARA Keijiro MUKAIYAMA shugo KURAISHI Masayuki SHIMIZU Hiroyuki NAKAGAWA Renzo MATSUE Hiroyuki KATO Department of Orthopedic Surgery Shinshu University School of Medicine

Posterior cervical fixation with various forms of instrumentation has been used for reconstruction in cases of traumatic disorders and degenerative or tumor-related dysfunction of the cervical spine. Recently, posterior plate and rod techniques using lateral mass screws or pedicle screws have been reported to show excellent fusion rates (Xu et al.,2010).

关键词：病例报告脊柱融合脊髓损伤颈椎椎弓根螺钉钢板功能障碍外伤性

Availability of Myoglobin as a Molecular Marker for Phylogenetic Relationships of Fish

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Journal of Agricultural Science and Technology(B) 2018年第2期8卷 131-143页

作者： Ming-Chih Huang Yoshihiro Ochiai shugo Watabe Department of Biological Sciences and Technology National University of Tainan 33 Sec.2 Shu-Lin St.Tainan 700-05 Taiwan R.O.C. Graduate School of Agricultural Science Tohoku University Aramaki Aoba-ku Sendai Miyagi 980-0845 Japan School of Marine Biosciences Kitasato University Minami-ku Sagamihara Kanagawa 252-0373 Japan

In order to elucidate the phylogenetic relationship of fish, DNA and deduced amino acid sequences of myoglobin （Mb） were used for the phylogenetic analyses based on different approaches, namely, maximum likelihood （ML）, neighbor joining （NJ）, unweighted pair group method with arithmetic means （UPGMA） and maximum parsimony （MP） methods in comparison with the conventional molecular markers, mitochondrial cytochrome b （cyt-b） and cytochrome c oxidase subunit I （COI）. The phylogenetic trees drawn based on Mb sequences were similar to those by the traditional classification based on the other molecular markers. The primary and secondary structures, as well as the modeled tertiary structures of Mbs were similar to each other, but were clearly distinguishable among those species. Such differences in structure would be associated with adaptation of Mb molecule to the physiological conditions of each species. These results suggest that Mb can be a molecular marker for the phylogenetic relationship of fish.

关键词： Myoglobin mitochondrial cytochrome b (cyt-b) cytochrome c oxidase subunit I (COI) phylogeny.

Efficacy and adverse events of cold vs hot polypectomy: A meta-analysis

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World Journal of Gastroenterology 2016年第23期22卷 5436-5444页

作者： Mikihiro Fujiya Hiroki Sato Nobuhiro Ueno Aki Sakatani Kazuyuki Tanaka Tatsuya Dokoshi shugo Fujibayashi Yoshiki Nomura Shin Kashima Takuma Gotoh Junpei Sasajima Kentaro Moriichi Jiro Watari Yutaka Kohgo Division of Gastroenterology and Hematological Oncology Department of MedicineAsahikawa Medical University Hyogo College of Medicine Division of GastroenteroelogyDepartment of Internal Medicine

AIM: To compare previously reported randomized controlled studies (RCTs) of cold and hot polypectomy, we systematically reviewed and clarify the utility of cold polypectomy over hot with respect to efficacy and adverse ***: A meta-analysis was conducted to evaluate the predominance of cold and hot polypectomy for removing colon polyps. Published articles and abstracts from worldwide conferences were searched using the keywords “cold polypectomy”. RCTs that compared either or both the effects or adverse events of cold polypectomy with those of hot polypectomy were collected. The patients’ demographics, endoscopic procedures, No. of examined lesions, lesion size, macroscopic and histologic findings, rates of incomplete resection, bleeding amount, perforation, and length of procedure were extracted from each study. A forest plot analysis was used to verify the relative strength of the effects and adverse events of each procedure. A funnel plot was generated to assess the possibility of publication ***: Ultimately, six RCTs were selected. No significant differences were noted in the average lesion size (less than 10 mm) between the cold and hot polypectomy groups in each study. Further, the rates of complete resection and adverse events, including delayed bleeding, did not differ markedly between cold and hot polypectomy. The average procedural time in the cold polypectomy group was significantly shorter than in the hot polypectomy ***: Cold polypectomy is a time-saving procedure for removing small polyps with markedly similar curability and safety to hot polypectomy.

关键词： Cold polypectomy Hot polypectomy Colon adenoma Conventional polypectomy Colon neoplasm Endoscopic mucosal resection Bleeding