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Activation of Trifluoromethylthio Moiety by Appending Iodonium Ylide under Copper Catalysis for Electrophilic Trifluoromethylation Reaction

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Chinese Journal of Chemistry 2016年第5期34卷 485-489页

作者： Ibrayim Saidalimu shugo suzuki Etsuko Tokunaga Norio Shibata Department of Frontier Materials Nagoya Institute of Technology Gokiso Showa-ku Nagoya 466-8555 Japan Department of Nanopharmaceutical Sciences Nagoya Institute oF Technology Gokiso Showa-ku Nagoya 466-8555 Japan

A novel iodonium-ylide compound 2 that appends a trifluoromethylthio （SCF3） group is disclosed as a new, shelf-stable electrophilic trifluoromethylation reagent. Unlike known shelf-stable electrophilic trifluoromethylation reagents, 2 has a stable SCF3 group which is activated by appending iodonium ylide under copper catalysis via sul- fonium ylide to generate a cationic trifluoromethyl （CF3） species. Reagent 2 was found to be an efficient electro- philic trifluoromethylation reagent for a wide range of silyl enol ethers 3 under copper catalysis. Cyclic and acyclic a-trifiuoromethyl ketones 4 were obtained by reagent 2 in moderate to good yields. On the other hand, a difluoro- methylthio analogue 5 did not affect intermolecular transfer difluoromethylation to substrates. Instead, intramolecu- lar 1,4-migration proceeded similar to the Stevens rearrangement to provide 6 in 21% yield, independent of the presence of nucleophiles 3.

关键词： trifluoromethylation difluoromethylation iodine sulfur ylide

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Usefulness of Monitoring Stroke Volume Variations for Fluid Management During Pediatric Living-Donor Liver Transplantation

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Open Journal of Anesthesiology 2012年第4期2卷 146-149页

作者： Yoshihiro Kasagi Manabu Hashimoto shugo Kasuya Seisuke Sakamoto Mureo Kasahara Yasuyuki suzuki Eiichi Inada Department of Anesthesia and Intensive Care National Center for Child Health and Development Okura Setagaya-ku Tokyo Japan Department of Anesthesiology and Pain Medicine Juntendo University School of Medicine Hongo Bunkyo-ku Tokyo Japan Transplantation Surgery National Center for Child Health and Development Okura Setagaya-ku Tokyo Japan

Purpose: Central venous pressure (CVP) is considered to be unsuitable as preload parameter. Stroke volume variation (SVV) has recently been reported to be effective as a preload and fluid responsiveness parameter, and its usefulness for fluid management during living-donor liver transplantation (LDLT). However, use of SVV has not been reported in children. Our aim is to evaluate the use of SVV as a target parameter of circulating blood volume during pediatric LDLT. Methods: This retrospective study was conducted in 40 consecutive patients aged between 5 and 109 months who underwent elective LDLT. Twenty patients underwent LDLT without FloTrac? (C group) and the rest patients underwent LDLT with the FloTrac? monitoring (F group). As a fluid management target, CVP was maintained at 10 mmHg in the C group and SVV at 10% in the F group. We compared MAP and CVP at the times of the greatest decrease within 5 minutes after reperfusion. Results: MAP after reperfusion was significantly decreased in both groups (P < 0.01), with the magnitude of decrease significantly greater in the C group compared with the F group (P = 0.02). MAP before and after reperfusion did not significantly differ between the groups. After reperfusion, CVP was nearly the same in both groups, with that in the C group slightly decreased and nearly no change in the F group. SVV after reperfusion was significantly increased (P < 0.001). Conclusion: When used as a target parameter for fluid management during pediatric LDLT, hemodynamic changes was less when SVV was used as the parameter of circulating blood volume.

关键词： Pediatric Living-Donor Liver Transplantation Fluid Management Stroke Volume Variation Reperfusion

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